SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D. C. 20549





                                    FORM 8-K



              CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934



       DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED): DECEMBER 20, 2002



                              HALSEY DRUG CO., INC.



               695 NORTH PERRYVILLE ROAD, ROCKFORD, ILLINOIS 61107


                                 (815-399-2060)





                                                                
Incorporated under the laws of        Commission File Number          I.R.S. Employer Identification Number
       State of New York                    1-10113                                11-0853640
ITEM 5. OTHER EVENTS DEBENTURE OFFERING On December 20, 2002, Halsey Drug Co., Inc. (the "Company") consummated a private offering of securities for an approximate aggregate purchase price of $26,385,000 (the "Offering"). The securities issued in the Offering consisted of 5% convertible senior secured debentures (the "Debentures"). The Debentures were issued by the Company pursuant to a certain Debenture Purchase Agreement dated December 20, 2002 (the "Purchase Agreement") by and among the Company, Care Capital LLC ("Care Capital"), Essex Woodlands Health Ventures V ("Essex"), Galen Partners III, L.P. and each of the Purchasers listed on the signature page thereto (collectively, the "2002 Debenture Investor Group"). Of the $26,385,000 million in Debentures issued in the Offering, approximately $15,885,000 of Debentures were issued in exchange for the surrender of like amount of principal and accrued interest outstanding under the Company's 10% convertible promissory notes issued pursuant to various working capital bridge loan transactions with Galen Partners III, L.P., Galen Partners International III, L.P., Galen Employee Fund III, L.P. (collectively, "Galen") and certain other lenders, during the period from August 15, 2001 through and including December 20, 2002. The Debentures, issued at par, will become due and payable as to principal on March 31, 2006. Interest on the principal amount of the Debentures, at the rate of 5% per annum, is payable on a quarterly basis. With the exception of the Debentures issued to Care Capital, interest will be paid by the Company's issuance of a debenture instrument substantially identical to the Debentures issued in the Offering, in the principal amount equal to the accrued interest for each quarterly period (the "Interest Debentures"). Debentures issued to Care Capital provide that fifty percent (50%) of the interest payments under such Debentures will be satisfied in cash with the balance satisfied by the Company's issuance of Interest Debentures. The Debentures issued to each of Care Capital and Essex are convertible at any time after issuance into shares of the Company's Common Stock, $.01 per value per share (the "Common Stock"). The Debentures issued to Galen and the other investors in the Offering (excluding Care Capital and Essex) are convertible at any time after the approval of the Company's shareholders and debentureholders of an amendment to the Company's Certificate of Incorporation to increase its authorized shares of Common Stock from 80,000,000 shares to such number of shares as shall provide sufficient authorized shares to permit the conversion of such Debentures and Company's outstanding convertible securities, as provided in the Purchase Agreement (see "Voting Agreement" below). Subject to the foregoing, the Debentures are convertible into shares of Common Stock at a price per share (the "Conversion Price") of $ .34. Until such time as the Company competes a Subsequent Material Offering (as defined below) the Conversion Price is subject to adjustment, from time to time, to equal the consideration per share received by the Company for its Common Stock, or the conversion/exercise price per share of the Company's Common Stock issuable under rights or options for the purchase of, or stock or other securities convertible into, Common Stock 2 ("Convertible Securities"), if lower than the then applicable Conversion Price. Following the Company's completion of a Subsequent Material Offering, the Conversion Price is subject to adjustment from time to time on a weighted-average dilution basis. A "Subsequent Material Offering" is the grant or issuance of Common Stock or Convertible Securities by the Company during any six month period for an aggregate gross consideration of at least $10,000,000. The Conversion Price is also subject to adjustment to give effect to additional Debentures, if any, that may be issued under the Purchase Agreement and in the event of a subsequent recapitalization of the Company's outstanding common stock purchase warrants issued to Galen in consideration for various bridge loans to the Company. The Interest Debentures are convertible at any time after issuance into shares of Common Stock at a price per share equal to the average of the closing bid and asked prices of the Common Stock for the twenty (20) trading days immediately preceding the applicable interest payment date under the Debentures, as reported by the Over-the-Counter ("OTC") Bulletin Board. Assuming the conversion of the Debentures at the initial Conversion Price of $ .34 per share, the Debentures are convertible into an aggregate of approximately 77,602,000 shares of the Company's Common Stock. The Purchase Agreement provides that the holders of the Debentures shall have the right to vote as part of a single class with all holders of the Company's Common Stock on all matters to be voted on by such stockholders. Each Debenture holder shall have such number of votes as shall equal the number of votes he would have had if such holder converted the entire outstanding principal amount of his Debenture into shares of Common Stock immediately prior to the record date relating to such vote; provided, however, that any Debentures held by Care Capital shall, for so long as they are held by Care Capital, have no voting rights. The Purchase Agreement also provided for the execution of a Debentureholder Agreement providing the holders of the Debentures with veto rights relating to certain material Company transactions as further described under the caption "Debentureholders Agreement" below. The Purchase Agreement provides that each of Care Capital and Essex has the right to designate for nomination a person to be a member of the Company's Board of Directors as of the closing date of the Offering (collectively, the Designees"). The Purchase Agreement further provides that the Designees shall be, if so requested by such Designee in its sole discretion, appointed to the Company's Executive Committee, Compensation Committee and any other Committee of the Board of Directors. Accordingly, effective as of the closing of the Purchase Agreement, the Board of Directors appointed each of Jerry Karabelas and Immanuel Thangaraj to the Company's Board of Directors. The Company has agreed to nominate and appoint to the Board of Directors, subject to shareholder approval, one designee of each of Care Capital and Essex for so long as each holds the Debentures. 3 The Company is a party to a certain Loan Agreement with Watson Pharmaceuticals, Inc. ("Watson") pursuant to which Watson has made a term loan to the Company in the principal amount of $17,500,000 (the "Watson Loan Agreement"). It was a condition to the completion of the Offering that the Watson Loan Agreement and related agreements with Watson be amended. See "Watson Loan Agreement Amendments" below for a description of the amendments to the Watson Loan Agreement. As part of the closing of the Purchase Agreement, the Company and certain holders of common stock purchase warrants issued in prior Company debenture offerings in 1998 and 1999 and pursuant to bridge loan transactions during the period 1998 through 2002, executed a certain Warrant Recapitalization Agreement providing for the recapitalization of approximately 8,145,736 warrants in exchange for the issuance of an aggregate of 5,970,083 shares of the Company's Common Stock (see "Warrant Recapitalization" below). Additional Terms of the Purchase Agreement, Debentures and Warrants Debentureholders Agreement As part of the closing of the Purchase Agreement, the Company and the purchasers of the Debentures executed a certain Debentureholders Agreement providing, among other things, that the approval of the holders of at least sixty six and two-thirds percent (66 2/3%) of the aggregate principal amount of the Debentures is required to authorize (a) any modification of the rights of the holders of the Debentures, (b) any issuance of securities of the Company which rank senior or pari passu to the Debentures, (c) any dividends or distributions on, or redemption of, any securities ranking junior in priority to the Debentures, other than dividends or distributions payable in the Company's Common Stock or cash interest paid to individual investors in the Company's 5% convertible senior secured debentures issued pursuant to that certain Debenture and Warrant Purchase Agreement (the "1998 Purchase Agreement") between the Company, Galen Partners III, L.P. and the other signatories thereto, dated March 10, 1998 (the "Galen Group Debentures") and issued pursuant to the Debenture and Warrant Purchase Agreement (the "1999 Purchase Agreement") between the Company, Oracle Strategic Partners, L.P. and the other signatories thereto, dated May 26, 1999 (the "Oracle Group Debentures" and together with the Galen Group Debentures, the "Existing Debentures"), (d) the merger or consolidation of the Company, the sale, transfer, lease or other disposition of all or substantially all of the Company's consolidated assets, or the liquidation, recapitalization or reorganization of the Company, other than any such transaction where the cash, securities and/or other liquid consideration received for the voting stock of the Company in such transaction is at least four (4) times the then applicable conversion price of the Debentures, (e) any increase in the number of members comprising the Company's Board of Directors above eleven (11) members, and (f) the consummation of a strategic alliance, business combination, licensing arrangement or other corporate partnering involving the issuance by the Company of in excess of $10,000,000 in equity securities of the Company. 4 The Debentureholders Agreement further provides that the holders of at least sixty six and two-thirds percent (66 2/3%) of the aggregate principal amount of the Debentures and Existing Debentures is required in order to authorize (a) any amendment to the Company's Certificate of Incorporation, (b) dividends or distributions on, or redemptions of, any securities ranking junior to the Existing Debentures, other than distributions or dividends payable in the Company's capital stock or cash interest paid to individual investors in the Existing Debentures, (c) any issuance of the Company's securities ranking senior or pari passu to the Existing Debentures, and (d) the completion of any transaction described in subsections (d), (e) and (f) in the preceding paragraph. Voting Agreement The Company is obligated under the Purchase Agreement to solicit shareholder approval to amend its Certificate of Incorporation to (i) provide the holders of the Debentures with "as converted" voting rights; and (ii) to increase its authorized shares of Common Stock from 80,000,000 to such number of shares as shall provide sufficient authorized shares to permit the conversion of the Debentures and the exercise and conversion of the Company's outstanding convertible securities, including the Watson Warrant (as defined under the caption "Watson Loan Agreement Amendments" below)(the "Charter Amendments"). The Company anticipates soliciting shareholder approval for the Charter Amendments at its upcoming 2003 Annual Meeting of Shareholders. In this regard, as part of the closing of the Purchase Agreement, each of Galen Partners III, L.P., Galen Partners International III, L.P., Galen Employee Fund III, L.P., Oracle Strategic Partners, L.P., Michael Reicher, the Company's Chief Executive Officer and Peter Clemens, the Company's Chief Financial Officer (collectively, the "Voting Agreement Parties") executed a Voting Agreement dated December 20, 2002 pursuant to which each agreed to vote all of their respective voting securities of the Company in favor of the Charter Amendments. The voting securities held by the Voting Agreement Parties represents an aggregate of approximately 64% of the voting rights under the Company's outstanding voting securities. Right of First Refusal The Purchase Agreement provides the holders of the Debentures and the holders of shares of Common Stock issued upon conversion of the Debentures (provided the Debentures remain outstanding and the shares received upon conversion have not been sold, transferred or otherwise disposed of) as well as the holders of the Galen Group Debentures with a right of first refusal relating to any subsequent issuance, sale or exchange of any shares of the Company's Common Stock or convertible securities, exclusive of certain excluded securities and offerings in an amount less than $200,000. 5 Secured Debt The Debentures are secured by a lien on all assets of the Company, tangible and intangible. In addition, each of Houba, Inc. and Halsey Pharmaceuticals, Inc., each a wholly-owned subsidiary of the Company, has executed in favor of the 2002 Debenture Investor Group an Unconditional Agreement of Guaranty of the Company's obligations under the Purchase Agreement. Each Guaranty is secured by all assets of such subsidiary, and, in the case of Houba, Inc., by a mortgage lien on its real estate. In addition, the Company has pledged the stock of each such subsidiary to the 2002 Debenture Investor Group to further secure its obligations under the Purchase Agreement. In accordance with the terms of a Subordination Agreement dated December 20, 2002 between the Company, the holders of the Debentures, the holders of the Existing Debentures and Watson, the liens on the Company's and its Subsidiaries' assets as well as the payment priority of the Debentures are (i) subordinate to the Company's lien and payment obligations in favor of Watson under the Watson Loan Agreement, and (ii) senior to the Company's lien and payment obligations in favor of the holders of the Existing Debentures in the aggregate principal amount of approximately $50,723,938. In addition to the subordination of the liens and the payment priority of the Existing Debentures in favor of the Debentures issued in the Offering, as part of the completion of the Offering, each of the holders of the Galen Group Debentures and the Oracle Group Debentures agreed to extend the maturity date of the Existing Debentures from March 15, 2003 to March 31, 2006. Conversion of Debentures at Company's Option Provided that no event of default relating to a failure to pay principal and interest under the Debentures shall exist and then be continuing, in the event that following December 20, 2005, (i) the average of the closing bid and asked prices per share of the Company's Common Stock, as reported by the OTC Bulletin Board (or the closing price per share as reported by the NASDAQ National Market or any Exchange on which the shares may then be traded) exceeds the product of (x) the then applicable Conversion Price of the Debentures, multiplied by (y) four (4), for each of the twenty (20) consecutive trading days during which the average daily trading volume for such twenty (20) trading day period is at least one million dollars ($1,000,000), or (ii) the Company shall have obtained the written consent of the holders of 75% of the principal amount of the Debentures then outstanding to convert the Debentures into Common Stock, then the Company may upon written notice to the holders of the Debentures require that all, but not less than all, of the outstanding principal amount of the Debentures be converted into shares of the Company's Common Stock at a price per share equal to the Conversion Price of the Debentures (as such Conversion Price may be adjusted pursuant to the terms of the Purchase Agreement). 6 Registration Rights As part of the closing of the Purchase Agreement, the Company executed in favor of the holders of the Debentures, the holders of the Existing Debentures, the holders of shares received in the Warrant Recapitalization Agreement (as described below under the caption "Warrant Recapitalization") and Watson, a Registration Rights Agreement providing for (i) the termination of the registration rights granted to the holders of the Existing Debentures under the 1998 Purchase Agreement and the 1999 Purchase Agreement, (ii) the termination of the registration rights granted to Galen relating to the common stock purchase warrants issued to Galen in consideration for various bridge loans to the Company (the "Galen Warrants"), and (iii) the grant of registration rights to Watson, the holders of the Debentures, the holders of the Existing Debentures, the holders of shares of common stock received pursuant to the Warrant Recapitalization Agreement (the "Warrant Recap Shares"), and Galen as holder of the Galen Warrants, to register under the Securities Act of 1933, as amended, the Warrant Recap Shares, the shares issuable on exercise of the Watson Warrant and the Galen Warrants, and the shares issuable on conversion of the Debentures and the Existing Debentures (collectively, the "Registrable Securities"). The Registration Rights Agreement provides each of Galen and Watson with two (2) demand registrations on Form S-1 (or any successor form) and the holders of 20% of the Registrable Securities with one (1) demand registration on Form S-1 (or any successor form). The Registration Rights Agreement also provides such parties with unlimited piggyback registration rights. Other Terms The Purchase Agreement contains other customary terms and provisions, including, without limitation, customary representations and warranties, affirmative covenants, negative covenants and requirements for the provision of certain financial information during the term that the Debentures remain outstanding, all of which are customary for the type of securities issued in the Offering. Reference is made to the Company's Press Release dated December 20, 2002 which describes, among other things, the completion of the Offering. The Press Release is hereby incorporated by this reference and is included as Exhibit 99.1 hereto. WATSON LOAN AGREEMENT AMENDMENTS As part of the closing of the Offering, the Watson Loan Agreement was amended to (i) extend the maturity date of the Watson Loan Agreement from March 31, 2003 to March 31, 2006, and (ii) increase the principal amount of the Watson Term Loan from $17,500,000 to $21,401,331 to reflect the inclusion of approximately $3,901,331 owed by the Company to Watson under a product supply agreement between the parties. In consideration for the amendment to the Watson Loan Agreement, the Company issued to Watson a Common Stock Purchase Warrant exercisable for 10,700,665 shares of the Company's 7 Common Stock (the "Watson Warrant"). The Watson Warrant has a term expiring December 31, 2009 and has an exercise price of $ .34 per share. Watson is also a party to the Registration Rights Agreement described above under the caption "Registration Rights". WARRANT RECAPITALIZATION As part of the completion of the transactions contemplated in the Purchase Agreement, the Company consummated the terms of a Warrant Recapitalization Agreement dated December 20, 2002 (the "Recapitalization Agreement") between the Company and certain holders of an aggregate of 8,145,736 Common Stock Purchase Warrants issued by the Company (i) pursuant to that certain Debenture and Warrant Purchase Agreement dated March 10, 1998 between the Company and the purchasers listed on the signature page thereto (the "1998 Warrant"), (ii) pursuant to that certain Debenture and Warrant Purchase Agreement dated May 26, 1999 between the Company and the purchasers listed on the signature page thereto (the "1999 Warrant"), and (iii) pursuant to various bridge loan transactions during the period from 1998 through 2002 (the "Bridge Loan Warrants" and collectively with the 1998 Warrants and 1999 Warrants, the "Recapitalization Warrants"). As part of the closing of the Recapitalization Agreement, the warrantholders as a party thereto surrendered to the Company for cancellation the Recapitalization Warrants in exchange for the issuance of an aggregate of 5,970,083 shares of Common Stock. ITEM 7. FINANCIAL STATEMENTS AND EXHIBITS. (b) EXHIBITS EXHIBIT NUMBER DESCRIPTION - ------ ----------- 4.1 Form of 5% Convertible Senior Secured Debenture. 10.1 Debenture and Warrant Purchase Agreement by and among Halsey Drug Co., Inc., Care Capital LLC, Essex Woodlands Health Ventures V and the other Purchasers listed on the signature page thereto. 10.2 Form of General Security Agreement of Halsey Drug Co., Inc. 10.3 Form of Agreement of Guaranty of Subsidiaries of Halsey Drug Co., Inc. 10.4 Form of Guarantor General Security Agreement. 10.5 Stock Pledge Agreement by and between Halsey Drug Co., Inc. and Care Capital LLC, as agent. 8 10.6 Voting Agreement. 10.7 Debentureholders Agreement. 10.8 Amendment to Debenture and Warrant Purchase Agreement between Halsey Drug Co., Inc., Galen Partners III, L.P. and other signatories thereto, amending the Debenture and Warrant Purchase Agreement dated March 10, 1998 between the Company, Galen Partners III, L.P. and the other signatories thereto. 10.9 Amendment to Debenture and Warrant Purchase Agreement between Halsey Drug Co., Inc., Oracle Strategic Partners, L.P. and the other signatories thereto, amending the Debenture and Warrant Purchase Agreement dated May 26, 1999 between the Company, Oracle Strategic Partners, L.P. and the other signatories thereto. 10.10 Amended and Restated 5% Convertible Senior Secured Debenture due March 31, 2006. 10.11 Second Amendment to Loan Agreement between Halsey Drug Co., Inc. and Watson Pharmaceuticals, Inc., amending the Loan Agreement dated March 29, 2000 between Halsey Drug Co., Inc. and Watson Pharmaceuticals, Inc. 10.12 Secured Promissory Note issued by Halsey Drug Co., Inc. in favor of Watson Pharmaceuticals, Inc. in the principal amount $17,500,000. 10.13 Secured Promissory Note issued by Halsey Drug Co., Inc. in favor of Watson Pharmaceuticals, Inc. in the principal amount of $3,901,331. 10.14 Second Amendment to Finished Goods Supply Agreement (Core Products) between Halsey Drug Co., Inc. and Watson Pharmaceuticals, Inc. amending the Finished Goods Supply Agreement (Core Products) dated March 29, 2000. 10.15 Watson Common Stock Purchase Warrant. 10.16 Registration Rights Agreement. 10.17 Warrant Recapitalization Agreement. 99.1 Press Release of Halsey Drug Co., Inc. dated December 23, 2002. 9 SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized. HALSEY DRUG CO., INC. By: /s/ Peter A. Clemens --------------------------------------- Peter A. Clemens Vice President & Chief Financial Officer Date: December 27, 2002 10 EXHIBIT INDEX EXHIBIT NUMBER DESCRIPTION - ------ ----------- 4.1 Form of 5% Convertible Senior Secured Debenture. 10.1 Debenture and Warrant Purchase Agreement, by and among Halsey Drug Co., Inc., Care Capital LLC, Essex Woodlands Health Ventures V and the other Purchasers listed on the signature page thereto. 10.2 Form of General Security Agreement of Halsey Drug Co., Inc. 10.3 Form of Agreement of Guaranty of Subsidiaries of Halsey Drug Co., Inc. 10.4 Form of Guarantor General Security Agreement. 10.5 Stock Pledge Agreement by and between Halsey Drug Co., Inc. and Care Capital LLC, as agent. 10.6 Voting Agreement. 10.7 Debentureholders Agreement. 10.8 Amendment to Debenture and Warrant Purchase Agreement between Halsey Drug Co., Inc., Galen Partners III, L.P. and other signatories thereto, amending the Debenture and Warrant Purchase Agreement dated March 10, 1998 between the Company, Galen Partners III, L.P. and the other signatories thereto. 10.9 Amendment to Debenture and Warrant Purchase Agreement between Halsey Drug Co., Inc., Oracle Strategic Partners, L.P. and the other signatories thereto, amending the Debenture and Warrant Purchase Agreement dated May 26, 1999 between the Company, Oracle Strategic Partners, L.P. and the other signatories thereto. 10.10 Amended and Restated 5% Convertible Senior Secured Debenture due March 31, 2006. 11 10.11 Second Amendment to Loan Agreement between Halsey Drug Co., Inc. and Watson Pharmaceuticals, Inc., amending the Loan Agreement dated March 29, 2000 between Halsey Drug Co., Inc. and Watson Pharmaceuticals, Inc. 10.12 Secured Promissory Note issued by Halsey Drug Co., Inc. in favor of Watson Pharmaceuticals, Inc. in the principal amount $17,500,000. 10.13 Secured Promissory Note issued by Halsey Drug Co., Inc. in favor of Watson Pharmaceuticals, Inc. in the principal amount of $3,901,331. 10.14 Second Amendment to Finished Goods Supply Agreement (Core Products) between Halsey Drug Co., Inc. and Watson Pharmaceuticals, Inc. amending the Finished Goods Supply Agreement (Core Products) dated March 29, 2000. 10.15 Watson Common Stock Purchase Warrant. 10.16 Registration Rights Agreement. 10.17 Warrant Recapitalization Agreement. 99.1 Press Release of Halsey Drug Co., Inc. dated December 23, 2002. 12


                                                                     EXHIBIT 4.1

THIS CONVERTIBLE SENIOR SECURED DEBENTURE AND THE COMMON STOCK ISSUABLE UPON
CONVERSION HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED (THE "ACT") NOR UNDER ANY STATE SECURITIES LAW AND MAY NOT BE PLEDGED,
SOLD, ASSIGNED, HYPOTHECATED OR OTHERWISE TRANSFERRED UNTIL (1) A REGISTRATION
STATEMENT WITH RESPECT THERETO IS EFFECTIVE UNDER THE ACT AND ANY APPLICABLE
STATE SECURITIES LAW OR (2) THE COMPANY RECEIVES AN OPINION OF COUNSEL TO THE
COMPANY OR OTHER COUNSEL TO THE HOLDER OF SUCH DEBENTURE REASONABLY SATISFACTORY
TO THE COMPANY THAT SUCH DEBENTURE AND/OR COMMON STOCK MAY BE PLEDGED, SOLD,
ASSIGNED, HYPOTHECATED OR TRANSFERRED WITHOUT AN EFFECTIVE REGISTRATION
STATEMENT UNDER THE ACT OR APPLICABLE STATE SECURITIES LAWS.

                              HALSEY DRUG CO., INC.
                     5% CONVERTIBLE SENIOR SECURED DEBENTURE
                               DUE MARCH 31, 2006

$______________                                                         No. N-__
December 20, 2002

         HALSEY DRUG CO., INC., a corporation organized under the laws of the
State of New York (the "Company"), for value received, hereby promises to pay to
_______________, or registered assigns (the "Payee" or "Holder"), upon due
presentation and surrender of this Debenture, on March 31, 2006 (the "Maturity
Date"), the principal amount of _____________ ($_________) and accrued interest
thereon as hereinafter provided.

         This Debenture was issued by the Company pursuant to a certain
Debenture Purchase Agreement dated as of December __, 2002 among the Company and
certain purchasers identified therein, including the Payee (together with the
Schedules and Exhibits thereto, the "Purchase Agreement") relating to the
purchase and sale of 5% Convertible Senior Secured Debentures due March 31, 2006
(together with the Interest Payment Debentures referred to below) (the
"Debentures") in the aggregate principal amount of $_____________. The holders
from time to time of the Debentures (including the Holder) are referred to
hereinafter as the "Holders". The Holder is entitled to the benefits of the
Purchase Agreement, including, without limitation, the rights upon the
occurrence and during the continuance of an Event of Default and the benefits of
security interests and guaranties referred to below. Reference is made to the
Purchase Agreement and the documents entered into pursuant thereto with respect
to certain additional rights of the Holder and obligations of the Company and
its Subsidiaries not expressly set forth herein. Capitalized terms used herein
but not otherwise defined herein shall have the meaning ascribed thereto in the
Purchase Agreement. All such rights and obligations set forth in the Purchase
Agreement are incorporated herein by reference.






                                   ARTICLE I

              PAYMENT OF PRINCIPAL AND INTEREST; METHOD OF PAYMENT

         1.1. Payment of the principal on this Debenture shall be made in cash,
in immediately available funds, such coin or currency of the United States of
America as at the time of payment shall be legal tender for the payment of
public and private debts. Interest (computed on the basis of a 360-day year of
twelve 30-day months) shall accrue on the unpaid portion of said principal
amount from time to time outstanding at the rate of five percent (5%) per annum
(the "Stated Interest Rate"), and shall be paid by the Company to the Payee at
three (3) month intervals, on each January 1, April 1, July 1 and October 1
during the term of this Debenture, commencing January 1, 2003, and on the
Maturity Date (each such date being an "Interest Payment Date") and on the dates
specified therefor in Article III hereof. The payment of accrued interest on
this Debenture shall be made in the form of 5% convertible senior secured
debentures (each, an "Interest Payment Debenture") identical in all respects to
this Debenture; provided, however, that (i) the principal amount of such
Interest Payment Debenture upon issuance shall be the accrued and unpaid
interest for the immediately preceding calendar quarter, (ii) the date of such
Interest Payment Debenture shall be its issue date, and (iii) the Conversion
Price (as defined in Section 3.1(a) hereof) of such debenture shall equal the
average of the closing bid and asked prices for the Company's Common Stock as
reported in the Over-the-Counter Bulletin Board ("OTC Bulletin Board")(or such
other over-the-counter market or exchange on which the Company's Common Stock
may then be traded or admitted for trading) for the twenty (20) trading days
immediately preceding the date of such interest payment. No cash interest
payments will be made on this Debenture, except on the Maturity Date pursuant to
the terms of the Interest Rate Debentures. Both principal hereof and interest
hereon are payable at the Holder's address above or such other address as the
Holder shall designate from time to time by written notice to the Company. The
Company will pay or cause to be paid all sums becoming due hereon for principal
by check or wire transfer, at the Holder's election, and interest in the form of
an Interest Payment Debenture, sent to the Holder's above address or to such
other address as the Holder may designate for such purpose from time to time by
written notice to the Company, without any requirement for the presentation of
this Debenture or making any notation thereon, except that the Holder hereof
agrees that payment of the final amount due shall be made only upon surrender of
this Debenture to the Company for cancellation. Prior to any sale or other
disposition of this instrument, the Holder hereof agrees to endorse hereon the
amount of principal paid hereon and the last date to which interest has been
paid hereon and to notify the Company of the name and address of the transferee.


         1.2. In the event any payment of principal or, (except to the extent
otherwise specified herein) interest or both shall remain unpaid for a period of
two (2) business days or more, a late charge equivalent to five (5%) percent of
each installment shall be charged and may be satisfied by the Company's issuance
of an Interest Payment Debenture having a principal amount which includes such
late charge. Interest on the indebtedness evidenced by this Debenture after
default or maturity accelerated shall be due and payable at the rate of seven
(7%) percent per annum, subject to the limitations of applicable law.





                                       2




         1.3.If this Debenture or any installment hereof becomes due and payable
on a Saturday, Sunday or public holiday under the laws of the State of New York,
the due date hereof shall be extended to the next succeeding full business day
and interest shall be payable at the rate of five (5%) percent per annum during
such extension. All payments received by the Holder shall be applied first to
the payment of all accrued interest payable hereunder.

                                   ARTICLE II

                             SECURITY/SUBORDINATION

         2.1. The obligations of the Company under this Debenture are secured
pursuant to security interests on and collateral assignments of, assets,
tangible and intangible, of the Company granted by the Company to the Holder and
the other Holders pursuant to a General Security Agreement dated as of December
__, 2002, and the collateral assignments referred to in the Purchase Agreement.
In addition, each of Houba, Inc. ("Houba") and Halsey Pharmaceuticals, Inc.,
each a wholly owned subsidiary of the Company (individually a "Guarantor" and
collectively, the "Guarantors"), has executed and delivered in favor of the
Holder and the other Holders a Continuing Unconditional Guaranty, dated an even
date herewith (each a "Guarantee"), guaranteeing the full and unconditional
payment when due of the amounts payable by the Company to the Holder and the
other Holders pursuant to the terms of their respective Debentures. The
obligations of each Guarantor under its Guaranty are secured (subject to the
Subordination Agreement) pursuant to security interests on and collateral
assignments of, assets, tangible and intangible, of such Guarantor granted by
the Guarantor to the Holder and the other Holders pursuant to a security
agreement dated as of December __, 2002, and the collateral assignments referred
to in the Purchase Agreement. The obligations of Houba under its Guaranty are
also secured (subject to the Subordination Agreement) pursuant to a mortgage on
real property located at 16235 State Road 17, Culver, Indiana. The rights of the
Holders with respect to the collateral described in the security agreements and
collateral assignments with the Company and the Guarantors as provided in the
Purchase Agreement are subject to the terms of the Subordination Agreement dated
of even date herewith by and among the Company, Watson Pharmaceuticals, Inc.,
the Holders and the other signatories thereto.

                                  ARTICLE III

                                   CONVERSION

         3.1. Conversion at Option of Holder. At any time after the Shareholders
Meeting Date,(the "Initial Conversion Date") until the earlier of (a) the
Maturity Date or (b) the conversion of the Debenture in accordance with Section
3.2 hereof, this Debenture is convertible in whole or in part at the Holder's
option into shares of Common Stock of the Company upon surrender of this
Debenture, at the office of the Company, accompanied by a written notice of
conversion in the form of Attachment II hereto, or otherwise in form reasonably
satisfactory to




                                       3




the Company duly executed by the registered Holder or its duly authorized
attorney. This Debenture is convertible on or after the Initial Conversion Date
into shares of Common Stock at a price per share of Common Stock equal to $____
per share, as such conversion price may be adjusted as provided in Sections 3.5,
3.6 and 3.7 hereof (as so adjusted) (the "Conversion Price"). No fractional
shares or scrip representing fractional shares will be issued upon any
conversion, but an adjustment in cash will be made, in respect of any fraction
of a share which would otherwise be issuable upon the surrender of this
Debenture for conversion. The Conversion Price is subject to adjustment as
provided in Sections 3.5, 3.6 and 3.7 hereof. Not later than three (3) days
following conversion and upon the Holder's compliance with the conversion
procedure described in Section 3.3 hereof, the Company shall deliver a
certificate for the number of full shares of Common Stock issuable upon
conversion and a check for any fractional share and, in the event the Debenture
is converted in part, a new Debenture of like tenor in the principal amount
equal to the remaining principal balance of this Debenture after giving effect
to such partial conversion.


         For purposes hereof the term "Shareholders Meeting Date" shall mean
that date on which the shareholders and the debentureholders amend the Company's
Certificate of Incorporation to increase the number of authorized shares of the
Company's Common Stock available for issuance from 80,000,000 to such number of
shares as shall equal the sum of (i) the Company's issued and outstanding Common
Stock, plus (ii) the number of shares of Common Stock issuable upon the
conversion and exercise of the Company's outstanding convertible securities,
plus (iii) the number of shares of Common Stock issuable upon conversion of the
Debentures and exercise of the Watson Warrant , plus (iv) 50 million shares, as
shall sum shall be rounded up to the nearest whole five million shares.

         3.2. Conversion at Option of the Company. So long as an Event of
Default as provided in Section 12.1(a) of the Purchase Agreement (concerning the
Company's failure to pay principal and interest under the Debentures) shall not
have occurred and be continuing, in the event that following December __, 2005,
(i) the average of the closing bid and asked prices per share of the Company's
Common Stock as reported by the OTC Bulletin Board (or such other exchange or
over-the-counter market on which the Shares may then be listed or admitted for
trading) exceeds the product of (x) the then Applicable Conversion Price (as
defined in Section 3.7 hereof), multiplied by (y) four (4), such average of bid
and ask prices to be determined for each of twenty (20) consecutive trading days
in which the average daily trading volume for such twenty (20) trading day
period exceeds one million dollars ($1,000,000) (based on the number of Shares
traded multiplied by the average of the closing bid and asked prices), or (ii)
the Company shall have obtained the written consent of the Holders of at least
75% of the principal amount of the Debentures then outstanding to convert the
Debentures into Common Stock, then at any time thereafter until the Maturity
Date the Company may upon written notice to the Holders of all Debentures (the
"Mandatory Conversion Notice") require that all, but not less than all, of the
outstanding principal amount of the Debentures be converted into shares of
Common Stock at a price per share equal to the Conversion Price then in effect.
The Mandatory Conversion Notice shall state (a) the date fixed for conversion
(the "Conversion Date") (which date shall not be prior to the date the Mandatory
Conversion Notice is given), (b) any disclosures required by law, (c) the
trading dates and closing prices of the Common Stock giving rise to the
Company's option to




                                       4




require conversion of the Debenture, (d) that the Debentures shall cease to
accrue interest after the day immediately preceding the Conversion Date, (e) the
place where the Debentures shall be delivered and (f) any other instructions
that Holders must follow in order to tender their Debentures in exchange for
certificates for Common Stock. No failure to mail such notice nor any defect
therein or in the mailing thereof shall affect the validity of the proceedings
for such conversion, except as to a Holder (i) to whom notice was not mailed or
(ii) whose notice was defective. An affidavit of the Secretary or an Assistant
Secretary of the Company or an agent employed by the Company that notice of
conversion has been mailed postage prepaid to the last address of the Holder
appearing on the Debenture registry books kept by the Company shall, in the
absence of fraud, be prima facie evidence of the facts stated therein. On and
after the Conversion Date, except as provided in the next two sentences, Holders
of the Debentures shall have no further rights except to receive, upon surrender
of the Debentures, a certificate or certificates for the number of shares of
Common Stock as to which the Debenture shall have been converted. Interest shall
accrue to and including the day prior to the Conversion Date and shall be paid
on the last day of the month in which Conversion Date occurs. No fractional
shares or scrip representing fractional shares will be issued upon any
conversion, but an adjustment in cash will be made, in respect of any fraction
of a share which would otherwise be issuable upon the surrender of this
Debenture for conversion.

         3.3. Registration of Transfer; Conversion Procedure. The Company shall
maintain books for the transfer and registration of the Debentures. Upon the
transfer of any Debenture in accordance with the provisions of the Purchase
Agreement, the Company shall issue and register the Debenture in the names of
the new Holders. The Debentures shall be signed manually by the Chairman, Chief
Executive Officer, President or any Vice President and the Secretary or
Assistant Secretary of the Company. The Company shall convert, from time to
time, any outstanding Debentures upon the books to be maintained by the Company
for such purpose upon surrender thereof for conversion properly endorsed and, in
the case of a conversion pursuant to Section 3.1 hereof, accompanied by a
properly completed and executed Conversion Notice attached hereto as Attachment
II. Subject to the terms of this Debenture, not later than three (3) days
following the surrender of this Debenture the Company shall issue and deliver to
or upon the written order of the Holder of such Debenture and in such name or
names as such Holder may designate, a certificate or certificates for the number
of full shares of Common Stock due to such Holder upon the conversion of this
Debenture. Such certificate or certificates shall be deemed to have been issued
and any person so designated to be named therein shall be deemed to have become
the Holder of record of such Shares as of the date of the surrender of this
Debenture.

         3.4. Company to Provide Common Stock. The Company has reserved the
remaining balance of its authorized but unissued and unreserved shares of Common
Stock to permit the conversion of the Debentures to the extent of its current
unissued and unreserved authorized Common Stock. In accordance with the
provisions of Section 9.12 of the Purchase Agreement, the Company covenants to
seek the approval of its shareholders and directors to amend its Certificate of
Incorporation (i) to increase its authorized shares from 80,000,000 to such
number of shares as shall equal the sum of (A) the Company's issued and
outstanding Common Stock, plus (B) the number of shares of Common Stock issuable
upon the conversion and exercise of the Company's outstanding convertible
securities, plus (C) the number of shares




                                       5




of Common Stock issuable upon conversion of the Debentures and exercise of the
Watson Warrant, plus (D) 50 million shares, as such sum shall be rounded up to
the nearest whole five million shares, and (ii) to provide voting rights to the
Holders on an as converted basis as a single class with the holders of the
Common Stock. Promptly upon receipt of shareholder approval to amend its
certificate of incorporation to increase its authorized shares, the Company
shall reserve out of its authorized but unissued shares of Common Stock a
sufficient number of shares to permit the conversion of the Debentures in full.
The shares of Common Stock which may be issued upon the conversion of the
Debentures shall be fully paid and non-assessable and free of preemptive rights.
The Company will comply with all securities laws regulating the offer and
delivery of the Shares upon conversion of the Debentures and will list such
shares on each national securities exchange, if any, upon which the Common Stock
may then be listed.

         3.5. Dividends; Reclassifications, etc. In the event that the Company
shall, at any time prior to the earlier to occur of (a) exercise of conversion
rights hereunder and (b) the Maturity Date: (i) declare or pay to the holders of
the Common Stock a dividend payable in any kind of shares of capital stock of
the Company; or (ii) change or divide or otherwise reclassify its Common Stock
into the same or a different number of shares with or without par value, or in
shares of any class or classes; or (iii) transfer its property as an entirety or
substantially as an entirety to any other company or entity; or (iv) make any
distribution of its assets to holders of its Common Stock as a liquidation or
partial liquidation dividend or by way of return of capital; then, upon the
subsequent exercise of conversion rights, the Holder shall receive, in addition
to for the shares of Common Stock to which it would otherwise be entitled upon
such exercise, such additional shares of stock or scrip of the Company, or such
reclassified shares of stock of the Company, or such shares of the securities or
property of the Company resulting from transfer, or such assets of the Company,
which it would have been entitled to receive had it exercised these conversion
rights prior to the happening of any of the foregoing events.

         3.6. Notice to Holder. If, at any time while this Debenture is
outstanding, the Company shall pay any dividend payable in cash or in Common
Stock, shall offer to the holders of its Common Stock for subscription or
purchase by them any shares of stock of any class or any other rights, shall
enter into an agreement to merge or consolidate with another corporation, shall
propose any capital reorganization or reclassification of the capital stock of
the Company, including any subdivision or combination of its outstanding shares
of Common Stock or there shall be contemplated a voluntary or involuntary
dissolution, liquidation or winding up of the Company, the Company shall cause
notice thereof to be mailed to the registered Holder of this Debenture at its
address appearing on the registration books of the Company, at least thirty (30)
days prior to the record date as of which holders of Common Stock shall
participate in such dividend, distribution or subscription or other rights or at
least thirty (30) days prior to the effective date of the merger, consolidation,
reorganization, reclassification or dissolution. If, at any time prior to the
earlier of (a) the Maturity Date, or (b) the Conversion of the Debenture, the
number of outstanding shares of Common Stock is (i) increased by a stock
dividend payable in shares of Common Stock or by a subdivision or split up of
shares of Common Stock, or (ii) decreased by a combination of shares of Common
Stock, then, simultaneously with the occurrence of such event, the Conversion
Price shall be adjusted automatically to a new amount equal to the product of
(A) the Conversion Price in effect on such record date and (B) the




                                       6




quotient obtained by dividing (x) the number of shares of Common Stock
outstanding on such record date (without giving effect to the events referred to
in the foregoing clauses (i) or (ii)) by (y) the number of shares of Common
Stock which would be outstanding immediately after the event referred to in the
foregoing clauses (i) or (ii).

         3.7. Adjustments to Conversion Price. In order to prevent dilution of
the conversion right granted hereunder, the Conversion Price shall be subject to
adjustment from time to time in accordance with this Section 3.7.

         The Conversion Price in effect at the time of the exercise of
conversion rights hereunder shall be subject to adjustment from time to time as
follows:

         (a) Until such time as the Company completes a Subsequent Material
Offering (as defined in Section 3.7(d) hereof), if the Company shall grant or
issue any shares of Common Stock, or grant or issue any rights or options for
the purchase of, or stock or other securities convertible into, Common Stock
(such convertible stock or securities being herein collectively referred to as
"Convertible Securities"), including in connection with a Subsequent Material
Offering, other than:

            (i) shares issued in a transaction described in subsection (c) of
this Section 3.7; or

            (ii) shares issued, subdivided or combined in transactions described
in Section 3.5 if and to the extent that the number of shares of Common Stock
received upon conversion of this Debenture shall have been previously adjusted
pursuant to Section 3.5 as a result of such issuance, subdivision or combination
of such securities;

for a consideration per share which is less than the Conversion Price in effect
immediately prior to such issuance or sale (the "Applicable Conversion Price"),
then the Applicable Conversion Price in effect immediately prior to such
issuance or sale shall, and thereafter, except as otherwise provided in
Subsection 3.7 (b) hereof, upon each issuance or sale for a consideration per
share which is less than the Applicable Conversion Price, the Applicable
Conversion Price shall, simultaneously with such issuance or sale, be adjusted,
so that such Applicable Conversion Price shall equal (A) the price per share
received by the Company, in the case of the issuance of Common Stock by the
Company, or (B) the exercise or conversion price of the Convertible Securities
issued by the Company, as applicable.

         (b) If at any time following the Company's completion of a Subsequent
Material Offering the Company shall grant or issue any shares of Common Stock,
or grant or issue any Convertible Securities, other than:

            (i) shares issued in a transaction described in subsection (c) of
this Section 3.7; or




                                       7







            (ii) shares issued, subdivided or combined in transactions described
in Section 3.5 if and to the extent that the number of shares of Common Stock
received upon conversion of this Debenture shall have been previously adjusted
pursuant to Section 3.5 as a result of such issuance, subdivision or combination
of such securities;

for a consideration per share which is less than the Fair Market Value (as
hereinafter defined) of the Common Stock, then the Applicable Conversion Price
shall, and thereafter upon each issuance or sale for a consideration per share
which is less than the Fair Market Value of the Common Stock, the Applicable
Conversion Price shall, simultaneously with such issuance or sale, be adjusted,
so that the Applicable Conversion Price shall equal a price determined by
multiplying the Applicable Conversion Price by a fraction, of which:

         (A)      the numerator shall be the sum of (i) the total number of
                  shares of Common Stock outstanding when the Applicable
                  Conversion Price became effective, plus (ii) the number of
                  shares of Common Stock which the aggregate consideration
                  received, as determined in accordance with Subsection 3.7(e),
                  for the issuance or sale of such additional Common Stock or
                  Convertible Securities deemed to be an issuance of Common
                  Stock as provided in Subsection 3.7(f), would purchase
                  (including any consideration received by the Company upon the
                  issuance of any shares of Common Stock since the date the
                  Applicable Conversion Price became effective not previously
                  included in any computation resulting in an adjustment
                  pursuant to this Section 3.7(b)) at the Fair Market Value of
                  the Common Stock; and

         (B)      the denominator shall be the total number of Shares of Common
                  Stock outstanding (or deemed to be outstanding as provided in
                  Subsection 3.7(f) hereof) immediately after the issuance or
                  sale of such additional shares.

         For purposes of this Section 3.7, "Fair Market Value", in respect of
any such issuance or sale, shall mean the average of the closing price of the
Common Stock for each of the twenty (20) consecutive trading days prior to such
issuance or sale on the principal national securities exchange on which the
Common Stock is traded; or if, during such period, shares of Common Stock are
not listed on a national securities exchange but are quoted on the National
Association of Securities Dealers Automatic Quotation System ("NASDAQ") National
Market System, the closing price per share as reported by such system during
such period, or the average of the bid and asked prices of the Common Stock in
the over-the-counter market at the close of trading during such period if the
shares are not traded on an exchange or listed on the NASDAQ National Market
System; or if the Common Stock is not traded on a national securities exchange
or in the over-the-counter market, the fair market value of a share of Common
Stock during such period as determined in good faith by the Board of Directors.




                                       8


         If, however, the Applicable Conversion Price thus obtained would result
in the issuance of a lesser number of shares upon conversion than would be
issued at the initial Conversion Price specified in Section 3.1, as appropriate,
the Applicable Conversion Price shall be such initial Conversion Price.

         Upon each adjustment of the Conversion Price solely pursuant to this
Section 3.7(b), the Holder shall thereafter be entitled to acquire upon
conversion under Section 3.1 or Section 3.2, at the Applicable Conversion Price,
the number of shares of Common Stock obtainable by multiplying the Conversion
Price in effect immediately prior to such adjustment by the number of shares of
Common Stock acquirable immediately prior to such adjustment and dividing the
product thereof by the Applicable Conversion Price resulting from such
adjustment.

         (c) Anything in this Section 3.7 to the contrary notwithstanding, no
adjustment in the Conversion Price shall be made in connection with:

            (i) the grant, issuance or exercise of any Convertible Securities
pursuant to the Company's qualified or non-qualified Employee Stock Option Plans
or any other bona fide employee benefit plan or incentive arrangement, adopted
or approved by the Company's Board of Directors or approved by the Company's
shareholders, as each may be amended from time to time, or under any other bona
fide employee benefit plan hereafter adopted by the Company's Board of
Directors; or

            (ii) the grant, issuance or exercise of any Convertible Securities
in connection with the hire or retention of any officer, director or key
employee of the Company, provided such grant is approved by the Company's Board
of Directors; or

            (iii) the issuance of any shares of Common Stock or Convertible
Securities issued in satisfaction of interest payments on the Debentures and the
Existing Debenture (as defined in the Purchase Agreement), including the
issuance of Common Stock or Convertible Securities issued in satisfaction of
interest payments on debenture instruments issued by the Company in satisfaction
of the interest payments on the Debentures and Existing Debentures; or

            (iv) the issuance of any shares of Common Stock pursuant to the
grant or exercise of Convertible Securities outstanding as of the date hereof,
including, without limitation, the Debentures (as defined in the Purchase
Agreement) (exclusive of any subsequent amendments thereto); or

            (v) the issuance of shares of Common Stock pursuant to the
Recapitalization Agreement.

         (d) For purposes hereof, "Subsequent Material Offering" shall mean the
grant or issuance of shares of Common Stock, or the grant or issuance of
Convertible Securities, during any six (6) month period for an aggregate gross
consideration (determined in accordance




                                       9




with Subsection 3.7 (e) hereof) of at least ten million dollars ($10,000,000)
for a consideration per share that is in excess of the then Applicable
Conversion Price.

         (e) For the purpose of Subsections 3.7(a), 3.7(b) and 3.7(d), the
following provisions shall also be applied:

            (i) In case of the issuance or sale of additional shares of Common
Stock for cash, the consideration received by the Company therefor shall be
deemed to be the amount of cash received by the Company for such shares, before
deducting therefrom any commissions, compensation or other expenses paid or
incurred by the Company for any underwriting of, or otherwise in connection
with, the issuance or sale of such shares.

            (ii) In the case of the issuance of Convertible Securities, the
consideration received by the Company therefor shall be deemed to be the amount
of cash, if any, received by the Company for the issuance of such rights or
options, plus the minimum amounts of cash and fair value of other consideration,
if any, payable to the Company upon the exercise of such rights or options or
payable to the Company upon conversion of such Convertible Securities.

            (iii) In the case of the issuance of shares of Common Stock or
Convertible Securities for a consideration in whole or in part, other than cash,
the consideration other than cash shall be deemed to be the fair market value
thereof as reasonably determined in good faith by the Board of Directors of the
Company (irrespective of accounting treatment thereof); provided, however, that
if such consideration consists of the cancellation of debt issued by the
Company, the consideration shall be deemed to be the amount the Company received
upon issuance of such debt (gross proceeds) plus accrued interest and, in the
case of original issue discount or zero coupon indebtedness, accrued value to
the date of such cancellation, but not including any premium or discount at
which the debt may then be trading or which might otherwise be appropriate for
such class of debt.

            (iv) In case of the issuance of additional shares of Common Stock
upon the conversion or exchange of any obligations (other than Convertible
Securities), the amount of the consideration received by the Company for such
Common Stock shall be deemed to be the consideration received by the Company for
such obligations or shares so converted or exchanged, before deducting from such
consideration so received by the Company any expenses or commissions or
compensation incurred or paid by the Company for any underwriting of, or
otherwise in connection with, the issuance or sale of such obligations or
shares, plus any consideration received by the Company in connection with such
conversion or exchange other than a payment in adjustment of interest and
dividends. If obligations or shares of the same class or series of a class as
the obligations or shares so converted or exchanged have been originally issued
for different amounts of consideration, then the amount of consideration
received by the Company upon the original issuance of each of the obligations or
shares so converted or exchanged shall be deemed to be the average amount of the
consideration received by the Company upon the original issuance of all such
obligations or shares. The amount of consideration received by the Company upon
the original issuance of the obligations or shares so





                                       10




converted or exchanged and the amount of the consideration, if any, other than
such obligations or shares, received by the Company upon such conversion or
exchange shall be determined in the same manner as provided in paragraphs (i)
and (ii) above with respect to the consideration received by the Company in case
of the issuance of additional shares of Common Stock or Convertible Securities.

            (v) In the case of the issuance of additional shares of Common Stock
as a dividend, the aggregate number of shares of Common Stock issued in payment
of such dividend shall be deemed to have been issued at the close of business on
the record date fixed for the determination of stockholders entitled to such
dividend and shall be deemed to have been issued without consideration;
provided, however, that if the Company, after fixing such record date, shall
legally abandon its plan to so issue Common Stock as a dividend, no adjustment
of the Applicable Conversion Price shall be required by reason of the fixing of
such record date.

         (f) For purposes of the adjustment provided for in Subsections 3.7(a)
and 3.7(b) above, if at any time the Company shall issue any Convertible
Securities, the Company shall be deemed to have issued at the time of the
issuance of such Convertible Securities the maximum number of shares of Common
Stock issuable upon conversion of the total amount of such Convertible
Securities.

         (g) On the expiration, cancellation or redemption of any Convertible
Securities, the Conversion Price then in effect hereunder shall forthwith be
readjusted to such Conversion Price as would have been obtained (a) had the
adjustments made upon the issuance or sale of such expired, canceled or redeemed
Convertible Securities been made upon the basis of the issuance of only the
number of shares of Common Stock theretofore actually delivered upon the
exercise or conversion of such Convertible Securities (and the total
consideration received therefor) and (b) had all subsequent adjustments been
made on only the basis of the Conversion Price as readjusted under this
subsection 3.7(g) for all transactions (which would have affected such adjusted
Conversion Price) made after the issuance or sale of such Convertible
Securities.

         (h) Anything in this Section 3.7 to the contrary notwithstanding, no
adjustment in the Conversion Price shall be required unless such adjustment
would require an increase or decrease of at least one cent per share in such
Conversion Price; provided, however, that any adjustments which by reason of
this subsection 3.7(h) are not required to be made shall be carried forward and
taken into account in making subsequent adjustments. All calculations under this
Section 3.7 shall be made to the nearest cent.

         (i) Upon any adjustment of any Conversion Price, then and in each such
case the Company shall promptly deliver a notice to the registered Holder of
this Debenture, which notice shall state the Conversion Price resulting from
such adjustment, setting forth in reasonable detail the method of calculation
and the facts upon which such calculation is based.

         3.8. Reorganization of the Company. If the Company is a party to a
merger or other transaction which reclassifies or changes its outstanding Common
Stock, upon




                                       11




consummation of such transaction this Debenture shall automatically become
convertible into the kind and amount of securities, cash or other assets which
the Holder of this Debenture would have owned immediately after such transaction
if the Holder had converted this Debenture at the Conversion Price in effect
immediately before the effective date of the transaction. Concurrently with the
consummation of such transaction, the person obligated to issue securities or
deliver cash or other assets upon conversion of this Debenture shall execute and
deliver to the Holder a supplemental Debenture so providing and further
providing for adjustments which shall be as nearly equivalent as may be
practical to the adjustments provided in this Article 3. The successor Company
shall mail to the Holder a notice describing the supplemental Debenture.

         If securities deliverable upon conversion of this Debenture, as
provided above, are themselves convertible into the securities of an affiliate
of a corporation formed, surviving or otherwise affected by the merger or other
transaction, that issuer shall join in the supplemental Debenture which shall so
provide. If this section applies, Section 3.5 does not apply.

                                   ARTICLE IV

                                  MISCELLANEOUS

         4.1. Default. Upon the occurrence of any one or more of the Events of
Default specified in the Purchase Agreement all amounts then remaining unpaid on
this Debenture may be declared to be, or automatically become, immediately due
and payable as provided in the Purchase Agreement.

         4.2. Collection Costs. In the event that this Debenture shall be placed
in the hands of an attorney for collection by reason of any event of default
hereunder, the undersigned agrees to pay reasonable attorney's fees and
disbursements and other reasonable expenses incurred by the Holder in connection
with the collection of this Debenture.

         4.3. Rights Cumulative; Specific Performances. The rights, powers and
remedies given to the Payee under this Debenture shall be in addition to all
rights, powers and remedies given to it by virtue of the Purchase Agreement, any
document or instrument executed in connection therewith, or any statute or rule
of law. Without limiting the generality of the foregoing, the Company and Holder
acknowledge and agree that the transactions contemplated by this Debenture are
unique. Accordingly, the Company acknowledges and agrees that in addition to the
other remedies to which the Holder may be entitled, the Holder shall be entitled
to a decree of a specific performance and injunctive and other equitable relief
to require the Company's compliance with its obligations hereunder.

         4.4. No Waivers. Any forbearance, failure or delay by the Payee in
exercising any right, power or remedy under this Debenture, the Purchase
Agreement, any documents or instruments executed in connection therewith or
otherwise available to the Payee shall not be deemed to be a waiver of such
right, power or remedy, nor shall any single or partial exercise of any right,
power or remedy preclude the further exercise thereof.





                                       12






         4.5. Amendments in Writing. Subject to the terms of the Purchase
Agreement, no modification or waiver of any provision of this Debenture shall be
effective unless it shall be in writing and signed by the Holder, and any such
modification or waiver shall apply only in the specific instance for which
given.

         4.6. Governing Law; Jurisdiction. (a) This Debenture and the rights of
the holders hereof shall be governed by, and construed in accordance with, the
laws of the State of New York wherein the terms of this Debenture were
negotiated, excluding to the greatest extent permitted by law any rule of law
that would cause the application of the laws of any jurisdiction other than the
State of New York.

         (b) The undersigned hereby irrevocably and unconditionally submits, for
itself and its property, to the nonexclusive jurisdiction of any New York State
court or United States Federal court sitting in New York City, and any appellate
court from any thereof, in any action or proceeding arising out of or relating
to this Debenture or for recognition or enforcement of any judgment, and each of
the parties hereto irrevocably and unconditionally agrees that all claims in
respect of any such action or proceeding may be heard and determined in any such
New York State court or, to the fullest extent permitted by law, in such United
States Federal court. The undersigned agrees that a final judgment in any such
action or proceeding shall be conclusive and may be enforced in other
jurisdictions by suit on the judgment or any other manner provided by law.
Nothing in this Debenture or any other Transaction Document shall affect any
right that any party may otherwise have to bring any action or proceeding
relating to this Debenture or any of the other Transaction Documents in the
courts of any jurisdiction.

         (c) The Company irrevocably and unconditionally waives, to the fullest
extent it may legally and effectively do so, any objection that it may now or
hereafter have to the laying of venue of any suit, action or proceeding arising
out of or in relation to this Debenture or any other transaction document to
which it is a party in any such New York State or United States Federal Court.
The Company hereby irrevocably waives, to the fullest extent permitted by law,
the defense of an inconvenient forum to the maintenance of such action or
proceeding in any such court.

         4.7. No Counterclaims. The Company waives the right to interpose
counterclaims or set-offs of any kind and description in any litigation arising
hereunder (whether or not arising out of or relating to this Debenture).

         4.8. Successors. The term "Payee" and "Holder" as used herein shall be
deemed to include the Holder and its successors, endorsees and assigns.

         4.9. Certain Waivers. The Company hereby waives presentment, demand for
payment, protest, notice of protest and notice of non-payment hereof.

         4.10. Stamp Tax. The Company will pay any documentary stamp taxes
attributable to the initial issuance of the Common Stock issuable upon the
conversion of this Debenture; provided, however, that the Company shall not be
required to pay any tax or taxes



                                       13




which may be payable in respect of any transfer involved in the issuance or
delivery of any certificates for the Common Stock in a name other than that of
the Holder in respect of which such Common Stock is issued, and in such case the
Company shall not be required to issue or deliver any certificate for the Common
Stock until the person requesting the same has paid to the Company the amount of
such tax or has established to the Company's satisfaction that such tax has been
paid.

         4.11. Mutilated, Lost, Stolen or Destroyed Debentures. In case this
Debenture shall be mutilated, lost, stolen or destroyed, the Company shall issue
and deliver in exchange and substitution for and upon cancellation of the
mutilated Debenture, or in lieu of and substitution for the Debenture,
mutilated, lost, stolen or destroyed, a new Debenture of like tenor and
representing an equivalent right or interest, but only upon receipt of evidence
reasonably satisfactory to the Company of such loss, theft or destruction and an
indemnity, if requested, also reasonably satisfactory to it.

         4.12. Maintenance of Office. The Company covenants and agrees that so
long as this Debenture shall be outstanding, it will maintain an office or
agency in New York (or such other place as the Company may designate in writing
to the holder of this Debenture) where notices, presentations and demands to or
upon the Company in respect of this Debenture may be given or made.

         4.13. WAIVER OF JURY TRIAL. THE COMPANY IRREVOCABLY WAIVES ALL RIGHT TO
TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON
CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR RELATING TO THIS DEBENTURE OR ANY
OTHER TRANSACTION DOCUMENT TO WHICH IT IS A PARTY IN THE NEGOTIATION,
ADMINISTRATION, PERFORMANCE OR ENFORCEMENT THEREOF.




                                       14



         IN WITNESS WHEREOF, Halsey Drug Co., Inc. has caused this Debenture to
be signed by its President and to be dated the day and year first above written.


ATTEST [SEAL]                         HALSEY DRUG CO., INC.


________________________________      By:____________________________________
                                         Name:  Michael Reicher
                                         Title:  Chief Executive Officer





                                  ATTACHMENT I

                                   Assignment


         For value received, the undersigned hereby assigns subject to the
provisions of Section of the Purchase Agreement, to ________ $_________________
principal amount of the 5% Convertible Senior Secured Debenture due March 31,
2006 evidenced hereby and hereby irrevocably appoints _______________ attorney
to transfer the Debenture on the books of the within named corporation with full
power of substitution in the premises.

Dated:

In the presence of:



___________________________________     ________________________________________





                                  ATTACHMENT II

                                CONVERSION NOTICE

                            TO: HALSEY DRUG CO., INC.


         The undersigned holder of this Debenture hereby irrevocably exercises
the option to convert $_________ principal amount of such Debenture (which may
be less than the stated principal amount thereof) into shares of Common Stock of
Halsey Drug Co., Inc., in accordance with the terms of such Debenture, and
directs that the shares of Common Stock issuable and deliverable upon such
conversion, together with a check (if applicable) in payment for any fractional
shares as provided in such Debenture, be issued and delivered to the undersigned
unless a different name has been indicated below. If shares of Common Stock are
to be issued in the name of a person other than the undersigned holder of such
Debenture, the undersigned will pay all transfer taxes payable with respect
thereto.



                           -----------------------------------------------------
                                         Name and address of Holder


                           -----------------------------------------------------
                                           Signature of Holder


         Principal amount of Debenture to be converted $
                                                        ------------------------


         If shares are to be issued otherwise then to the holder:



- ----------------------------
Name of Transferee
                                      Address of Transferee

                                      ------------------------------------------

                                      ------------------------------------------

                                      ------------------------------------------

                                      ------------------------------------------


                                      Social Security Number of Transferee


                                      ------------------------------------------




                                                                    EXHIBIT 10.1



                                                               DECEMBER 20, 2002

To the Purchaser(s) Set Forth on Exhibit A hereto:

         HALSEY DRUG CO., INC., a New York corporation (the "Company"), agrees
with you as follows (capitalized terms used in this Agreement without definition
have the meanings assigned to them in Article XX):

                                   ARTICLE I

                        AUTHORIZATION OF THE SECURITIES;
                         ADJUSTMENT OF CONVERSION PRICE

         1.1. Authorization of Securities. (a) The Company represents that it
has taken all corporate action necessary to authorize the issuance and sale of
its 5% Convertible Senior Secured Debentures due March 31, 2006 in the aggregate
principal amount of up to $35 million substantially in the form of Exhibit B
hereto (such Debentures, together with the Debenture instruments evidencing
interest payments on the Debentures in accordance with Section 1.1, as they may
be amended, supplemented or otherwise modified from time to time in accordance
with their terms, the "Debentures" or the "Securities").

         (b) The Debentures are to be sold severally, and not jointly, pursuant
to this Agreement to you (each of you is sometimes referred to herein as a
"Purchaser").

         (c) Interest on the Debentures (including on Debenture instruments
issued pursuant to this sentence) is payable at the rate of 5% per annum in the
form of Debenture instruments substantially identical to the Debentures;
provided, however, that fifty percent (50%) of the interest payments payable
under the Debentures issued to Care Capital Investments II, LP shall be paid in
cash with the balance of such interest payments payable in like Debentures, all
as more particularly specified in the Debenture. Each Debenture held by Galen,
Galen Partners International III, L.P., Galen Employee Fund III, L.P. and any
Additional Investor, or any affiliate thereof is convertible, at any time after
the Shareholders Meeting Date, (i) in whole or in part at any time or from time
to time at the option of the holder of such Debenture into a number of shares of
the Company's Common Stock (the "Common Stock") initially at the rate of one
share of Common Stock for each $.34 in principal amount of the respective
Debenture to be converted and (ii) following the third anniversary of the
issuance of the respective Debenture, in whole at the option of the Company in
the circumstances set forth in Section 3.2 of the respective Debenture. Each
Debenture held by Care Capital Investments II, LP or Essex Woodlands Health
Ventures Fund V is convertible (i) in whole or in part at any time or from time
to time at the option of the holder of such Debenture into a number of shares of
Common Stock initially at the rate of one share of Common Stock for each [$___]
in principal amount of the respective Debenture to be converted and (ii)
following the third anniversary of the issuance of the respective Debenture, in
whole at the option of the Company in the circumstances set forth in Section 3.2
of the respective Debenture. For purposes of this Agreement, the term "Shares"
shall






mean the shares of Common Stock which may be issued upon conversion of all or a
portion of the principal amount of the Debentures. The term Shares does not
include any other shares of Common Stock or other capital stock of the Company.

         (d) The Company and the Purchasers acknowledge and agree that the
conversion price of the Debentures shall be calculated on the Closing Date and
on any subsequent issuance of Debentures pursuant to Article III hereof (i)
based on a fully-diluted valuation of the Company of $47.4 million prior to the
Closing of the transactions provided in this Debenture Purchase Agreement,
assuming a per share value of Common Stock equal to the conversion price of the
Debentures, and (ii) to provide that the Debentures issued to the Purchasers
shall be convertible into such number of Shares as shall represent forty two and
four tenths percent (42.4%) (the "Aggregate Ownership Percentage") of the
Company's Common Stock on the Closing Date, assuming the Company's issuance of
Debentures in an aggregate principal amount of $35 million. The Aggregate
Ownership Percentage shall be proportionately adjusted to the extent the Company
issues Debentures in an aggregate principal amount less than $35 million. For
purposes of the foregoing calculations, excluding common stock purchase options
exercisable for up to 5,031,950 shares of Common Stock issued and outstanding on
the Closing Date and listed on Section 1.1 of the Schedule of Exceptions, all
shares of Common Stock underlying any convertible debentures, warrants, options
and other convertible securities of the Company outstanding at the Closing Date
shall be included, including, without limitation, the Watson Warrant, after
giving effect to any change in the number of shares of Common Stock issuable
under such convertible securities as a result of the completion of the
transactions set forth in this Debenture Purchase Agreement and the application
of the anti-dilution provisions contained in any such convertible securities.

         1.2. Adjustment of Conversion Price. (a) The prices at which Shares may
be acquired upon conversion of the Debentures are subject to adjustment as set
forth in the Debentures. Without limiting the anti-dilution provisions contained
in the Debentures, including, without limitation, Section 3.7 thereof, the
Purchasers and the Company acknowledge and agree that in the event the common
stock purchase warrants described in Exhibit O hereto exercisable for an
aggregate of 11,475,116 shares of Common Stock (collectively, the "Remaining
Galen Warrants") are exercised, converted, recapitalized or otherwise exchanged
or substituted (the "Warrant Exchange Transaction") on or before December 15,
2003 for an aggregate number of shares which is less than or greater than
11,475,116 shares of Common Stock, the conversion price of the Debentures shall
be adjusted in order to provide that the number of Shares issuable upon
conversion of the Debentures shall equal the Aggregate Ownership Percentage as
if the Warrant Exchange Transaction had been completed immediately prior to the
Closing Date and the Company had issued the resulting shares of Common Stock in
such transaction as of the Closing Date.

         (b) In accordance with Article III hereof, the Company, from time to
time, may issue additional Debentures pursuant to this Agreement; provided,
however, that (i) the aggregate principal amount of the Debentures shall not
exceed $35 million, and (ii) that no Debentures (other than the Debenture
instruments evidencing interest payments on the Debentures in accordance with
Section 1.1) shall be issued after August 30, 2003 (the "Termination Date").
Upon the execution of the Joinder Agreement appended as Exhibit J hereto by a
Purchaser and the Company's issuance of a Debenture to such Purchaser, the
conversion





                                       2




price of the Debentures issued on the Closing Date and the conversion price of
any Debenture issued at any time after the Closing Date as provided in this
Section 1.2 (b) and Article III hereof, shall be adjusted to give effect to the
requirements of Section 1.1(d) hereof, including, without limitation, after
giving effect to any change in the number of shares of Common Stock issuable
under the Company's outstanding convertible securities (exclusive of the
Debentures) as a result of the Company's issuance of additional Debentures
following the Closing Date and the application of the anti-dilution provisions
contained in the Company's convertible securities.

                                   ARTICLE II

             SALE AND PURCHASE OF THE SECURITIES; SECURITY DOCUMENTS

         2.1. Sale and Purchase of the Securities. At the Closing, on the terms
and subject to the conditions and in reliance on the representations and
warranties contained herein, or made pursuant hereto, the Company shall issue,
sell and deliver to each Purchaser and such Purchaser's designees, and each
Purchaser, severally and not jointly, will purchase from the Company, the
Debentures for the purchase prices set forth opposite such Purchaser's name on
Exhibit A.

         2.2. Company Security Documents. All of the obligations of the Company
under the Transaction Documents to or for the benefit of the Purchasers (or
their agents and representatives) shall be secured by the following items
(collectively, the "Company Debenture Collateral"), each of which, except for
Permitted Liens, shall be (i) junior and subordinate to the lien granted to
Watson pursuant to the Watson Term Loans, and (ii) senior and superior to those
liens granted to the investors in the Existing Debentures, all as more
specifically set forth in the Subordination Agreement:

         (a) A lien on all the personal property and assets of the Company now
existing or hereinafter acquired granted pursuant to a Company General Security
Agreement substantially in the form attached as Exhibit E hereto and dated of
even date herewith between the Company and Galen Partners III, L.P. ("Galen"),
as agent for the Purchasers (such agreement, as supplemented, amended or
otherwise modified from time to time in accordance with its terms, the "Company
General Security Agreement"), including, without limitation, a lien on and
security interest in all of the issued and outstanding shares of common stock of
Houba, Inc. and Halsey Pharmaceuticals, Inc. pursuant to a separate Stock Pledge
Agreement substantially in the form attached as Exhibit L hereto and dated of
even date herewith between the Company and Galen, as agent for the Purchasers
(such agreement, as supplemented, amended or otherwise modified from time to
time in accordance with its terms, the "Stock Pledge Agreement"):

         (b) Collateral assignments of all leases, contracts, patents,
copyrights, trademarks and service marks of the Company.

         2.3. Guaranties. All of the obligations of the Company under the
Debentures shall be guaranteed pursuant to Continuing Unconditional Secured
Guaranties substantially in the form of Exhibit F attached hereto (each, a
"Guaranty" and collectively, the "Guaranties") by each of the following
subsidiaries of the Company (each, a "Guarantor"):

         (a) Houba, Inc.; and




                                       3





         (b) Halsey Pharmaceuticals, Inc.

         2.4. Guarantor Security Documents. All of the obligations of the
Guarantors under the Guaranties shall be secured by the following (collectively,
the "Guarantor Debenture Collateral") each of which, except for Permitted Liens,
shall be a lien ranking (i) junior and subordinate to the lien granted to Watson
pursuant to the Watson Term Loans, and (ii) senior and superior to those liens
granted to the investors in the Existing Debentures, all as more specifically
set forth in the Subordination Agreement:

         (a) A lien on all of the personal property and assets of the respective
Guarantors now existing or hereinafter acquired, granted pursuant to a
Guarantors General Security Agreement dated of even date herewith between the
Guarantors and Galen, as agent for the Purchasers substantially in the form of
Exhibit G attached hereto (such agreement, as supplemented, amended or otherwise
modified from time to time in accordance with its terms, the "Guarantors
Security Agreement").

         (b) Collateral assignments of all leases, contracts, patents,
copyrights, trademarks and service marks of the Guarantors.

         (c) A mortgage granted by Houba Inc. on real property owned by Houba
Inc. located at 16235 State Road 17, Culver, Indiana (the "Mortgage").

                                  ARTICLE III

                                     CLOSING

         The closing of the purchase and sale of the Securities (the "Closing")
will take place at the offices of St. John & Wayne, L.L.C., Two Penn Plaza East,
Newark, New Jersey 07105 simultaneously with the execution of this Agreement, or
such other place, time and date as shall be mutually agreed to by the Company
and the Purchasers. Such time and date is herein referred to as the "Closing
Date". The Company and the Purchasers acknowledge and agree that the Debentures
may be sold by the Company on one or more Closing Dates. Upon the issuance of
additional Debentures under this Agreement, any additional Purchaser (each an
"Additional Investor") shall be required to execute a Joinder Agreement in the
form attached as Exhibit J hereto (such agreement, as supplemented, amended or
otherwise modified from time to time in accordance with its terms, the "Joinder
Agreement"), which Joinder Agreement shall include the aggregate principal
amount of the Debentures issued to such Purchaser, provided that so long as Care
Capital Investments II, LP or Essex Woodlands Health Ventures Fund V (or their
respective affiliates (as such term is defined in Rule 501(b) under the
Securities Act ("Rule 501(b)")) shall hold Debentures (each such person a "2002
Holder"), the prior written consent of all 2002 Holders shall be required prior
to the issuance of any Debentures to any Additional Investors, which consent
shall be within their sole and absolute discretion. Any Additional Investors in
the Debentures executing a Joinder Agreement shall be deemed a Purchaser for all
purposes of this Agreement. Upon the issuance of any Debenture following the
Closing Date, the conversion price of the Debentures shall be adjusted as
provided in Section 1.2(b) hereof. Notwithstanding anything else contained
herein or in the Transaction Documents to the contrary, the Company shall issue
no Debentures (other than the Debenture instruments evidencing interest payments
on the Debentures in accordance with Section 1.1) after the Termination Date.




                                       4



         On the Closing Date, the Company shall deliver to each Purchaser a
Debenture, dated the Closing Date, in the principal amount set forth opposite
the name of such Purchaser in Exhibit A. The Company shall deliver the foregoing
Debentures against receipt by the Company from each Purchaser of an amount equal
to the aggregate purchase price for the Debentures to be purchased by such
Purchaser at the Closing, as set forth opposite the name of such Purchaser on
Exhibit A, in each case by wire transfer in immediately available funds in U.S.
dollars to an account designated by the Company or a certified or official bank
check payable to the order of the Company drawn upon or issued by a bank which
is a member of the New York Clearinghouse for banks.

                                   ARTICLE IV

                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

         As a material inducement to each Purchaser to enter into and perform
its obligations under this Agreement, except as set forth in the Schedule of
Exceptions attached hereto as Exhibit C (the "Schedule of Exceptions"), the
Company hereby represents and warrants to you as follows:

         4.1. Organization and Existence, etc. The Company is a corporation duly
organized, validly existing and in good standing under the laws of New York and
is qualified to do business in such other jurisdictions as the nature or conduct
of its operations or the ownership of its properties require such qualification.
The Company does not own or lease any property or engage in any activity in any
jurisdiction that might require qualification to do business as a foreign
corporation in such jurisdiction and where the failure to so qualify could
reasonably be expected to have a Material Adverse Effect or subject the Company
to a material liability. The Company has furnished the Purchasers with true,
correct and complete copies of its Certificate of Incorporation, By-Laws and all
amendments thereto, as of the date hereof.

         As used in this Agreement, "Material Adverse Effect" means (a) a
material adverse effect on, or change in, the business, prospects, properties,
operations, condition (financial or other) or results of operations of the
Company and its Subsidiaries, taken as a whole or (b) a material adverse effect
on (i) the ability of the Company or any of the Guarantors to perform its
respective obligations or (ii) the rights or remedies of any Purchaser under any
Transaction Document.

         4.2. Subsidiaries and Affiliates. Section 4.2 of the Schedule of
Exceptions sets forth the name, jurisdiction of incorporation and authorized and
outstanding capitalization of each entity in which the Company owns securities
having a majority of the voting power in the election of directors or persons
serving equivalent functions (each a "Subsidiary"). Except as disclosed in
Section 4.2 of the Schedule of Exceptions, all of the outstanding shares of
capital stock of each of the Subsidiaries are duly and validly authorized, are
validly issued and are fully paid and nonassessable and have been offered,
issued, sold and delivered in compliance with applicable Federal and state
securities laws. Except as set forth in Section 4.2 of the Schedule of
Exceptions, the Company has, and upon the Closing will have, no Subsidiaries and
will not own of record or beneficially any capital stock or equity interest or
investment in any corporation, association or business entity. Except as
disclosed in Section 4.2 of the Schedule of Exceptions, each Subsidiary is a
corporation duly organized, validly existing and in good standing under the




                                       5



laws of its jurisdiction of incorporation and has all requisite corporate power
and authority to carry on its business as now conducted and proposed to be
conducted. Except as set forth in Section 4.2 of the Schedule of Exceptions, no
Subsidiary owns or leases any property or engages in any activity in any
jurisdiction which might require such Subsidiary to qualify to do business as a
foreign corporation in such jurisdiction and where the failure to so qualify
could reasonably be expected to have a Material Adverse Effect or subject such
Subsidiary to a material liability.

         4.3. Capitalization. (a) As of the date hereof, the Company's
authorized capital stock consists of 80,000,000 shares of Common Stock, par
value $.01 per share, of which 15,065,240 shares are outstanding and 66,037,354
shares are reserved for issuance for the purposes set forth in Section 4.3 of
the Schedule of Exceptions. Set forth in Section 4.3 of the Schedule of
Exceptions is a complete and correct list, as of the date hereof, and as of the
Closing Date, of the number of shares of Common Stock held by the Company's
public shareholders generally, shareholders holding in excess of 5% of the
Company's Common Stock and all holders of options, warrants, debentures and
other securities convertible or exercisable for Common Stock. Such schedule is
complete and correct in all respects.

         (b) All the issued and outstanding shares of capital stock of the
Company are (i) duly authorized and validly issued, (ii) fully paid and
nonassessable and (iii) have been offered, issued, sold and delivered by the
Company in compliance with applicable Federal and state securities laws. Other
than as set forth in Section 4.3 of the Schedule of Exceptions there are no
outstanding preemptive, conversion or other rights, options, warrants, calls,
agreements or commitments granted or issued by or binding upon the Company or
any Subsidiary, for the purchase or acquisition of any shares of its capital
stock or securities convertible into or exercisable or exchangeable for capital
stock.

         4.4. Authorization. (a) Each of the Company and the Guarantors has all
requisite corporate power and authority (i) to execute and deliver, and to
perform and observe their respective obligations under, this Agreement, the
Debentures, the Company General Security Agreement, the Stock Pledge Agreement,
the Guarantors Security Agreement, the Guaranties, the Mortgage, the Mortgage
Subordination Agreement, the Recapitalization Agreement, the Watson Term Loan
Amendment, the 2002 Watson Term Loan, the Registration Rights Agreement, the
Watson Consent, the Watson Supply Agreement, the Watson Supply Agreement
Amendment, the Watson Warrant, the Subscription Agreement with each Purchaser,
the Debentureholders Agreement, the Subordination Agreement, the Galen Bridge
Lenders Consent, the Existing Debenture Amendments, the Galen Bridge Lenders
Consent and the Existing Debentureholder Consent (collectively, the "Transaction
Documents") to which it is a respective party, and (ii) to consummate the
transactions contemplated hereby and thereby, including, without limitation, the
grant of any security interest, mortgage, payment trust, guaranty or other
security arrangement by the Company in, on or in respect of the Company
Debenture Collateral, and by any and all of the Guarantors in, on or in respect
of the Guarantor Debenture Collateral.

         (b) All corporate action on the part of (i) the Company and the
directors and, except as set forth in Section 4.4(b) of the Schedule of
Exceptions or as otherwise provided in Sections 9.7 and 9.12 hereof, the
stockholders of the Company necessary for the authorization, execution, delivery
and performance by the Company of the Transaction Agreements and the
transactions contemplated therein, and for the authorization, issuance and
delivery of the Securities, has been taken and (ii) each Guarantor and their
respective directors and stockholders




                                       6



necessary for the authorization, execution, delivery and performance by each
Guarantor of the Guarantors General Security Document, the Guaranties and, in
the case of Houba, Inc. the Mortgage, and the transactions contemplated therein
or in any other Transaction Document with respect to the Guarantors, has been
taken.

         4.5. Binding Obligations; No Material Adverse Contracts, etc. The
Transaction Documents constitute valid and binding obligations of the Company
and the Guarantors enforceable in accordance with their respective terms. Except
as set forth in Section 4.5 of the Schedule of Exceptions and as provided in
Section 9.12 hereof, the execution, delivery and performance by the Company and
the Guarantors of the Transaction Documents and compliance therewith will not
result in any violation of and will not conflict with, or result in a breach of
any of the terms of, or constitute a default, or accelerate or permit the
acceleration of any rights or obligations, under, any provision of state, local,
Federal or foreign law to which the Company or either of the Guarantors is
subject, the Certificate of Incorporation, as amended, or the By-Laws, as
amended, of the Company or either of the Guarantors, the Watson Term Loans(as
amended by the Watson Term Loan Amendment and the Watson Consent, as
applicable), the Watson Supply Agreement Amendment, and the Existing Debentures
(as amended by the Existing Debentures Amendments and the Existing
Debentureholder Consent) or any other mortgage, indenture, agreement,
instrument, judgment, decree, order, rule or regulation or other restriction to
which the Company or either of the Guarantors is a party or by which it is
bound, and except for Permitted Liens, result in the creation of any mortgage,
pledge, lien, encumbrance or charge upon any of the properties or assets of the
Company or either of the Guarantors pursuant to any such term. Except as set
forth in Section 4.3 of the Schedule of Exceptions, no stockholder of the
Company or either Guarantor has or will have any preemptive rights or rights of
first refusal by reason of the issuance of the Securities or Shares issuable
upon conversion or exercise of the Securities.

         4.6. Compliance with Instruments, etc. Neither the Company nor any
Subsidiary (a) is in violation of its organizational documents, (b) is in
default, and no event has occurred which, with the giving of notice, or the
lapse of time, or both, would constitute such a default, in the due performance
or observance of any term, covenant or condition contained in any material
agreement, including, without limitation, the Watson Term Loans, the Watson
Supply Agreement, the Watson Supply Agreement Amendment and the Existing
Debentures, any license, indenture or other instrument to which it is a party or
by which it is bound or to which any of its property or assets is subject or (c)
is in violation of any law, ordinance, governmental rule, regulation or court
decree to which it or its property may be subject (including without limitation
any laws and regulations relating to the biotechnology and pharmaceutical
industry) except for such violations under clause (b) and (c) that would not,
individually or in the aggregate, have a Material Adverse Effect.

         4.7. Litigation. Except as set forth in Section 4.7 of the Schedule of
Exceptions, there are no actions, suits or proceedings (including governmental
or administrative proceedings), investigations, third-party subpoenas or
inquiries by any regulatory agency, body or other governmental authority, to
which the Company or any of the Subsidiaries is a party or is subject, or to
which any of their authorizations, consents and approvals or other properties or
assets, is subject, which is pending, or, to the best knowledge of the Company,
threatened or contemplated against the Company or any Subsidiary, or any of such
property or assets, that, individually or in the aggregate, could reasonably be
expected to have a Material Adverse Effect.



                                       7



The Company is not subject to any actions, suits or proceedings (including
governmental or administrative proceedings), investigation, third-party
subpoenas or inquiries by any regulatory agency, body or other governmental
authority or any third Person regarding its accounting practices or policies.

         4.8. Financial Information; SEC Documents. (a) The Company has
furnished to the Purchasers complete and correct copies of the consolidated
financial statements of the Company and its Subsidiaries, including consolidated
balance sheets as of December 31, 2001 and 2000 and consolidated statements of
operations, changes in cash flows and stockholders' equity, covering the three
years ended December 31, 2001, all of which statements have been certified by
Grant Thornton LLP, independent accountants within the meaning of the Securities
Act of 1933, as amended (the "Securities Act") and the rules and regulations
thereunder, and all of which statements are included or incorporated by
reference in the Company's Annual Report on Form 10-K for the fiscal year ended
December 31, 2001 filed with the Securities and Exchange Commission (the
"Commission") under the Securities Exchange Act of 1934, as amended (the
"Exchange Act"). Such financial statements have been prepared in conformity with
generally accepted accounting principles in the United States ("US GAAP")
applied on a consistent basis throughout the periods involved, except as
otherwise stated therein and fairly present the consolidated financial position
of the Company and its Subsidiaries as of the dates thereof and their
consolidated results of operations for such periods. The Company's auditors have
raised no material issues nor delivered any material correspondence with respect
to any of the Company's financial statements or financial affairs.

         (b) The Company has also furnished to the Purchasers the unaudited
consolidated balance sheet of the Company and its Subsidiaries as of September
30, 2002, and the related unaudited consolidated statements of operations,
consolidated statements of cash flow and consolidated statements of
stockholders' equity for the nine months ended September 30, 2002 and September
30, 2001. Such financial statements were prepared in conformity with US GAAP
applied on a basis consistent with the financial statements referred to in
paragraph (a) of this Section and fairly present the consolidated financial
position of the Company and its Subsidiaries as of such date and their
consolidated results of operations for such periods (subject to normal year-end
adjustments).

         (c) None of the documents filed by the Company with the Commission
since December 31, 1997 contain any untrue statement of a material fact or omit
to state a material fact required to be stated therein or necessary in order to
make the statements contained therein not false or misleading in light of the
circumstances in which they were made. There are no facts which the Company has
not disclosed to the Purchasers which, individually or in the aggregate, could
reasonably be expected to have a Material Adverse Effect.

         (d) Except as set forth in Section 4.8 of the Schedule of Exceptions or
in the Company's Quarterly Report on Form 10-Q for the quarter ended September
30, 2002, subsequent to December 31, 2001, (i) none of the Company or any
Guarantor has incurred any liability or obligations, direct or indirect, or
entered into any transactions not in the ordinary course of business, in either
case which is material to the Company or any Guarantor, as a whole, (ii) there
has not been any material change in the short-term debt or long-term debt of any
of the Company or any Guarantor, (iii) there has been no material change in the
Company's accounting





                                       8




principles and (iv) none of the Company or any Guarantor has taken any actions
which would have been prohibited under Article X if taken after the date hereof.

         (e) Except as set forth in the Company's Quarterly Report on Form 10-Q
for the quarter ended September 30, 2002, since December 31, 2001, there has
been no Material Adverse Effect with respect to the Company and its
Subsidiaries.

         4.9. Offering Exemption. (a) None of the Company, its affiliates, as
such term is defined in Rule 501(b)) or any Person acting on its or their behalf
has engaged or will engage, in connection with the offering and sale of the
Securities, in any form in general solicitation or general advertising within
the meaning of Rule 502(c) under the Securities Act, and none of the Company, or
any of its affiliates, as such term is defined in Rule 501(b) has, directly or
indirectly, solicited any offer to buy, sell or offer to sell or otherwise
negotiate in respect of, in the United States or to any United States citizen or
resident, any security which is or would be integrated with the sale of the
Securities in a manner that would require the Securities to be registered under
the Securities Act. Assuming the accuracy of the representations and warranties
given by the Purchasers in Article V below, the offering, sale and issuance of
the Securities have been, are, and will be exempt from registration under the
Securities Act, and such offering, sale and issuance is also exempt from
registration under applicable state securities and "blue sky" laws.

         (b) None of the Company or any Guarantor is, or upon consummation of
the transactions contemplated under the Transaction Documents, will be, subject
to registration as an "investment company" under the Investment Company Act of
1940, as amended.

         4.10. Permits; Governmental and Other Approvals. (a) Other than as set
forth in Section 4.10 of the Schedule of Exceptions or in the Company's Annual
Report on Form 10-K for the fiscal year ended December 31, 2001 or the Company's
Quarterly Report on Form 10-Q for the nine months ended September 30, 2002
(collectively, the "Company Reports") each of the Company and its Subsidiaries
possesses all necessary consents, approvals, authorizations, orders,
registrations, stamps, filings, qualifications, licenses, permits or other
analogous acts by, of, from or with all public, regulatory or governmental
agencies, bodies and authorities and all other third parties, to own, lease and
operate its respective properties and to carry on its business as now conducted
and proposed to be conducted except to the extent that the failure to obtain any
such consents, approvals, authorizations, orders, registrations, stamps,
filings, qualifications, licenses or permits would not have a Material Adverse
Effect. Other than as set forth in Section 4.10 of the Schedule of Exceptions,
or as otherwise contemplated in Article VI and IX hereof, no approval, consent,
authorization or other order of, and no designation, filing, registration,
qualification or recording with, any governmental authority or any other Person
is required in connection with the Company's valid execution, delivery and
performance of this Agreement or the offer, issuance and sale of the Securities
by the Company to the Purchasers or the consummation of any other transaction
contemplated on the part of the Company hereby.

         (b) Without limiting the generality of the representations and
warranties made in Section 4.10(a), the Company represents and warrants that (i)
it and the Guarantors are in compliance with all applicable provisions of the
Federal Food, Drug, and Cosmetic Act (the "FDC Act"), except where any such
noncompliance could not reasonably be expected to have a Material Adverse
Effect; (ii) its products and those of the Guarantors are not adulterated or




                                       9



misbranded and are in lawful distribution; and (iii) it and the Guarantors are,
and will be, in compliance with the following specific requirements: (A) the
Company and the Guarantors have registered all of their facilities with the
United States Food and Drug Administration (the "FDA"), (B) the Company and the
Guarantors have listed their drug products with the FDA, (C) each drug product
marketed by the Company or any Guarantor is the subject of an application
approved by the FDA, (D) all drug products marketed by the Company or either
Guarantor comply with any conditions of approval and the terms of the
application submitted to the FDA, (E) all of the Company's and the Guarantors'
drug products are manufactured in compliance with the FDA's good manufacturing
practice regulations, (F) all of the Company's and the Guarantors' products are
labeled and promoted in accordance with the terms of the marketing application
and the provisions of the FDC Act, (G) all adverse events relating to the
Company and the Guarantors that were required to be reported to the FDA have
been reported to the FDA in a timely manner, (H) each of the Company and the
Guarantors is in compliance with the terms of the consent agreement entered into
by the Company with the United States Attorney for the Eastern District of New
York on behalf of the FDA on June 29, 1993, as amended, (I) to the Company's
best knowledge, neither the Company nor any Guarantor is employing or utilizing
the services of any individual who has been debarred under the FDC Act, (J) all
stability studies required to be performed for products distributed by the
Company or a Guarantor have been completed or are ongoing in accordance with the
applicable FDA requirements, (K) none of the Company's or a Guarantors' products
have been exported for sale outside the United States, and (L) each of the
Company and the Guarantors is in compliance with the provisions of the
Prescription Drug Marketing Act, to the extent applicable; except, with respect
to subclause (iii)(E), (iii)(H), (iii)(G), (iii)(K) and (iii)(L) above, where
any such noncompliance could not reasonably be expected to have a Material
Adverse Effect.

         (c) Without limiting the generality of the representations and
warranties made in Section 4.10(a), the Company also represents and warrants
that it and the Guarantors are in compliance with all applicable provisions of
the Controlled Substances Act (the "CSA") and that the Company and the
Guarantors are in compliance with the following specific requirements, except
where such noncompliance could not reasonably be expected to have a Material
Adverse Effect: (i) the Company and the Guarantors are registered with the Drug
Enforcement Administration (the "DEA") at each facility where controlled
substances are exported, imported, manufactured or distributed; (ii) all
controlled substances are stored and handled pursuant to DEA security
requirements; (iii) all records and inventories of receipt and distributions of
controlled substances are maintained in the manner and form as required by DEA
regulations; (iv) all reports, including, but not limited to, ARCOS,
manufacturing quotas, production quotas, and disposals, have been submitted to
the DEA in a timely manner; (v) all adverse events, including thefts or
significant losses of controlled substances, have been reported to the DEA in a
timely manner; (vi) to the Company's best knowledge, neither the Company nor any
Guarantor is employing any individual, with access to controlled substances, who
has previously been convicted of a felony involving controlled substances; and
(vii) any imports or exports of controlled substances have been conducted in
compliance with the CSA and DEA regulations.

         4.11. Sales Representatives, Customers and Key Employees. (a) To the
best knowledge of the Company, no independent sales representatives, customers,
officers or key employees or group of key employees of the Company or any
Guarantor has any intention to terminate his, her or its relationship with the
Company or such Guarantor on or after the Closing or in the case of employees,
leave, the employ of the Company or any of the Guarantors on and




                                       10



after the Closing, nor has the Company or any of the Guarantors discussed or
taken any steps to terminate the employment of any officer or key employee or
group of key employees. Other than as set forth in Section 4.11 of the Schedule
of Exceptions, all personnel of the Company and any of the Guarantors are
employed on an "at will" basis and may be terminated upon notice of not more
than 30 days.

         (b) To the Company's best knowledge, no employee of the Company or any
of the Guarantors, or any consultant (including any scientific advisor) with
whom the Company or any of the Guarantors has contracted, is in violation of any
term of any employment contract, proprietary information agreement, licenses, or
any other agreement relating to the right of any such individual to be employed
by, or to contract with, the Company or any of the Guarantors because of the
nature of the business conducted by the Company and the Guarantors; and the
continued employment by the Company or any of the Guarantors of their present
employees, and the performance of the Company's and the Guarantor's contracts
with its independent contractors, will not result in any such violation, except
where any such violation could not reasonably be expected to have a Material
Adverse Effect. None of the Company or any of the Guarantors has received any
written, or to the best knowledge of the Company, oral notice alleging that any
such violation has occurred.

         (c) All of the Company's and any of the Guarantor's consultants
(including scientific advisors), officers and key employees are subject to
customary non-disclosure, non-competition and assignment of invention
agreements.

         4.12. Copyrights, Trademarks and Patents; Licenses. (a) Section 4.12 of
the Schedule of Exceptions sets forth a list of all of the Company's and any
Guarantor's patents, patent applications, trademarks, copyrights, trademark
registrations and applications therefor, patent, trademark or trade name
licenses, service marks, domain names, contracts with employees or others
relating in whole or in part to disclosure, assignment or patenting of any
inventions, discoveries, improvements, processes, formulae or other know-how,
and all patent, trademark or trade names or copyright licenses which are in
force (referred to collectively as "Intellectual Property Rights"). The
Intellectual Property Rights are, to the best of the Company's best knowledge,
fully valid and are in full force and effect.

         (b) The Company or a Guarantor owns outright all of the Intellectual
Property Rights listed on Section 4.12 of the Schedule of Exceptions attached
hereto free and clear of all liens and encumbrances except for the Permitted
Liens, and does not pay, and is not required to pay, any royalty to anyone under
or with respect to any of them.

         (c) Neither the Company nor any Guarantor has licensed anyone to use
any of such Intellectual Property Rights and has no knowledge of, nor has it
received any notice relating to, the infringing use by the Company or any
Guarantor of any Intellectual Property Rights.

         (d) The Company has no knowledge, nor has it received any notice (i) of
any conflict with the asserted rights of others with respect to any Intellectual
Property Rights used in, or useful to, the operation of the business conducted
by the Company and the Guarantors or with respect to any license under which the
Company or a Guarantor is licensor or licensee; or (ii) that the Intellectual
Property Rights infringe upon the rights of any third party.




                                       11




         (e) Except as set forth in Section 4.12 of the Schedule of Exceptions,
neither the Company nor any Guarantor is a party to any license agreement
pursuant to which the Company is the licensor or licensee of any Intellectual
Property Rights.

         4.13. Inventory. All inventory of the Company and the Subsidiaries
consists of a quality and quantity usable and salable in the ordinary course of
business, except for obsolete items and items of below-standard quality, all of
which have been written off or written down to net realizable value on the
consolidated balance sheet of the Company and its Subsidiaries as of June 30,
2002. The quantities of each type of inventory (whether raw materials,
work-in-process, or finished goods) are not excessive, but are reasonable and
warranted in the present circumstances of the Company.

         4.14. Registration Rights. Except as provided for in this Agreement or
as set forth in Section 4.14 of the Schedule of Exceptions, neither the Company
nor any Guarantor is under any obligation to register any of its currently
outstanding securities or any of its securities which may hereafter be issued
under the Securities Act in connection with any sale thereof.

         4.15. No Discrimination; Labor Matters. Neither the Company nor any
Guarantor in any manner or form discriminates, fosters discrimination or permits
discrimination against any Person based on gender or age, or belonging to any
minority race or believing in any minority creed or religion. No charge of
discrimination in employment, whether by reason of age, gender, race, religion
or other legally protected category that has been asserted or is now pending or,
to the best knowledge of the Company and the Guarantors, threatened before the
United States Equal Employment Opportunity Commission or other federal or
governmental authorities. The Company and each Guarantor is in compliance with
all applicable laws respecting employment practices, terms and conditions of
employment and wages and hours and is not and has not engaged in any unfair
labor practice. The Company and each Guarantor has withheld and paid to the
appropriate governmental authorities or is holding for payment not yet due to
governmental authorities, all amounts required to be withheld from such
employees of the Company or the Guarantors and is not liable for any arrears of
wages, taxes, penalties or other sums for failure to comply with any of the
foregoing. Except as set forth in Section 4.15 of the Schedule of Exceptions, in
connection with the operation of the Company's and each Guarantor's business,
(a) there is no unfair labor practice charge or complaint against the Company or
any Guarantor pending before the National Labor Relations Board or any other
governmental agency arising out of the Company's or any Guarantor's activities
and the Company has no knowledge, nor has it received notice of any facts or
information that would give rise thereto; (b) there is no significant labor
trouble, labor strike, material controversy, material unsettled grievance,
dispute, request for representation, slowdown or stoppage actually pending
against or affecting the Company or any of the Guarantors and, to the best
knowledge of the Company, none is or has been threatened; and (c) none of the
Company or any of the Guarantors has any collective bargaining agreements with
respect to any personnel nor is the Company aware of any current attempts to
organize or establish any labor union or employee association with respect to
any personnel, nor is there any certification, interim certifications or
voluntary recognition of any such union with regard to a bargaining unit.

         4.16. Environmental Matters. (a) Without limiting the generality of the
representations and warranties given in Section 4.10(a), each of the Company and
the Subsidiaries has obtained all environmental, health and safety permits,
licenses and other


                                       12



authorizations necessary or required for the operation of its business, except
where the failure to possess such franchises, licenses, permits or other
authority could not reasonably be expected to have a Material Adverse Effect,
and all such permits, licenses and other authorizations are in full force and
effect and each of the Company and, except as set forth in Section 4.16 of the
Schedule of Exceptions, the Subsidiaries is in compliance with all terms and
conditions of such permits, except where such noncompliance could not reasonably
be expected to have a Material Adverse Effect.

         (b) There is no proceeding pending or, to the best knowledge of the
Company, threatened, which may result in the denial, rescission, termination,
modification or suspension of any environmental or health or safety permits,
licenses or other authorizations necessary for the operation of the business of
the Company and the Subsidiaries.

         (c) During the occupancy by the Company or any Subsidiary of any real
property owned or leased by the Company or such Subsidiary, neither the Company
nor any Subsidiary, and to the best knowledge of the Company, no other Person,
has caused or permitted materials to be generated, released, stored, treated,
recycled, disposed of on, under or at such parcels, which materials, if known to
be present, would require cleanup, removal or other remedial or responsive
action under any environmental laws. To the best knowledge of the Company, there
are no underground storage tanks and no polychlorinated biphenyls ("PCB's"), PCB
contaminated oil or asbestos on any property leased by the Company or any
Subsidiary.

         (d) Except as set forth in Section 4.16 of the Schedule of Exceptions,
neither the Company nor any Subsidiary is subject to any judgment, decree, order
or citation related to or arising out of environmental laws, or has received
notice that it has been named or listed as a potentially responsible party by
any Person in any matter arising under environmental laws.

         (e) To the Company's best knowledge, each of the Company and the
Subsidiaries has disposed of all waste in full compliance with all environmental
laws.

         4.17. Taxes. The Company and each of the Guarantors have (a) filed all
necessary income, franchise and other material tax returns, domestic and
foreign, (b) paid all taxes shown as due thereunder and (c) withheld and paid to
the appropriate tax authorities all amounts required to be withheld from wages,
salaries and other remuneration to employees. The Company has no knowledge, nor
has it received notice, of any tax deficiency which might be assessed against
the Company or any Guarantor which, if so assessed, could reasonably be expected
to have a Material Adverse Effect.

         4.18. Employee Benefit Plans and Similar Arrangements. (a) Section 4.18
of the Schedule of Exceptions lists all employee benefit plans and collective
bargaining, labor and employment agreements or other similar arrangements in
effect to which the Company, the Guarantors, and any of their respective ERISA
Affiliates are a party or by which the Company, the Guarantors, and any of
respective ERISA Affiliates are bound, legally or otherwise, including, without
limitation, any profit-sharing, deferred compensation, bonus, stock option,
stock purchase, pension, retainer, consulting, retirement, severance, welfare or
incentive plan, agreement or arrangement; any plan, agreement or arrangement
providing for fringe benefits or perquisites to employees, officers, directors
or agents, including but not limited to benefits relating to employer-supplied
automobiles, clubs, medical, dental, hospitalization, life insurance




                                       13



and other types of insurance, retiree medical, retiree life insurance and any
other type of benefits for retired and terminated employees; any employment
agreement; or any other "employee benefit plan" (within the meaning of Section
3(3) of the Employee Retirement Income Security Act of 1974, as amended through
the date of this Agreement ("ERISA")) (herein referred to individually as "Plan"
and collectively as "Plans"). For purposes of this Agreement, "ERISA Affiliate"
means (i) any corporation which at any time on or before the Closing Date is or
was a member of the same controlled group of corporations (within the meaning of
Section 414(b) of the Internal Revenue Code of 1986, as amended (the "Code")) as
the Company, its Subsidiaries, or any ERISA Affiliate; (ii) any partnership,
trade or business (whether or not incorporated) which at any time on or before
the Closing Date is or was under common control (within the meaning of Section
414(c) of the Code) with the Company, its Subsidiaries, or any ERISA Affiliate;
and (iii) any entity which at any time on or before the Closing Date is or was a
member of the same affiliated service group (within the meaning of Section
414(m) of the Code) as the Company, its Subsidiaries or any ERISA Affiliate, or
any corporation described in clause (i) or any partnership, trade or business
described in clause (ii) of this paragraph.

         (b) True and complete copies of the following documents with respect to
any Plan of the Company, its Subsidiaries, and each ERISA Affiliate, as
applicable, have been made available to each of the Purchasers: (i) the most
recent Plan document and trust agreement (including any amendments thereto and
prior plan documents, if amended within the last two years), (ii) the last two
Form 5500 filings and schedules thereto, (iii) the most recent Internal Revenue
Service ("IRS") determination letter, (iv) all summary plan descriptions, (v) a
written description of each material non-written Plan, (vi) each written
communication to employees intended to describe a Plan or any benefit provided
by such Plan, (vii) the most recent actuarial report, and (viii) all
correspondence with the IRS, the Department of Labor and the Pension Benefit
Guaranty Corporation (the "PBGC") concerning any controversy. Each report
described in clause (vii) accurately reflects the funding status of the Plan to
which it relates and subsequent to the date of such report there has been no
adverse change in the funding status or financial condition of such Plan.

         (c) Each Plan is and has been maintained in compliance with applicable
law, including but not limited to ERISA, and the Code and with any applicable
collective bargaining agreements or other contractual obligations.

         (d) With respect to any Plan that is subject to Section 412 of the Code
("412 Plan"), there has been no failure to make any contribution or pay any
amount due as required by Section 412 of the Code, Section 302 of ERISA or the
terms of any such Plan, and no funding waiver has been requested or received
from the IRS. The assets of the Company, its Subsidiaries, or and ERISA
Affiliates are not now, nor will they after the passage of time be, subject to
any lien imposed under Section 412(n) of the Code by reason of a failure of the
Company, any Subsidiary, or any ERISA Affiliate to make timely installments or
other payments required under Section 412 of the Code.

         (e) No Plan subject to Title IV of ERISA has any Unfunded Pension
Liability. For purpose of this Agreement, "Unfunded Pension Liability" means, as
of any determination date, the amount, if any, by which the present value of all
benefit liabilities (as that term is defined in Section 4001(a)(16) of ERISA) of
a plan subject to Title IV of ERISA exceeds the fair




                                       14



market value of all assets of such plan, all determined using the actuarial
assumptions that would be used by the PBGC in the event of a termination of the
plan on such determination date.

         (f) Except as shown on Section 4.18 of the Schedule of Exceptions,
there are no pending, or to the best knowledge of the Company, its Subsidiaries,
and ERISA Affiliates, threatened claims, investigations, actions or lawsuits,
other than routine claims for benefits in the ordinary course, asserted or
instituted against (i) any Plan or its assets, (ii) any ERISA Affiliate with
respect to any 412 Plan, or (iii) any fiduciary with respect to any Plan for
which the Company, its Subsidiaries, or any ERISA Affiliate may be directly or
indirectly liable, through indemnification obligations or otherwise.

         (g) Except as set forth in Section 4.18 of the Schedule of Exceptions,
none of the Company, any Subsidiary, or any ERISA Affiliate has incurred and or
reasonably expects to incur (i) any withdrawal liabilities as defined in Section
4201 of ERISA ("Withdrawal Liability") and no event has occurred which, with the
giving of notice under Section 4219 of ERISA, would result in Withdrawal
Liabilities, or any liability under Section 4063, 4064, or 4243, or (ii) any
outstanding liability under Title IV of ERISA with respect to any 412 Plan.

         (h) Except as shown on Section 4.18 of the Schedule of Exceptions,
within the last five years, none of the Company, any Subsidiary or any ERISA
Affiliate has transferred any assets or liabilities of a 412 Plan subject to
Title IV of ERISA which had, at the date of such transfer, an Unfunded Pension
Liability or has engaged in a transaction which may reasonably be subject to
Section 4212(c) or Section 4069 of ERISA.

         (i) None of the Company, any Subsidiary, or any ERISA Affiliate has
engaged, directly or indirectly, in a non-exempt prohibited transaction (as
defined in Section 4975 of the Code or Section 406 of ERISA) in connection with
any Plan.

         (j) No "reportable event" (within the meaning of Section 4043 of ERISA)
has occurred with respect to any Plan.

         (k) Neither the Company nor any of its Subsidiaries provides, or has
provided, retiree welfare benefits for the benefit of any present or former
employee or director.

         (l) Neither the Company nor any of its Subsidiaries has made any
commitment or any formal plan to create any additional Plan or to modify or
terminate (except to the extent required by applicable law) any existing Plan.

         (m) Neither the Company nor any of its Subsidiaries is a party to any
plan, agreement or arrangement pursuant to the terms of which the consummation
or announcement of any transaction contemplated by this Agreement will result
(either alone or in connection with the occurrence of any additional or further
acts or events) in any benefit under any Plan being established or becoming
accelerated or immediately vested and payable.

         (n) The provisions of Section 280G of the Code will not apply with
respect to any payment made or to be made pursuant to or in connection with any
Plan.





                                       15





         4.19. Personal Property. The Company and the Guarantors have good and
marketable title to each item of equipment, machinery, furniture, fixtures,
vehicles, structures and other personal property, tangible and intangible,
included as an asset in the Financial Statements filed as part of the Company
Reports, free and clear of any security interests, options, liens, claims,
charges or encumbrances whatsoever, except as set forth in Section 4.19 of the
Schedule of Exceptions and as disclosed in the Company General Security
Agreement and the Guarantors General Security Agreement. The tangible personal
property owned or used by the Company and each of the Guarantors on the date
hereof in the operation of its business is adequate for the business conducted
by the Company and each of the Guarantors.

         4.20. Real Property. (a) The Company and the Guarantors do not own any
fee simple interest in real property other than as set forth in Section 4.20 of
the Schedule of Exceptions (the "Owned Property"). The Company and the
Guarantors do not lease or sublease any real property other than as set forth on
Schedule 4.20 (the "Leased Property"). The Company has previously made available
to the Purchasers a true and complete copy of all of the lease and sublease
agreements, as amended to date (the "Leases") relating to the Owned Property and
the Leased Property. The Company and each Guarantor enjoys a peaceful and
undisturbed possession of the Owned Property and Leased Property. No Person
other than the Company or any Guarantor has any right to use or occupy any part
of the Owned Property and the Leased Property. The Leases are valid, binding and
in full force and effect, all rent and other sums and charges payable thereunder
are current, no notice of default or termination under any of the Leases is
outstanding, no termination event or condition or uncured default on the part of
the Company or, to the best of the Company's knowledge, on the part of the
landlord, sublandlord, as the case may be, thereunder, exists under the Leases,
and no event has occurred and no condition exists which, with the giving of
notice, or the lapse of time, or both, would constitute such a default or
termination event or condition. There are no subleases, licenses or other
agreements granting to any Person other than the Company or the Guarantors any
right to possession, use, occupancy or enjoyment of the Premises demised by the
Leases. Each Owned Property and Leased Property is used in the conduct of the
Company's or the Guarantors' business.

         (b) Without limiting the generality of the representations and
warranties given in Section 4.10(a), all permits, licenses, franchises,
approvals and authorizations (collectively, the "Real Property Permits") of all
governmental authorities having jurisdiction over each Leased Property and from
all insurance companies and fire rating and other similar boards and
organizations (collectively, the "Insurance Organizations"), required have been
issued to the Company and the Guarantors to enable each Leased Property or Owned
Property to be lawfully occupied and used for all the purposes for which they
are currently occupied and used and have been lawfully issued and are in full
force and effect, except where the failure to possess such permits, licenses,
franchises, approvals and authorizations, individually or in the aggregate,
could not reasonably be expected to have a Material Adverse Effect.

         (c) Neither the Company nor the Guarantors have received any notice nor
have they any knowledge of any pending, threatened or contemplated condemnation
proceeding affecting any Leased Property or the Owned Property or any part
thereof.

         4.21. Disclosure. The information heretofore provided and to be
provided in connection with this Agreement, including, without limitation, the
Schedule of Exceptions and the Exhibits hereto, the Transaction Documents and
each of the agreements, documents,



                                       16



certificates and writings previously furnished to the Purchasers or their
representatives, do not and will not contain any untrue statement of a material
fact and do not and will not omit to state a material fact necessary in order to
make the statements and writings contained herein and therein not false or
misleading in the light of the circumstances under which they were made. There
are no facts that (individually or in the aggregate) could reasonably be
expected to have a Material Adverse Effect, which has not been set forth herein
or in the Company Reports.

         4.22. Solvency. On the Closing Date (both before and after giving
effect to its Guaranty and the transactions contemplated by the Transaction
Documents), Houba, Inc. will be Solvent. As used herein, the term "Solvent"
means, with respect to Houba, Inc. on a particular date, that on and as of such
date (a) the fair market value of the assets of such Guarantor is greater than
the total amount of liabilities (including, without limitations, contingent
liabilities) of such Guarantor, (b) the present fair saleable value of the
assets of such Guarantor is greater than the amount that will be required to pay
the probable liabilities of such Guarantor on its debts as they become absolute
and matured, (c) such Guarantor is able to realize upon its assets, through
sale, use or borrowing, and is able to pay its debts and other liabilities,
including contingent obligations, as they mature and (d) such Guarantor does not
have unreasonably small capital.

         4.23. Insurance. Each of the Company and the Guarantors maintains, with
financially sound and reputable insurers, insurance against loss or damage by
theft, fire, explosion and other risks customarily insured against by companies
in the line of business of the Company or the Guarantors, in amounts sufficient
to prevent the Company or the Guarantors from becoming a co-insurer of the
property insured as well as insurance against other hazards and risks and
liability to persons and property to the extent and in the manner customary for
companies in similar businesses similarly situated or as may be required by law,
including, without limitation, general liability, fire and business interruption
insurance, and product liability insurance as may be required pursuant to any
license agreement to which the Company or the Guarantors is a party or by which
it is bound.

         4.24 Non-Competes. Except as set forth in Section 4.24 of the Schedule
of Exceptions, and as contemplated by Section 4.11(c), the Company and its
Subsidiaries are not subject to any non-compete or similar arrangements with any
Persons that restrict or may restrict the Company and its Subsidiaries from
carrying on its business as now conducted and as it is proposed to be conducted.

         4.25 Product Warranty. Except as set forth in Section 4.25 of the
Schedule of Exceptions, or as reflected or reserved against in the Financial
Statements, (a) to the knowledge of the Company, each product manufactured by
the Company or any Subsidiary has been in material conformity with all
applicable contractual commitments of the Company or any Subsidiary, and (b) no
product currently manufactured by the Company or any Subsidiary is subject to
any guaranty, warranty or indemnity of a contractual nature other than the
applicable standard terms and conditions, if any, applicable to the sale or
delivery of such product.

         4.26. Minute Books. The minute books of the Company and the
Subsidiaries furnished to the Purchasers for review are accurate and complete.




                                       17





                                   ARTICLE V

                REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS

         As a material inducement to the Company to enter into and perform its
obligations under this Agreement, each Purchaser severally (as to itself and not
with respect to any other Purchaser) represents and warrants to the Company that
it is acquiring the Securities for investment for its own account and is not
acquiring any of the Securities with the view to, or for resale in connection
with, any distribution thereof. Each Purchaser understands that none of the
Securities have been registered under the Securities Act. If any Purchaser
should in the future decide to dispose of any Securities, it is understood that
the Purchaser may do so only in compliance with the Securities Act. Each
Purchaser will be required to complete and execute the form of Subscription
Agreement attached as Exhibit D hereto. Each Purchaser acknowledges that the
Company will rely upon the representations made by such Purchaser in the
Subscription Agreement in connection with the issuance of the Securities to be
sold hereunder.

                                   ARTICLE VI

                     CONDITIONS TO CLOSING OF THE PURCHASERS

         The obligation of each Purchaser to purchase the Securities at the
Closing is subject to the fulfillment to such Purchaser's satisfaction on or
prior to the Closing Date of each of the following conditions, unless otherwise
waived by such Purchaser:

         6.1. Representations and Warranties Correct; No Default. The
representations and warranties of the Company set forth in Article IV hereof
shall be true and correct when made, and shall be true and correct on the
Closing Date with the same force and effect as if they had been made on and as
of the Closing Date. No Event of Default, or any other event which, with the
giving of notice, the lapse of time, or both, would constitute an Event of
Default, shall have occurred and be continuing on the date of this Agreement or
on the Closing Date.

         6.2. Performance. All covenants, agreements and conditions contained in
this Agreement to be performed or complied with by the Company on or prior to
the Closing Date shall have been performed or complied with by the Company.

         6.3. Compliance Certificate. The Company shall have delivered to the
Purchaser a certificate of the Company, executed by the Company's President,
dated the Closing Date, certifying to the fulfillment of the conditions
specified in Sections 6.1 and 6.2 of this Agreement and other matters as the
Purchaser shall reasonably request.

         6.4. No Impediments. None of the Company, or any of the Guarantors, or
any Purchaser shall be subject to (a) any order, decree or injunction of a court
or administrative or governmental body or agency of competent jurisdiction
directing that the transactions provided for in the Transaction Documents or any
material aspect thereof not be consummated as contemplated by the Transaction
Documents or (b) there shall not be any action, suit, proceeding, complaint,
charge, hearing, inquiry or investigation before or by any court or
administrative or governmental body or agency pending or, to the Company's best
knowledge, threatened, wherein an unfavorable order, decree or injunction would
prevent the performance of



                                       18



any of the Transaction Documents or the consummation of any material aspect of
the transactions or events contemplated thereby, declare unlawful any aspect of
the transactions or events contemplated by the Transaction Documents, cause any
material aspect of the transactions contemplated by the Transaction Documents to
be rescinded or have a Material Adverse Effect.

         6.5. Waivers/Elections of Rights of First Refusal. The Company shall
have obtained from each Person other than a Purchaser and who has any current
effective right of first refusal with respect to the Securities, a written
waiver or election of such right in form and substance reasonably satisfactory
to the Purchasers.

         6.6. Watson Consent; Amendment to Watson Term Loans; Subordination
Agreement. The Company shall have obtained (a) the consent of Watson to the
consummation of the transactions contemplated by the Transaction Agreements,
including, without limitation, the issuance of the Securities, the incurrence of
the Indebtedness evidenced by the Debentures and the grant of the liens covering
the assets of the Company and the Guarantors in favor of the Purchasers as
provided herein, which consent shall be in form and substance reasonably
acceptable to the Purchasers (the "Watson Consent"); (b) an amendment to the
loan documents evidencing the 2000 Watson Term Loan, duly executed by the
Company, the Guarantors and Watson, providing for (i) the extension of the
maturity date of the Watson Term Loan from March 31, 2003 to March 31, 2006,
(ii) the Company's issuance of the Watson Warrant exercisable for 10,700,665
shares of Common Stock, which amendments to the Watson Term Loan shall be in
form and substance reasonably acceptable to the Purchasers and (iii) the
issuance of a new term consent to the issuance of a new term loan to the Company
by Watson to take into account the excess payments made by Watson to the Company
of approximately $3,901,331 (the "2002 Watson Term Loan") (the "Watson Term Loan
Amendment"); (c) consent to the issuance of the 2002 Watson Term Loan pursuant
to the Watson Term Loan Amendment and the Watson Supply Agreement in form and
substance reasonably acceptable to the Purchasers (the "Watson Supply Agreement
Amendment"); and (d) a Subordination Agreement substantially in the form
attached hereto as Exhibit M by and among the Company, Watson, the Purchasers,
the holders of the Existing Debentures and certain other parties signatory
thereto (such agreement, as supplemented, amended or otherwise modified from
time to time in accordance with its terms, the "Subordination Agreement")
confirming, among other things, their relative rights with respect to the
Company Debenture Collateral and the Guarantors Debenture Collateral,
respectively.

         6.7. Consent of Holders of Existing Debentures. The Company shall have
obtained (a) the consent of the holders of the Existing Debentures to waive the
Indebtedness, lien, registration rights, and charter amendment restrictions
contained in each of the Debenture and Warrant Purchase Agreements pursuant to
which the Existing Debentures were issued (the "Existing Debentureholders
Consent"); (b) an amendment to each of the Debenture and Warrant Purchase
Agreements pursuant to which the Existing Debentures were issued, duly executed
by the Company and each holder of the Existing Debentures, providing for (i) the
extension of the maturity date of the Existing Debentures from March 15, 2003 to
March 31, 2006, and (ii) the exercise of any preemptive rights granted to the
holders of the Existing Debentures on a pro rata basis with the Purchasers of
the Debentures under this Agreement (the "Existing Debenture Amendments"); (c)
the Subordination Agreement and; (d) the Debenture Dilution Waiver. Each of the
Existing Debentureholders Consent and the Existing Debenture Amendments shall be
in form and substance reasonably acceptable to the Purchasers.



                                       19





         6.8. Consent of Galen Bridge Lenders. The Company shall have (a)
obtained from the Galen Bridge Lenders the consent to surrender and convert the
Galen Bridge Notes in exchange for and into Debentures in form and substance
reasonably acceptable to the Purchasers (the "Galen Bridge Lenders Consent"),
and (b) prepaid any Galen Bridge Notes not so surrendered and converted in
accordance with their terms and the terms of the Galen Bridge Loan Agreement
(other than Galen Bridge Notes held by Galen, which must be converted in
accordance with subsection 6.8(a)).

         6.9. Recapitalization Agreement. The Company shall have executed the
Recapitalization Agreement in substantially the form of Exhibit N hereto (the
"Recapitalization Agreement") and shall have caused each of the holders of the
Company's Common Stock purchase warrants listed on the signature page thereto
(the "Warrant Holders") to have executed the Recapitalization Agreement,
providing for the Warrant Holders surrender to the Company of the common stock
purchase warrants described in Schedule A to the Recapitalization Agreement in
exchange for an aggregate of approximately 5,970,083 shares of the Company's
Common Stock and the transaction contemplated thereby shall have been
consummated.

         6.10. Other Agreements and Documents. The Company shall have executed
and delivered to each Purchaser this Agreement, issued to such Purchaser all of
the Securities and the Company and each of the Guarantors, as applicable, shall
have executed and delivered the following agreements and documents:

         (a) The Company General Security Agreement;

         (b) The Guaranties;

         (c) The Guarantors Security Agreement;

         (d) The Stock Pledge Agreement;

         (e) Financing Statements and Termination Statements on Form UCC-1 and
Form UCC-3 (or the applicable form), respectively, with respect to all personal
property and assets of the Company and each Guarantor;

         (f) A certified copy of the Certificate of Incorporation of the Company
and each Guarantor and all amendments thereto;

         (g) Resolutions by the Board of Directors of each of the Company and
the Guarantors approving the execution, delivery and performance of this
Agreement and the other Transaction Documents and the transactions contemplated
hereby and thereby;

         (h) A copy of the By-Laws of the Company and each Guarantor as amended
to date, certified as being true by a principal officer of the Company;

         (i) A Certificate of Good Standing and Tax Status from the state of
incorporation of the Company and each Guarantor and from every state in which
any of them is qualified to do business;

         (j) The Mortgage;



                                       20





         (k) The Mortgage Subordination Agreement;

         (l) The Watson Consent;

         (m) The Watson Term Loan Amendment;

         (n) The 2002 Watson Term Loan

         (o) The Watson Supply Agreement Amendment;

         (p) The Subordination Agreement;

         (q) The Watson Warrant;

         (r) The Registration Rights Agreement;

         (s) The Galen Bridge Lenders Consent;

         (t) The Existing Debentureholders Consent;

         (u) The Existing Debenture Amendments;

         (v) The Debentureholders Agreement;

         (w) The Subscription Agreement with each Purchaser

         (x) The Voting Agreement; and

         (y) The Recapitalization Agreement.

         6.11. Consents. In addition to the consents described in Section 6.6,
6.7 and 6.8, the Company shall have obtained all necessary consents or waivers,
if any, from all parties governmental and private to any other material
agreements to which the Company is a party or by which it is bound immediately
prior to the Closing in order that the transactions contemplated by the
Transaction Agreements may be consummated and the business of the Company may be
conducted by the Company after the Closing without adversely affecting the
Company.

         6.12. Legal Investment. As of the Closing Date, there shall not have
been any change in any law, statute, ordinance, rule, code, approvals,
governmental restriction, regulation, permit, order, writ, injunction, judgment
or decree, applicable to any of the Purchasers that would prevent the
performance of this Agreement or any other Transaction Document or the
consummation of any material aspect of the transactions contemplated hereby or
thereby by such Purchaser, in each case to the extent that it would deprive such
Purchaser of the principal benefits of such transactions.

         6.13. Proceedings and Other Documents. All corporate and other
proceedings taken or required to be taken by the Company and any Guarantor in
connection with the transactions contemplated by this Agreement and the other
Transaction Documents to be



                                       21



consummated prior to the Closing shall have been taken, except as otherwise
provided in Sections 9.7 and 9.12 hereof, and the Purchasers shall have received
such other documents, in form and substance reasonably satisfactory to the
Purchasers and their counsel, as to such other matters incident to the
transactions contemplated hereby as the Purchasers may reasonably request.

         6.14. Opinion of Counsel. The Purchasers shall have received the
opinion of St. John & Wayne, L.L.C., counsel to the Company, dated the Closing
Date, substantially in the form of Exhibit H attached hereto.

         6.15. Reconstitution of the Board of Directors. The Board of Directors
of the Company shall have been reconstituted to consist of 11 members, comprised
as follows: (a) one member, who shall be a designee of Care Capital Investments
II, LP, (b) one member, who shall be a designee of Essex Woodlands Health
Ventures Fund V, (c) up to two members, who shall be executive officers of the
Company, (d) three members, who shall be designees of the holders of the March
1998 Debentures, (e) one member, who shall be a designee of the holders of the
May 1999 Debentures, and (f) three members (increased to the extent of any
reduction in the number of Board member also serving as executive officers of
the Company), who shall be independent directors nominated and elected to the
Board by the then current board members, subject to the consent to the
appointment and election of such independent Board members by each Board member
who is a designee of Care Capital Investments II, LP or Essex Woodlands Health
Ventures Fund V. The Company shall have provided the Purchasers with the
resignation of such members of the Company's current Board of Directors so as to
reconstitute the Board of Directors as provided in this Section 6.15.
Notwithstanding the foregoing, the designees of the holders of the March 1998
Debentures to the Board of Directors shall be reduced from three to two
commencing as of and following the second Annual Meeting of the Company's
shareholders which occurs following the date of this Agreement.

         6.16. Authorized Shares. The Company shall have received from each of
Galen, Galen Partners International III, L.P., Galen Employee Fund III, L.P. and
Oracle Strategic Partners, L.P. (collectively, the "Institutional Existing
Debentureholders") a written consent authorizing the Company to release, on a
pro rata basis, (a) from its authorized but unissued reserved shares of Common
Stock such number of shares of Common Stock, otherwise reserved for the
Institutional Existing Debentureholders (the "Institutional Existing
Debentureholders Reserved Shares"), as are necessary to permit the conversion at
any time on or after the Closing of all of the Debentures purchased hereunder by
each of Care Capital Investments II, LP and Essex Woodlands Health Ventures Fund
V, and (b) from the Institutional Existing Debentureholders Reserved Shares such
number of additional shares of Common Stock as necessary to be reserved to take
into account any change in the Conversion Price (as defined in the Debenture) of
the Debentures purchased hereunder by each of Care Capital Investments II, LP
and Essex Woodlands Health Ventures Fund V.



                                       22






                                  ARTICLE VII

                      CONDITIONS TO CLOSING OF THE COMPANY

         The Company's obligation to sell the Securities at the Closing is
subject to the fulfillment to its satisfaction on or prior to the Closing Date
of each of the following conditions, unless otherwise waived by the Company:

         7.1. Representations. The representations and warranties of each of the
Purchasers set forth in Article V hereof and in the Subscription Agreement shall
be true and correct when made, and shall be true and correct on the Closing Date
with the same force and effect as if they had been made on and as of the Closing
Date.

         7.2. Legal Investment. As of the Closing Date, there shall not have
been any change in any law, statute, ordinance, rule, code, approvals,
governmental restriction, regulation, permit, order, writ, injunction, judgment
or decree, applicable to the Company that would prevent the performance of this
Agreement or any other Transaction Document or the consummation of any material
aspect of the transactions contemplated hereby or thereby by the Company, in
each case to the extent that it would deprive the Company of the principal
benefits of such transactions.

         7.3. Payment of Purchase Price. The Company shall have received payment
in full of the purchase price for the Securities.

                                  ARTICLE VIII

                                   PREPAYMENT

         No Optional Prepayments. Without limiting the Company's conversion
rights as provided in Section 3.2 of the Debentures, the Company may not at any
time, without the prior written consent of the holders of all of the holders of
the outstanding Debentures, prepay any Debenture, the Watson Term Loans, the
Existing Debentures or any other indebtedness existing now or hereafter, in
whole or in part.

                                   ARTICLE IX

                              AFFIRMATIVE COVENANTS

         The Company hereby covenants and agrees, so long as any Securities
remain outstanding, as follows:

         9.1. Maintenance of Corporate Existence, Properties and Leases; Taxes;
Insurance. The Company shall and shall cause each of the Guarantors to, maintain
in full force and effect its corporate existence, rights and franchises and all
terms of licenses and other rights to use licenses, trademarks, trade names,
service marks, copyrights, patents, processes or any other Intellectual Property
Rights owned or possessed by it and necessary to the conduct of its business,
except where failure to maintain such rights, franchises and terms of licenses
and other





                                       23



rights to use such Intellectual Property Rights could not reasonably be expected
to have a Material Adverse Effect.

         (a) The Company shall, and shall cause the Guarantors to, keep each of
its properties necessary to the conduct of its business in good repair, working
order and condition, reasonable wear and tear excepted, and from time to time
make all needful and proper repairs, renewals, replacements, additions and
improvements thereto; and the Company shall, and shall cause the Guarantors to,
at all times comply with each provision of all leases to which it is a party or
under which it occupies property, except where any such noncompliance could not
reasonably be expected to have a Material Adverse Effect.

         (b) The Company shall and shall cause each of the Guarantors to (i)
promptly pay and discharge, or cause to be paid and discharged when due and
payable, all lawful taxes, assessments and governmental charges or levies
imposed upon the income, profits, assets, property or business of the Company
and the Guarantors, (ii) withhold and promptly pay to the appropriate tax
authorities all amounts required to be withheld from wages, salaries and other
remuneration to employees, and (iii) promptly pay all claims or Indebtedness
(including, without limitation, claims or demands of workmen, materialmen,
vendors, suppliers, mechanics, carriers, warehousemen and landlords) which, if
unpaid might become a lien upon the assets or property of the Company or the
Guarantors; provided, however, that any such tax, lien, assessment, charge or
levy need not be paid if (i) the validity thereof shall be contested timely and
in good faith by appropriate proceedings, (ii) the Company or the Guarantors
shall have set aside on its books adequate reserves with respect thereto, and
(iii) the failure to pay shall not be prejudicial in any material respect to the
holders of the Securities, and provided further that the Company or the
Guarantors will pay or cause to be paid any such tax, lien, assessment, charge
or levy forthwith upon the commencement of proceedings to foreclose any lien
which may have attached as security therefor. The Company shall and shall cause
the Guarantors to pay or cause to be paid all other Indebtedness incident to the
operations of the Company or the Guarantors.

         (c) The Company shall and shall cause each of the Guarantors to, keep
its assets which are of an insurable character insured by financially sound and
reputable insurers against loss or damage by theft, fire, explosion and other
risks customarily insured against by companies in the line of business of the
Company or the Guarantors, in amounts sufficient to prevent the Company or the
Guarantors from becoming a co-insurer of the property insured; and the Company
shall and shall cause the Guarantors to maintain, with financially sound and
reputable insurers, insurance against other hazards and risks and liability to
persons and property to the extent and in the manner customary for companies in
similar businesses similarly situated or as may be required by law, including,
without limitation, general liability, fire and business interruption insurance,
and product liability insurance as may be required pursuant to any license
agreement to which the Company or the Guarantors is a party or by which it is
bound.

         9.2. Basic Financial Information. The Company shall furnish the
following reports to each Purchaser (or any transferee of any Securities), so
long as the Purchaser is a holder of any Securities:

                  (a) within 30 days after the end of each of the 12 monthly
         accounting periods in each fiscal year (or when furnished to the
         Company's Board of Directors, if earlier), unaudited consolidated
         statements of income and retained earnings and cash flows of the




                                       24



         Company and its Subsidiaries for each monthly period and for the period
         from the beginning of such fiscal year to the end of such monthly
         period, together with consolidated balance sheets of the Company and
         its Subsidiaries as at the end of each monthly period, setting forth in
         each case comparisons to budget and to corresponding periods in the
         preceding fiscal year, which statements will be prepared in accordance
         with US GAAP consistently applied, and will fairly present the
         consolidated financial position of the Company and its Subsidiaries as
         of the dates thereof and their consolidated results of operations for
         such periods;

                  (b) within 90 days after the end of each fiscal year (or
         within five days after being filed with the Commission, if sooner),
         consolidated statements of income and retained earnings and cash flows
         of the Company and its Subsidiaries for the period from the beginning
         of each fiscal year to the end of such fiscal year, and consolidated
         balance sheets as at the end of such fiscal year, setting forth in each
         case in comparative form corresponding figures for the preceding fiscal
         year, which statements will be prepared in accordance with US GAAP,
         consistently applied, and will fairly present the consolidated
         financial position of the Company and its Subsidiaries as of the dates
         thereof and their consolidated results of operations for such periods,
         and will be accompanied by:

                           (i) a report of the Company's independent certified
                  public accounting firm;

                           (ii) a report from such accounting firm addressed to
                  the Purchasers, stating that in making the audit necessary to
                  express their opinion on the financial statements, nothing has
                  come to their attention which would lead them to believe that
                  an Event of Default has occurred with respect to this
                  Agreement or the Debentures or, if such accountants have
                  reason to believe that any such Event of Default has occurred,
                  a letter specifying the nature thereof; and

                           (iii) the management letter of such accounting firm;

                  (c) within 45 days after the end of each quarterly accounting
         period in each fiscal year (or within five days after being filed with
         the Commission, if sooner) consolidated statements of income and
         retained earnings and cash flows of the Company and its Subsidiaries
         for such quarterly accounting period and for the period from the
         beginning of each fiscal year to the end of such quarterly accounting
         period and consolidated balance sheets as at the end of such quarterly
         accounting period, setting forth in each case in comparative form
         corresponding figures for the preceding quarterly accounting period,
         which statements will be prepared in accordance with US GAAP,
         consistently applied, and will fairly represent the consolidated
         financial position of the Company and its Subsidiaries as of the dates
         thereof and their consolidated results of operations for such periods;

                  (d) within 45 days after the end of each quarterly accounting
         period in each fiscal year, a certificate of the Chief Financial
         Officer of the Company stating that the Company is in compliance with
         the terms of this Agreement and any other material contract or
         commitment to which the Company or any of its Subsidiaries is a party
         or by which any of them is bound, or if the Company or any of its
         Subsidiaries is not in



                                       25



         compliance, specifying the nature and period of noncompliance, and what
         actions the Company or such Subsidiary has taken and proposes to take
         with respect thereto. Notwithstanding the foregoing, the certificate
         delivered at the end of each fiscal year of the Company shall be signed
         by both the Chief Executive Officer and the Chief Financial Officer of
         the Company and shall be delivered within 90 days after the end of the
         fiscal year;

                  (e) promptly upon receipt thereof, but in no event later than
         three business days, any additional reports or other detailed
         information concerning significant aspects of the operations and
         condition, financial or otherwise, of the Company and its Subsidiaries,
         given to the Company by its independent accountants;

                  (f) at least 30 days prior to the end of each fiscal year, a
         detailed annual operating budget and business plan for the Company and
         its Subsidiaries for the succeeding twelve-month period. Such budgets
         shall be prepared on a monthly basis, displaying consolidated
         statements of anticipated income and retained earnings, consolidated
         statements of anticipated cash flow and projected consolidated balance
         sheets, setting forth in each case the assumptions (which assumptions
         and projections shall represent and be based upon the good faith
         judgment in respect thereof of the Chief Executive Officer of the
         Company) behind the projections contained in such financial statements,
         and which budgets shall have been approved by the Board of Directors of
         the Company prior to the beginning of each twelve-month period for
         which such budget shall have been prepared and, promptly upon
         preparation thereof, any other budgets that the Company may prepare and
         any revisions of such annual or other budgets;

                  (g) within ten days after transmission or receipt thereof,
         copies of all financial statements, proxy statements and reports which
         the Company sends to its stockholders or directors, and copies of all
         registration statements and all regular, special or periodic reports
         which it or any of its officers or directors files with the Commission,
         the American Stock Exchange (the "AMEX"), the National Association of
         Securities Dealers Automated Quotation System ("NASDAQ") or with any
         other securities exchange or over-the-counter market on which any of
         the securities of the Company are then listed or approved for trading,
         copies of all press releases and other statements made generally
         available by the Company to the public concerning material developments
         in the business of the Company and its Subsidiaries and copies of
         material communications sent to or received from stockholders,
         directors or committees of the Board of Directors of the Company or any
         of its Subsidiaries and copies of all material communications sent to
         and received from any lender to the Company; and

                  (h) with reasonable promptness such other information and
         financial data concerning the Company as any Person entitled to receive
         materials under this Section 9.2 may reasonably request.
         Notwithstanding the foregoing, all confidential information furnished
         at any time by or on behalf of the Company or its Subsidiaries to any
         Purchaser (or any transferee of any Securities) shall be subject to the
         provisions of Section 19.13.

         9.3. Notice of Adverse Change. The Company shall promptly give notice
to all holders of any Securities (but in any event within two days) after
becoming aware of the existence of any condition or event which constitutes, or
the occurrence of, any of the following:




                                       26





                  (a) any Event of Default or any default that with the passage
         of time or the giving of notice would constitute an Event of Default;

                  (b) the institution or threatening of institution of any
         action, suit or proceeding against the Company or any Subsidiary before
         any court, administrative agency or arbitrator, including, without
         limitation, any action of a foreign government or instrumentality,
         which, if adversely decided, could reasonably be expected to have a
         Material Adverse Effect;

                  (c) any information relating to the Company or any Subsidiary
         which could reasonably be expected to have a Material Adverse Effect;
         or

                  (d) any failure by the Company or any of its Subsidiaries to
         comply with the provisions of Section 9.4 below.

         Any notice given under this Section 9.3 shall specify the nature and
period of existence of the condition, event, information, development or
circumstance, the anticipated effect thereof and what actions the Company or any
Guarantor, as the case may be, has taken and proposes to take with respect
thereto.

         9.4. Compliance With Agreements; Compliance With Laws. The Company
shall comply and cause its Subsidiaries to comply, with the terms and conditions
of all material agreements, commitments or instruments to which the Company or
any of its Subsidiaries is a party or by which it or they may be bound. The
Company shall and shall cause each of its Subsidiaries to duly comply with any
laws, ordinances, rules and regulations of any foreign, Federal, state or local
government or any agency thereof, or any writ, order or decree, and conform to
all valid requirements of governmental authorities relating to the conduct of
their respective businesses, properties or assets, including, but not limited
to, the requirements of the FDA Act, the Prescription Drug Marketing Act, the
CSA, the Employee Retirement Income Security Act of 1978, the Environmental
Protection Act, the Occupational Safety and Health Act, the Foreign Corrupt
Practices Act and the rules and regulations of each of the agencies
administering such acts, in each case except for any such noncompliance that
could not reasonably be expected to have a Material Adverse Effect.

         9.5. Protection of Licenses, etc. The Company shall and shall cause its
Subsidiaries to, maintain, defend and protect to the best of their ability
licenses and sublicenses (and to the extent the Company or a Subsidiary is a
licensee or sublicensee under any license or sublicense, as permitted by the
license or sublicense agreement), trademarks, trade names, service marks,
patents and applications therefor and other proprietary information or
Intellectual Property Rights owned or used by it or them and shall keep
duplicate copies of any licenses, trademarks, service marks or patents owned or
used by it, if any, at a secure place selected by the Company.

         9.6. Accounts and Records; Inspections. (a) The Company shall keep true
records and books of account in which full, true and correct entries will be
made of all dealings or




                                       27




transactions in relation to the business and affairs of the Company and its
Subsidiaries in accordance with US GAAP applied on a consistent basis.

         (b) The Company (subject to the terms and conditions contained in
Section 19.13) shall permit each holder of any Securities or any of such
holder's officers, employees or representatives during regular business hours of
the Company, upon reasonable notice and as often as such holder may reasonably
request, to visit and inspect the offices and properties of the Company and its
Subsidiaries and to make extracts or copies of the books, accounts and records
of the Company or its Subsidiaries, and to discuss the affairs, finances and
accounts of the Company and its Subsidiaries, with the Company's (or
Subsidiary's) directors and officers, its independent public accountants,
consultants and attorneys.

         (c) Nothing contained in this Section 9.6 shall be construed to limit
any rights that a holder of any Securities may have with respect to the books
and records of the Company and its Subsidiaries, to inspect its properties or to
discuss its affairs, finances and accounts.

         (d) The Company will retain a firm of independent certified public
accountants reasonably acceptable to the Purchasers (an "Approved Accounting
Firm") to audit the Company's financial statements at the end of each fiscal
year. In the event the services of an Approved Accounting Firm or any firm of
independent public accountants hereafter employed by the Company are terminated,
the Company will promptly thereafter request the firm of independent public
accountants whose services are terminated to deliver to the Purchasers a letter
of such firm setting forth its understanding as to the reasons for the
termination of their services and whether there were, during the two most recent
fiscal years or such shorter period during which said firm had been retained by
the Company any disagreements between them and the Company on any matter of
accounting principles or practices, financial statement disclosure, or auditing
scope or procedure. In its notice, the Company shall state whether the change of
accountants was recommended or approved by the Board of Directors or any
committee thereof. In the event of such termination, the Company will promptly
thereafter engage another Approved Accounting Firm.

         9.7. Board Members and Meetings. (a) So long as the Purchasers own any
Debentures, the Board of Directors of the Company shall be comprised of 11
members. The Company agrees to hold meetings of its Board of Directors at least
four times a year, at no more than three month intervals. So long as the
Purchasers own any Debentures, Care Capital Investments II, LP shall have the
right to designate for nomination one person, and Essex Woodlands Health
Ventures Fund V shall have the right to designate for nomination one person
(collectively, the "Designees"), to be members of the Company's Board of
Directors and the Company shall cause (i) such Designees to be elected to the
Board of Directors on the Closing Date, (ii) such Designees to be nominated for
election at each Annual Meeting of Shareholders of the Company, and at each
special meeting of the shareholders of the Company called for the purpose of
electing directors of the Company and at any time at which the shareholders of
the Company have the right to elect directors of the Company, and shall
recommend that the Company's shareholders vote in favor of the election of such
nominees, and (iii) such Designees shall be, if so requested by such Designee in
its sole discretion, appointed to the Company's Executive Committee,
Compensation Committee and any other committee of the Company. So long as the
Purchasers own any Debentures, at each Annual Meeting of the Shareholders of the




                                       28



Company held thereafter, the Designees shall be, if so requested by such
Designee in its sole discretion, appointed to the Company's Executive Committee
and Compensation Committee and any other committee of the Company. Directors
shall be reimbursed for their reasonable travel and related expenses in
attending Board meetings.

         (b) In lieu of having its Designee nominated for election as a director
of the Company as set forth above, each of Care Capital Investments II, LP and
Essex Woodlands Health Ventures Fund V may, at its election and upon written
notice to the Company, appoint a nonvoting "observer", who shall (i) be provided
by the Company with all notices of meetings, consents, minutes and other
materials that are provided to the Board of Directors (or any committee thereof)
at the same time as such materials are provided to the Board of Directors (or
any committees thereof) and (ii) be entitled to attend all meetings of the Board
of Directors, including all meetings of the Company's Executive Committee, Audit
Committee and Compensation Committee and any other committee of the Company;
provided, however, that any such information provided to a nonvoting "observer"
shall be subject to the provisions of Section 19.13.

         (c) So long as the Purchasers own any Debentures, each of Care Capital
Investments II, LP and Essex Woodlands Health Ventures shall have the right to
have a representative join the Company's Scientific Advisory Board, subject to
the approval of the Company's Board of Directors and subject further to the
provisions of Section 19.13.

         9.8. Maintenance of Office. The Company will maintain its principal
office at the address of the Company set forth in Section 19.5 of this Agreement
where notices, presentments and demands in respect of this Agreement and any of
the Securities may be made upon the Company, until such time as the Company
shall notify the holders of the Securities in writing, at least 30 days prior
thereto, of any change of location of such office.

         9.9. Use of Proceeds. The Company shall use all the proceeds received
from the sale of the Securities pursuant to this Agreement for general working
capital.

         9.10. Payment of Debentures. The Company shall pay the principal of and
interest on the Debentures in the time, the manner and the form provided in the
Debentures.

         9.11. Reporting Requirements. The Company shall comply with its
reporting and filing obligations pursuant to Section 13 or 15(d) of the Exchange
Act. The Company shall provide copies of such reports, including, without
limitation, reports on Form 10-K, 10-Q, 8-K and Schedule 14A promulgated under
the Exchange Act, or substantially the same information required to be contained
in any successor form, to each holder of any Securities promptly upon filing
with the Commission.

         9.12. Amendments to the Company's Certificate of Incorporation. (a) The
Company will present to its shareholders and debentureholders for consideration
at the Company's next Annual Meeting of Shareholders: (i) a proposal to amend
the Company's Certificate of Incorporation to increase the number of authorized
shares of the Company's Common Stock available for issuance from 80,000,000 to
such number of shares as shall equal



                                       29



the sum of (A) the Company's issued and outstanding Common Stock, plus (B) the
number of shares of Common Stock issuable upon the conversion and exercise of
the Company's outstanding convertible securities, plus (C) the number of shares
of Common Stock issuable upon conversion of the Debentures and exercise of the
Watson Warrant, plus (D) 50 million shares, as shall sum shall be rounded up to
the nearest whole five million shares; (ii) a proposal to amend the Company's
Certificate of Incorporation to provide that holders of the Debentures shall
have the right to vote as part of a single class with all holders of Common
Stock of the Company on all matters to be voted on by such stockholders with the
holders of the Debentures having such number of votes as shall equal the number
of votes they would have had such holders converted the entire outstanding
principal amount of the Debentures into Shares immediately prior to the record
date relating to such vote, provided, however, that any Debentures held by Care
Capital Investments II, LP shall, for so long as they are held by Care Capital
Investments II, LP, have no such voting rights and the Certificate of
Incorporation and the Debentures shall so state; and (iii) a proposal to elect
as directors one Designee of each of Care Capital Investments II, LP and Essex
Woodlands Health Ventures Fund V, which Designees shall also be appointed, if so
requested by such Designee in its sole discretion, to the Company's Executive
Committee and Compensation Committee and any other committee of the Company,.
Upon receipt of shareholder approval of any such charter amendments, the Company
will promptly file such amendment to its Certificate of Incorporation with the
Secretary of State of the State of New York.

         (b) Each of Galen, Galen Partners International III, L.P., Galen
Employee Fund III, L.P., Oracle Strategic Partners, L.P., Michael Reicher Trust,
Robert W. Baird & Co., Inc., TTEE FBO Michael K. Reicher IRA, trusts created for
the benefit of Michael K. Reicher, the Company's Chairman and Chief Executive
Officer and Peter Clemens, the Company's Chief Financial Officer, as investors
in the Existing Debentures, has executed and delivered a Voting Agreement in
substantially the form attached hereto as Exhibit I (such agreement, as
supplemented, amended or otherwise modified from time to time in accordance with
its terms, the "Voting Agreement") providing that, among other things, each such
Person shall vote the shares of the Company's Common Stock (including shares
underlying the Existing Debentures) owned by it in favor of the proposals
described in Section 9.12(a) above. Each of Galen, Galen Partners International
III, L.P., Galen Employee Fund III, L.P., Oracle Strategic Partners, L.P.,
Michael Reicher and Peter Clemens severally represents and warrants that such
Voting Agreement has been duly authorized, executed and delivered by such Person
and is such Person's legal, valid and binding agreement, enforceable against it
in accordance with its terms.

         Notwithstanding anything to the contrary contained herein, (i) the
Company will use its best efforts to cause the approvals and amendments provided
herein to be obtained in accordance with the terms hereof and otherwise as soon
as reasonably possible, and (ii) the Board of Directors will recommend to the
Company's shareholders and debentureholders the approval of the amendments to
the Company's Certificate of Incorporation as provided in this Section 9.12.

         9.13. Director and Officer Insurance Coverage. As soon as practicable,
but in any event within 30 days following the Closing, the Company shall obtain
"directors and officers" insurance ("D&O Insurance") mutually acceptable to the
Purchasers and the Company covering those persons who are directors and officers
of the Company, which D&O Insurance shall provide at least a minimum of
$5,000,000 of coverage per director. The Company shall maintain



                                       30



a such D&O Insurance covering its directors and officers with financially sound
and reputable insurers insuring the Company's directors and officers from the
liability and expense customarily insured under such "director and officer"
insurance policies.

         9.14. Further Assurances. From time to time the Company shall execute
and deliver to the Purchasers and the Purchasers shall execute and deliver to
the Company such other instruments, certificates, agreements and documents and
take such other action and do all other things as may be reasonably requested by
the other party in order to implement or effectuate the terms and provisions of
this Agreement and the transactions contemplated hereby and any of the
Securities.

                                   ARTICLE X

                               NEGATIVE COVENANTS

         The Company hereby covenants and agrees, so long as any Purchaser owns
any Debentures, it will not (and not allow any of the Guarantors to), directly
or indirectly, without the prior written consent of the holders of at least
66 2/3% in aggregate principal amount of the Debentures then outstanding, as
follows:

         10.1. Stay, Extension and Usury Laws. At any time insist upon, plead,
or in any manner whatsoever claim or take the benefit or advantage of, any stay,
extension or usury law wherever enacted, now or at any time hereinafter in
force, which may affect the covenants or the performance of the Debentures, the
Company hereby expressly waiving all benefit or advantage of any such law, or by
resort to any such law, hinder, delay or impede the execution of any power
herein granted to the holders of the Debentures but will suffer and permit the
execution of every such power as though no such law had been enacted.

         10.2. Reclassification. Effect any reclassification, combination or
reverse stock split of the Common Stock of the Company.

         10.3. Liens. Except as otherwise provided in this Agreement or any
other Transaction Document, create, incur, assume or permit to exist any
mortgage, pledge, lien, security interest or encumbrance on any part of its
properties or assets, or on any interest it may have therein, now owned or
hereafter acquired, nor acquire or agree to acquire property or assets under any
conditional sale agreement or title retention contract, except that the
foregoing restrictions shall not apply to:

                  (a) liens for taxes, assessments and other governmental
         charges, if payment thereof shall not at the time be required to be
         made, and provided such reserve as shall be required by US GAAP
         consistently applied shall have been made therefor;

                  (b) liens of workmen, materialmen, vendors, suppliers,
         mechanics, carriers, warehouseman and landlords or other like liens,
         incurred in the ordinary course of business for sums not then due or
         that are being contested in good faith and provided that an adverse
         decision in such contest would not materially affect the business of
         the Company;




                                       31





                  (c) liens securing Indebtedness of the Company or any
         Subsidiary which are permitted under Section 10.4(b) or (g);

                  (d) statutory liens of landlords, statutory liens of banks and
         rights of set-off, and other liens imposed by law, in each case
         incurred in the ordinary course of business (i) for amounts not yet
         overdue or (ii) for amounts that are overdue and that are being
         contested in good faith by appropriate proceedings, so long as reserves
         or other appropriate provisions, if any, as shall be required by US
         GAAP, shall have been made for any such contested amounts;

                  (e) liens incurred or deposits made in the ordinary course of
         business in connection with workers' compensation, unemployment
         insurance and other types of social security, or to secure the
         performance of tenders, statutory obligations, surety and appeal bonds,
         bids, leases, government contracts, trade contracts, performance and
         return-of-money bonds and other similar obligations (exclusive of
         obligations for the payment of borrowed money);

                  (f) any attachment or judgment lien not otherwise constituting
         an Event of Default, or an event which, with the giving of notice, the
         lapse of time, or both, would not otherwise constitute an Event of
         Default;

                  (g) easements, rights-of-way, restrictions, encroachments, and
         other minor defects or irregularities in title, in each case which do
         not and will not interfere with the ordinary conduct of the business of
         the Company or any of its Subsidiaries, except where such interference
         could not reasonably be expected to have a Material Adverse Effect;

                  (h) any (i) interest or title of a lessor or sublessor under
         any lease, (ii) restriction or encumbrance that the interest or title
         of such lessor or sublessor may be subject to, or (iii) subordination
         of the interest of the lessee or sublessee under such lease to any
         restriction or encumbrance referred to in the preceding clause (ii), so
         long as the holder of such restriction or encumbrance agrees to
         recognize the rights of such lessee or sublessee under such lease;

                  (i) liens in favor of customs and revenue authorities arising
         as a matter of law to secure payment of customs duties in connection
         with the importation of goods;

                  (j) any zoning or similar law or right reserved to or vested
         in any governmental office or agency to control or regulate the use of
         any real property;

                  (k) liens securing obligations (other than obligations
         representing Indebtedness for borrowed money) under operating,
         reciprocal easement or similar agreements entered into in the ordinary
         course of business of the Company and its Subsidiaries;

                  (l) the liens listed in Section 10.3(l) of the Schedule of
         Exceptions ("Permitted Liens"); and



                                       32





                  (m) the replacement, extension or renewal of any lien
         permitted by this Section 10.3 upon or in the same property theretofore
         subject or the replacement, extension or renewal (without increase in
         the amount or change in any direct or contingent obligor) of the
         Indebtedness secured thereby.

         10.4. Indebtedness. Create, incur, assume, suffer, permit to exist, or
guarantee, directly or indirectly, any Indebtedness, excluding:

                  (a) The endorsement of instruments for the purpose of deposit
         or collection in the ordinary course of business;

                  (b) Indebtedness which may, from time to time be incurred or
         guaranteed by the Company which in the aggregate principal amount does
         not exceed $500,000 and is subordinate to the Indebtedness under this
         Agreement on terms reasonably satisfactory to the Purchasers;

                  (c) Indebtedness existing on the date hereof and described in
         Section 10.4 of the Schedule of Exceptions;

                  (d) Indebtedness relating to contingent obligations of the
         Company and its Subsidiaries under guaranties in the ordinary course of
         business of the obligations of suppliers, customers, and licensees of
         the Company and its Subsidiaries;

                  (e) Indebtedness relating to loans from the Company to its
         Subsidiaries or Indebtedness owed to any of the Guarantors;

                  (f) Indebtedness relating to capital leases in an amount not
         to exceed $500,000;

                  (g) Indebtedness relating to a working capital line of credit
         in an amount not to exceed $10,000,000;

                  (h) Accounts or notes payable arising out of the purchase of
         merchandise or services in the ordinary course of business; or

                  (i) The Debentures.

         For purposes hereof, the term "Indebtedness" shall mean and include (A)
all items which would be included on the liability side of a balance sheet (but
also shall include any "off-balance sheet financings") of the Company (or a
Subsidiary) as of the date on which indebtedness is to be determined, excluding
capital stock, surplus, capital and earned surplus reserves, which, in effect,
were appropriations of surplus or offsets to asset values (other than reserves
in respect of obligations, the amount, applicability or validity of which is, at
such date, being contested in good faith by the Company or a Subsidiary, as
applicable), deferred credits of amounts representing capitalization of leases;
(B) the full amount of all indebtedness of others guaranteed or endorsed
(otherwise than for the purpose of collection) by the Company (or a Subsidiary)
for which the Company (or a Subsidiary) is obligated, contingently or otherwise,
to purchase or otherwise acquire, or for the payment or purchase of which the
Company (or a Subsidiary) has agreed, contingently or otherwise, to advance or
supply funds, or with respect to



                                       33



which the Company (or a Subsidiary) is contingently liable, including, without
limitation, indebtedness for borrowed money and indebtedness guaranteed or
supported indirectly by the Company (or a Subsidiary) through an agreement,
contingent or otherwise (x) to purchase the indebtedness, or (y) to purchase,
sell, transport or lease (as lessee or lessor) property, or to purchase or sell
services at prices or in amounts designed to enable the debtor to make payment
of the indebtedness or to assure the owner of the indebtedness against loss, or
(z) to supply funds to or in any other manner invest in the debtor; and (C)
indebtedness secured by any mortgage, pledge, security interest or lien whether
or not the indebtedness secured thereby shall have been assumed; provided,
however, that such term shall not mean and include any indebtedness (x) in
respect to which monies sufficient to pay and discharge the same in full shall
have been deposited with a depositary, agency or trustee in trust for the
payment thereof, or (y) as to which the Company (or Subsidiary) is in good faith
contesting, provided that an adequate reserve therefor has been set up on the
books of the Company or any of its consolidated Subsidiaries.

         10.5. Arm's Length Transactions. Enter into any transaction, contract
or commitment or take any action other than at Arm's Length. For purposes
hereof, the term "Arm's Length" means a transaction or negotiation in which each
party is completely independent of the other, seeks to obtain terms which are
most favorable to it and has no economic or other interest in making concessions
to the other party.

         10.6. Immaterial Subsidiaries. The Company shall not permit any of the
Immaterial Subsidiaries to commence any business operations of a type or scope
not currently conducted by them, nor permit any Immaterial Subsidiary to acquire
any rights or property not currently owned by it.

         10.7. Loans and Advances. Except for loans and advances outstanding as
of the Closing Date and set forth in Section 10.7 of the Schedule of Exceptions,
directly or indirectly, make any advance or loan to, or guarantee any obligation
of, any person, firm or entity, except for intercompany loans or advances in the
ordinary course of business and those provided for in this Agreement. The
Company and the Guarantors shall comply in all material respects with the
requirements of the Sarbanes-Oxley Act of 2002, and the rules and regulations
promulgated thereunder, as amended from time to time.

         10.8. Intercompany Transfers; Transactions With Affiliates; Diversion
of Corporate Opportunities. (a) Make any intercompany transfers of monies or
other assets in any single transaction or series of transactions, except as
otherwise permitted in this Agreement.

         (b) Engage in any transaction with any of the officers, directors,
employees or "affiliates" (as such term is defined in Rule 501(b)) of the
Company or of its Subsidiaries, except on terms no less favorable to the Company
or the Subsidiary as could be obtained at Arm's Length.

         (c) Divert (or permit anyone to divert) any business or opportunity of
the Company or any Subsidiary to any other corporate or business entity.

         10.9. Investments. Make any investments in, or purchase any stock,
option, warrant, or other security or evidence of Indebtedness of, any Person
(exclusive of any Subsidiary), other than obligations of the United States
Government or certificates of deposit or




                                       34



other instruments maturing within one year from the date of purchase from
financial institutions with capital in excess of $100 million.

         10.10. Other Business. Enter into or engage, directly or indirectly, in
any business other than the business currently conducted or proposed to be
conducted as disclosed to the Purchasers prior to the date hereof by the Company
or any Subsidiary.

         10.11. Employee Benefit Plans and Compensation. Except as contemplated
by this Agreement:

                  (a) enter into or materially amend any agreement to provide
         for or otherwise establish any written or unwritten employee benefit
         plan, program or other arrangement of any kind, covering current or
         former employees of the Company or its Subsidiaries except for any such
         plan, program or arrangement expressly permitted under an existing
         agreement listed in Section 4.18 the Schedule of Exceptions; provided,
         however, that no such plan, program or arrangement may be established
         or implemented if such action would have a material effect on the terms
         of employment of the employees of the Company or its Subsidiaries; or

                  (b) provide for or agree to any material increase in any
         benefit provided to current or former employees of the Company or its
         Subsidiaries over that which is provided to such individuals pursuant
         to a plan or arrangement disclosed in Section 4.18 of the Schedule of
         Exceptions as of the Closing Date; or

                  (c) provide for or agree to any increase in the annual
         compensation of any of the employees of the Company or its
         Subsidiaries, except for (i) annual salary increases in the ordinary
         cause of business consistent with past practice (not to exceed a 10%
         increase over such employee's annual salary compensation on the date
         hereof), and (ii) normal and customary annual bonuses to employees (not
         to exceed $350,000 in the aggregate in any fiscal year in the absence
         of the approval of the Board of Directors).

         10.12. Capital Expenditures. Other than for capital expenditures
contained in any budget approved by the Board of Directors, make or commit to
make, or permit any of its Subsidiaries to make or commit to make, any capital
expenditures in excess of $250,000 in the aggregate during any fiscal year of
the Company.

         10.13. Amendment, Etc. of Certain Document. Except as otherwise
specifically provided for herein, amend, modify, change in any manner any term
or condition of the Watson Term Loans, the Existing Debentures or any agreement
or other instrument or document entered into by the Company or any Guarantor in
connection therewith or pursuant thereto, or give any consent, waiver or
approval thereunder, waive any default under or any breach of any term or
condition thereof, agree in any manner to any other amendment, modification or
change of any term or condition thereof or take any other action in connection
therewith that would impair the value of the interest or the rights of any
Purchaser under this Agreement or any other Transaction Document, or permit any
of the Guarantors to do any of the foregoing without the prior written consent
of all the Purchasers.


                                       35





         10.14. Formation of Subsidiaries. Organize or invest, or permit any
Subsidiary to organize or invest, in any new corporation, partnership, joint
venture, limited liability company, trust or estate of which (or in which) (a)
more than 50% of the issued and outstanding capital stock having ordinary voting
power to elect a majority of the board of directors of such corporation
(irrespective of whether at the time capital stock of any other class of such
corporation shall or might have voting power upon the occurrence of any
contingency), the interest in the capital or profits of such partnership, joint
venture or limited liability company or the beneficial interest in such trust or
estate, is at the time directly or indirectly owned or controlled by the
Company, any of its Subsidiaries or any of their respective officers or
directors, or (b) a material minority investment in any such entity is directly
or indirectly owned or controlled by the Company, any of its Subsidiaries or any
of their respective officers or directors.

         10.15 Prohibition on Certain Cash Interest Payments. The Company shall
not make any cash interest payments to Galen, Galen Partners International III,
L.P., Galen Employee Fund III, L.P. or Oracle Strategic Partners, L.P., pursuant
to the March 1998 Debentures or the May 1999 Debentures, notwithstanding
anything else to the contrary contained therein or elsewhere, without the prior
written consent of all 2002 Holders, which consent shall be within their sole
and absolute discretion.

                                   ARTICLE XI

                              INTENTIONALLY OMITTED

                                  ARTICLE XII

                                EVENTS OF DEFAULT

         12.1. Events of Default. If any of the following events shall occur and
be continuing on or before the Security Interest Termination Date, an "Event of
Default" shall be deemed to have occurred:

                  (a) if the Company shall default in the payment of (i) any
         part of the principal of any Debenture (including, without limitation,
         the principal of any Interest Payment Debenture), when the same shall
         become due and payable, whether at maturity or at a date fixed for
         prepayment or by acceleration or otherwise, or (ii) the interest on any
         Debenture (including, without limitation, interest on any Interest
         Payment Debentures), when the same shall become due and payable, and in
         the case of an interest payment such default shall have continued
         without cure for ten days from the scheduled date of payment of such
         interest;

                  (b) the Company shall fail to issue to a Holder the Shares
         issuable upon conversion of a Debenture pursuant to the instructions
         provided by such Holder and in accordance with the terms of such
         Debenture;

                  (c) except or provided in Section 12.1(b), if the Company
         shall default in the performance of any of the covenants contained in
         Articles IX or X, and, in the case of a default under Sections 9.1
         through and including 9.8 or Section 10.3 (exclusive of Section
         10.3(c)), such default shall have continued without cure for 30 days
         after written


                                       36




         notice (a "Default Notice") is given to the Company with respect to
         such covenant by any holder or holders of the Debentures (and the
         Company shall give to all other holders of the Debentures at the time
         outstanding prompt written notice of the receipt of such Default
         Notice, specifying the default referred to therein); provided, however,
         that such 30-day grace period shall not apply in the event the Company
         fails to promptly give notice as provided in Section 9.3;

                  (d) except as provided in Sections 12.1(b) or 12.1(c), if the
         Company or any of the Guarantors shall default in the performance of
         any other agreement contained in any Transaction Document or in any
         other agreement executed in connection with this Agreement and such
         default shall not have been remedied to the satisfaction of the holders
         of 66 2/3% in aggregate principal amount of the Debentures then
         outstanding, within 45 days after a Default Notice shall have been
         given to the Company (and the Company shall give to all other holders
         of Debentures at the time outstanding prompt written notice of the
         receipt of such Default Notice, specifying the default referred to
         therein) provided, however, that such thirty-five (35) day grace period
         shall not apply in the event the Company fails to give notice as
         provided in Section 9.3;

                  (e) if any representation or warranty made by the Company, any
         Guarantor or any of their officers in any Transaction Document or in or
         any certificate delivered pursuant thereto shall prove to have been
         incorrect when made;

                  (f) if (i) any default shall occur under any indenture,
         mortgage, agreement, instrument or commitment evidencing, or under
         which there is at the time outstanding, any Indebtedness of the Company
         or a Subsidiary, in excess of $250,000, or which results in such
         Indebtedness, in an aggregate amount (with other defaulted
         Indebtedness) in excess of $750,000 becoming (or being declared by its
         holders or, on its behalf, by an agent or trustee therefor to be) due
         and payable prior to its due date; or (ii) irrespective of the monetary
         thresholds specified in subclause (i) above, any default, event of
         default or any other condition shall occur or exist under the Watson
         Term Loans or any Existing Debentures (as such term is defined in the
         Watson Term Loan and the Existing Debentures, respectively) which shall
         be continuing after the respective grace period, if any, specified in
         the Watson Term Loans and the Existing Debentures, and the effect of
         which is to accelerate, or to permit the acceleration of, the maturity
         of the Indebtedness outstanding thereunder; or (iii) a Change of
         Control shall have occurred;

                  (g) if any of the Company or its Subsidiaries shall default in
         the observance or performance of any term or provision of an agreement
         to which it is a party or by which it is bound which default could
         reasonably be expected to have a Material Adverse Effect and such
         default is not waived or cured within the applicable grace period;

                  (h) if the Company shall fail to obtain from the DEA a raw
         material import registration authorizing the Company to import raw
         poppy for use in the Company's manufacturing operations, on or before
         December 31, 2004;

                  (i) if the Watson Supply Agreement shall have been terminated
         in accordance with its terms and the Company fails, within a period of
         60 days from the effective date of such termination, to secure
         alternative supply and distribution arrangements with third


                                       37





         parties or to commence the marketing and sale of the products that are
         the subject of such agreement (each an "Alternative Arrangement"),
         which Alternative Arrangements are reasonably expected to generate
         revenues during the 12-month period commencing with the start of such
         Alternative Arrangements of not less than 70% of the revenues derived
         form the Core Products Agreement for the fiscal year immediately
         preceding the termination of the Core Products Agreement;

                  (j) if a final judgment which, either alone or together with
         other outstanding final judgments against the Company and its
         Subsidiaries, exceeds an aggregate of $750,000 shall be rendered
         against the Company or any Subsidiary and such judgment shall have
         continued undischarged or unstayed for 60 days after entry thereof;

                  (k) if the Company or any Subsidiary shall generally not pay
         its debts as such debts become due or shall make an assignment for the
         benefit of creditors generally, or shall admit in writing its inability
         to pay its debts generally; or if any proceeding shall be instituted by
         or against the Company or any Subsidiary seeking to adjudicate it as
         bankrupt or insolvent, or seeking liquidation, winding up,
         reorganization, arrangement, adjustment, protection, relief or
         composition of it or its debts under any law relating to bankruptcy,
         insolvency or the reorganization or relief of debtors, or seeking entry
         of an order for relief or the appointment of a receiver, trustee,
         custodian or other similar official for it or for any substantial part
         of its property and, in the case of such proceeding instituted against
         it (but not instituted by it) that is being diligently contested by it
         in good faith, either such proceeding shall remain undismissed or
         unstayed for a period of 90 days or any of the actions sought in such
         proceeding (including, without limitation, the entry of an order for
         relief against, or the appointment of a receiver, trustee, custodian or
         other similar official for, it or any substantial part of its property)
         shall occur; or if any writ of attachment or execution or any similar
         process shall be issued or levied against it or any substantial part of
         its property which is either not released, stayed, bonded or vacated
         within 90 days after its issue or levy or any of the actions sought or
         relief sought in any proceeding pursuant to which such writ or similar
         process shall be issued or initiated shall occur or be granted; or if
         the Company or any Subsidiary takes corporate action in furtherance of
         any of the aforesaid purposes or conditions;

                  (l) if any provision of any Transaction Document shall for any
         reason cease to be valid and binding on, or enforceable against, the
         Company or any Guarantor, or the Company or any Guarantor shall so
         assert in writing; or

                  (m) any Transaction Document (or any financing statement)
         which purports:

                           (i) to create, perfect or evidence a lien on or
                  security interest in any Company Debenture Collateral or
                  Guarantor Debenture Collateral in favor of the Purchasers (or
                  their agents and representatives), or to provide for the
                  priority of any such lien or security interest over the
                  interest of any other party in the same Collateral, shall
                  cease to create, or to preserve the enforceability, perfection
                  or first priority (subject to the Subordination Agreement and,
                  if applicable, the Mortgage Subordination Agreement) of, such
                  lien and security interest; or



                                       38




                           (ii) to provide for the priority in right of payment
                  of the Company's obligations under the Transaction Documents
                  to or in favor of the Purchasers (or their agents or
                  representatives) shall cease to preserve such priority.

         12.2. Remedies. (a) Except as provided in Section 12.2(b) or (c)
hereof, upon the occurrence and during the continuance of an Event of Default,
any holder or holders of 66 2/3% in aggregate principal amount of the Debentures
at the time outstanding may at any time (unless all defaults shall theretofore
have been remedied) at its or their option, by written notice or notices to the
Company (i) declare all the Debentures to be due and payable, whereupon the same
shall forthwith mature and become due and payable, together with interest
accrued thereon, without presentment, demand, protest or notice, all of which
are hereby waived by the Company; and (ii) declare any other amounts payable to
the Purchasers under this Agreement or as contemplated hereby due and payable;
provided, however, that in the event of an actual or deemed entry of an order
for relief with respect to the Company under the Federal Bankruptcy Code, the
Debentures, together with interest accrued thereon, shall automatically become
and be due and payable, without presentment, demand, protest or notice of any
kind, all of which are hereby waived by the Company.

         (b) Notwithstanding anything to the contrary contained in Section
12.2(a), in the event that at any time after the principal of the Debentures
shall so become due and payable and prior to the date of maturity stated in the
Debentures all arrears of principal of and interest on the Debentures (with
interest at the rate specified in the Debentures on any overdue principal and,
to the extent legally enforceable, on any interest overdue) shall be paid by or
for the account of the Company, then the holder or holders of at least a 66 2/3%
in aggregate principal amount of the Debentures then outstanding, by written
notice or notices to the Company, may (but shall not be obligated to) waive such
Event of Default and its consequences and rescind or annul such declaration, but
no such waiver shall extend to or affect any subsequent Event of Default or
impair any right resulting therefrom. If any holder of a Debentures shall give
any notice or take any other action with respect to a claimed default, the
Company, forthwith upon receipt of such notice or obtaining knowledge of such
other action will give written notice thereof to all other holders of the
Debentures then outstanding, describing such notice or other action and the
nature of the claimed default.


         (c) Notwithstanding anything to the contrary contained in Section
12.2(a), upon the occurrence of an Event of Default specified in Section
12.1(b), the Company and the Purchasers agree that a Holder will suffer damages
and that it would not be feasible to ascertain the extent of such damages with
precision. Accordingly, the Company agrees to pay liquidated damages
("Liquidated Damages") to each applicable Holder for any such continuing Event
of Default, as follows: Liquidated Damages shall accrue on the principal amount
of the Securities at a rate of $2.00 per calendar day per $1,000 principal
amount of Debentures for the first 90 days immediately following each such Event
of Default, and such Liquidated Damages shall increase by an additional $2.00
per calendar day per $1,000 principal amount of Debentures at the beginning of
each subsequent 90-day period. As provided in Section 19.6 hereof, the remedy of
Liquidated Damages shall be cumulative, and shall not exclude the availability
of any other remedies hereunder or under the Transaction Documents (including,
without limitation, the payment of late charges and default interest as provided
in the Debentures).




                                       39






         12.3. Enforcement. In case any one or more Events of Default shall
occur and be continuing, the holder of a Debenture then outstanding may proceed
to protect and enforce the rights of such holder by an action at law, suit in
equity or other appropriate proceeding, whether for the specific performance of
any agreement in favor of the Purchasers which is contained in any of the
Transaction Documents or in such Debenture or for an injunction against a
violation of any of the terms hereof or thereof, or in aid of the exercise of
any power granted hereby or thereby or by law (including, without limitation,
the right to enforce the Company Debenture Collateral, the Guaranties and the
Guarantor Debenture Collateral, each in accordance with its respective terms).
Each such holder agrees that it will give written notice to the other holders of
Debentures prior to instituting any such action. In case of a default in the
payment of any principal of or interest on any Debenture, the Company will pay
to the holder thereof such further amount as shall be sufficient to cover the
cost and the expenses of collection, including, without limitation, reasonable
attorney's fees, expenses and disbursements. No course of dealing and no delay
on the part of any holder of any Debenture in exercising any rights shall
operate as a waiver thereof or otherwise prejudice such holder's rights. No
right conferred hereby or by any Debenture upon any holder thereof shall be
exclusive of any other right referred to herein or therein or now available at
law or in equity, by statute or otherwise.

                                  ARTICLE XIII

                                 INDEMNIFICATION

         13.1. To the greatest extent permitted by applicable law, the Company
agrees to indemnify each Purchaser against and hold it harmless from all claims,
losses, damages, liabilities (or actions in respect thereof), obligations,
penalties, awards, judgments, expenses (including, without limitation,
reasonable fees and expenses of counsel) or disbursements (each a "Loss")
arising out of or resulting from: (i) the breach of any representation or
warranty of the Company in any Transaction Document or in any agreement,
certificate or instrument delivered pursuant thereto; (ii) the breach of any
agreement by the Company contained in any Transaction Document or any agreement,
certificate of instrument delivered pursuant thereto; or (iii) Care Capital
Investments II, LP 's and Essex Woodlands Health Ventures' representation on the
Company's Board of Directors and any committees thereof or as an observer
thereon.

         13.2. Anything in Section 13.1 to the contrary notwithstanding, no
claim may be asserted nor may any action be commenced against the Company for
breach of any representation or warranty contained herein, unless notice of such
Purchaser's intention to assert any such claim or commence any such action is
received by the Company describing in writing in reasonable detail the facts and
circumstances with respect to the subject matter of such claim or action on or
prior to the date on which the representation or warranty on which such claim or
action is based ceases to survive as set forth in Section 19.2. With respect to
any claim or action as to which such notice shall have been given, the
Purchasers shall be entitled to assert a claim or commence an action for
indemnification with respect thereto at any time after the giving of such
notice, regardless of whether any such claim or action may be asserted or
commenced prior to or after the date on which the representation or warranty on
which such claim or action is based ceases to survive as set forth in Section
19.2.

         13.3. Such Purchaser agrees to give the Company prompt written notice
of any claim, assertion, event or proceeding by a third party of which it has
actual knowledge




                                       40



concerning any Losses as to which it intends to request indemnification
hereunder. The Company shall have the right to direct, through counsel of the
Company's own choosing, the defense or settlement of any such claim or
proceeding at the Company's own expense. If the Company elects to assume the
defense of any such claim or proceeding, such Purchaser may participate in such
defense, but in such case the expenses of such Purchaser shall be paid by such
Purchaser. Such Purchaser shall cooperate with the Company in the defense or
settlement thereof, and the Company shall reimburse such Purchaser for its
reasonable out-of-pocket expenses in connection therewith. If the Company elects
to direct the defense of any such claim or proceeding, such Purchaser shall not
pay, or permit to be paid, any part of any claim or demand arising from such
asserted liability, unless the Company consents in writing to such payment or
unless the Company, subject to the last sentence of this Section 13.3, withdraws
from the defense of such asserted liability, or unless a final judgment from
which no appeal may be taken by or on behalf of the Company is entered against
such Purchaser for such liability. If the Company shall fail to defend any such
claim or proceeding, or if, after commencing or undertaking any defense, fails
to prosecute or withdraws from such defense, such Purchaser shall have the right
to undertake the defense or settlement thereof, at the Company's expense. If
such Purchaser assumes the defense of any such claim or proceeding pursuant to
this Section 13.3 and proposes to settle such claim or proceeding prior to a
final judgment thereon or to forego appeal with respect thereto, then such
Purchaser shall give the Company prompt written notice thereof and the Company
shall have the right to participate in the settlement or assume or reassume the
defense of such claim or proceeding.

                                  ARTICLE XIV

                              AMENDMENT AND WAIVER

         14.1. No amendment of any provision of this Agreement, including any
amendment of this Article XIV, shall be valid unless the same shall be in
writing and signed by (a) the Company, and each of Galen, Care Capital
Investments II, LP or Essex Woodlands Health Ventures Fund V, so long as they
(or their affiliates (as such term is defined in Rule 501(b)) shall hold
Debentures, and (b) the holders of at least 51 % in the aggregate principal
amount of the Debentures then outstanding, and no waiver by any party of any
default, misrepresentation, or breach of warranty or covenant hereunder or under
any other Transaction Document, whether intentional or not, shall be deemed to
extend to any prior or subsequent default, misrepresentation, or breach of
warranty or covenant hereunder or thereunder or affect in any way any rights
arising by virtue of any prior or subsequent such occurrence.

         14.2. The Company and each holder of a Debenture and each holder of a
Share, respectively, then or thereafter outstanding shall be bound by any
amendment or waiver effected in accordance with the provisions of this Article
XIV, whether or not such Debenture and Share, respectively, shall have been
marked to indicate such modification, but any Debenture and Share, respectively,
issued thereafter shall bear a notation as to any such modification. Promptly
after obtaining the written consent of the holders of Debentures and the holders
of Shares, respectively, herein provided, the Company shall transmit a copy of
such modification to all of the holders of the Debentures and the holders of
Shares, respectively, then outstanding.




                                       41





                                   ARTICLE XV

                             EXCHANGE OF DEBENTURES

         15.1. Subject to Section 16.2, at any time at the request of any holder
of one or more of the Debentures to the Company at its office provided under
Section 19.5, the Company at its expense (except for any transfer tax or any
other tax arising out of the exchange) will issue in exchange therefor new
Debentures, in such denomination or denominations ($100,000 or any larger
multiple of $100,000, plus one Debenture in a lesser denomination, if required)
as such holder may request, in aggregate principal amount equal to the unpaid
principal amount of the Debenture or Debentures surrendered and substantially in
the form thereof, dated as of the date to which interest has been paid on the
Debenture or Debentures surrendered (or, if no interest has yet been so paid
thereon, then dated the date of the Debenture or Debentures so surrendered) and
payable to such Person or persons or order as may be designated by such holder.

         15.2. Intentionally Omitted.

                                  ARTICLE XVI

                             TRANSFER OF DEBENTURES

         16.1. Notification of Proposed Sale. (a) Subject to Section 16.1(b),
each holder of a Debenture by acceptance thereof agrees that it will give the
Company ten days written notice prior to selling or otherwise disposing of such
Debenture. No such sale or other disposition shall be made unless (i) the holder
shall have supplied to the Company an opinion of counsel for the holder
reasonably acceptable to the Company to the effect that no registration under
the Securities Act is required with respect to such sale or other disposition,
or (ii) an appropriate registration statement with respect to such sale or other
disposition shall have been filed by the Company and declared effective by the
Commission.

         (b) If the holder of a Debenture has obtained an opinion of counsel
reasonably acceptable to the Company to the effect that the sale of its
Debenture may be made without registration under the Securities Act pursuant to
compliance with Rule 144 (or any successor rule under the Securities Act), the
holder need not provide the Company with the notice required in Section 16.1(a).

         16.2. Intentionally Omitted.

                                  ARTICLE XVII

                  RIGHT OF FIRST REFUSAL; ADDITIONAL INVESTMENT

         17.1. Right of First Refusal. Each holder of the Debentures, holder of
Shares (provided any Debentures remain outstanding and the Shares received upon
conversion have not been sold, transferred or otherwise disposed of) (the
"Common Holder"), holders of the March 1998 Debentures (the "Existing 1998
Debentureholders") and holders of shares of Common Stock issued upon the
conversion of the March 1998 Debentures (provided any March 1998 Debentures
remain outstanding and the shares of Common Stock received upon conversion have



                                       42



not been sold, transferred or otherwise disposed of) (the "Old Common Holders")
shall be entitled to the following right of first refusal:

                  (a) Except in the case of Excluded Securities, the Company
         shall not issue, sell or exchange, agree to issue, sell or exchange, or
         reserve or set aside for issuance (except as provided in Section 6.16),
         sale or exchange (i) any shares of Common Stock, (ii) any other equity
         security of the Company, (iii) any debt security of the Company which
         by its terms is convertible into or exchangeable for, with or without
         consideration, any equity security of the Company, (iv) any security of
         the Company that is a combination of debt and equity or (v) any option,
         warrant or other right to subscribe for, purchase or otherwise acquire
         any equity security or any such debt security of the Company
         (collectively, the "Equity Securities") unless in each case, the
         Company shall have first offered to sell to the holders of Debentures,
         the Common Holders, the Existing 1998 Debentureholders and the Old
         Common Holders, the Equity Securities, at a price and on such other
         terms as shall have been specified by the Company in writing delivered
         to each of the holders of Debentures, the Common Holders, the Existing
         1998 Debentureholders and the Old Common Holders (the "Offer"), which
         Offer by its terms shall remain open and irrevocable for a period of 30
         days from the date it is delivered by the Company to the holders of
         Debentures, the Common Holders, the Existing 1998 Debentureholders and
         the Old Common Holders; provided, however, that such issuance, sale or
         exchange of equity securities shall result in gross proceeds to the
         Company (whether at the time of issuance or upon conversion, exercise,
         or exchange thereof) of an amount in excess of $200,000 (the "Minimum
         Offering Threshold"). For purposes of computing the Minimum Offering
         Threshold, all offerings, issuances, sales and exchanges of Equity
         Securities during any rolling 12-month period shall be aggregated.

                  (b) Each of the holders of Debentures, the Common Holders, the
         Existing 1998 Debentureholders and the Old Common Holders shall have
         the right to purchase up to its pro rata share of the Equity Securities
         determined at the time of the consummation of the Company's issuance of
         Equity Securities. The "pro rata share" of each holder of Debentures,
         Common Holder, Existing 1998 Debentureholders and the Old Common
         Holders shall be that amount of the Equity Securities multiplied by a
         fraction, the numerator of which is the sum of (i) Shares underlying
         the Debenture held by such Person if such Person is the holder of a
         Debenture, (ii) the number of Shares of Common Stock issued to such
         Common Holder upon conversion of a Debenture if such Person is a Common
         Holder, (iii) the number of shares of Common Stock underlying the March
         1998 Debentures held by such Person if such Person is an Existing 1998
         Debentureholder and (iv) the number of shares of Common Stock issued to
         an Existing 1998 Debentureholder upon conversion of a March 1998
         Debenture if such Person is an Old Common Holder, and the denominator
         of which is the sum of (x) the total number of shares of Common Stock
         underlying the Debentures issued pursuant to this Agreement and (y) the
         total number of shares of Common Stock underlying the March 1998
         Debentures.

                  (c) Notice of the intention of each holder of a Debenture,
         Common Holder, Existing 1998 Debentureholder or Old Common Holder to
         accept, in whole or in part, an Offer shall be evidenced by a writing
         signed by such person, as the case may be and delivered to the Company
         prior to the end of the 30-day period commencing with the date



                                       43



         of such Offer (or, if later within ten days after the delivery or
         giving of any written notice of a material change in such Offer),
         setting forth such portion (specifying number of shares, principal
         amount or the like) of the Equity Securities such Person elects to
         purchase (the "Notice of Acceptance").

                  (d) In the event that all holders of Debentures, Common
         Holders, Existing 1998 Debentureholders and Old Common Holders do not
         elect to purchase all of the Equity Securities, the persons which have
         provided notice of their intention to exercise the refusal rights as
         provided in subparagraph (c) above shall have the right to purchase, on
         a pro rata basis, any unsubscribed portion of the Equity Securities
         during a period of ten days following the 30-day period provided in
         subparagraph (c) above. Following such additional ten-day period, in
         the event the holders of the Debentures, the Common Holders, Existing
         1998 Debentureholders and the Old Common Holders have not elected to
         purchase all of the Equity Securities, the Company shall have 90 days
         from the expiration of the foregoing 40-day period to sell all or any
         part of such Equity Securities as to which a Notice of Acceptance has
         not been given by any of such persons (the "Refused Securities") to any
         other Person or Persons on the terms provided in the Offer. Upon the
         closing of the sale to such other Person or Persons of all the Refused
         Securities, which shall include payment of the purchase price to the
         Company in accordance with the terms of the Offer, if the holders of
         Debentures, the Common Holders, Existing 1998 Debentureholders and Old
         Common Holders have timely submitted a Notice of Acceptance, it and
         they shall purchase from the Company, and the Company shall sell to
         such persons, as the case may be, the Equity Securities in respect of
         which a Notice of Acceptance was delivered to the Company, at the terms
         specified it the Offer. The purchase by the holders of Debentures,
         Common Holders, Existing 1998 Debentureholders and the Old Common
         Holders of any Equity Securities is subject in all cases to the
         preparation, execution and delivery by the Company to such persons of a
         purchase agreement and other customary documentation relating to such
         Equity Securities as is satisfactory in form and substance to such
         persons and each of their respective counsel.

                  (e) In each case, any Equity Securities not purchased by the
         holders of Debentures, the Common Holders, Existing 1998
         Debentureholders and the Old Common Holders or by a Person or Persons
         in accordance with Section 17.1(d) hereof may not be sold or otherwise
         disposed of until they are again offered to such persons under the
         procedures specified in Sections 17.1(a), (c) and (d) hereof.

                  (f) The rights of the holders of Debentures, the Common
         Holders, Existing 1998 Debentureholders and the Old Common Holders
         under this Section 17.1 shall not apply to the following securities
         (the "Excluded Securities"):

                  (i)      Common Stock or options to purchase such Common
                           Stock, issued to officers, employees or directors of,
                           or consultants to, the Company, pursuant to any
                           agreement, plan or arrangement approved by the Board
                           of Directors of the Company;

                  (ii)     Common Stock issued as a stock dividend or upon any
                           stock split or other subdivision or combination of
                           shares of Common Stock;




                                       44




                  (iii)    shares issued upon conversion of the Debentures or
                           the Existing Debentures or exercise of the warrants
                           issued in connection with the issuance of the
                           Existing Debentures;

                  (iv)     any securities issued for consideration other than
                           cash pursuant to a merger, consolidation,
                           acquisition, strategic alliance or similar business
                           combination approved by the Board of Directors and at
                           the Company's Annual Meeting of Shareholders; or

                  (v)      any debentures issued in satisfaction of interest
                           payments under the Existing Debentures, including
                           debentures instruments issued in satisfaction of
                           interest payments on those debenture instruments.

                  (g) Notwithstanding anything to the contrary contained herein,
         a holder of a Debenture or a Common Holder (other than an initial
         Purchaser) shall not be considered as such for purposes of this Section
         17.1 only, unless such Person then holds Debentures with an outstanding
         principal amount of at least $200,000 or Shares issued upon conversion
         of at least $200,000 in principal of Debentures or a combination of
         Debentures and Shares such that the outstanding principal of the
         Debentures held by such Person plus the amount of principal of
         Debentures converted into Shares held by such Person equals or exceeds
         $200,000.

                                 ARTICLE XVIII

                                 CO-SALE RIGHTS

         18.1. In the event that Galen Partners, L.P., Galen Partners
International III, L.P., Galen Employee Fund III, L.P., Oracle Strategic
Partners L.P., Michael Reicher, Chief Executive Officer of the Company or Peter
Clemens, Chief Financial Officer of the Company intends to transfer, directly or
indirectly, in one or in a series of related transactions, any shares of the
Company's Common Stock owned by it/him or any principal amount of the Existing
Debentures or Debentures owned by it/him, such transferor (the "Selling Security
Holder") shall notify the Holders in writing of such proposed transfer and its
terms and conditions and within 15 business days of the date of such notice,
each Holder shall notify the Selling Security Holder if such Holder elects to
participate in the proposed transfer described in the written notice provided by
the Selling Security Holder (a "Transfer"). Any Purchaser that fails to notify
the Selling Security Holder within such 15 business day period shall be deemed
to have waived its rights hereunder with respect to the Transfer described in
the Selling Security Holder's written notice. Each Holder that notifies the
Selling Security Holder that it intends to participate in the proposed Transfer,
shall have the right to sell at the same price and on the same terms and
conditions as the Selling Security Holder (a) in the case of a sale of shares of
the Company's Common Stock by the Selling Security Holder, a number of shares of
Common Stock equal to the shares of Common Stock proposed to be sold in the
Transfer multiplied by a fraction, the numerator of which shall be the number of
shares of Common Stock owned by the Holder (inclusive of all shares underlying
the Debentures) and the denominator of which shall be the sum of (i) the
Company's outstanding shares of Common Stock, plus (ii) the shares underlying
the Debentures and the Existing Debentures, and (b) in the case of the proposed
sale of Existing Debentures or Debentures by such Selling Security Holder, the
principal amount of the Existing



                                       45



Debentures or Debentures proposed to be sold in the Transfer multiplied by a
fraction, the numerator of which shall be the aggregate principal amount of the
Debentures owned by the Holder and the denominator of which shall be the
aggregate principal amount of the Company's outstanding Existing Debentures and
Debentures. Nothing in this Article XVIII shall be construed to limit the
ability of the Selling Security Holder to complete the Transfer prior to the
passage of ten business days notice period provided above, provided that
sufficient accommodation is made to permit the Holders to complete the sale of
their Common Stock and Debentures hereunder within ten business days of the
election by such Holders to exercise their co-sale rights hereunder. The
exercise or non-exercise of the rights of any Holder with respect to any
particular Transfer shall not waive any such Holder's rights to participate in a
subsequent Transfer.

                                  ARTICLE XIX

                                  MISCELLANEOUS

         19.1. Governing Law. This Agreement and the rights of the parties
hereunder shall be governed in all respects by the laws of the State of New York
wherein the terms of this Agreement were negotiated, excluding to the greatest
extent permitted by law any rule of law that would cause the application of the
laws of any jurisdiction other than the State of New York.

         19.2. Survival of Representations. Subject to the terms of this
Agreement, the representations, warranties, covenants and agreements contained,
in the Transaction Documents and in any agreements, certificates or other
instruments delivered pursuant thereto shall survive (a) any investigation made
by or on behalf the Purchasers and (b) the Closing until the maturity date of
the Debentures (as such date may be extended by the parties).

         19.3. Successors and Assigns. Except as otherwise expressly provided
herein, the provisions hereof shall inure to the benefit of, and be binding upon
and enforceable by and against, the parties hereto and their respective
successors, assigns, heirs, executors and administrators. No party may assign
any of its rights hereunder without the prior written consent of the other
parties; provided, however, that any Purchaser may assign any of its rights
under any of the Transaction Documents to (a) any "affiliate" (as such term is
defined in Rule 501(b)) of such Purchaser or (b) any Person to whom such
Purchaser shall transfer any Securities in accordance with the terms of the
Transaction Documents; provided further, that notwithstanding anything herein or
in the Transaction Documents to the contrary, no opinion of counsel shall be
necessary for a transfer or assignment of the Debentures or any rights under any
of the Transaction Documents (except for the Watson Warrant) by a Purchaser that
is a partnership, corporation or limited liability company to any general
partner, limited partner, retired partner, shareholder, member, retired member,
officer, director or affiliates of such Purchaser, or the members or retired
members of the foregoing, as applicable, or the estates, beneficiaries and
family members of any such general partner, limited partners, retired partners,
shareholders, members, retired members, officers, directors and affiliates and
any trusts for the benefit of any of the foregoing persons, provided, that in
each case the transferee will be subject to the applicable terms of the
Transaction Documents to the same extent as such transferee were an original
Purchaser hereunder.



                                       46





         19.4. Entire Agreement. This Agreement (including the Exhibits and
Schedules hereto), the other Transaction Documents and any other documents
delivered pursuant hereto and simultaneously herewith constitute the full and
entire understanding and agreement between the parties with regard to the
subject matter hereof and thereof.

         19.5. Notices, etc. All notices, demands or other communications given
hereunder shall be in writing and shall be sufficiently given if transmitted by
facsimile or delivered either personally or by a nationally recognized courier
service marked for next business day delivery or sent in a sealed envelope by
first class mail, postage prepaid and either registered or certified, return
receipt requested, addressed as follows:


         (a) if to the Company:

                   Halsey Drug Co., Inc.
                   695 N. Perryville Road
                   Rockford, Illinois  61107
                   Attention: Mr. Michael Reicher
                   Chief Executive Officer
                   Facsimile: (815) 399-9710

         (b) if to a Purchaser, to the address set forth on Exhibit A attached
hereto, or to such other address with respect to any party hereto as such party
may from time to time notify (as provided above) the other parties hereto. Any
such notice, demand or communication shall be deemed to have been given (i) on
the date of delivery, if delivered personally, (ii) on the date of facsimile
transmission, receipt confirmed, (iii) one business day after delivery to a
nationally recognized overnight courier service, if marked for next day delivery
or (iv) five business days after the date of mailing, if mailed. Copies of any
notice, demand or communication given to (x) the Company, shall be delivered to
St. John & Wayne, L.L.C., Two Penn Plaza East, Newark, New Jersey 07105-2249
Attn.: John P. Reilly, Esq., or such other address as may be directed and (y)
any Purchaser, shall be delivered to Wolf, Block, Schorr and Solis-Cohen LLP,
250 Park Avenue, New York, New York 10177 Attn.: George N. Abrahams, Esq.,
Facsimile: (212) 672-1109, or such other address as may be directed.

         19.6. Delays, Omissions or Waivers. No delay or omission to exercise
any right, power or remedy accruing to any holder of any Securities upon any
breach or default of the Company under this Agreement shall impair any such
right, power or remedy of such holder nor shall it be construed to be a waiver
of any such breach or default, or an acquiescence, therein, or of or in any
similar breach or default thereafter occurring; nor shall any waiver of any
single breach or default be deemed a waiver of any other breach or default
theretofore or thereafter occurring. Any waiver, permit, consent or approval of
any kind or character on the part of any holder of any breach or default under
this Agreement, or any waiver on the part of any holder of any provisions or
conditions of this Agreement must be, made in writing and shall be effective
only to the extent specifically set forth in such writing. All remedies, either
under this Agreement or by law or otherwise afforded to any holder, shall be
cumulative and not alternative. Notwithstanding anything set forth herein or in
any Transaction Document, if the consent of or the waiver by any 2002 Holder is
needed or otherwise desirable under any




                                       47



Transaction Document and the Company, or any affiliate thereof, pays or other
gives consideration to any 2002 Holder, or an affiliate thereof, for such
consent or waiver the Company shall offer the same to all other 2002 Holders.

         19.7. Independence of Covenants and Representations and Warranties. All
covenants hereunder shall be given independent effect so that if a certain
action or condition constitutes a default under a certain covenant, the fact
that such action or condition is permitted by another covenant shall not affect
the occurrence of such default. In addition, all representations and warranties
hereunder shall be given independent effect so that if a particular
representation or warranty proves to be incorrect or is breached, the fact that
another representation or warranty concerning the same or similar subject matter
is correct or is not breached will not affect the incorrectness of or a breach
of a representation and warranty hereunder.

         19.8. Rights and Obligations; Severability. Unless otherwise expressly
provided herein, each Purchaser's rights and obligations hereunder are several
rights and obligations, not rights and obligations jointly held with any other
person. In case any provision of this Agreement shall be invalid, illegal or
unenforceable, the validity, legality and enforceability of the remaining
provisions shall not in any way be affected or impaired thereby.

         19.9. Agent's Fees. (a) Except as provided in Section 19.9 of the
Schedule of Exceptions, the Company hereby (i) represents and warrants that the
Company has not retained a finder or broker in connection with the transactions
contemplated by this Agreement and (ii) agrees to indemnify and to hold the
Purchasers harmless of and from any liability for commission or compensation in
the nature of an agent's fee to any broker, Person, and the costs and expenses
of defending against such liability or asserted liability, including, without
limitation, reasonable attorney's fees, arising from any act by the Company or
any of the Company's employees or representatives; provided, however, that the
Company will have the right to defend against such liability by
representative(s) of its own choosing, which representative(s) shall be approved
by the holders of a majority in aggregate principal amount of the Debentures and
the holders of a majority of the Shares (which approval shall not be
unreasonably withheld or delayed). In the event that the Company shall fail to
undertake the defense within 30 days of any notice of such claim, the Purchasers
shall have the right to undertake the defense, compromise or settlement of such
claim upon written notice to the Company by holders of a majority in principal
amount of the Debentures and the holders of a majority of the Shares and the
Company will be responsible for and shall pay all reasonable costs and expenses
of defending such liability or asserted liability and any amounts paid in
settlement.

         (b) Each Purchaser (i) severally represents and warrants that it has
retained no finder or broker in connection with the transactions contemplated by
this Agreement and (ii) hereby severally agrees to indemnify and to hold the
Company harmless from any liability for any commission or compensation in the
nature of an agent's or finder's fee to any broker or other Person (and the
costs, including reasonable legal fees, and expenses of defending against such
liability or asserted liability) for which such Purchaser, or any of its
employees or representatives, are responsible.

         19.10. Expenses. The Company shall bear its own expenses and legal fees
incurred on its behalf with respect to the negotiation, execution and
consummation of the



                                       48



transactions contemplated by this Agreement, and the Company will reimburse the
Purchasers for all of the reasonable expenses incurred by the Purchasers and
their affiliates with respect to the negotiation, execution and consummation of
the transactions contemplated by this Agreement and the transactions
contemplated hereby and due diligence conducted in connection therewith,
including the fees and disbursements of counsel and auditors for the Purchasers.
Such reimbursement shall be paid on the Closing Date.

         19.11. Jurisdiction. (a) Each of the parties hereto hereby irrevocably
and unconditionally submits, for itself and its property, to the nonexclusive
jurisdiction of any New York State court or United States Federal court sitting
in New York City, and any appellate court from any thereof, in any action or
proceeding arising out of or relating to this Agreement or any of the other
Transaction Documents to which it is a party or to whose benefit it is entitled,
or for recognition or enforcement of any judgment, and each of the parties
hereto irrevocably and unconditionally agrees that all claims in respect of any
such action or proceeding may be heard and determined in any such New York State
court or, to the fullest extent permitted by law, in such United States Federal
court. Each of the parties hereto agrees that a final judgment in any such
action or proceeding shall be conclusive and may be enforced in other
jurisdictions by suit on the right that any party may otherwise have to bring
any action or proceeding relating to this Agreement or any of the other
Transaction Documents in the courts of any other jurisdiction.

         (b) Each of the parties hereto irrevocably and unconditionally waives,
to the fullest extent it may legally and effectively do so, any objection that
it may now or hereafter have to the laying of venue of any suit, action or
proceeding arising out of or in relation to this Agreement or any other
Transaction Document to which it is a party in any such New York State or United
States Federal court sitting in New York City. Each of the parties hereto hereby
irrevocably waives, to the fullest extent permitted by law, the defense of an
inconvenient forum to the maintenance of such action or proceeding in any such
court.

         19.12. Waiver of Jury Trial. EACH OF THE PARTIES HERETO HEREBY
IRREVOCABLY WAIVES ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR
COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR
RELATING TO ANY TRANSACTION DOCUMENT OR THE ACTIONS OF ANY PARTY IN THE
NEGOTIATION, ADMINISTRATION, PERFORMANCE OR ENFORCEMENT THEREOF.

         19.13. Confidentiality. (a) Each of the Purchasers hereby agrees to
keep (and to cause its affiliates, employees, agents, attorneys, accountants and
other professional advisors to keep) confidential the confidential information
provided to it by or on behalf of the Company or its Subsidiaries pursuant to or
in connection with the Agreement or any other Transaction Document, provided
that, such information may be disclosed (i) solely in connection with the
performance of the transactions contemplated by this Agreement and any other
Transaction Document to (A) its affiliates, directors, officers and employees
who have a need to know such information and its agents, attorneys, accountants
and other professional advisors or (B) the other Purchasers, (ii) in response to
any order of any court or other governmental or administrative body or agency or
as may be required by any law binding upon any of the Purchasers, (iii) in
connection with the exercise of any remedies under any Transaction Document or
the enforcement of rights hereunder and thereunder, (iv) with the consent of the
Company or (v) to



                                       49



the extent such information (A) is on the date hereof, or at or before the time
such disclosure becomes, publicly available other than as a result of a breach
by such disclosing Person of the obligation set forth in this Agreement or (B)
at or before the time of such disclosure becomes available to any Purchaser on a
nonconfidential basis from a source other than the Company or its Subsidiaries,
which source is not known to the recipient of such information to have breached
a confidentiality agreement with the Company or its Subsidiaries in respect of
such information.

         (b) Each Purchaser hereby agrees that in the event such Purchaser is
requested or required other than by applicable law (by interrogatory, request
for information or documents, subpoena, deposition, civil investigative demand
or other process) to disclose any information pursuant to clause (ii) above,
such Purchaser will, except to the extent such notice would cause such Purchaser
to be in violation of law, provide the Company with prompt notice of any such
request or requirement so that the Company may seek an appropriate protective
order or other similar assurance to prevent disclosure of such information or
waive compliance with the provisions of this Section 19.13. Such Purchaser may
not oppose action by the Company to obtain an appropriate protective order or
other reliable assurance that confidential treatment will be accorded such
information, provided that such Purchaser may oppose the Company's action to
obtain an appropriate protective order or other reliable assurance in the event
that, in connection with any action, suit or other legal or equitable proceeding
(including any bankruptcy proceeding), such Purchaser reasonably believes that
the failure to publicly disclose such information would materially and adversely
affect such Purchaser's ability to protect or exercise its rights and remedies
hereunder or under any other Transaction Document.

         (c) The Purchasers may also disclose, subject to their compliance with
the requirements of clause (b) above, such information to the extent the
Purchasers reasonably believe it is appropriate to in connection with any
action, suit or other legal or equitable proceeding (including any bankruptcy
proceeding) to protect or otherwise exercise their rights and remedies hereunder
or under any other Transaction Document in any legal or equitable proceeding.

         (d) In furtherance to the foregoing, each of the Purchasers agrees that
its right to request any information pursuant to Section 9.2(g) or to avail
itself of the provisions of Section 9.6(b) shall be conditioned on its
continuing compliance with the requirements of this Section 19.13.

         19.14 Prohibition on Certain Cash Interest Payments. Each of the
Company, Galen and Oracle Strategic Partners, L.P., agree that the Company shall
not make any cash interest payments to Galen or Oracle Strategic Partners, L.P.,
pursuant to the March 1998 Debentures or the May 1999 Debentures,
notwithstanding anything else to the contrary contained therein or elsewhere,
without the prior written consent of all 2002 Holders, which consent shall be
within their sole and absolute discretion.

         19.15 Titles and Subtitles. The titles of the articles, sections and
subsections of this Agreement are for convenience of reference only and are not
to be considered in construing this Agreement.



                                       50



         19.16 Counterparts. This Agreement may be executed in any number of
counterparts, each of which shall be an original, but all of which together
shall constitute one instrument.

                                   ARTICLE XX

                              CERTAIN DEFINED TERMS

         As used in this Agreement, the following terms shall have the following
meanings:

                  "Agreement" means this Debenture Purchase Agreement, dated as
         of December 20, 2002, between the Company, Care Capital Investments II,
         LP, Essex Woodlands Health Ventures and the other Purchasers listed on
         the signature page hereto.

                  "Alternative Arrangement" has the meaning specified in Section
         12.1(i) of this Agreement.

                  "AMEX" has the meaning specified in Section 9.2(g) of this
         Agreement.

                  "Approved Accounting Firm" has the meaning specified in
         Section 9.6(d) of this Agreement.

                  "ARCOS" means the Automation of Reports and Consolidated
         Orders System which monitors the flow of DEA controlled substances from
         their point of manufacture to point of sale or distribution.

                  "Arm's Length" has the meaning specified in Section 10.5 of
         this Agreement.

                  "Change of Control" means the occurrence of any of the
         following: (a) the consummation of any transaction the result of which
         is that any Person or group (as such term is used in Section 13(d)(3)
         of the Exchange Act), other than Galen or any affiliate thereof or any
         group comprised of any of the foregoing, owns, directly or indirectly,
         51% of the Common Equity of the Company, (b) the Company consolidates
         with, or merges with or into, another Person (other than a direct or
         indirect wholly owned Subsidiary) or sells, assigns, conveys,
         transfers, leases or otherwise disposes of all or substantially all of
         the Company's assets or the assets of the Company and its Subsidiaries
         taken as a whole to any person, or any Person consolidates with, or
         merges with or into, the Company, in any such event pursuant to a
         transaction in which the outstanding Voting Stock of the Company, as
         the case may be, is converted into or exchanged for cash, securities or
         other property, other than any such transaction where the outstanding
         Voting Stock of the Company, as the case may be, is converted into or
         exchanged for Voting Stock of the surviving or transferee corporation
         and the beneficial owners of the Voting Stock of the Company
         immediately prior to such transaction own, directly or indirectly, not
         less than a majority of the Voting Stock of the surviving or transferee
         corporation immediately after such transaction, (c) the Company, either
         individually or in conjunction with one or more Subsidiaries sells,
         assigns, conveys, transfers, leases or otherwise disposes of, or the
         Subsidiaries sell, assign, convey, transfer, lease or otherwise dispose
         of, all or




                                       51



         substantially all of the properties and assets of the Company and its
         Subsidiaries, taken as a whole (either in one transaction or a series
         of related transactions), including capital stock of the Subsidiaries,
         to any Person (other than the Company or a wholly owned Subsidiary of
         the Company), or (d) during any two year period commencing subsequent
         to the date of this Agreement, individuals who at the beginning of such
         period constituted the Board of Directors of the Company (together with
         any new directors whose election by such Board of Directors or whose
         nomination for election by the stockholders of the Company was approved
         by the directors then still in office) who were either directors at the
         beginning of such period or whose election or nomination for election
         was previously so approved cease for any reason to constitute a
         majority of the Board of Directors then in office; provided, however,
         that a Person shall not be deemed to have ceased being a director for
         such purpose if such Person shall have resigned or died or if the
         involuntary removal of such Person was made at the direction of persons
         holding a majority in principal amount of the outstanding Debentures.
         For purposes of this definition, (i) the term "Common Equity" of the
         Company means all capital stock of the Company that is generally
         entitled to vote in the election of members of the Board of Directors
         and (ii) the term "Voting Stock" of the Company means securities of any
         class of capital stock of the Company entitling the holders thereof to
         vote in the election of members of the Board of Directors.

                  "Closing" and "Closing Date" have the respective meanings
         specified in Article III of this Agreement.

                  "Code" has the meaning specified in Section 4.18(a) of this
         Agreement.

                  "Commission" has the meaning specified in Section 4.8(a) of
         this Agreement.

                  "Common Holder" has the meaning specified in Section 17.1 of
         this Agreement.

                  "Common Stock" has the meaning specified in Section 1.1 of
         this Agreement.

                  "Company" means Halsey Drug Co., Inc., a New York corporation.

                  "Company Debenture Collateral" has the meaning specified in
         Section 2.2.

                  "Company General Security Agreement" has the meaning specified
         in Section 2.2(a) of this Agreement.

                  "Company Reports" has the meaning specified in Section 4.10 of
         this Agreement.

                  "Core Products Agreement" has the meaning specified in Section
         12.1(i) of this Agreement.

                  "CSA" has the meaning specified in Section 4.10(c) of this
         Agreement.

                  "D&O Insurance" has the meaning specified in Section 9.14 of
         this Agreement.

                  "DEA" has the meaning specified in Section 4.10(c) of this
         Agreement.



                                       52



                  "Debenture Dilution Waiver" means the Debenture Dilution
         Waiver to be signed by each of the Existing Debentureholders prior to
         the Closing Date serving to waive the dilution adjustments provisions
         of the Existing Debentures and the common stock purchase warrants
         issued with the Existing Debentures relating to the issuance of the
         Common Stock by the Company in accordance with the Recapitalization
         Agreement.

                  "Debentures" has the meaning specified in Section 1.1 of this
         Agreement.

                  "Debentureholders Agreement" means the Debentureholders
         Agreement (as such agreement may be supplemented, amended or otherwise
         modified from time to time in accordance with its terms) dated as of
         December 20, 2002 between the Company, the holders of the Existing
         Debentures and the Purchasers substantially in the form attached as
         Exhibit K hereto.

                  "Default Notice" has the meaning specified in Section 12.1(c)
         of this Agreement.

                  "Designee" has the meaning specified in Section 9.7 of this
         Agreement.

                  "ERISA" has the meaning specified in Section 4.18(a) of this
         Agreement.

                  "ERISA Affiliates" has the meaning specified in Section
         4.18(a) of this Agreement.

                  "Exchange Act" has the meaning specified in Section 4.8(a) of
         this Agreement.

                  "Excluded Securities" has the meaning specified in Section
         17.1(f) of this Agreement.

                  "Existing 1998 Debentureholders" has the meaning specified in
         Section 17.1 of this Agreement.

                  "Existing Debentures" means, collectively, the March 1998
         Debentures and the May 1999 Debentures, as such debentures may be
         supplemented, amended or otherwise modified from time to time,
         including, without limitation, by the Existing Debenture Amendments.

                  "Existing Debenture Amendments" has the meaning specified in
         Section 6.7 of this Agreement.

                  "Existing Debentureholders Consent" has the meaning specified
         in Section 6.7 of this Agreement.

                  "Event of Default" has the meaning specified in Section 12.1
         of this Agreement.

                  "FDA" has the meaning specified in Section 4.10(b) of this
         Agreement.

                  "FDC Act" has the meaning specified in Section 4.10(b) of this
         Agreement.

                  "412 Plan" has the meaning specified in Section 4.18(d) of
         this Agreement.



                                       53



                  "Galen" has the meaning specified in Section 2.2(a) of this
         Agreement.

                  "Galen Bridge Lenders" means, collectively, Galen and the
         other lenders pursuant to that certain Galen Bridge Loan Agreement.

                  "Galen Bridge Lenders' Consent" has the meaning specified in
         Section 6.8 of this Agreement.

                  "Galen Bridge Loan Agreement" means the Bridge Loan Agreement
         dated as of August 15, 2001 (as amended on January 9, 2002, April 15,
         2002 and May 8, 2002, and as further supplemented, amended or otherwise
         modified from time to time in accordance with its terms) between the
         Company, Galen and certain other lenders listed on the signature pages
         thereto.

                  "Galen Bridge Notes" means the 10% convertible senior secured
         promissory notes issued by the Company to the Galen Bridge Lenders
         under the Galen Bridge Loan Agreement.

                  "Guaranty" and "Guaranties" has the meaning specified in
         Section 2.3 of this Agreement.

                  "Guarantor" has the meaning specified in Section 2.3 of this
         Agreement.

                  "Guarantor Debenture Collateral" has the meaning specified in
         Section 2.4 of this Agreement.

                  "Guarantors Security Agreement" has the meaning specified in
         Section 2.4(a) of this Agreement.

                  "Holders" shall mean the Purchasers or any Person to whom a
         Purchaser or transferee of a Purchaser has assigned, transferred or
         otherwise conveyed any Debenture or Shares.

                  "Immaterial Subsidiaries" means Blue Cross Products, Inc., The
         Medi-Gum Corporation, H.R. Cenci Laboratories, Inc., and Cenci Powder
         Products, Inc.

                  "Indebtedness" has the meaning specified in Section 10.4 of
         this Agreement.

                  "Insurance Organizations" has the meaning specified in Section
         4.20 of this Agreement.

                  "Institutional Existing Debentureholders" has the meaning
         provided in Section 6.16 of this Agreement.

                  "Institutional Existing Debentureholders Reserved Shares" has
         the meaning provided in Section 6.16 of this Agreement.

                  "Intellectual Property Rights" has the meaning specified in
         Section 4.12(a) of this Agreement.




                                       54



                  "Joinder Agreement" was the meaning specified in Article III
         of this Agreement.

                  "IRS" has the meaning specified in Section 4.18(b) of this
         Agreement.

                  "Leased Property" has the meaning specified in Section 4.20 of
         this Agreement.

                  "Leases" has the meaning specified in Section 4.20 of this
         Agreement.

                  "Loss" has the meaning specified in Section 13.1 of this
         Agreement.

                  "March 1998 Debentures" means the 5% convertible secured
         debentures due March 15, 2003 (as such debentures may be supplemented,
         amended, or otherwise modified from time to time) issued pursuant to
         that certain Debenture and Warrant Purchase Agreement dated March 10,
         1998 between the Company and the Purchasers listed on the signature
         page thereto.

                  "Material Adverse Effect" has the meaning specified in Section
         4.1 of this Agreement.

                  "May 1999 Debentures" means the 5% convertible secured
         debentures due March 15, 2003 (as such debentures may be supplemented,
         amended, or otherwise modified from time to time) issued pursuant to
         that certain Debenture and Warrant Purchase Agreement dated May 26,
         1999 between the Company and the Purchasers listed on the signature
         page thereto.

                  "Minimum Offering Threshold" has the meaning specified in
         Section 17.1(a) of this Agreement.

                  "Mortgage" has the meaning specified in Section 2.4(c) of this
         Agreement.

                  "Mortgage Subordination Agreement" shall mean that certain
         Subordination Agreement, dated the date hereof, between Houba, Galen
         and Oracle Strategic Partners, L.P. relating to real property owned by
         Houba.

                  "NASDAQ" has the meaning specified in Section 9.2(g) of this
         Agreement.

                  "Offer" has the meaning specified in Section 17.1(a) of this
         Agreement.

                  "Old Common Holders" has the meaning specified in Section 17.1
         of this Agreement.

                  "Owned Property" has the meaning specified in Section 4.20 of
         this Agreement.

                  "PBGC" has the meaning specified in Section 4.18(b) of this
         Agreement

                  "PCB" has the meaning specified in Section 4.16(c) of this
         Agreement.

                  "Permitted Liens" has the meaning specified in Section 10.3(l)
         of this Agreement.



                                       55



                  "Person" means any individual, corporation, limited liability
         company, partnership, association, trust or any other entity or
         organization, including a government or political subdivision or an
         agency or instrumentality thereof.

                  "Plan" has the meaning specified in Section 4.18(a) of this
         Agreement.

                  "Purchaser" has the meaning specified in Section 1.1 of this
         Agreement.

                  "Real Property Permits" has the meaning specified in Section
         4.20 of this Agreement.

                  "Recapitalization Agreement" has the meaning specified in
         Section 6.9 of this Agreement.

                  "Refused Securities" has the meaning specified in Section
         17.1(d) of this Agreement.

                  "Registration Rights Agreement" means that certain
         Registration Rights Agreement, dated the date hereof, between the
         Company, the Purchasers, Watson, the holders of the March 1998
         Debentures, the holders of the May 1999 Debentures and the other
         parties listed on Schedule 1 thereto.

                  "Remaining Galen Warrants" has the meaning provided in Section
         1.2.

                  The terms "register," "registered" and "registration" shall
         refer to a registration effected by preparing and filing a registration
         statement in compliance with the Securities Act and applicable rules
         and regulations thereunder, and the declaration or ordering of the
         effectiveness of such registration statement.

                  "Rule 501(b)" has the meaning specified in Article III of this
         Agreement.

                  "Schedule of Exceptions" has the meaning specified in Article
         IV of this Agreement.

                  "Securities" has the meaning specified in Section 1.1 of this
         Agreement.

                  "Securities Act" has the meaning specified in Section 4.8(a)
         of this Agreement.

                  "Security Interest Termination Date" shall mean the first date
         on which each of the following events shall have occurred: (a) all of
         the Company's and the Guarantors' obligations and liabilities under the
         Transaction Documents (except for the Watson Term Loan Amendment, the
         2002 Watson Term Loan, the Registration Rights Agreement, the Watson
         Consent, the Watson Supply Agreement, the Watson Supply Agreement
         Amendment, the Watson Warrant, the Existing Debenture Amendments and
         the Existing Debentureholder Consent) shall have been either or both of
         (i) indefeasibly paid in full or, as applicable, indefeasibly
         discharged, or (ii) irrevocably converted in accordance with this
         Agreement and the Debentures, (b) none of the Company's or Guarantors'
         obligations or liabilities (whether actual or contingent) shall remain
         outstanding, except (with respect to subsection (a) and this subsection
         (b)) for the Company's obligations



                                       56




         under the Registration Rights Agreement, and (c) Galen, acting as agent
         for the Purchasers under the applicable Transaction Documents, shall
         have delivered written notification to the Company and the Guarantors
         of the satisfaction of the conditions in subsections (a) and (b) above.

                  "Selling Security Holder" has the meaning specified in Section
         18.1 of this Agreement.

                  "Shareholders Meeting Date" means that date on which the
         shareholders and the debentureholders amend the Company's Certificate
         of Incorporation to increase the number of authorized shares of the
         Common Stock available for issuance from 80,000,000 to such number of
         shares as shall equal the sum of (a) the Company's issued and
         outstanding Common Stock, plus (b) the number of shares of Common Stock
         issuable upon the conversion and exercise of the Company's outstanding
         convertible securities, plus (c) the number of shares of Common Stock
         issuable upon conversion of the Debentures and exercise of the Watson
         Warrant , plus (d) 50 million shares, as shall sum shall be rounded up
         to the nearest whole five million shares.

                  "Shares" has the meaning specified in Section 1.1 of this
         Agreement.

                  "Solvent" has the meaning specified in Section 4.22 of this
         Agreement.

                  "Stock Pledge Agreement" has the meaning specified in Section
         2.2(a) of this Agreement.

                  "Subordination Agreement" has the meaning specified in Section
         6.6 of this Agreement.

                  "Subsidiary" has the meaning specified in Section 4.2 of this
         Agreement.

                  "Termination Date" has the meaning specified in Section 1.2(b)
         of this Agreement.

                  "2000 Watson Term Loan" means that certain Term Loan Agreement
         for an aggregate principal amount of $17,500,000 between the Company
         and Watson dated March 29, 2000, as such agreement may be supplemented,
         amended or otherwise modified from time to time, including, without
         limitation, by the Watson Term Loan Amendment.

                  "2002 Holder" has the meaning set forth in Article III of this
         Agreement.

                  "2002 Watson Term Loan" has the meaning specified in Section
         6.6 of this Agreement.

                  "Transaction Documents" has the meaning specified in Section
         4.4(a) of this Agreement.

                  "Transfer" has the meaning specified in Section 18.1 of this
         Agreement.

                                       57





                  "Unfunded Pension Liability" has the meaning specified in
         Section 4.18(e) of this Agreement.

                  "US GAAP" has the meaning specified in Section 4.8(a) of this
         Agreement.

                  "Voting Agreement" has the meaning specified in Section
         9.12(b) of this Agreement.

                  "Watson" means Watson Pharmaceuticals, Inc., a Nevada
         corporation.

                  "Watson Consent" has the meaning specified in Section 6.6 of
         this Agreement.

                  "Watson Supply Agreement " means the Finished Goods Supply
         Agreement (Core Products) dated March 29, 2000, as amended by that
         certain Amendment and Supplement No. 1 to Finished Goods Supply
         Agreement (Core Products) dated August 8, 2001.

                  "Watson Supply Agreement Amendment" has the meaning specified
         in Section 6.6 of this Agreement.

                  "Watson Term Loans" mean that certain (a) 2000 Watson Term
         Loan and (b) 2002 Watson Term Loan for an aggregate principal amount of
         $3,901,331.

                  "Watson Term Loan Amendment" has the meaning specified in
         Section 6.6 of this Agreement.

                  "Watson Warrant" means a Common Stock Purchase Warrant issued
         by the Company to Watson on the Closing Date exercisable for 10,700,665
         shares of Common Stock at an exercise price per share equal to the
         conversion price of the Debentures.

                  "Withdrawal Liability" has the meaning specified in Section
         4.18(g) of this Agreement.


                           [SIGNATURE PAGES TO FOLLOW]



                                       58




         If the Purchaser is in agreement with the foregoing the Purchaser shall
sign where indicated below and thereupon this letter shall become a binding
agreement between such Purchaser and the Company.

                                 HALSEY DRUG CO., INC.



                                 By:
                                    --------------------------------------------
                                    Michael Reicher
                                    Chief Executive Officer



Solely as to the Provisions of
Sections 9.12(b) and 19.14 and Articles XVIII and XIX hereof

GALEN PARTNERS III, L.P.
BY: CLAUDIUS, L.L.C., GENERAL PARTNER

By:
   ------------------------------------
         Srini Conjeevaram
         General Partner



GALEN PARTNERS INTERNATIONAL III, L.P.
By: Claudius, L.L.C., General Manager



By:
   ------------------------------------
         Srini Conjeevaram
         General Partner



GALEN EMPLOYEES FUND III, L.P.
By:  Wesson Enterprises, Inc.



By:
   ------------------------------------
         Bruce F. Wesson
         General Partner





                                       59






ORACLE STRATEGIC PARTNERS, L.P.



By:
   ------------------------------------
         Name:
         Title:

MICHAEL REICHER TRUST
c/o Halsey Drug Co., Inc.
695 North Perryville Rd.
Crimson Building #2
Rockford, Ill. 61107

- ----------------------------------------
By: Michael K. Reicher
Its: Trustee

ROBERT W. BAIRD & CO., INC., TTEE
FBO Michael K. Reicher IRA
c/o Halsey Drug Co., Inc.
695 North Perryville Rd.
Crimson Building #2
Rockford, Ill. 61107


- ----------------------------------------
By: Robert W. Baird
Its: Trustee



- ----------------------------------------
Peter Clemens



                                       60




PURCHASERS


                                               
GALEN PARTNERS III, L.P.                          GALEN PARTNERS INTERNATIONAL, III, L.P.
By: Claudius, L.L.C., General Partner             By: Claudius, L.L.C., General Partner
610 Fifth Avenue, 5th Fl.                         610 Fifth Avenue, 5th Floor
New York, New York  10019                         New York, New York  10020


- -------------------------------------             -------------------------------------
By: Srini Conjeevaram                             By: Srini Conjeevaram
Its: General Partner                              Its: General Partner


GALEN EMPLOYEE FUND III, L.P.                     ESSEX WOODLANDS HEALTH
By: Wesson Enterprises, Inc.                      VENTURES V, L.P.
610 Fifth Avenue, 5th Floor                       By: Essex Woodlands Health Ventures V, L.L.C.,
New York, New York 10020                          its General Partner
                                                  190 South LaSalle Street, Suite 2800
                                                  Chicago, IL 60603


- -------------------------------------             -------------------------------------
By: Bruce F. Wesson                               By: Immanuel Thangaraj
Its: General Partner                              Its: Managing Director

CARE CAPITAL INVESTMENTS, L.P.                    BERNARD SELZ
By: Care Capital, L.L.C., General Partner         c/o Furman Selz
Princeton Overlook One                            230 Park Avenue
100 Overlook Center, Suite 102                    New York, New York  10069
Princeton, New Jersey 08540


- -------------------------------------             -------------------------------------
By:
Its:

MICHAEL WEISBROT                                  SUSAN WEISBROT
1136 Rock Creek Road                              1136 Rock Creek Road
Gladwyne, Pennsylvania  19035                     Gladwyne, Pennsylvania  19035


- -------------------------------------             -------------------------------------
61 GREG WOOD ROGER GRIGGS c/o D.R. International c/o Tom Jennings 7474 No. Figueroa Street 7300 Turfway Road Los Angeles, California 90041 Suite 300 Florence, KY 41042 - ------------------------------------- ------------------------------------- GEORGE E. BOUDREAU 222 Elbow Lane Haverford, PA 19041 - -------------------------------------
62 EXHIBIT A LIST OF PURCHASERS AND ALLOCATION OF SECURITIES 63 EXHIBIT B FORM OF DEBENTURE EXHIBIT C SCHEDULE OF EXCEPTIONS EXHIBIT D SUBSCRIPTION AGREEMENT EXHIBIT E COMPANY GENERAL SECURITY AGREEMENT EXHIBIT F GUARANTY AGREEMENT EXHIBIT G GUARANTORS SECURITY AGREEMENT EXHIBIT H LEGAL OPINION EXHIBIT I VOTING AGREEMENT EXHIBIT J FORM OF JOINDER AGREEMENT EXHIBIT K DEBENTUREHOLDERS AGREEMENT EXHIBIT L STOCK PLEDGE AGREEMENT EXHIBIT M SUBORDINATION AGREEMENT EXHIBIT N RECAPITALIZATION AGREEMENT EXHIBIT O REMAINING GALEN ENTITIES WARRANTS TABLE OF CONTENTS
Page ---- ARTICLE I AUTHORIZATION OF THE SECURITIES; ADJUSTMENT OF CONVERSION PRICE.................................... 1 1.1. Authorization of Securities................................................................ 1 1.2. Adjustment of Conversion Price............................................................. 2 ARTICLE II SALE AND PURCHASE OF THE SECURITIES; SECURITY DOCUMENTS........................................... 3 2.1. Sale and Purchase of the Securities........................................................ 3 2.2. Company Security Documents................................................................. 3 2.3. Guaranties................................................................................. 3 2.4. Guarantor Security Documents............................................................... 4 ARTICLE III CLOSING.......................................................................................... 4 ARTICLE IV REPRESENTATIONS AND WARRANTIES OF THE COMPANY..................................................... 5 4.1. Organization and Existence, etc............................................................ 5 4.2. Subsidiaries and Affiliates................................................................ 5 4.3. Capitalization............................................................................. 6 4.4. Authorization.............................................................................. 6 4.5. Binding Obligations; No Material Adverse Contracts, etc.................................... 7 4.6. Compliance with Instruments, etc........................................................... 7 4.7. Litigation................................................................................. 7 4.8. Financial Information; SEC Documents....................................................... 8 4.9. Offering Exemption......................................................................... 9 4.10. Permits; Governmental and Other Approvals.................................................. 9 4.11. Sales Representatives, Customers and Key Employees......................................... 10 4.12. Copyrights, Trademarks and Patents; Licenses............................................... 11 4.13. Inventory.................................................................................. 12 4.14. Registration Rights........................................................................ 12 4.15. No Discrimination; Labor Matters........................................................... 12 4.16. Environmental Matters...................................................................... 12
Page ---- 4.17. Taxes...................................................................................... 13 4.18. Employee Benefit Plans and Similar Arrangements............................................ 13 4.19. Personal Property.......................................................................... 16 4.20. Real Property.............................................................................. 16 4.21. Disclosure................................................................................. 16 4.22. Solvency................................................................................... 17 4.23. Insurance.................................................................................. 17 ARTICLE V REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS................................................... 18 ARTICLE VI CONDITIONS TO CLOSING OF THE PURCHASERS........................................................... 18 6.1. Representations and Warranties Correct; No Default......................................... 18 6.2. Performance................................................................................ 18 6.3. Compliance Certificate..................................................................... 18 6.4. No Impediments............................................................................. 18 6.5. Waivers/Elections of Rights of First Refusal............................................... 19 6.6. Watson Consent; Amendment to Watson Term Loans; Subordination Agreement.................... 19 6.7. Consent of Holders of Existing Debentures.................................................. 19 6.8. Consent of Galen Bridge Lenders............................................................ 20 6.9. Recapitalization Agreement................................................................. 20 6.10. Other Agreements and Documents............................................................. 20 6.11. Consents................................................................................... 21 6.12. Legal Investment........................................................................... 21 6.13. Proceedings and Other Documents............................................................ 21 6.14. Opinion of Counsel......................................................................... 22 6.15. Reconstitution of the Board of Directors................................................... 22 6.16. Authorized Shares.......................................................................... 22 ARTICLE VII CONDITIONS TO CLOSING OF THE COMPANY............................................................. 23 7.1. Representations............................................................................ 23 7.2. Legal Investment........................................................................... 23 7.3. Payment of Purchase Price.................................................................. 23 ARTICLE VIII PREPAYMENT...................................................................................... 23 ARTICLE IX AFFIRMATIVE COVENANTS............................................................................. 23
Page ---- 9.1. Maintenance of Corporate Existence, Properties and Leases; Taxes; Insurance................ 23 9.2. Basic Financial Information................................................................ 24 9.3. Notice of Adverse Change................................................................... 26 9.4. Compliance With Agreements; Compliance With Laws........................................... 27 9.5. Protection of Licenses, etc................................................................ 27 9.6. Accounts and Records; Inspections.......................................................... 27 9.7. Board Members and Meetings................................................................. 28 9.8. Maintenance of Office...................................................................... 29 9.9. Use of Proceeds............................................................................ 29 9.10. Payment of Debentures...................................................................... 29 9.11. Reporting Requirements..................................................................... 29 9.12. Amendments to the Company's Certificate of Incorporation................................... 29 ARTICLE X NEGATIVE COVENANTS................................................................................. 31 10.1. Stay, Extension and Usury Laws............................................................. 31 10.2. Reclassification........................................................................... 31 10.3. Liens...................................................................................... 31 10.4. Indebtedness............................................................................... 33 10.5. Arm's Length Transactions.................................................................. 34 10.6. Immaterial Subsidiaries.................................................................... 34 10.7. Loans and Advances......................................................................... 34 10.8. Intercompany Transfers; Transactions With Affiliates; Diversion of Corporate Opportunities....................................................... 34 10.9. Investments................................................................................ 34 10.10. Other Business............................................................................. 35 10.11. Employee Benefit Plans and Compensation.................................................... 35 10.12. Capital Expenditures....................................................................... 35 10.13. Amendment, Etc. of Certain Document........................................................ 35 10.14. Formation of Subsidiaries.................................................................. 36 ARTICLE XI Intentionally omitted............................................................................. 36 ARTICLE XII EVENTS OF DEFAULT................................................................................ 36 12.1. Events of Default.......................................................................... 36 12.2. Remedies................................................................................... 39
Page ---- 12.3. Enforcement................................................................................ 40 ARTICLE XIII INDEMNIFICATION................................................................................. 40 ARTICLE XIV AMENDMENT AND WAIVER............................................................................. 41 ARTICLE XV EXCHANGE OF DEBENTURES............................................................................ 42 ARTICLE XVI TRANSFER OF DEBENTURES........................................................................... 42 16.1. Notification of Proposed Sale.............................................................. 42 16.2. Intentionally Omitted...................................................................... 42 ARTICLE XVII RIGHT OF FIRST REFUSAL; ADDITIONAL INVESTMENT................................................... 42 17.1. Right of First Refusal..................................................................... 42 ARTICLE XVIII CO-SALE RIGHTS................................................................................. 45 ARTICLE XIX MISCELLANEOUS.................................................................................... 46 19.1. Governing Law.............................................................................. 46 19.2. Survival of Representations................................................................ 46 19.3. Successors and Assigns..................................................................... 46 19.4. Entire Agreement........................................................................... 47 19.5. Notices, etc............................................................................... 47 19.6. Delays, Omissions or Waivers............................................................... 47 19.7. Independence of Covenants and Representations and Warranties............................... 48 19.8. Rights and Obligations; Severability....................................................... 48 19.9. Agent's Fees............................................................................... 48 19.10. Expenses................................................................................... 48 19.11. Jurisdiction............................................................................... 49 19.12. Waiver of Jury Trial....................................................................... 49 19.13. Confidentiality............................................................................ 49 ARTICLE XX CERTAIN DEFINED TERMS............................................................................. 51
- ------------------------------------------------------------------------------- HALSEY DRUG CO., INC. $ 35,000,000 5% CONVERTIBLE SENIOR SECURED DEBENTURE DUE MARCH 31, 2006 HALSEY DRUG CO., INC. DEBENTURE PURCHASE AGREEMENT DATED AS OF DECEMBER 20, 2002

                                                                    EXHIBIT 10.2

                              HALSEY DRUG CO., INC.

                       COMPANY GENERAL SECURITY AGREEMENT

               THIS COMPANY GENERAL SECURITY AGREEMENT ("Company Security
Agreement") is made and entered into as of December 20, 2002 by and between
HALSEY DRUG CO., INC., a New York corporation (the "Debtor"), with its principal
place of business at 695 North Perryville Road, Rockford, Illinois 61107, and
GALEN PARTNERS III, L.P., a Delaware limited partnership ("Galen"), with its
principal place of business at 610 Fifth Avenue, 5th Floor, New York, New York
10020 acting in its capacity as agent for the Purchasers (as such term is
defined below) (in such capacity, the "Agent") for the benefit of the
Purchasers.

                               W I T N E S S E T H

               WHEREAS, Galen, certain other purchasers (together with Galen,
the "Purchasers") and the Debtor have entered into a Debenture Purchase
Agreement dated as of the date hereof (as the same may be amended, modified,
supplemented or restated from time to time, the "Purchase Agreement"; terms
which are capitalized herein and not otherwise defined shall have the meanings
ascribed to them in the Purchase Agreement); and

               WHEREAS, the Purchasers have required, as a condition precedent
to the effectiveness of the Purchase Agreement, that the Debtor (i) grant to the
Agent, for the ratable benefit of the Purchasers, a security interest in and to
the Collateral (as defined in Section II below) and (ii) execute and deliver
this Company Security Agreement in order to secure the payment and performance
by the Debtor of the obligations owing by the Debtor to the Purchasers under the
Purchase Agreement, the Debentures, the other Transaction Documents (as defined
in the Subordination Agreement) and each of the agreements, documents and
instruments delivered by the Debtor pursuant thereto or in connection therewith
(collectively, the "Obligations").

               NOW, THEREFORE, in consideration of the premises and in order to
induce the Purchasers to enter into and perform the Purchase Agreement, the
Debtor hereby agrees as follows:

                  SECTION I. CREATION OF SECURITY INTEREST.

                  A.       Security Interest. The Debtor hereby pledges,
assigns and grants to the Agent a continuing perfected lien and security
interest, having priority over any and all other security interests (except as
otherwise provided in the Subordination Agreement), in all of the Debtor's
right, title and interest in and to the Collateral in order to secure the
payment and performance of all Obligations owing by the Debtor.

                  B.       Debtor Remains Liable. Anything herein to the
contrary notwithstanding, (i) the Debtor shall remain liable under the contracts
and agreements included in the Debtor's Collateral to the extent set forth
therein to perform all of its duties and obligations thereunder to the same
extent as if this Company Security Agreement had not been executed, (ii) the
exercise by the Agent

of any of the rights hereunder shall not release the Debtor from any of its
duties or obligations under the contracts and agreements included in the
Collateral and (iii) neither the Agent nor any Purchaser shall have any
obligation or liability under the contracts and agreements included in the
Collateral by reason of this Company Security Agreement, the Purchase Agreement
or any other Transaction Document, nor shall the Agent or any Purchaser be
obligated to perform any of the obligations or duties of the Debtor thereunder
or to take any action to collect or enforce any claim for payment assigned
hereunder.

                  SECTION II. COLLATERAL.

                  For purposes of this Company Security Agreement, the term
"Collateral" shall mean all of the kinds and types of property described in
subsections A. through G. of this Section II, whether now owned or hereafter at
any time arising, acquired or created by the Debtor and wherever located, and
includes all replacements, additions, accessions, substitutions, repairs,
proceeds and products relating thereto or therefrom, and all documents, ledger
sheets and files of the Debtor relating thereto and all Proceeds of Collateral.
"Proceeds" hereunder include (i) whatever is now or hereafter received by the
Debtor upon the sale, exchange, collection or other disposition of any item of
Collateral, whether such proceeds constitute inventory, accounts, accounts
receivable, general intangibles, instruments, securities (including, without
limitation, United States of America Treasury Bills), credits, claims, demands,
documents, letters of credit and letter of credit proceeds, chattel paper,
documents of title, certificates of title, certificates of deposit, warehouse
receipts, bills of lading, leases, deposit accounts, money, tax refund claims,
contract rights, royalties, goods, equipment, payment under insurance (whether
or not the Agent is the loss payee thereof), or any indemnities, warranties or
guaranties, payable by reason of loss or damage to or otherwise with respect to
any or the foregoing Collateral, and (ii) any such items which are now or
hereafter acquired by the Debtor with any proceeds of Collateral hereunder.

                  A.       Accounts. All of the Debtor's accounts, whether now
existing or existing in the future, including without limitation (i) all
accounts receivable (whether or not specifically listed on schedules furnished
to the Agent), including, without limitation, all accounts created by or arising
from all of the Debtor's sales of goods or rendition of services made under any
of Debtor's trade names, or through any of its divisions, (ii) all unpaid
seller's rights (including rescission, replevin, reclamation and stoppage in
transit) relating to the foregoing or arising therefrom, (iii) all rights to any
goods represented by any of the foregoing, including returned or repossessed
goods, (iv) all reserves and credit balances held by the Debtor with respect to
any such accounts receivable or account debtors, (v) all health-care-insurance
receivables, (vi) deposit accounts, (vii) letter-of-credit rights, (viii)
instruments (including, without limitation, promissory notes) and (ix) all
guarantees or collateral for any of the foregoing (all of the foregoing property
and similar property being hereinafter referred to as "Accounts");

                  B.       Inventory. All of the Debtor's inventory, including
without limitation (i) all raw materials, work in process, parts, components,
assemblies, supplies and materials used or consumed in the Debtor's businesses,
wherever located and whether in the possession of the Debtor or any other Person
(for the purposes of this Company Security Agreement, the term "Person" "Person"
means any individual, sole proprietorship, partnership, joint venture, trust,
unincorporated organization, association, corporation, limited liability
company, institution, entity, party or government, including any division,
agency or department thereof); (ii) all goods, wares and merchandise,

                                       2

finished or unfinished, held for sale or lease or leased or furnished or to be
furnished under contracts of service, wherever located and whether in the
possession of the Debtor or any other Person or entity; and (iii) all goods
returned to or repossessed by the Debtor (all of the foregoing property being
hereinafter referred to as "Inventory");

                  C.       Equipment. All of the equipment owned or leased by
the Debtor, including, without limitation, machinery, equipment, office
equipment and supplies, computers and related equipment, furniture, furnishings,
tools, tooling, jigs, dies, fixtures, manufacturing implements, fork lifts,
trucks, trailers, motor vehicles, and other equipment (all of the foregoing
property being hereinafter referred to as "Equipment");

                  D.       Intangibles. All of the Debtor's general intangibles
(including, without limitation, payment intangibles), instruments, securities
(including, without limitation, United States of America Treasury Bills),
credits, claims, demands, documents, letters of credit and letter of credit
proceeds, chattel paper, documents of title, certificates of title, certificates
of deposit, warehouse receipts, bills of lading, leases which are permitted to
be assigned or pledged, deposit accounts, money, tax refund claims, contract
rights which are permitted to be assigned or pledged (all of the foregoing
property being hereinafter referred to as "Intangibles"); and

                  E.       Intellectual Property. All of the Debtor's
intellectual property, including, without limitation, New Drug Applications,
Investigatory New Drug Applications, Abbreviated New Drug Applications,
Alternative New Drug Applications, registrations and quotas as issued by the
Drug Enforcement Administration and/or the Attorney General of the United States
pursuant to the Controlled Substances Act, certifications, permits and approvals
of federal and state governmental agencies, patents, patent applications,
trademarks, trademark applications, service marks, service mark applications,
trade names, domain names, technical knowledge and processes, formal or informal
licensing arrangements which are permitted to be assigned or pledged,
blueprints, technical specifications, computer software, programs, databases,
copyrights, copyright applications and all confidential and proprietary
information, including, without limitation, know-how, trade secrets,
manufacturing and production processes and techniques, inventions, research and
development information, databases and data, including, without limitation,
technical data, financial and marketing and business data, pricing and cost
information and business and marketing plans, and all embodiments thereof, and
rights thereto, including, without limitation, all of the Debtor' rights to use
the patents, trademarks, copyrights, service marks, or other property of the
aforesaid nature of other Persons now or hereafter licensed to the Debtor,
together with the goodwill of the business symbolized by or connected with the
Debtor's trademarks, copyrights, service marks, licenses and the other rights
included in this Section II(E).

                  F.       Distributions. All interest, dividends,
distributions, cash, instruments and other property from time to time received,
receivable or otherwise distributed in respect of or in exchange for any or all
of the then existing Collateral.

                  G.       Subsidiaries. All of the shares of stock or other
securities of Houba, Inc. and Halsey Pharmaceuticals, Inc., and the
certificates, if any, representing such shares or other securities, and all
dividends, distributions, return of capital, cash, instruments and other
property from time to time received, receivable or otherwise distributed in
respect of or in exchange for any or all of such shares or securities and all
subscription warrants, rights or options issued thereon or with respect

                                       3

thereto, and all Investment Property, all, to the extent applicable, as further
set forth in the Stock Pledge Agreement.

                  SECTION III. THE DEBTOR'S REPRESENTATIONS AND WARRANTIES.

                  A.       Places of Business. The Debtor has no other place of
business, or warehouses in which it leases space, other than those set forth on
Section IIIA of Schedule A, a copy of which is attached hereto and made a part
hereof ("Schedule A").

                  B.       Location of Collateral. Except for the movement of
Collateral from time to time from one place of business or warehouse listed on
Section IIIA of Schedule A, to another place of business or warehouse listed on
Section IIIA of such Schedule A, the Collateral is located at the Debtor's chief
executive office or other places of business or warehouses listed on such
Section IIIA of Schedule A, and not at any other location.

                  C.       Restrictions on Collateral Disposition. None of the
Collateral is subject to contractual obligations that may restrict or inhibit
the Agent's rights or ability to sell or dispose of the Collateral or any part
thereof after the occurrence of an Event of Default except (i) the rights of
Watson under the Watson Loan Agreement and the documents executed in connection
therewith, including, without limitation, the Watson Security Agreement dated as
of March 29, 2000 (the "Watson Security Agreement"); (ii) the rights of the
investors in the 5% convertible senior secured debentures due March 31, 2006
issued pursuant to a certain Debenture and Warrant Purchase Agreement dated
March 10, 1998, as amended, between the Company and the purchasers listed on the
signature page thereto (the "March 1998 Debentures"); and (iii) the rights of
the investors in the 5% convertible senior secured debentures due March 31, 2006
issued pursuant to a curtain Debenture and Warrant Purchase Agreement dated May
26, 1999, as amended, between the Company and the purchasers listed on the
signature page thereto (the "May 1999 Debentures").

                  D.       Status of Accounts. Each Account is based on an
actual and bona fide rendition of services or sale of goods/products to
customers, made by the Debtor in the ordinary course of its business; the
Accounts created are its exclusive property and are not and shall not be subject
to any lien, consignment arrangement, encumbrance, security interest or
financing statement whatsoever, except (i) the lien in favor of Watson under the
Watson Loan Agreement and the documents executed in connection therewith,
including, without limitation, the Watson Security Agreement, (ii) the lien in
favor of the investors in the March 1998 Debentures and (iii) the lien in favor
of the investors in the May 1999 Debentures, and to the best knowledge of the
Debtor, the Debtor's customers have accepted the goods/products and services,
and owe and are obligated to pay the full amounts stated in the invoices
according to their terms, without any dispute, offset, defense or counterclaim.

                  E.       Copyrights, Trademarks and Patents.

                  (i)        Debtor owns outright all of the Intellectual
Property Rights listed on Section 4.12 of the Schedule of Exceptions attached to
the Purchase Agreement free and clear of all liens and encumbrances except for
the Permitted Encumbrances and pays no royalty to anyone under or with respect
to any of them.

                                       4

                  (ii)       Debtor has not licensed to anyone the use of any of
such Intellectual Property Rights and has no knowledge of the infringing use by
the Company or any Guarantor of any intellectual property rights of third
parties.

                  (iii)      The Debtor has no knowledge, nor has it received
any notice (a) of any conflict with the asserted rights of others with respect
to any Intellectual Property Rights used in, or useful to, the operation of the
business conducted by the Company and the Guarantors or with respect to any
license under which the Company or a Guarantor is licensor or licensee; or (b)
that the Intellectual Property Rights infringe upon the rights of any third
party.

                  (iv)       The Debtor has made or performed all filings,
recordings and other acts and has paid all required fees and taxes to maintain
and protect its interest in each and every item of intellectual property in full
force and effect throughout the world, and to protect and maintain its interest
therein including, without limitation, recordations of any of its interests in
patents and trademarks with the U.S. Patent and Trademark Office and in
corresponding national and international patent offices, and recordation of any
of its interests in any copyrights with the U.S. Copyright Office and in
corresponding national and international copyright offices. The Debtor has used
proper statutory notice in connection with its use of each patent, trademark and
copyright.

                  F.       Inventory. All inventory of the Debtor consists of a
quality and quantity usable and salable in the ordinary course of business,
except for obsolete items and items of below-standard quality, all of which have
been or will be written off or written down to net realizable value on the
consolidated balance sheet of the Debtor and its Subsidiaries as of September
30, 2001. The quantities of each type of inventory (whether raw materials,
work-in-process, or finished goods) are not excessive, but are reasonable and
warranted in the present circumstances of the Debtor.

                  G.       Ownership. The Debtor is the legal and beneficial
owner of the Collateral of the Debtor free and clear of any lien, claim, option
or right of others, except for the security interest created under this Company
Security Agreement, the Watson Security Agreement and the Company security
agreements executed in connection with the March 1998 Debentures and the May
1999 Debentures. No effective financing statement or other instrument similar in
effect covering all or any part of such Collateral or listing the Debtor or any
trade name of the Debtor is on file in any recording office, except such as may
have been filed relating to the Watson Loan Agreement, the March 1998 Debentures
and the May 1999 Debentures. The Agent has, for the benefit of the Purchasers, a
valid and perfected security interest in the Collateral, which security
interest, has priority over any and all other security interests (except as
otherwise provided in the Subordination Agreement) in such Collateral.

                                       5

                  SECTION IV. COVENANTS OF THE DEBTOR.

                  A.       Defend Against Claims. The Debtor will defend the
Collateral against all claims and demands of all persons at any time claiming
the same or any interest therein unless both the Agent and the Debtor determine
that the claim or demand is not material and that, consequently, such defense
would not be consistent with good business judgment. The Debtor will not permit
any lien notices with respect to the Collateral or any portion thereof to exist
or be on file in any public office except for those in favor of the Agent and
those permitted under the terms of the Purchase Agreement.

                                       6

                  B.       Change in Collateral Location. The Debtor will not
(i) change its corporate name, (ii) change the location of its chief executive
office or establish any place of business other than those specified in Section
IIIA of Schedule A, or (iii) move or permit movement of the Collateral from the
locations specified therein except from one such location to another such
location, unless in each case the Debtor shall have given the Agent at least
thirty (30) days prior written notice thereof, and shall have, in advance,
executed and caused to be filed and/or delivered to the Agent any financing
statements or other documents required by the Agent to perfect the security
interest of the Agent in the Collateral in accordance with Section IV.C. hereof,
all in form and substance satisfactory to the Agent.

                  C.       Additional Financing Statements. Promptly upon the
reasonable request of the Agent, the Debtor will execute and deliver or use its
best efforts to procure any document, give any notices, execute and file any
financing statements, mortgages or other documents, all in form and substance
satisfactory to the Agent, mark any chattel paper, deliver any chattel paper or
instruments to the Agent and take any other actions that are necessary or, in
the opinion of the Agent, desirable to perfect or continue the perfection of the
Agent's security interest in the Collateral, to protect the Collateral against
the rights, claims, or interests of third persons, or to effect the purposes of
this Company Security Agreement. The Debtor will pay the costs incurred in
connection with any of the foregoing.

                  D.       Additional Liens; Transfers. Without the prior
written consent of the Agent, the Debtor will not, in any way, hypothecate or
create or permit to exist any lien, security interest, charge or encumbrance on
or other interest in the Collateral, other than those permitted under the terms
of the Purchase Agreement and the liens in favor of Watson pursuant to the
Watson Loan Agreement and documents relative thereto[, the investors in the
March 1998 Debentures and the investors in the May 1999 Debentures], and Debtor
will not sell, transfer, assign, pledge, collaterally assign, exchange or
otherwise dispose of the Collateral, other than the sale of Inventory in the
ordinary course of business and the sale of obsolete or worn out Equipment.
Notwithstanding the foregoing, if the proceeds of any such sale consist of
notes, instruments, documents of title, letters of credit or chattel paper, such
proceeds shall be promptly delivered to the Agent to be held as Collateral
hereunder. If the Collateral, or any part thereof, is sold, transferred,
assigned, exchanged, or otherwise disposed of in violation of these provisions,
the security interest of the Agent shall continue in such Collateral or part
thereof notwithstanding such sale, transfer, assignment, exchange or other
disposition, and the Debtor will hold the proceeds thereof for the benefit of
the Agent, and promptly transfer such proceeds to the Agent in kind.

                  E.       Contractual Obligations. The Debtor will not enter
into any contractual obligations which may restrict or inhibit the Agent's
rights or ability to sell or otherwise dispose of the Collateral or any part
thereof after the occurrence or during the continuance of an Event of Default.

                  F.       Agent's Right to Protect Collateral. Upon the
occurrence or continuance of an Event of Default, the Agent shall have the right
at any time to make any payments and do any other acts the Agent may deem
necessary to protect the security interests of the Purchasers in the Collateral,
including, without limitation, the rights to pay, purchase, contest or
compromise any encumbrance, charge or lien which, in the reasonable judgment of
the Agent, appears to be prior to or superior to the security interests granted
hereunder, and appear in and defend any action or

                                       7

proceeding purporting to affect its security interests in, and/or the value of,
the Collateral. The Debtor hereby agrees to reimburse the Agent for all payments
made and expenses incurred under this Company Security Agreement including
reasonable fees, expenses and disbursements of attorneys and paralegals acting
for the Agent, including any of the foregoing payments under, or acts taken to
protect its security interests in, the Collateral, which amounts shall be
secured under this Company Security Agreement, and agrees it shall be bound by
any payment made or act taken by the Agent hereunder absent the Agent's gross
negligence or willful misconduct. The Agent shall have no obligation to make any
of the foregoing payments or perform any of the foregoing acts.

                  G.       Further Obligations With Respect to Accounts. In
furtherance of the continuing assignment and security interest in the Accounts
of the Debtor granted pursuant to this Company Security Agreement, upon the
creation of Accounts, upon the Agent's request, the Debtor will execute and
deliver to the Agent in such form and manner as the Agent may require, solely
for its convenience in maintaining records of Collateral, such confirmatory
schedules of Accounts, and other appropriate reports designating, identifying
and describing the Accounts as the Agent may reasonably require. In addition,
upon the Agent's request, the Debtor shall provide the Agent with copies of
agreements with, or purchase orders from, the customers of the Debtor and copies
of invoices to customers, proof of shipment or delivery and such other
documentation and information relating to said Accounts and other Collateral as
the Agent may reasonably require. Furthermore, upon Agent's request, the Debtor
shall deliver to the Agent any documents or certificates of title issued with
respect to any property included in the Collateral, and any promissory notes,
letters of credit or instruments related to or otherwise in connection with any
property included in the Collateral, which in any such case came into the
possession of the Debtor, or shall cause the issuer thereof to deliver any of
the same directly to the Agent, in each case with any necessary endorsements in
favor of the Agent. Failure to provide the Agent with any of the foregoing shall
in no way affect, diminish, modify or otherwise limit the security interests
granted herein. The Debtor hereby authorizes the Agent to regard the Debtor's
printed name or rubber stamp signature on assignment schedules or invoices as
the equivalent of a manual signature by the Debtor's authorized officers or
agents.

                  H.       Insurance. The Debtor agrees to maintain public
liability insurance, third party property damage insurance and replacement value
insurance on the Collateral under such policies of insurance, with such
insurance companies, in such amounts and covering such risks as are at all times
satisfactory to the Agent in its commercially reasonable judgment. All policies
covering the Collateral are to name the Agent as an additional insured and the
loss payee in case of loss, and are to contain such other provisions as the
Agent may reasonably require to fully protect the Agent's interest in the
Collateral and to any payments to be made under such policies. Debtor will
provide notice to Agent prior to any change in coverage.

                  I.       Taxes. The Debtor agrees to pay, when due, all taxes
lawfully levied or assessed against the Debtor or any of the Collateral before
any penalty or interest accrues thereon; provided, however, that, unless such
taxes have become a Federal tax or Employment Retirement Security Income Act
lien on any of the assets of the Debtor, no such tax need be paid if the same is
being contested, in good faith, by appropriate proceedings promptly instituted
and diligently conducted and if an adequate reserve or other appropriate
provision shall have been made therefor as required in order to be in conformity
with generally accepted accounting principles and procedures

                                       8

in effect in the United States of America.

                  J.       Compliance with Laws. The Debtor agrees to comply in
all material respects with all requirements of law applicable to the Collateral
or any part thereof, or to the operation of its business or its assets
generally, unless the Debtor contests, in good faith, by appropriate legal
administrative or other proceedings promptly instituted and diligently
conducted, any such requirements of law in a reasonable manner and in good
faith. The Debtor agrees to maintain in full force and effect, its respective
licenses and permits granted by any governmental authority as may be necessary
or advisable for the Debtor to conduct its business in all material respects.

                  K.       Maintenance of Property. The Debtor agrees to keep
all property useful and necessary to its business in good working order and
condition (ordinary wear and tear excepted) and not to commit or suffer any
waste with respect to any of its properties.

                  L.       Environmental and Other Matters. The Debtor will
conduct its business so as to comply in all respects with all environmental,
land use, occupational, safety or health laws, regulations, directions,
ordinances, criteria and guidelines in all jurisdictions in which it is or may
at any time be doing business, except to the extent that the Debtor is
contesting, in good faith by appropriate legal, administrative or other
proceedings promptly instituted and diligently conducted, any such law,
regulation, direction, ordinance, criteria, guideline, or interpretation thereof
or application thereof; provided, further, that the Debtor shall comply with the
order of any court or other governmental authority relating to such laws unless
the Debtor shall currently be prosecuting an appeal, proceedings for review or
administrative proceedings and shall have secured a stay of enforcement or
execution or other arrangement postponing enforcement or execution pending such
appeal, proceedings for review or administrative proceedings.

                  M.       Intellectual Property. With respect to each item of
its intellectual property, the Debtor agrees to take, at its expense, all
necessary steps, including, without limitation, in the U.S. Patent and Trademark
Office, the U.S. Copyright Office and any other governmental authority, to (i)
maintain the validity and enforceability of such intellectual property and
maintain such intellectual property in full force and effect, and (ii) pursue
the registration and maintenance of each patent, trademark, or copyright
registration or application, now or hereafter included in such intellectual
property Collateral of the Debtor, including, without limitation, the payment of
required fees and taxes, the filing of responses to office actions issued by the
U.S. Patent and Trademark Office, the U.S. Copyright Office or other
governmental authorities, the filing of applications for renewal or extension,
the filing of affidavits under Sections 8 and 15 of the U.S. Trademark Act, the
filing of divisional, continuation, continuation-in-part, reissue and renewal
applications or extensions, the payment of maintenance fees and the
participation in interference, reexamination, opposition, cancellation,
infringement and misappropriation proceedings. Neither the Debtor nor the
Grantor shall, without the prior written consent of the Agent, discontinue use
of or otherwise abandon any intellectual property Collateral, or abandon any
right to file an application for any patent, trademark or copyright, unless the
Debtor shall have previously determined that such use or the pursuit or
maintenance of such intellectual property is no longer desirable in the conduct
of the Debtor's business and that the loss thereof would not be reasonably
likely to have a Material Adverse Effect, in which case, the Debtor will give
prompt notice of any such abandonment to the Agent.

                  N.       Further Assurances. The Debtor shall take all such
further actions and

                                       9

execute all such further documents and instruments (including, but not limited
to, collateral assignments of Intellectual Property and Intangibles or any
portion thereof) as the Agent may at any time reasonably determine in its sole
discretion to be necessary or desirable to further carry out and consummate the
transactions contemplated by the Purchase Agreement and the documentation
relating thereto, including this Company Security Agreement, and to perfect or
protect the liens (and the priority status thereof) of the Agent in the
Collateral.

                  SECTION V. REMEDIES.

                  A.       Obtaining the Collateral Upon Default. If any Event
of Default shall have occurred and be continuing, then and in every such case,
subject to any mandatory requirements of applicable law then in effect, the
Agent, in addition to any rights now or hereafter existing under applicable law
and subject to the Subordination Agreement, shall have all rights as a secured
creditor under the Uniform Commercial Code in all relevant jurisdictions and
may:

                  (i)        personally, or by agents or attorneys, immediately
         retake possession of the Collateral or any part thereof, from the
         Debtor or any other Person who then has possession of any part thereof,
         with or without notice or process of law, and for that purpose may
         enter upon the Debtor's premises where any of the Collateral is located
         and remove the same and use in connection with such removal any and all
         services, supplies, aids and other facilities of the Debtor;

                  (ii)       instruct the obligor or obligors on any agreement,
         instrument or other obligation (including, without limitation, the
         Accounts) constituting the Collateral to make any payment required by
         the terms of such instrument or agreement directly to the Agent;

                  (iii)      withdraw all monies, securities and instruments
         held pursuant to any pledge arrangement for application to the
         Obligations;

                  (iv)       sell, assign or otherwise liquidate, or direct the
         Debtor to sell, assign or otherwise liquidate, any or all of the
         Collateral or any part thereof, and take possession of the proceeds of
         any such sale or liquidation;

                  (v)        take possession of the Collateral or any part
         thereof, by directing the Debtor in writing to deliver the same to the
         Agent at any place or places designated by the Agent, in which event
         the Debtor shall at its own expense:

                             (a)     forthwith cause the same to be moved to the
                  place or places so designated by the Agent and there delivered
                  to the Agent,

                             (b)     store and keep any Collateral so delivered
                  to the Agent at such place or places pending further action by
                  the Agent as provided in Section V.B., and

                             (c)     while the Collateral shall be so stored and
                  kept, provide such guards and maintenance services as shall be
                  necessary to protect the same and to preserve and maintain the
                  Collateral in good condition;

         it being understood that the Debtor's obligation to so deliver the
         Collateral is of the essence of this Company Security Agreement and
         that, accordingly, upon application to a court of

                                       10

         equity having jurisdiction, the Agent shall be entitled to a decree
         requiring specific performance by the Debtor of said obligation.

                  B.       Disposition of the Collateral. Subject to the
Subordination Agreement, any collateral repossessed by the Agent under or
pursuant to Section V.A. and any other Collateral whether or not so repossessed
by the Agent, may be sold, assigned, leased or otherwise disposed of under one
or more contracts or as an entirety, and without the necessity of gathering at
the place of sale the property to be sold, and in general in such manner, at
such time or times, at such place or places and on such terms as the Agent may,
in compliance with any mandatory requirements of applicable law, determine to be
commercially reasonable. Any of the Collateral may be sold, leased or otherwise
disposed of, in the condition in which the same existed when taken by the Agent
or after any overhaul or repair which the Agent shall determine to be
commercially reasonable. Any such disposition which shall be a private sale or
other private proceedings permitted by such requirements shall be made upon not
less than ten (10) days' written notice to the Debtor specifying the time at
which such disposition is to be made and the intended sale price or other
consideration therefor, and shall be subject, for the ten (10) days after the
giving of such notice, to the right of the Debtor or any nominee of the Debtor
to acquire the Collateral involved at a price or for such other consideration at
least equal to the intended sale price or other consideration so specified. Any
such disposition which shall be a public sale permitted by such requirements
shall be made upon not less than ten (10) days' written notice to the Debtor
specifying the time and place of such sale and, in the absence of applicable
requirements of law, shall be by public auction (which may, at the option of the
Agent, be subject to reserve), after publication at least once in The New York
Times not less than ten (10) days prior to the date of sale. If The New York
Times is not then being published, publication may be made in lieu thereof in
any newspaper then being circulated in the City of New York, New York, as the
Agent may elect. All requirements of reasonable notice under this Section V.B.
shall be met if such notice is mailed, postage prepaid at least ten (10) days
before the time of such sale or disposition, to the Debtor at its address set
forth herein or such other address as the Debtor may have, in writing, provided
to the Agent. The Agent may, if it deems it reasonable, postpone or adjourn any
sale of any collateral from time to time by an announcement at the time and
place of the sale to be so postponed or adjourned without being required to give
a new notice of sale. The proceeds realized from the sale of any Collateral
shall be applied as follows: first, to the reasonable costs, expenses and
attorneys' fees and expenses incurred by Agent for collection and for
acquisition, completion, protection, removal, storage, sale and delivery of the
Collateral; second, to interest due on any of the Obligations and any fees
payable under this Agreement; and third, to the principal of the Obligations. If
any deficiency shall arise, Guarantors shall remain liable to Agent and
Purchasers therefor.

                  C.       Power of Attorney. The Debtor hereby irrevocably
authorizes and appoints the Agent, or any Person or agent the Agent may
designate, as the Debtor's attorney-in-fact, at the Debtor's cost and expense,
to exercise all of the following powers upon and at any time after the
occurrence and during the continuance of an Event of Default, which powers,
being coupled with an interest, shall be irrevocable until all of the
Obligations owing by the Debtor shall have been paid and satisfied in full:

                  (i)        accelerate or extend the time of payment,
         compromise, issue credits, bring suit or administer and otherwise
         collect Accounts or proceeds of any Collateral;

                                       11

                  (ii)       receive, open and dispose of all mail addressed to
         the Debtor and notify postal authorities to change the address for
         delivery thereof to such address as the Agent may designate;

                  (iii)      give customers indebted on Accounts notice of the
         Agent's interest therein and/or to instruct such customers to make
         payment directly to the Agent for the Debtor's account;

                  (iv)       convey any item of Collateral to any purchaser
         thereof;

                  (v)        give any notices or record any liens under Section
         IV.C. hereof; and

                  (vi)       make any payments or take any acts under Section
         IV.F. hereof.

The Agent's authority under this Section V.C. shall include, without limitation,
the authority to execute and give receipt for any certificate of ownership,
transfer title to any item of Collateral, sign the Debtor's name on all
financing statements or any other documents deemed necessary or appropriate to
preserve, protect or perfect the security interest in the Collateral and to file
the same, prepare, file and sign the Debtor's name on any notice of lien,
assignment or satisfaction of lien or similar document in connection with any
Account and prepare, file and sign Debtor's name on a proof of claim in
bankruptcy or similar document against any customer of the Debtor, and to take
any other actions arising from or incident to the rights, powers and remedies
granted to the Agent in this Company Security Agreement. This power of attorney
is coupled with an interest and is irrevocable by the Debtor.

                  D.       Waiver of Claims. Except as otherwise provided in
this Company Security Agreement, the Debtor HEREBY WAIVES, TO THE EXTENT
PERMITTED BY APPLICABLE LAW, NOTICE AND JUDICIAL HEARING IN CONNECTION WITH THE
AGENT'S TAKING POSSESSION OF OR DISPOSING OF ANY OF THE COLLATERAL, INCLUDING,
WITHOUT LIMITATION, ANY AND ALL PRIOR NOTICE AND HEARING FOR ANY PREJUDGMENT
REMEDY OR REMEDIES AND ANY SUCH RIGHT WHICH THE DEBTOR WOULD OTHERWISE HAVE
UNDER THE CONSTITUTION OR ANY STATUTE OF THE UNITED STATES OR OF ANY STATE, and
the Debtor hereby further waives, to the extent permitted by law:

                  (i)        all damages occasioned by such taking of
         possession, except any damages which are the direct result of the
         Agent's gross negligence or willful misconduct;

                  (ii)       all other requirements as to the time, place and
         terms of sale or other requirements with respect to the enforcement of
         the Agent's rights hereunder, except as expressly provided herein; and

                  (iii)      all rights of redemption, appraisement, valuation,
         stay, extension or moratorium now or hereafter in force under any
         applicable law in order to prevent or delay the enforcement of this
         Company Security Agreement or the absolute sale of the Collateral or
         any portion thereof, and the Debtor, for itself and all who may claim
         under it, insofar as it or they now or hereafter lawfully may, hereby
         waives the benefit of all such laws.

                                       12

Any sale of, or the grant of options to purchase, or any other realization upon
any Collateral shall operate to divest all right, title, interest, claim and
demand, either at law or in equity, of the Debtor therein and thereto, and shall
be a perpetual bar both at law and in equity against the Debtor and against any
and all persons claiming or attempting to claim the Collateral so sold, optioned
or realized upon, or any part thereof, from, through and under the Debtor.

                                       13

                  E.       Remedies Cumulative. Each and every right, power and
remedy hereby specifically given to the Agent shall be in addition to every
other right, power and remedy specifically given under this Company Security
Agreement, under the Purchase Agreement or under other documentation relating
thereto or now or hereafter existing at law or in equity, or by statute, and
each and every right, power and remedy whether specifically herein given or
otherwise existing may be exercised from time to time or simultaneously and as
often and in such order as may be deemed expedient by the Agent. All such
rights, powers and remedies shall be cumulative and the exercise or the
beginning of exercise of one shall not be deemed a waiver of the right to
exercise of any other or others. No delay or omission of the Agent in the
exercise of any such right, power or remedy and no renewal or extension of any
of the Obligations shall impair any such right, power or remedy or shall be
construed to be a waiver of any default or Event of Default or any acquiescence
therein.

                  SECTION VI. MISCELLANEOUS PROVISIONS.

                  A.       Notices. All notices, approvals, consents or other
communications required or desired to be given hereunder shall be delivered in
person, by facsimile transmission followed promptly by first class mail, by a
nationally recognized courier service marked for next business day delivery or
by overnight mail, and delivered, if to the Agent, then to the attention of
Bruce F. Wesson c/o Galen Partners III, L.P., 610 Fifth Avenue, Fifth Floor, New
York, New York 10020, fax no. (212) 218-4999, with a copy to George N. Abrahams,
Esq., Wolf, Block, Schorr and Solis-Cohen, 250 Park Avenue, New York, New York
10177, fax no. (212) 986-0604 and if to Debtor, then to the attention of Mr.
Michael Reicher, 695 N. Perryville Road, Rockford, Illinois 61107, with a copy
to John P. Reilly, Esq., St. John & Wayne, L.L.C., 2 Penn Plaza East, Newark, NJ
07105, fax no. (973) 491-3555.

                  B.       Headings. The headings in this Company Security
Agreement are for purposes of reference only and shall not affect the meaning or
construction of any provision of this Company Security Agreement.

                  C.       Severability. The provisions of this Company Security
Agreement are severable, and if any clause or provision shall be held invalid or
unenforceable in whole or in part in any jurisdiction, then such invalidity or
unenforceability shall affect, in that jurisdiction only, such clause or
provision, or part thereof, and shall not in any manner affect such clause or
provision in any other jurisdiction or any other clause or provision of this
Company Security Agreement in any jurisdiction.

                  D.       Amendments, Waivers and Consents. Any amendment or
waiver of any provision of this Company Security Agreement and any consent to
any departure by the Debtor from any provision of this Company Security
Agreement shall be effective only if made or given in writing signed by the
Agent.

                  E.       Interpretation of Agreement. All terms not defined
herein shall have the meaning set forth in the applicable Uniform Commercial
Code. Acceptance of or acquiescence in a course of performance rendered under
this Company Security Agreement shall not be relevant in determining the meaning
of this Company Security Agreement even though the accepting or acquiescing
party had knowledge of the nature of the performance and opportunity for
objection.

                                       14

                  F.       Continuing Security Interest. This Company Security
Agreement shall create a continuing security interest in the Collateral, and
shall (i) remain in full force and effect until the Security Interest
Termination Date, (ii) be binding upon the Debtor, and its successors and
assigns and (iii) inure to the benefit of the Agent and its successors and
assigns.

                  G.       Reinstatement. To the extent permitted by law, this
Company Security Agreement shall continue to be effective or be reinstated if at
any time any amount received by the Agent in respect of the Obligations owing by
the Debtor is rescinded or must otherwise be restored or returned by the Agent
upon the occurrence or during the pendency of any Event of Default, all as
though such payments had not been made.

                  H.       Survival of Provisions. All representations,
warranties and covenants of the Debtor contained herein shall survive the
execution and delivery of this Company Security Agreement, and shall terminate
only upon the full and final indefeasible payment and performance by the Debtor
of the Obligations secured hereby.

                  I.       Setoff. The Agent shall have all rights of setoff
available at law or in equity.

                  J.       Power of Attorney. In addition to the powers granted
to the Agent under Section V.C., the Debtor hereby irrevocably authorizes and
appoints the Agent, or any Person or agent the Agent may designate, as the
Debtor's attorney-in-fact, at the Debtor's cost and expense, to exercise all of
the following powers, which being coupled with an interest, shall be irrevocable
until all of the Obligations shall have been indefeasibly paid and satisfied in
full:

                  (i)        after the occurrence of an Event of Default, to
         receive, take, endorse, sign, assign and deliver, all in the name of
         the Agent or the Debtor, any and all checks, notes, drafts, and other
         documents or instruments relating to the Collateral; and

                  (ii)       to request, at any time from customers indebted on
         Accounts, verification of information concerning the Accounts and the
         amounts owing thereon.

                  K.       Indemnification; Authority of the Agent. Neither the
Agent nor any director, officer, employee, attorney or agent of the Agent shall
be liable to the Debtor for any action taken or omitted to be taken by it or
them hereunder, except for its or their own gross negligence or willful
misconduct, nor shall the Agent be responsible for the validity, effectiveness
or sufficiency of this Company Security Agreement or of any document or security
furnished pursuant hereto. The Agent and its directors, officers, employees,
attorneys and agents shall be entitled to rely on any communication, instrument
or document reasonably believed by it or them to be genuine and correct and to
have been signed or sent by the proper person or persons. The Debtor agrees to
indemnify and hold harmless the Agent and any other person from and against any
and all costs, expenses (including reasonable fees, expenses and disbursements
of attorneys and paralegals (including, without duplication, reasonable charges
of inside counsel)), claims or liability incurred by the Agent or such person
hereunder, unless such claim or liability shall be due to willful misconduct or
gross negligence on the part of the Agent or such person.

                  L.       Release; Termination of Agreement. Subject to the
provisions of Section VI.G. hereof, this Company Security Agreement shall
terminate upon full and final indefeasible payment and performance of all the
Obligations owing by the Debtor. At such time, the Agent shall,

                                       15

at the request of the Debtor, reassign and redeliver to the Debtor all of the
Collateral hereunder which has not been sold, disposed of, retained or applied
by the Agent in accordance with the terms hereof. Such reassignment and
redelivery shall be without warranty by or recourse to the Agent, except as to
the absence of any prior assignments by the Agent of its interest in the
Collateral, and shall be at the expense of the Debtor.

                  M.       Counterparts. This Company Security Agreement may be
executed in one or more counterparts, each of which shall be deemed an original
but all of which shall together constitute one and the same agreement.

                  N.       Governing Law. This Company Security Agreement and
the rights of the parties hereunder shall be governed by, and construed in
accordance with, the laws of the State of New York wherein the terms of this
Company Security Agreement were negotiated, excluding to the greatest extent
permitted by law any rule of law that would cause the application of the laws of
any jurisdiction other than the State of New York.

                  O.       SUBMISSION TO JURISDICTION.

                  (i)        Each of the parties hereto hereby irrevocably and
unconditionally submits, for itself and its property, to the nonexclusive
jurisdiction of any New York State court or United States Federal court sitting
in New York City, and any appellate court from any thereof, in any action or
proceeding arising our of or relating to this Company Security Agreement or any
of the other Transaction Documents (as such term is defined in the Purchase
Agreement) (the "Transaction Documents") to which it is a party, or for
recognition or enforcement of any judgment, and each of the parties hereto
irrevocably and unconditionally agrees that all claims in respect of any such
action or proceeding may be heard and determined in any such New York State
court or, to the fullest extent permitted by law, in such United States Federal
court. Each of the parties hereto agrees that a final judgment in any such
action or proceeding shall be conclusive and may be enforced in other
jurisdictions by suit on the right that any party may otherwise have to bring
any action or proceeding relating to this Company Security Agreement or any of
the other Transaction Documents in the courts of any other jurisdiction.

                  (ii)       Each of the parties hereto irrevocably and
unconditionally waives, to the fullest extent it may legally and effectively do
so, any objection that it may now or hereafter have to the laying of venue of
any suit, action or proceeding arising out of or in relation to this Company
Security Agreement or any other Transaction Document to which it is a party in
any such New York State or United States Federal court sitting in New York City.
Each of the parties hereto hereby irrevocably waives, to the fullest extent
permitted by law, the defense of an inconvenient forum to the maintenance of
such action or proceeding in any such court.

                  P.       SERVICE OF PROCESS. THE DEBTOR HEREBY IRREVOCABLY
AGREES THAT SERVICE OF PROCESS IN ANY LEGAL ACTION OR PROCEEDING WITH RESPECT TO
THIS COMPANY SECURITY AGREEMENT MAY BE EFFECTED BY MAILING A COPY THEREOF BY
REGISTERED OR CERTIFIED MAIL, POSTAGE PREPAID, TO THE DEBTOR AT ITS ADDRESS SET
FORTH IN SECTION VI.A. HEREOF.

                                       16

                  Q.       LIMITATION OF LIABILITY. THE AGENT SHALL NOT HAVE ANY
LIABILITY TO THE DEBTOR (WHETHER SOUNDING IN TORT, CONTRACT, OR OTHERWISE) FOR
LOSSES SUFFERED BY THE DEBTOR IN CONNECTION WITH, ARISING OUT OF, OR IN ANY WAY
RELATED TO THE TRANSACTIONS OR RELATIONSHIPS CONTEMPLATED BY THIS COMPANY
SECURITY AGREEMENT, OR ANY ACT, OMISSION OR EVENT OCCURRING IN CONNECTION
THEREWITH, UNLESS IT IS DETERMINED BY A FINAL AND NONAPPEALABLE JUDGMENT OR
COURT ORDER BINDING ON THE AGENT, THAT THE LOSSES WERE THE RESULT OF ACTS OR
OMISSIONS CONSTITUTING GROSS NEGLIGENCE OR WILLFUL MISCONDUCT.

                  R.       Delays; Partial Exercise of Remedies. No delay or
omission of the Agent to exercise any right or remedy hereunder, whether before
or after the happening of any Event of Default, shall impair any such right or
shall operate as a waiver thereof or as a waiver of any such Event of Default.
No single or partial exercise by the Agent of any right or remedy shall preclude
any other or further exercise thereof, or preclude any other right or remedy.

                  S.       JURY TRIAL. EACH OF THE DEBTOR AND THE AGENT HEREBY
IRREVOCABLY WAIVES ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR
COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR
RELATING TO ANY TRANSACTION DOCUMENT OR THE ACTIONS OF ANY PARTY IN THE
NEGOTIATION, ADMINISTRATION, PERFORMANCE OR ENFORCEMENT THEREOF.

                  T.       Subject to Subordination Agreement. Notwithstanding
anything to the contrary contained herein, the rights and remedies of the Agent
and the Purchasers, and the obligations of the Debtor, under this Company
Security Agreement are subject to the Subordination Agreement, as it may be
amended, supplemented or otherwise modified from time to time.

                           [SIGNATURE PAGE TO FOLLOW]

                                       17

               IN WITNESS WHEREOF, the Debtor has caused this Company Security
Agreement to be duly executed and delivered as of the day and year first above
written.

                                                  HALSEY DRUG CO., INC.

                                                  By:___________________________
                                                  Name:
                                                  Title:

               By its acceptance hereof, as of the day and year first above
written, the Agent agrees to be bound by the provisions hereof applicable to it.

                                                  GALEN PARTNERS III, L.P.

                                                  By:___________________________
                                                  Name:
                                                  Title:

                                       18

                                   SCHEDULE A

IIIA      PLACES OF BUSINESS

          1.  695 N. Perryville Road, Rockford, Illinois 61107
          2.  77 Brenner Drive, Congers, New York
          3.  125 Wells Avenue, Congers, New York


                                                                    EXHIBIT 10.3

                    CONTINUING UNCONDITIONAL SECURED GUARANTY
                                       BY
                                   HOUBA INC.

         WHEREAS, HALSEY DRUG CO., INC., a New York corporation (the
"Borrower"), entered into a Debenture Purchase Agreement dated as of December
20, 2002 (as amended through the date hereof, the "Purchase Agreement"; terms
used herein and not otherwise defined shall have the meanings given to them in
the Purchase Agreement) with the Purchasers listed on Exhibit A thereto (each a
"Lender" and collectively, the "Lenders");

         WHEREAS, pursuant to the Purchase Agreement, the Lenders have made
financial accommodations to the Borrower in accordance with the terms of the
Purchase Agreement;

         WHEREAS, Houba Inc. (the "Guarantor") will continue to receive certain
benefits from the accommodations hereinabove described and is therefore willing
to guaranty the prompt payment and performance of the obligations of the
Borrower, on the terms set forth in this Continuing Unconditional Secured
Guaranty ("Guaranty");

         WHEREAS, pursuant to the Purchase Agreement, the Lenders have required
that the Guarantor execute and deliver this Guaranty to Galen Partners III,
L.P., a Delaware limited partnership, acting in its capacity as agent for the
Lenders (the "Agent"), for the benefit of the Lenders, as a condition to the
effectiveness of the Purchase Agreement; and

         WHEREAS, the extension of credit by the Lenders to the Borrower is
necessary and desirable to the conduct and operation of the business of the
Borrower and will inure to the financial benefit of the Guarantor.

         NOW, THEREFORE, for value received and in consideration of any loan,
advance, or financial accommodation of any kind whatsoever heretofore, now or
hereafter made, given or granted to the Borrower by the Lenders (including,
without limitation, the loans evidenced by the Debenture as made by the Lenders
to the Borrower pursuant to, the Purchase Agreement) and other good and valuable
consideration (the sufficiency and receipt of which are hereby acknowledged),
the Guarantor unconditionally guarantees to the Agent for the benefit of the
Lenders (i) the full and prompt payment and performance when due, whether at
maturity or earlier, by reason of acceleration or otherwise, and at all times
thereafter, of all liabilities of the Borrower to the Lenders and (ii) the
prompt, full and faithful discharge by the Borrower of each and every term,
condition, agreement, representation, warranty or covenant now or hereafter made
by the Borrower to the Lenders, in each case, and the Agent under these clauses
(i) and (ii), pursuant to the Purchase Agreement, the Debentures, the other
Transaction Documents (as defined in the Subordination Agreement) or any
document or instrument delivered by the Borrower to the Lenders in connection
therewith or pursuant thereto (which, together with the liabilities described in
clause (i) hereof, are collectively referred to herein as the "Borrower's
Liabilities"). The Guarantor further agrees to pay all reasonable out-of-pocket
costs and expenses, including, without limitation, all court costs and
reasonable attorneys' and paralegals' fees paid or incurred by the Lenders and
the Agent (on behalf of the Lenders),

in endeavoring to collect all or any part of the Borrower's Liabilities from, or
in prosecuting any action against the Guarantor or any other guarantor of all or
any part of the Borrower's Liabilities.

         Notwithstanding any provision of this Guaranty to the contrary, it is
intended that this Guaranty, and any liens and security interests granted by the
Guarantor to secure this Guaranty, not constitute a Fraudulent Conveyance (as
defined below). Consequently, the Guarantor agrees that if this Guaranty, or any
liens or security interests securing this Guaranty, would, but for the
application of this sentence, constitute a Fraudulent Conveyance, this Guaranty
and each such lien and security interest shall be valid and enforceable only to
the maximum extent that would not cause this Guaranty or such lien or security
interest to constitute a Fraudulent Conveyance, and this Guaranty shall
automatically be deemed to have been amended accordingly at all relevant times.
For purposes hereof, "Fraudulent Conveyance" means a transfer of property or the
incurrence of liability which would be avoidable under Section 548 or 544(b) of
the "Bankruptcy Code" (as hereinafter defined) or under the provisions of any
applicable fraudulent conveyance or fraudulent transfer law or similar law of
any state, nation or other governmental unit, as in effect from time to time.

         The Guarantor hereby agrees that, except as hereinafter provided, and
to the extent permitted by applicable law, its obligations under this Guaranty
shall be unconditional, irrespective of (i) the validity or enforceability of
the Borrower's Liabilities or any part thereof, or of any Debenture or other
document evidencing all or any part of the Borrower's Liabilities, (ii) the
absence of any attempt to collect the Borrower's Liabilities from the Borrower
or any other guarantor or other action to enforce the same, (iii) the waiver or
consent by the Agent, any Lender or Lenders with respect to any provision of any
instrument evidencing the Borrower's Liabilities, or any part thereof, or any
other agreement heretofore, now or hereafter executed by the Borrower and
delivered to the Agent, the Lender or Lenders, (iv) failure by the Agent or any
Lender to take any steps to perfect and maintain its security interest in, or to
preserve its rights to, any security or collateral for the Borrower's
Liabilities, (v) the institution of any proceeding under Chapter 11 of Title 11
of the United States Code (11 U.S.C. Section 101 et seq.), as amended (the
"Bankruptcy Code"), or any similar proceeding, by or against the Borrower, or
the Agent's or any Lender's election in any such proceeding of the application
of Section 1111(b)(2) of the Bankruptcy Code, (vi) any borrowing or grant of a
security interest by the Borrower as debtor-in-possession, under Section 364 of
the Bankruptcy Code, (vii) the disallowance, under Section 502 of the Bankruptcy
Code, of all or any portion of the Lenders' claim(s) for repayment of the
Borrower's Liabilities, or (viii) any other circumstance which might otherwise
constitute a legal or equitable discharge or defense of a guarantor.

         The Guarantor hereby waives diligence, presentment, demand of payment,
filing of claims with a court in the event of receivership or bankruptcy of the
Borrower, protest or notice with respect to the Borrower's Liabilities and all
demands whatsoever, and covenants that this Guaranty will not be discharged,
except by complete performance of the obligations and liabilities contained
herein. Upon the occurrence and during the continuance of an Event of Default
under the Purchase Agreement, Lenders holding a majority in outstanding
principal amount of the Debentures may, at their sole election, proceed directly
and at once, without notice, against the Guarantor to collect and recover the
full amount or any portion of the Borrower's Liabilities, without first
proceeding against

                                       2

any other person, firm, or corporation, or against any security or collateral
for the Borrower's Liabilities.

         The Guarantor hereby unconditionally and irrevocably agrees not to
exercise any rights that it may now have or hereafter acquire against the
Borrower or any other insider guarantor that arise from the existence, payment,
performance or enforcement of the Borrower's Liabilities under or in respect of
this Guaranty, the Purchase Agreement, the Debentures, the other Transaction
Documents or any document or instrument delivered by the Borrower to the Lenders
in connection therewith or pursuant thereto, including, without limitation, any
right of subrogation, reimbursement, exoneration, contribution or
indemnification and any right to participate in any claim or remedy of the Agent
or the Lenders against the Borrower or any other insider guarantor or any
Collateral, whether or not such claim, remedy or right arises in equity or under
contract, statute or common law, including, without limitation, the right to
take or receive from the Borrower or any other insider guarantor, directly or
indirectly, in cash or other property or by set-off or in any other manner,
payment or security on account of such claim, remedy or right, unless and until
the Security Interest Termination Date. If any amount shall be paid to any
Guarantor in violation of the immediately preceding sentence at any time prior
to the indefeasible payment in full in cash of the Borrower's Liabilities and
all other amounts payable under this Guaranty, such amount shall be received and
held in trust for the benefit of the Lenders, shall be segregated from other
property and funds of the Guarantor and shall forthwith be paid or delivered to
the Agent in the same form as so received (with any necessary endorsement or
assignment) to be credited and applied to the Borrower's Liabilities and all
other amounts payable under this Guaranty, whether matured or unmatured, in
accordance with the terms of the Debentures and the Purchase Agreement, or to be
held as collateral for any Borrower's Liabilities or other amounts payable under
this Guaranty thereafter arising. Upon the Security Interest Termination Date,
except in the case of a Reinstatement Event (as defined below), the Agent and
the Lenders will, at the Guarantor's request and expense, execute and deliver to
the Guarantor appropriate documents, without recourse and without representation
or warranty, necessary to evidence the transfer by subrogation to the Guarantor
of an interest in the Borrower's Liabilities resulting from such payment made by
the Guarantor pursuant to this Guaranty.

         The Lenders are hereby authorized, without notice or demand and without
affecting the liability of the Guarantor hereunder, at any time and from time to
time to (i) renew, extend, accelerate or otherwise change the time for payment
of, or other terms relating to the Borrower's Liabilities or otherwise modify,
amend or change the terms of any debenture, note or other agreement, document or
instrument now or hereafter executed by the Borrower and delivered to the
Lenders; (ii) accept partial payments on the Borrower's Liabilities; (iii) take
and hold security or collateral for the payment of the Borrower's Liabilities
guaranteed hereby, or for the payment of this Guaranty, or for the payment of
any other guaranties of the Borrower's Liabilities or other liabilities of the
Borrower, and exchange, enforce, waive and release any such security or
collateral; (iv) apply such security or collateral and direct the order or
manner of sale thereof as in their sole discretion they may determine; and (v)
settle, release, compromise, collect or otherwise liquidate the Borrower's
Liabilities and any security or collateral therefor in any manner, without
affecting or impairing the obligations of the Guarantor hereunder. The holders
of the majority of the outstanding principal amount of the Debentures shall have
the exclusive right to determine the time and manner of application of any
payments or credits, whether received from the Borrower or any other source, and
such determination shall be binding on the Guarantor. All such payments and
credits may be

                                       3

applied, reversed and reapplied, in whole or in part, to any of the Borrower's
Liabilities as the Lenders shall determine in their sole discretion without
affecting the validity or enforceability of this Guaranty (unless otherwise
required pursuant to the Purchase Agreement).

         The Guarantor hereby assumes responsibility for keeping itself informed
of the financial condition of the Borrower, and any and all endorsers and/or
other guarantors of any instrument or document evidencing all or any part of the
Borrower's Liabilities and of all other circumstances bearing upon the risk of
nonpayment of the Borrower's Liabilities or any part thereof that diligent
inquiry would reveal and the Guarantor hereby agrees that neither the Agent nor
the Lenders shall have any duty to advise the Guarantor of information known to
any of them regarding such condition or any such circumstances or to undertake
any investigation not a part of their respective regular business routines. If
the Agent or any Lender, in their respective sole discretions, undertake at any
time or from time to time to provide any such information to the Guarantor, the
Agent or such Lender, as the case may be, shall not be under any obligation to
update any such information or to provide any such information to the Guarantor
on any subsequent occasion.

         The Guarantor consents and agrees that neither the Agent nor the
Lenders shall be under any obligation to marshall any assets in favor of the
Guarantor or against or in payment of any or all of the Borrower's Liabilities.
The Guarantor further agrees that, to the extent that the Borrower makes a
payment or payments to the Lenders or the Lenders receive any proceeds of
collateral, which payment or payments or any part thereof are subsequently
invalidated, declared to be fraudulent or preferential, set aside and/or
required to be repaid to the Borrower, its estate, trustee, receiver or any
other party, including, without limitation, the Guarantor, under any bankruptcy
law or state or federal statutory or common law, then to the extent of such
payment or repayment, the Borrower's Liabilities or the part thereof which has
been paid, reduced or satisfied by such amount, and the Guarantor's obligations
hereunder with respect to such portion of the Borrower's Liabilities, shall be
reinstated and continued in full force and effect as of the date such initial
payment, reduction or satisfaction occurred. Notwithstanding anything else to
the contrary contained herein, the Guarantor consents and agrees that this
Guaranty shall continue to be effective or be reinstated, as the case may be, if
at any time any payment of any of the Borrower's Liabilities is rescinded or
must otherwise be returned by any Lender or any other Person upon the
insolvency, bankruptcy or reorganization of the Borrower or the Guarantor or
otherwise, all as though such payment had not been made (each such continuation
or reinstatement, a "Reinstatement Event").

         Until the Security Interest Termination Date, the Guarantor hereby
waives any and all claims (including, without limitation, any claim for
reimbursement, contribution or subrogation) of the Guarantor against the
Borrower, any endorser or any other guarantor of all or any part of the
Borrower's Liabilities, or against any of the Borrower's properties, arising by
reason of any payment by the Guarantor to the Lenders pursuant to the provisions
hereof.

         Each Lender may, to the extent and in the manner set forth in the
Purchase Agreement, sell or assign the Borrower's Liabilities or any part
thereof, or grant participations therein, and in any such event each and every
permitted assignee or holder of, or participant in, all or any of the Borrower's
Liabilities shall have the right to enforce this Guaranty, by suit or otherwise

                                       4

for the benefit of such assignee, holder, or participant, as fully as if herein
by name specifically given such right.

         The Guarantor hereby represents and warrants that: (a) it is a
corporation duly organized, validly existing and in good standing under the laws
of the State of Indiana; (b) it is duly authorized and empowered to execute and
deliver this Guaranty; (c) all corporate action on the part of the Guarantor
requisite for the due execution and delivery of this Guaranty and the due
granting and creation of the security interests referred to herein has been duly
and effectively taken; (d) the Guarantor's chief executive office is located at
695 North Perryville Road, Rockford, Illinois 61107 and (e) execution, delivery
and performance of this Guaranty will not result in any violation of, conflict
with, or result in a breach of, any of the terms of, or constitute a default
under, any agreements, contracts, court orders or consent decrees, the
Certificate of Incorporation or the By-laws, as amended, of the Guarantor.

         This Guaranty shall be binding upon the Guarantor and upon the
successors (including without limitation, any receiver, trustee or debtor in
possession of or for the Guarantor) of the Guarantor and shall inure to the
benefit of the Lenders and their respective successors and permitted assigns.
Notwithstanding anything contained herein to the contrary, this Guaranty may not
be assigned by the Guarantor without the prior written consent of the Lenders.

         This Guaranty shall continue in full force and effect, and the Lenders
shall be entitled to make loans and advances and extend financial accommodations
to the Borrower on the faith hereof, until the Security Interest Termination
Date and the Purchase Agreement has been terminated and the Debentures canceled.
The Guarantor hereby unconditionally and irrevocably waives any right to revoke
this Guaranty and acknowledges that this Guaranty is continuing in nature and
applies to all Borrower's Liabilities, whether existing now or in the future.

         Notwithstanding anything to the contrary contained herein, the rights
and remedies of the Agent and the Lenders, and the obligations of the
Guarantors, under this Guaranty are subject to the Subordination Agreement, as
it may be amended, supplemented or otherwise modified from time to time.

         Wherever possible each provision of this Guaranty shall be interpreted
in such manner as to be effective and valid under applicable law, but if any
provision of this Guaranty shall be prohibited by or invalid under such law,
such provision shall be ineffective to the extent of such prohibition or
invalidity without invalidating the remainder of such provision or the remaining
provisions of this Guaranty.

         THIS GUARANTY SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH,
THE LAWS OF THE STATE OF NEW YORK WHEREIN THE TERMS OF THIS GUARANTY WERE
NEGOTIATED, EXCLUDING TO THE GREATEST EXTENT PERMITTED BY LAW ANY RULE OF LAW
THAT WOULD CAUSE THE APPLICATION OF ANY JURISDICTION OTHER THAN THE STATE OF NEW
YORK.

         The Guarantor hereby irrevocably and unconditionally submits, for
itself and its

                                       5

property, to the nonexclusive jurisdiction of any New York State court or United
States Federal court sitting in New York City, and any appellate court from any
thereof, in any action or proceeding arising our of or relating to this Guaranty
or any of the other Transaction Documents (as such term is defined in the
Purchase Agreement) (the "Transaction Documents") to which it is a party, or for
recognition or enforcement of any judgment, and each of the parties hereto
irrevocably and unconditionally agrees that all claims in respect of any such
action or proceeding may be heard and determined in any such New York State
court or, to the fullest extent permitted by law, in such United States Federal
court. The Guarantor agrees that a final judgment in any such action or
proceeding shall be conclusive and may be enforced in other jurisdictions by
suit on the right that any party may otherwise have to bring any action or
proceeding relating to this Guaranty or any of the other Transaction Documents
in the courts of any other jurisdiction.

         The Guarantor irrevocably and unconditionally waives, to the fullest
extent it may legally and effectively do so, any objection that it may now or
hereafter have to the laying of venue of any suit, action or proceeding arising
out of or in relation to this Guaranty or any other Transaction Document to
which it is a party in any such New York State or United States Federal court
sitting in New York City. The Guarantor hereby irrevocably waives, to the
fullest extent permitted by law, the defense of an inconvenient forum to the
maintenance of such action or proceeding in any such court.

         EACH OF THE PARTIES HERETO HEREBY IRREVOCABLY WAIVES ALL RIGHT TO TRIAL
BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON CONTRACT,
TORT OR OTHERWISE) ARISING OUT OF OR RELATING TO ANY TRANSACTION DOCUMENT OR THE
ACTIONS OF ANY PARTY IN THE NEGOTIATION, ADMINISTRATION, PERFORMANCE OR
ENFORCEMENT THEREOF.

                           [SIGNATURE PAGE TO FOLLOW]

                                       6

         IN WITNESS WHEREOF, this Guaranty has been duly executed by the
undersigned as of this 20th day of December, 2002.

                                                  HOUBA, INC.

                                                  By:___________________________
                                                     Name:
                                                     Title:

                                       7


                                                                    EXHIBIT 10.4

                      GUARANTORS GENERAL SECURITY AGREEMENT

         THIS GUARANTORS GENERAL SECURITY AGREEMENT ("Guarantors Security
Agreement") is made and entered into as of December 20, 2002, among Houba, Inc.
("Houba"), an Indiana corporation, with its principal place of business at 16235
State Road 17, Culver, Indiana 46511, Halsey Pharmaceuticals, Inc. ("HPI"), a
Delaware corporation, with its principal place of business at 695 North
Perryville Road, Rockford, Illinois 61107 (Houba and HPI are each hereinafter
referred to as a "Guarantor" and both of which are collectively referred to as
the "Guarantors"), and Galen Partners III, L.P., a Delaware limited partnership,
with its principal place of business at 610 Fifth Avenue, Fifth Floor, New York,
New York 10020 ("Galen" or "Agent"), acting in its capacity as agent for the
Purchasers (in such capacity, the "Agent") for the benefit of the Purchasers.

                               W I T N E S S E T H

         WHEREAS, Galen, certain other purchasers (together with Galen, the
"Purchasers") and Halsey Drug Co., Inc. (the "Company") have entered into a
Debenture Purchase Agreement dated as of the date hereof (as the same may be
amended, modified, supplemented or restated from time to time, the "Purchase
Agreement"; terms which are capitalized herein and not otherwise defined shall
have the meanings ascribed to them in the Purchase Agreement);

         WHEREAS, each of the Guarantors has executed and delivered to the
Purchasers a Continuing Unconditional Secured Guaranty dated the date hereof
(each a "Guaranty") of the Company's obligations under the Purchase Agreement
(collectively, the "Obligations"); and

         WHEREAS, the Purchasers have required, as a condition precedent to the
effectiveness of the Purchase Agreement, that each Guarantor (i) grant to the
Agent, for the ratable benefit of the Purchasers, a security interest in and to
the Collateral (as defined in Section II below) and (ii) execute and deliver
this Guarantors Security Agreement in order to secure the payment and
performance by such Guarantor of the Guaranty.

         NOW, THEREFORE, in consideration of the premises and in order to induce
the Purchasers to enter into and perform the Purchase Agreement, each Guarantor
hereby agrees as follows:

         SECTION I. CREATION OF SECURITY INTEREST.

         A.       Security Interest. Each Guarantor hereby pledges, assigns and
grants to the Agent a continuing perfected lien and security interest having
priority over any and all other security interest (except as otherwise provided
in the Subordination Agreement), in all of such Guarantor's right, title and
interest in and to the Collateral (as defined in Section II below) in order to
secure the payment and performance of all Obligations owing by such Guarantor.

         B.       Guarantors Remains Liable. Anything herein to the contrary
notwithstanding, (i) the Guarantors shall remain liable under the contracts and
agreements included in the Guarantors' Collateral to the extent set forth
therein to perform all of their duties and obligations thereunder to the same
extent as if this Guarantors General Security Agreement had not been executed,
(ii) the exercise by the Agent of any of the rights hereunder shall not release
the Guarantors from any of their duties or obligations under the contracts and
agreements included in the Collateral and (iii) neither the Agent nor any
Purchaser shall have any obligation or liability under the contracts and
agreements included in the Collateral by reason of this Guarantors Security
Agreement, the Purchase Agreement or any other Transaction Document, nor shall
the Agent or any Purchaser be obligated to perform any of the obligations or
duties of the Guarantors thereunder or to take any action to collect or enforce
any claim for payment assigned hereunder.

         SECTION II. COLLATERAL.

         For purposes of this Guarantors Security Agreement, the term
"Collateral" shall mean, with respect to each Guarantor, all of the kinds and
types of property described in subsections A. through E. of this Section II,
whether now owned or hereafter at any time arising, acquired or created by such
Guarantor and wherever located, and includes all replacements, additions,
accessions, substitutions, repairs, proceeds and products relating thereto or
therefrom, and all documents, ledger sheets and files of such Guarantor relating
thereto and all Proceeds of Collateral. "Proceeds" hereunder include (i)
whatever is now or hereafter received by such Guarantor upon the sale, exchange,
collection or other disposition of any item of Collateral, whether such proceeds
constitute inventory, accounts, accounts receivable, general intangibles,
instruments, securities (including, without limitation, United States of America
Treasury Bills), credits, claims, demands, documents, letters of credit and
letter of credit proceeds, chattel paper, documents of title, certificates of
title, certificates of deposit, warehouse receipts, bills of lading, leases,
deposit accounts, money, tax refund claims, contract rights, royalties, goods,
equipment, payment under insurance (whether or not the Agent is the loss payee
thereof, or any indemnities, warranties or guaranties, payable by reason of loss
or damage to or otherwise with respect to any or the foregoing Collateral, and
(ii) any such items which are now or hereafter acquired by such Guarantor with
any proceeds of Collateral hereunder.

         A.       Accounts. All of such Guarantor's accounts, whether now
existing or existing in the future, including without limitation (i) all
accounts receivable (whether or not specifically listed on schedules furnished
to the Agent), including, without limitation, all accounts created by or arising
from all of such Guarantor's sales of goods or rendition of services made under
any of such Guarantor's trade names, or through any of its divisions, (ii) all
unpaid seller's rights (including rescission, replevin, reclamation and stoppage
in transit) relating to the foregoing or arising therefrom, (iii) all rights to
any goods represented by any of the foregoing, including returned or repossessed
goods, (iv) all reserves and credit balances held by such Guarantor with respect
to any such accounts receivable or account debtors, (v) all
health-care-insurance receivables, (vi) deposit accounts, (vii) letter-of-credit
rights, (viii) instruments (including, without limitation, promissory notes) and
(ix) all guarantees or collateral for any of the foregoing (all of the foregoing
property and similar property being hereinafter referred to as "Accounts");

                                      -2-

         B.       Inventory. All of such Guarantor's inventory, including
without limitation (i) all raw materials, work in process, parts, components,
assemblies, supplies and materials used or consumed in such Guarantor's
businesses, wherever located and whether in the possession of such Guarantor or
any other Person (for the purposes of this Guarantors General Security
Agreement, the term "Person" means any individual, sole proprietorship,
partnership, joint venture, trust, unincorporated organization, association,
corporation, limited liability company, institution, entity, party or
government, including any division, agency or department thereof); (ii) all
goods, wares and merchandise, finished or unfinished, held for sale or lease or
leased or furnished or to be furnished under contracts of service, wherever
located and whether in the possession of such Guarantor or any other person or
entity; and (iii) all goods returned to or repossessed by such Guarantor (all of
the foregoing property being hereinafter referred to as "Inventory");

         C.       Equipment. All of the equipment owned or leased by such
Guarantor, including, without limitation, machinery, equipment, office equipment
and supplies, computers and related equipment, furniture, furnishings, tools,
tooling, jigs, dies, fixtures, manufacturing implements, fork lifts, trucks,
trailers, motor vehicles, and other equipment (all of the foregoing property
being hereinafter referred to as "Equipment");

         D.       Intangibles. All of such Guarantor's general intangibles
(including, without limitation, payment intangibles) instruments, securities
(including without limitation United States of America Treasury Bills), credits,
claims, demands, documents, letters of credit and letter of credit proceeds,
chattel paper, documents of title, certificates of title, certificates of
deposit, warehouse receipts, bills of lading, leases which are permitted to be
assigned or pledged, deposit accounts, money, tax refund claims, contract rights
which are permitted to be assigned or pledged (all of the foregoing property
being hereinafter referred to as "Intangibles"); and

         E.       Intellectual Property. All of each Guarantor's intellectual
property, including, without limitation, New Drug Applications, Investigatory
New Drug Applications, Abbreviated New Drug Applications, Alternative New Drug
Applications, registrations and quotas as issued by the Drug Enforcement
Administration and/or the Attorney General of the United States pursuant to the
Controlled Substances Act, certifications, permits and approvals of federal and
state governmental agencies, patents, patent applications, trademarks, trademark
applications, service marks, service mark applications, trade names, domain
names, technical knowledge and processes, formal or informal licensing
arrangements which are permitted to be assigned or pledged, blueprints,
technical specifications, computer software, programs, databases, copyrights,
copyright applications and all confidential and proprietary information,
including, without limitation, know-how, trade secrets, manufacturing and
production processes and techniques, inventions, research and development
information, databases and data, including, without limitation, technical data,
financial and marketing and business data, pricing and cost information and
business and marketing plans, and all embodiments thereof, and rights thereto,
including, without limitation, all of such Guarantor' rights to use the patents,
trademarks, copyrights, service marks, or other property of the aforesaid nature
of other Persons now or hereafter licensed to such Guarantor, together with the
goodwill of the business symbolized by or connected with such Guarantor's
trademarks, copyrights, service marks, licenses and the other rights included in
this Section II(E).

                                      -3-

         F.       Distributions. All interest, dividends, distributions, cash,
instruments and other property from time to time received, receivable or
otherwise distributed in respect of or in exchange for any or all of the then
existing Collateral.

                                      -4-

         SECTION III. THE GUARANTORS' REPRESENTATIONS AND
                      WARRANTIES.

         Each Guarantor severally represents and warrants as follows:

         A.       Places of Business. Such Guarantor has no places of business,
or warehouses in which it leases space, other than those set forth on Section
IIIA of Schedule A, a copy of which is attached hereto and made a part hereof
("Schedule A").

         B.       Location of Collateral. Except for the movement of Collateral
from time to time from one place of business or warehouse listed on Section IIIA
of Schedule A to another place of business or warehouse listed on Section IIIA
of such Schedule A, the Collateral is located at such Guarantor's chief
executive offices or other places of business or warehouses listed on such
Section IIIA of Schedule A, and not at any other location.

         C.       Restrictions on Collateral Disposition. None of the Collateral
is subject to contractual obligations that may restrict or inhibit the Agent's
rights or ability to sell or dispose of the Collateral or any part thereof after
the occurrence of an Event of Default except (i) the rights of Watson under the
Watson Loan Agreement and the documents executed in connection therewith,
including, without limitation, the Watson Security Agreement dated as of March
29, 2000 (the "Watson Security Agreement"); (ii) the rights of the investors in
the 5% convertible senior secured debentures due March 31, 2006 issued pursuant
to a certain Debenture and Warrant Purchase Agreement dated March 10, 1998, as
amended, between the Company and the purchasers listed on the signature page
thereto (the "March 1998 Debentures"); and (iii) the rights of the investors in
the 5% convertible senior secured debentures due March 31, 2006 issued pursuant
to certain Debenture and Warrant Purchase Agreement dated May 26, 1999, as
amended, between the Company and the purchasers listed on the signature page
thereto (the "May 1999 Debentures").

         D.       Status of Accounts. Status of Accounts. Each Account is based
on an actual and bona fide rendition of services or sale of goods/products to
customers, made by such Guarantor in the ordinary course of its business; the
Accounts created are its exclusive property and are not and shall not be subject
to any lien, consignment arrangement, encumbrance, security interest or
financing statement whatsoever, except (i) the lien in favor of Watson under the
Watson Loan Agreement and the documents executed in connection therewith,
including, without limitation, the Watson Security Agreement, (ii) the lien in
favor of the investors in the March 1998 Debentures and (iii) the lien in favor
of the investors in the May 1999 Debentures, and to the best knowledge of such
Guarantor, such Guarantor's customers have accepted the goods/products and
services, and owe and are obligated to pay the full amounts stated in the
invoices according to their terms, without any dispute, offset, defense or
counterclaim.

         E.       Copyrights, Trademarks and Patents.

                  (i)      Each of the Guarantors owns outright all of the
Intellectual Property Rights listed on Section 4.12 of the Schedule of
Exceptions attached to the Purchase Agreement free

                                      -5-

and clear of all liens and encumbrances except for the Permitted Encumbrances
and pays no royalty to anyone under or with respect to any of them.

                  (ii)     Each of the Guarantors has not licensed to anyone
the use of any of such Intellectual Property Rights and has no knowledge of the
infringing use by the Company or any Guarantor of any intellectual property
rights of third parties.

                  (iii)    Each of the Guarantors has no knowledge, nor has it
received any notice (a) of any conflict with the asserted rights of others with
respect to any Intellectual Property Rights used in, or useful to, the operation
of the business conducted by the Company and the Guarantors or with respect to
any license under which the Company or a Guarantor is licensor or licensee; or
(b) that the Intellectual Property Rights infringe upon the rights of any third
party.

                  (iv)     Each of the Guarantors has made or performed all
filings, recordings and other acts and has paid all required fees and taxes to
maintain and protect its interest in each and every item of intellectual
property in full force and effect throughout the world, and to protect and
maintain its interest therein including, without limitation, recordations of any
of its interests in patents and trademarks with the U.S. Patent and Trademark
Office and in corresponding national and international patent offices, and
recordation of any of its interests in any copyrights with the U.S. Copyright
Office and in corresponding national and international copyright offices. Each
of the Guarantors has used proper statutory notice in connection with its use of
each patent, trademark and copyright.

         F.       Inventory. All inventory of the Guarantors consists of a
quality and quantity usable and salable in the ordinary course of business,
except for obsolete items and items of below-standard quality, all of which have
been or will be written off or written down to net realizable value on the
consolidated balance sheet of the Guarantors and its Subsidiaries as of June 30,
2002. The quantities of each type of inventory (whether raw materials,
work-in-process, or finished goods) are not excessive, but are reasonable and
warranted in the present circumstances of the Guarantors.

         G.       Ownership. Each of the Guarantors is the legal and beneficial
owner of the Collateral of the Guarantors free and clear of any lien, claim,
option or right of others, except for the security interest created under this
Guarantors General Security Agreement, the Watson Security Agreement and the
Company Security Agreements executed in connection with the March 1998
Debentures and the May 1999 Debentures. No effective financing statement or
other instrument similar in effect covering all or any part of such Collateral
or listing the Guarantors or any trade name of the Guarantors is on file in any
recording office, except such as may have been filed relating to the Watson Loan
Agreement, the March 1998 Debentures and the May 1999 Debentures. The Agent has,
for the benefit of the Purchasers, a valid and perfected security interest in
the Collateral which security interest has priority over any and all other
security interests (except as provided in the Subordination Agreement) in such
Collateral.

         SECTION IV. COVENANTS OF THE GUARANTORS.

                                       -6-

         Each Guarantor agrees (which agreements shall be several as to each
Guarantor except as otherwise provided) as follows:

         A.       Defend Against Claims. Such Guarantor will defend the
Collateral against all claims and demands of all Persons at any time claiming
the same or any interest therein unless both the Agent and such Guarantor
determine that the claim or demand is not material and that, consequently, such
defense would not be consistent with good business judgment. Such Guarantor will
permit any lien notices with respect to the Collateral or any portion thereof to
exist or be on file in any public office except for those in favor of the Agent
and those permitted under the terms of the Purchase Agreement.

         B.       Change in Collateral Location. Such Guarantor will not (i)
change its corporate name, (ii) change the location of its chief executive
office or establish any place of business other than those specified in Section
IIIA of Schedule A, or (iii) move or permit movement of the Collateral from the
locations specified thereon except from one such location to another such
location, unless in each case such Guarantor shall have given the Agent at least
thirty (30) days prior written notice thereof, and shall have, in advance,
executed and caused to be filed and/or delivered to the Agent any financing
statements or other documents required by the Agent to perfect the security
interest of the Agent in the Collateral in accordance with Section IV.C. hereof,
all in form and substance satisfactory to the Agent.

         C.       Additional Financing Statements. Promptly upon the reasonable
request of the Agent, such Guarantor will execute and deliver or use its best
efforts to procure any document, give any notices, execute and file any
financing statements, mortgages or other documents, all in form and substance
satisfactory to the Agent, mark any chattel paper, deliver any chattel paper or
instruments to the Agent and take any other actions that are necessary or, in
the opinion of the Agent, desirable to perfect or continue the perfection and
the first priority of the Agent's security interest in the Collateral, to
protect the Collateral against the rights, claims, or interests of third
persons, or to effect the purposes of this Guarantors Security Agreement. Such
Guarantor will pay the costs incurred in connection with any of the foregoing.

         D.       Additional Liens; Transfers. Without the prior written consent
of the Agent, such Guarantor will not, in any way, hypothecate or create or
permit to exist any lien, security interest, charge or encumbrance on or other
interest in the Collateral, other than those permitted under the terms of the
Purchase Agreement and the lien in favor of Watson pursuant to the Watson Loan
Agreement and documents relative thereto, the investors in the March 1998
Debentures and the investors in the May 1999 Debentures, and such Guarantor will
not sell, transfer, assign, pledge, collaterally assign, exchange or otherwise
dispose of the Collateral, other than the sale of Inventory in the ordinary
course of business and the sale of obsolete or worn out Equipment.
Notwithstanding the foregoing, if the proceeds of any such sale consist of
notes, instruments, documents of title, letters of credit or chattel paper, such
proceeds shall be promptly delivered to the Agent to be held as Collateral
hereunder. If the Collateral, or any part thereof, is sold, transferred,
assigned, exchanged, or otherwise disposed of in violation of these provisions,
the security interest of the Agent shall continue in such Collateral or part
thereof notwithstanding such sale, transfer, assignment, exchange or other
disposition, and such Guarantor will hold the proceeds thereof for the benefit
of the Agent, and promptly transfer such proceeds to the Agent in kind.

                                      -7-

         E.       Contractual Obligations. Such Guarantor will not enter into
any contractual obligations which may restrict or inhibit the Agent's rights or
ability to sell or otherwise dispose of the Collateral or any part thereof after
the occurrence or during the continuance of an Event of Default.

         F.       Agent's Right to Protect Collateral. Upon the occurrence or
continuance of an Event of Default, the Agent shall have the right at any time
to make any payments and do any other acts the Agent may deem necessary to
protect the security interests of the Purchasers in the Collateral, including,
without limitation, the rights to pay, purchase, contest or compromise any
encumbrance, charge or lien which, in the reasonable judgment of the Agent,
appears to be prior to or superior to the security interests granted hereunder,
and appear in and defend any action or proceeding purporting to affect its
security interests in, and/or the value of, the Collateral. The Guarantors
hereby jointly and severally agree to reimburse the Agent for all payments made
and expenses incurred under this Guarantors Security Agreement including
reasonable fees, expenses and disbursements of attorneys and paralegals acting
for the Agent, including any of the foregoing payments under, or acts taken to
protect its security interests in, the Collateral, which amounts shall be
secured under this Guarantors Security Agreement, and agree they shall be bound
by any payment made or act taken by the Agent hereunder absent the Agent's gross
negligence or willful misconduct. The Agent shall have no obligation to make any
of the foregoing payments or perform any of the foregoing acts.

         G.       Further Obligations With Respect to Accounts. In furtherance
of the continuing assignment and security interest in the Accounts of such
Guarantor granted pursuant to this Guarantors Security Agreement, upon the
creation of Accounts, upon the Agent's request, such Guarantor will execute and
deliver to the Agent in such form and manner as the Agent may require, solely
for its convenience in maintaining records of Collateral, such confirmatory
schedules of Accounts, and other appropriate reports designating, identifying
and describing the Accounts as the Agent may reasonably require. In addition,
upon the Agent's request, such Guarantor shall provide the Agent with copies of
agreements with, or purchase orders from, the customers of such Guarantor and
copies of invoices to customers, proof of shipment or delivery and such other
documentation and information relating to said Accounts and other Collateral as
the Agent may reasonably require. Furthermore, upon the Agent's request, such
Guarantor shall deliver to the Agent any documents or certificates of title
issued with respect to any property included in the Collateral, and any
promissory notes, letters of credit or instruments related to or otherwise in
connection with any property included in the Collateral, which in any such case
came into the possession of such Guarantor, or shall cause the issuer thereof to
deliver any of the same directly to the Agent, in each case with any necessary
endorsements in favor of the Agent. Failure to provide the Agent with any of the
foregoing shall in no way affect, diminish, modify or otherwise limit the
security interests granted herein. Each Guarantor hereby authorizes the Agent to
regard such Guarantor's printed name or rubber stamp signature on assignment
schedules or invoices as the equivalent of a manual signature by such
Guarantor's authorized officers or agents.

         H.       Insurance. Such Guarantor agrees to maintain public liability
insurance, third party property damage insurance and replacement value insurance
on the Collateral under such policies of insurance, with such insurance
companies, in such amounts and covering such risks as

                                      -8-

are at all times satisfactory to the Agent in its commercially reasonable
judgment. All policies covering the Collateral are to name the Agent as an
additional insured and the loss payee in case of loss, and are to contain such
other provisions as the Agent may reasonably require to fully protect the
Agent's interest in the Collateral and to any payments to be made under such
policies. Guarantor will provide notice to Agent prior to any change in
coverage.

         I.       Taxes. Such Guarantor agrees to pay, when due, all taxes
lawfully levied or assessed against such Guarantor or any of the Collateral
before any penalty or interest accrues thereon; provided, however, that, unless
such taxes have become a Federal tax or Employment Retirement Security Income
Act lien on any of the assets of such Guarantor, no such tax need be paid if the
same is being contested, in good faith, by appropriate proceedings promptly
instituted and diligently conducted and if an adequate reserve or other
appropriate provision shall have been made therefor as required in order to be
in conformity with generally accepted accounting principles and procedures in
effect in the United States of America.

         J.       Compliance with Laws. Such Guarantor agrees to comply in all
material respects with all requirements of law applicable to the Collateral or
any part thereof, or to the operation of its business or its assets generally,
unless such Guarantor contests in good faith, by appropriate legal,
administrative or other proceeding promptly instituted and diligently conducted,
any such requirements of law in a reasonable manner and in good faith. Such
Guarantor agrees to maintain in full force and effect, its respective licenses
and permits granted by any governmental authority as may be necessary or
advisable for such Guarantor to conduct its business in all material respects.

         K.       Maintenance of Property. Such Guarantor agrees to keep all
property useful and necessary to its business in good working order and
condition (ordinary wear and tear excepted) and not to commit or suffer any
waste with respect to any of its properties.

         L.       Environmental and Other Matters. Such Guarantor will conduct
its business so as to comply in all respects with all environmental, land use,
occupational, safety or health laws, regulations, directions, ordinances,
criteria and guidelines in all jurisdictions in which it is or may at any time
be doing business, except to the extent that such Guarantor is contesting, in
good faith by appropriate legal, administrative or other proceedings, promptly
instituted and diligently conducted, any such law, regulation, direction,
ordinance, criteria, guideline, or interpretation thereof or application
thereof; provided, further, that such Guarantor shall comply with the order of
any court or other governmental authority relating to such laws unless such
Guarantor shall currently be prosecuting an appeal, proceedings for review or
administrative proceedings and shall have secured a stay of enforcement or
execution or other arrangement postponing enforcement or execution pending such
appeal, proceedings for review or administrative proceedings.

         M.       Intellectual Property. With respect to each item of its
intellectual property, each of the Guarantors agrees to take, at its expense,
all necessary steps, including, without limitation, in the U.S. Patent and
Trademark Office, the U.S. Copyright Office and any other governmental
authority, to (i) maintain the validity and enforceability of such intellectual
property and maintain such intellectual property in full force and effect, and
(ii) pursue the registration and maintenance of each patent, trademark, or
copyright registration or application,

                                      -9-

now or hereafter included in such intellectual property Collateral of the
Guarantors, including, without limitation, the payment of required fees and
taxes, the filing of responses to office actions issued by the U.S. Patent and
Trademark Office, the U.S. Copyright Office or other governmental authorities,
the filing of applications for renewal or extension, the filing of affidavits
under Sections 8 and 15 of the U.S. Trademark Act, the filing of divisional,
continuation, continuation-in-part, reissue and renewal applications or
extensions, the payment of maintenance fees and the participation in
interference, reexamination, opposition, cancellation, infringement and
misappropriation proceedings. Neither the Guarantors nor the Grantor shall,
without the prior written consent of the Agent, discontinue use of or otherwise
abandon any intellectual property Collateral, or abandon any right to file an
application for any patent, trademark or copyright, unless the Guarantors shall
have previously determined that such use or the pursuit or maintenance of such
intellectual property is no longer desirable in the conduct of the Guarantors'
business and that the loss thereof would not be reasonably likely to have a
Material Adverse Effect, in which case, the Guarantors will give prompt notice
of any such abandonment to the Agent.

         N.       Further Assurances. Such Guarantor shall take all such further
actions and execute all such further documents and instruments (including, but
not limited to, collateral assignments of Intellectual Property and Intangibles
or any portion thereof) as the Agent may at any time reasonably determine in its
sole discretion to be necessary or desirable to further carry out and consummate
the transactions contemplated by the Purchase Agreement and the documentation
relating thereto, including this Guarantors Security Agreement, and to perfect
or protect the liens (and the priority status thereof) of the Agent in the
Collateral.

         SECTION V. REMEDIES.

         A.       Obtaining the Collateral Upon Default. If any Event of Default
shall have occurred and be continuing, then and in every such case, subject to
any mandatory requirements of applicable law then in effect, the Agent, in
addition to any rights now or hereafter existing under applicable law and
subject to the Subordination Agreement, shall have all rights as a secured
creditor under the Uniform Commercial Code in all relevant jurisdictions and
may:

                  (i)      personally, or by agents or attorneys, immediately
         retake possession of the Collateral or any part thereof, from any
         Guarantor or any other Person who then has possession of any part
         thereof, with or without notice or process of law, and for that purpose
         may enter upon such Guarantor's premises where any of the Collateral is
         located and remove the same and use in connection with such removal
         any and all services, supplies, aids and other facilities of such
         Guarantor;

                  (ii)     instruct the obligor or obligors on any agreement,
         instrument or other obligation (including, without limitation, the
         Accounts) constituting the Collateral to make any payment required by
         the terms of such instrument or agreement directly to the Agent;

                  (iii)    withdraw all monies, securities and instruments held
         pursuant to any pledge arrangement for application to the Obligations;

                                      -10-

                  (iv)     sell, assign or otherwise liquidate, or direct any
         Guarantor to sell, assign or otherwise liquidate, any or all of the
         Collateral or any part thereof, and take possession of the proceeds of
         any such sale or liquidation;

                  (v)      take possession of the Collateral or any part
         thereof, by directing any Guarantor in writing to deliver the same to
         the Agent at any place or places designated by the Agent, in which
         event such Guarantor shall at its own expense:

                           a.       forthwith cause the same to be moved to the
                  place or places so designated by the Agent and there delivered
                  to the Agent,

                           b.       store and keep any Collateral so delivered
                  to the Agent at such place or places pending further action by
                  the Agent as provided in Section V.B., and

                           c.       while the Collateral shall be so stored and
                  kept, provide such guards and maintenance services as shall be
                  necessary to protect the same and to preserve and maintain the
                  Collateral in good condition;

                  it being understood that any Guarantor's obligation to so
                  deliver the Collateral is of the essence of this Guarantors
                  Security Agreement and that, accordingly, upon application to
                  a court of equity having jurisdiction, the Agent shall be
                  entitled to a decree requiring specific performance by such
                  Guarantor of said obligation.

         B.       Disposition of the Collateral. Subject to the Subordination
Agreement any collateral repossessed by the Agent under or pursuant to Section
V.A. and any other Collateral whether or not so repossessed by the Agent, may be
sold, assigned, leased or otherwise disposed of under one or more contracts or
as an entirety, and without the necessity of gathering at the place of sale the
property to be sold, and in general in such manner, at such time or times, at
such place or places and on such terms as the Agent may, in compliance with any
mandatory requirements of applicable law, determine to be commercially
reasonable. Any of the Collateral may be sold, leased or otherwise disposed of,
in the condition in which the same existed when taken by the Agent or after any
overhaul or repair which the Agent shall determine to be commercially
reasonable. Any such disposition which shall be a private sale or other private
proceedings permitted by such requirements shall be made upon not less than ten
(10) days' written notice to such Guarantor specifying the time at which such
disposition is to be made and the intended sale price or other consideration
therefor, and shall be subject, for the ten (10) days after the giving of such
notice, to the right of such Guarantor or any nominee of such Guarantor to
acquire the Collateral involved at a price or for such other consideration at
least equal to the intended sale price or other consideration so specified. Any
such disposition which shall be a public sale permitted by such requirements
shall be made upon not less than ten (10) days' written notice to such Guarantor
specifying the time and place of such sale and, in the absence of applicable
requirements of law, shall be by public auction (which may, at the option of the
Agent, be subject to reserve), after publication at least once in The New York
Times not less than ten (10) days prior to the date of sale. If The New York
Times is not then being

                                      -11-

published, publication may be made in lieu thereof in any newspaper then being
circulated in the City of New York, New York, as the Agent may elect. All
requirements of reasonable notice under this Section V.B. shall be met if such
notice is mailed, postage prepaid at least ten (10) days before the time of such
sale or disposition, to the Guarantor at its address set forth herein or such
other address as the Guarantor may have, in writing, provided to the Agent. The
Agent may, if it deems it reasonable, postpone or adjourn any sale of any
collateral from time to time by an announcement at the time and place of the
sale to be so postponed or adjourned without being required to give a new notice
of sale. The proceeds realized from the sale of any Collateral shall be applied
as follows: first, to the reasonable costs, expenses and attorneys' fees and
expenses incurred by Agent for collection and for acquisition, completion,
protection, removal, storage, sale and delivery of the Collateral; second, to
interest due on any of the Obligations and any fees payable under this
Agreement; and third, to the principal of the Obligations. If any deficiency
shall arise, Guarantors shall remain liable to Agent and Purchasers therefor.

         C.       Power of Attorney. Each Guarantor hereby irrevocably
authorizes and appoints the Agent, or any Person or agent the Agent may
designate, as such Guarantor's attorney-in-fact, at such Guarantor's cost and
expense, to exercise all of the following powers upon and at any time after the
occurrence and during the continuance of an Event of Default, which powers,
being coupled with an interest, shall be irrevocable until all of the
Obligations owing by such Guarantor shall have been paid and satisfied in full:

                  (i)      accelerate or extend the time of payment, compromise,
         issue credits, bring suit or administer and otherwise collect Accounts
         or proceeds of any Collateral;

                  (ii)     receive, open and dispose of all mail addressed to
         such Guarantor and notify postal authorities to change the address for
         delivery thereof to such address as the Agent may designate;

                  (iii)    give customers indebted on Accounts notice of the
         Agent's interest therein, and/or to instruct such customers to make
         payment directly to the Agent for such Guarantor's account;

                  (iv)     convey any item of Collateral to any purchaser
         thereof;

                  (v)      give any notices or record any liens under
         Section IV.C. hereof; and

                  (vi)     make any payments or take any acts under
         Section IV.F. hereof.

The Agent's authority under this Section V.C. shall include, without limitation,
the authority to execute and give receipt for any certificate of ownership or
any document, transfer title to any item of Collateral, sign such Guarantor's
name on all financing statements or any other documents deemed necessary or
appropriate to preserve, protect or perfect the security interest in the
Collateral and to file the same, prepare, file and sign such Guarantor's name on
any notice of lien, assignment or satisfaction of lien or similar document in
connection with any Account and prepare, file and sign such Guarantor's name on
a proof of claim in bankruptcy or similar document against any customer of such
Guarantor, and to take any other actions arising from or incident to the rights,
powers and

                                      -12-

remedies granted to the Agent in this Guarantors Security Agreement. This power
of attorney is coupled with an interest and is irrevocable by such Guarantor.

         D.       Waiver of Claims. Except as otherwise provided in this
Guarantors Security Agreement, EACH GUARANTOR HEREBY WAIVES, TO THE EXTENT
PERMITTED BY APPLICABLE LAW, NOTICE AND JUDICIAL HEARING IN CONNECTION WITH THE
AGENT'S TAKING POSSESSION OF OR DISPOSING OF ANY OF THE COLLATERAL, INCLUDING,
WITHOUT LIMITATION, ANY AND ALL PRIOR NOTICE AND HEARING FOR ANY PREJUDGMENT
REMEDY OR REMEDIES AND ANY SUCH RIGHT WHICH ANY GUARANTOR WOULD OTHERWISE HAVE
UNDER THE CONSTITUTION OR ANY STATUTE OF THE UNITED STATES OR OF ANY STATE, and
each Guarantor hereby further waives, to the extent permitted by law:

                  (i)      all damages occasioned by such taking of possession
                  except any damages which are the direct result of the Agent's
                  gross negligence or willful misconduct;

                  (ii)     all other requirements as to the time, place and
                  terms of sale or other requirements with respect to the
                  enforcement of the Agent's rights hereunder, except as
                  expressly provided herein; and

                  (iii)    all rights of redemption, appraisement, valuation,
                  stay, extension or moratorium now or hereafter in force under
                  any applicable law in order to prevent or delay the
                  enforcement of this Guarantors Security Agreement or the
                  absolute sale of the Collateral or any portion thereof, and
                  such Guarantor, for itself and all who may claim under it,
                  insofar as it or they now or hereafter lawfully may, hereby
                  waives the benefit of all such laws.

Any sale of, or the grant of options to purchase, or any other realization upon
any Collateral shall operate to divest all right, title, interest, claim and
demand, either at law or in equity, of such Guarantor therein and thereto, and
shall be a perpetual bar both at law and in equity against such Guarantor and
against any and all persons claiming or attempting to claim the Collateral so
sold, optioned or realized upon, or any part thereof, from, through and under
such Guarantor.

         E.       Remedies Cumulative. Each and every right, power and remedy
hereby specifically given to the Agent shall be in addition to every other
right, power and remedy specifically given under this Guarantors Security
Agreement, under the Purchase Agreement or under other documentation relating
thereto or now or hereafter existing at law or in equity, or by statute, and
each and every right, power and remedy whether specifically herein given or
otherwise existing may be exercised from time to time or simultaneously and as
often and in such order as may be deemed expedient by the Agent. All such
rights, powers and remedies shall be cumulative and the exercise or the
beginning of exercise of one shall not be deemed a waiver of the right to
exercise of any other or others. No delay or omission of the Agent in the
exercise of any such right, power or remedy and no renewal or extension of any
of the Obligations shall impair any such right, power or remedy or shall be
construed to be a waiver of any Default or Event of Default or any acquiescence
therein.

                                      -13-

         SECTION VI. MISCELLANEOUS PROVISIONS.

         A.       Notices. All notices, approvals, consents or other
communications required or desired to be given hereunder shall be delivered in
person, by facsimile transmission followed promptly by first class mail, by a
nationally recognized courier service marked for next business day delivery or
by overnight mail, and delivered if to the Agent, then to the attention of Bruce
F. Wesson, c/o Galen Partners III, L.P., 610 Fifth Avenue, Fifth Floor, New
York, New York 10020, fax no. (212) 218-4990, with a copy to George N. Abrahams,
Esq., c/o Wolf, Block, Schorr and Solis-Cohen, 250 Park Avenue, New York, New
York 10177, fax no. (212) 986-0604, and if to the Guarantors, then to c/o Halsey
Drug Co., Inc., attention of Mr. Michael Reicher, 695 N. Perryville Road,
Rockford, Illinois 61107, with a copy to John P. Reilly, Esq., St. John & Wayne,
L.L.C., 2 Penn Plaza East, Newark, NJ 07105, fax no. (973) 491-3555.

         B.       Headings. The headings in this Guarantors Security Agreement
are for purposes of reference only and shall not affect the meaning or
construction of any provision of this Guarantors Security Agreement.

         C.       Severability. The provisions of this Guarantors Security
Agreement are severable, and if any clause or provision shall be held invalid or
unenforceable in whole or in part in any jurisdiction, then such invalidity or
unenforceability shall affect, in that jurisdiction only, such clause or
provision, or part thereof, and shall not in any manner affect such clause or
provision in any other jurisdiction or any other clause or provision of this
Guarantors Security Agreement in any jurisdiction.

         D.       Amendments, Waivers and Consents. Any amendment or waiver of
any provision of this Guarantors Security Agreement and any consent to any
departure by any Guarantor from any provision of this Guarantors Security
Agreement shall be effective only if made or given in writing signed by the
Agent.

         E.       Interpretation of Agreement. All terms not defined herein
shall have the meaning set forth in the applicable Uniform Commercial Code.
Acceptance of or acquiescence in a course of performance rendered under this
Guarantors Security Agreement shall not be relevant in determining the meaning
of this Guarantors Security Agreement even though the accepting or acquiescing
party had knowledge of the nature of the performance and opportunity for
objection.

         F.       Continuing Security Interest. This Guarantors General Security
Agreement shall create a continuing security interest in the Collateral and
shall (i) remain in full force and effect until the Security Interest
Termination Date, (ii) be binding upon each Guarantor, and its successors and
assigns and (iii) inure to the benefit of the Agent and its successors and
assigns.

         G.       Reinstatement. To the extent permitted by law, this Guarantors
Security Agreement shall continue to be effective or be reinstated if at any
time any amount received by the Agent in respect of the Obligations owing by the
Guarantors is rescinded or must otherwise be restored or returned by the Agent
upon the occurrence or during the pendency of any Event of Default, all as
though such payments had not been made.

                                      -14-

         H.       Survival of Provisions. All representations, warranties and
covenants of the Guarantors contained herein shall survive the execution and
delivery of this Guarantors Security Agreement, and shall terminate only upon
the full and final indefeasible payment and performance by the Guarantors of the
Obligations secured hereby.

         I.       Setoff. The Agent shall have all rights of setoff available at
law or in equity.

         J.       Power of Attorney. In addition to the powers granted to the
Agent under Section V.C., each Guarantor hereby irrevocably authorizes and
appoints the Agent, or any Person or agent the Agent may designate, as such
Guarantor's attorney-in-fact, at such Guarantor's cost and expense, to exercise
all of the following powers, which being coupled with an interest, shall be
irrevocable until all of the Obligations shall have been indefeasibly paid and
satisfied in full:

                  (i)      after the occurrence of an Event of Default, to
         receive, take, endorse, sign, assign and deliver, all in the name of
         the Agent or such Guarantor, any and all checks, notes, drafts, and
         other documents or instruments relating to the Collateral; and

                  (ii)     to request, at any time from customers indebted on
         Accounts, verification of information concerning the Accounts and the
         amounts owing thereon.

         K.       Indemnification; Authority of the Agent. Neither the Agent nor
any director, officer, employee, attorney or agent of the Agent shall be liable
to any Guarantor for any action taken or omitted to be taken by it or them
hereunder, except for its or their own gross negligence or willful misconduct,
nor shall the Agent be responsible for the validity, effectiveness or
sufficiency of this Guarantors Security Agreement or of any document or security
furnished pursuant hereto. The Agent and its directors, officers, employees,
attorneys and agents shall be entitled to rely on any communication, instrument
or document reasonably believed by it or them to be genuine and correct and to
have been signed or sent by the proper person or persons. Each Guarantor agrees
to indemnify and hold harmless the Agent and any other person from and against
any and all costs, expenses (including reasonable fees, expenses and
disbursements of attorneys and paralegals (including, without duplication,
reasonable charges of inside counsel)), claims or liability incurred by the
Agent or such person hereunder, unless such claim or liability shall be due to
willful misconduct or gross negligence on the part of the Agent or such person.

         L.       Release; Termination of Agreement. Subject to the provisions
of Section VI.G. hereof, this Guarantors Security Agreement shall terminate upon
full and final indefeasible payment and performance of all the Obligations owing
by each Guarantor. At such time, the Agent shall, at the request of any
Guarantor, reassign and redeliver to such Guarantor all of the Collateral
hereunder which has not been sold, disposed of, retained or applied by the Agent
in accordance with the terms hereof. Such reassignment and redelivery shall be
without warranty by or recourse to the Agent, except as to the absence of any
prior assignments by the Agent of its interest in the Collateral, and shall be
at the expense of such Guarantor.

                                      -15-

         M.       Counterparts. This Guarantors Security Agreement may be
executed in one or more counterparts, each of which shall be deemed an original
but all of which shall together constitute one and the same agreement.

         N.       GOVERNING LAW. This Guarantors Security Agreement and the
rights of the parties hereunder shall be governed by, and construed in
accordance with, the laws of the State of New York wherein the terms of this
Guarantors Security Agreement were negotiated, excluding to the greatest extent
permitted by law any rule of law that would cause the application of the laws of
any jurisdiction other than the State of New York.

         O.       SUBMISSION TO JURISDICTION.

         (i)      Each of the parties hereto hereby irrevocably and
unconditionally submits, for itself and its property, to the nonexclusive
jurisdiction of any New York State court or United States Federal court sitting
in New York City, and any appellate court from any thereof, in any action or
proceeding arising our of or relating to this Guarantors Security Agreement or
any of the other Transaction Documents (as such term is defined in the
Subordination Agreement) to which it is a party, or for recognition or
enforcement of any judgment, and each of the parties hereto irrevocably and
unconditionally agrees that all claims in respect of any such action or
proceeding may be heard and determined in any such New York State court or, to
the fullest extent permitted by law, in such United States Federal court. Each
of the parties hereto agrees that a final judgment in any such action or
proceeding shall be conclusive and may be enforced in other jurisdictions by
suit on the right that any party may otherwise have to bring any action or
proceeding relating to this Guarantors Security Agreement or any of the other
Transaction Documents in the courts of any other jurisdiction.

         (ii)     Each of the parties hereto irrevocably and unconditionally
waives, to the fullest extent it may legally and effectively do so, any
objection that it may now or hereafter have to the laying of venue of any suit,
action or proceeding arising out of or in relation to this Guarantors Security
Agreement or any other Transaction Document to which it is a party in any such
New York State or United States Federal court sitting in New York City. Each of
the parties hereto hereby irrevocably waives, to the fullest extent permitted by
law, the defense of an inconvenient forum to the maintenance of such action or
proceeding in any such court.

         P.       SERVICE OF PROCESS. EACH GUARANTOR HEREBY IRREVOCABLY AGREES
THAT SERVICE OF PROCESS IN ANY LEGAL ACTION OR PROCEEDING WITH RESPECT TO THIS
GUARANTORS SECURITY AGREEMENT MAY BE EFFECTED BY MAILING A COPY THEREOF BY
REGISTERED OR CERTIFIED MAIL, POSTAGE PREPAID, TO SUCH GUARANTOR AT ITS ADDRESS
SET FORTH IN SECTION VI.A. HEREOF.

         Q.       LIMITATION OF LIABILITY. THE AGENT SHALL NOT HAVE ANY
LIABILITY TO ANY GUARANTOR (WHETHER SOUNDING IN TORT, CONTRACT, OR OTHERWISE)
FOR LOSSES SUFFERED BY ANY GUARANTOR IN CONNECTION WITH, ARISING OUT OF, OR IN
ANY WAY RELATED TO THE TRANSACTIONS OR RELATIONSHIPS CONTEMPLATED BY THIS
GUARANTORS SECURITY AGREEMENT,

                                      -16-

OR ANY ACT, OMISSION OR EVENT OCCURRING IN CONNECTION THEREWITH, UNLESS IT IS
DETERMINED BY A FINAL AND NONAPPEALABLE JUDGMENT OR COURT ORDER BINDING ON THE
AGENT, THAT THE LOSSES WERE THE RESULT OF ACTS OR OMISSIONS CONSTITUTING GROSS
NEGLIGENCE OR WILLFUL MISCONDUCT.

         R.       Delays; Partial Exercise of Remedies. No delay or omission of
the Agent to exercise any right or remedy hereunder, whether before or after the
happening of any Event of Default, shall impair any such right or shall operate
as a waiver thereof or as a waiver of any such Event of Default. No single or
partial exercise by the Agent of any right or remedy shall preclude any other or
further exercise thereof, or preclude any other right or remedy.

         S.       JURY TRIAL. EACH OF THE GUARANTORS AND THE AGENT HEREBY
IRREVOCABLY WAIVES ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR
COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR
RELATING TO ANY TRANSACTION DOCUMENT OR THE ACTIONS OF ANY PARTY IN THE
NEGOTIATION, ADMINISTRATION, PERFORMANCE OR ENFORCEMENT THEREOF.

         T.       Subject To Subordination Agreement. Notwithstanding anything
to the contrary contained herein, the rights and remedies of agent and the
purchases, and the obligations of the guarantors, under this guarantors general
security agreement are subject to the subordination agreement, as it may be
amended, supplemented or otherwise modified from time to time.

                           [SIGNATURE PAGE TO FOLLOW]

                                      -17-

         IN WITNESS WHEREOF, each Guarantor has caused this Guarantors Security
Agreement to be duly executed and delivered as of the day and year first above
written.

                                                  HOUBA, INC.

                                                  By:___________________________
                                                  Name:
                                                  Title:

                                                  HALSEY PHARMACEUTICALS, INC.

                                                  By:___________________________
                                                  Name:
                                                  Title:

         By its acceptance hereof, as of the day and year first above written,
the Agent agrees to be bound by the provisions hereof applicable to it.

                                                  GALEN PARTNERS III, L.P.

                                                  By:___________________________
                                                  Name:
                                                  Title:

                                   SCHEDULE A

SECTION III.A

- -    Houba

             16235 State Road 17, Culver, Indiana 46511.

- -    HPI

             695 N. Perryville Road, Rockford, Illinois 61107.

                                      -19-


                                                                    EXHIBIT 10.5

                             STOCK PLEDGE AGREEMENT

                  THIS STOCK PLEDGE AGREEMENT (this "AGREEMENT") dated December
20, 2002 from HALSEY DRUG CO., INC., a New York corporation (the "PLEDGOR"),
GALEN PARTNERS III, L.P., a Delaware limited partnership ("GALEN"), acting in
its capacity as agent for the Purchasers, as hereinafter defined (the "AGENT" or
the "PLEDGEE") for the benefit of the Purchasers.

                  WHEREAS, the Pledgor is entering into a Debenture Purchase
Agreement dated as of December 20, 2002 (the "PURCHASE AGREEMENT") with various
purchasers, including the Agent (collectively, the "PURCHASERS"); and

                  WHEREAS, it is a condition precedent to the effectiveness of
the Purchase Agreement that the Pledgor shall have executed this Agreement and
made the pledges referred to herein in favor of the Pledgee, for the ratable
benefit of the Purchasers, as contemplated hereby.

                  NOW, THEREFORE, in consideration of the premises and to induce
the Purchasers and the Pledgee to enter into the Purchase Agreement, and for
other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the Pledgor hereby agrees with the Pledgee as follows:

                  1.       Definitions. Unless the context otherwise requires,
all terms used but not expressly defined herein shall have the meanings given to
them in the Purchase Agreement, or, if they are not defined in the Purchase
Agreement, but are defined in the New York Uniform Commercial Code (the "CODE"),
they shall have the same meaning herein as in the Code.

                  2.       Pledge of the Pledged Stock; Power of Attorney.

                  (a)      As security for the prompt payment and performance
when due of the obligations owing by the Pledgor to the Purchasers under the
Purchase Agreement, the Debentures, the other Transaction Documents (as defined
in the Subordination Agreement) and under the agreements, documents and
instruments delivered by the Pledgor pursuant thereto or in connection therewith
(collectively, the "OBLIGATIONS"), the Pledgor hereby pledges to the Pledgee,
for the ratable benefit of the Purchasers, and grants to the Pledgee, for the
ratable benefit of the Purchasers, a lien on and security interest having
priority over any and all other security interests (except as otherwise provided
in the Subordination Agreement), in the following (collectively the "PLEDGED
COLLATERAL"): (i) all of the issued and outstanding shares of common stock of
Houba, Inc. ("HOUBA" or a "SUBSIDIARY") and Halsey Pharmaceuticals, Inc. ("HPI"
or a "SUBSIDIARY" and together with Houba, the "SUBSIDIARIES") which shares are
more particularly described on Schedule A attached hereto (the "PLEDGED STOCK"),
(ii) all additional shares of common stock at any time issued to the Pledgor by
Houba or HPI, (iii) the certificates evidencing all Pledged Collateral, (iv)
subject to Section 6 hereof, all dividends, cash, securities, investment
property, instruments and other property from time to time received, receivable
or otherwise distributed in respect of or in exchange for any or all of the
Pledged Stock and such shares and securities and (v) all proceeds of any and all
Pledged Collateral

                                        1

(including, without limitation, proceeds constituting any property of the types
described above). The Pledgor shall deliver to the Pledgee original stock
certificates for all of the Pledged Stock, each accompanied by an undated stock
power executed in blank by the Pledgor.

                  (b)      The Pledgee shall have no obligation with respect to
the Pledged Collateral or any other property held or received by it hereunder
except to use reasonable care in the custody thereof. The Pledgee may hold the
Pledged Collateral in the form in which it is received by it.

                  (c)      The Pledgor, to the fullest extent permitted by law,
hereby constitutes and irrevocably appoints the Pledgee (and any officer or
agent of the Pledgee, with full power of substitution and revocation) as the
Pledgor's true and lawful attorney-in-fact, in the Pledgor's stead and in the
name of the Pledgor or in the name of the Pledgee, to transfer, upon the
occurrence and during the continuance of an Event of Default or at any time the
Pledgee, based on all the facts and circumstances then existing, and in the
exercise of its commercially reasonable credit judgment, reasonably believes,
and has so notified the Pledgor in writing, that, in connection with the
Purchase Agreement and the agreements, documents and instruments delivered by
the Pledgor pursuant thereto or in connection therewith, fraud has occurred with
respect to the Pledgor or any other Person (for the purposes of this Agreement,
the term "Person" means any individual, corporation, limited liability company,
partnership, association, trust or any other entity or organization, including a
government or political subdivision or an agency or instrumentality thereof,
controlling, controlled by, or under common control with the Pledgor which has a
material adverse effect on the operations or condition (financial or otherwise)
of the Pledgor and its subsidiaries, taken as a whole (a "FRAUD"), the Pledged
Collateral on the books of Houba and HPI, as applicable, in whole or in part, to
the name of the Pledgee or such other Person or Persons as the Pledgee may
designate and, upon the occurrence and during the continuance of an Event of
Default or at any time the Pledgee, based on all the facts and circumstances
then existing, and in the exercise of its commercially reasonable credit
judgment, reasonably believes, and has so notified the Pledgor in writing, that
Fraud has occurred, to take all such other and further actions as the Pledgor
could have taken with respect to the Pledged Collateral which the Pledgee in its
reasonable judgment determines to be necessary or appropriate to accomplish the
purposes of this Agreement.

                  (d)      The powers of attorney granted pursuant to this
Agreement and all authority hereby conferred are granted and conferred solely to
protect the Pledgee's interests in the Pledged Collateral and shall not impose
any duty upon the attorney-in-fact to exercise such powers. Such powers of
attorney shall be irrevocable prior to the payment in full of the Obligations,
and, shall not be terminated prior thereto or affected by any act of the Pledgor
or other Persons or by operation of law. The foregoing power of attorney, being
coupled with an interest, is irrevocable so long as any Obligation remains
outstanding.

                  (e)      Except to the extent that the Pledgee releases its
pledge of any of the Pledged Collateral, each Person who shall be a transferee
of the beneficial ownership of any of the Pledged Collateral shall be deemed to
have irrevocably appointed the Pledgee, with full power of substitution and
revocation, as such Person's true and lawful attorney-in-fact in such Person's
name and otherwise to do any and all acts herein permitted and to exercise any
and all powers herein conferred; provided, however, no Person shall exercise any
such power of attorney unless an Event of Default shall have occurred and be
continuing or from and after such time as such Person has notified the Pledgor
in

                                        2

writing that based on all the facts and circumstances then existing, and in the
exercise of its commercially reasonable judgment, such Person reasonably
believes that Fraud has occurred.

                  3.       Rights of the Pledgor; Voting.

                  (a)      During the term of this Agreement and subject to the
Subordination Agreement, and so long as the Pledgor has not received a Voting
Notice (as defined below) from the Pledgee following (i) the occurrence and
during the continuance of an Event of Default or (ii) from and after such time
as the Pledgee determines that based on all the facts and circumstances then
existing, and in the exercise of its commercially reasonable judgment, the
Pledgee reasonably believes that Fraud has occurred, the Pledgor shall have the
right to vote any of the Pledged Collateral in all corporate matters except
those which would contravene this Agreement, the Purchase Agreement or any of
the agreements, documents and instruments delivered by the Pledgor and each
Subsidiary pursuant thereto unless the Pledgee consents in writing thereto.

                  (b)      Subject to the Subordination Agreement, upon the
occurrence and during the continuance of an Event of Default or from and after
such time as the Pledgee has notified the Pledgor in writing that based on all
the facts and circumstances then existing, and in the exercise of its
commercially reasonable judgment, Pledgee reasonably believes that Fraud has
occurred, the Pledgor shall give the Pledgee at least fifteen (15) days' prior
notice of (i) any meeting of stockholders of any of the Subsidiaries or any
meeting of directors of any of the Subsidiaries convened for any purpose and
(ii) any written consent which the Pledgor proposes to execute as the
stockholder of any of the Subsidiaries or which any of the representatives of
the Pledgor proposes to execute as a director of any of the Subsidiaries.
Subject to the Subordination Agreement, during the continuance of an Event of
Default and from and after such time as the Pledgee determines that based on all
the facts and circumstances then existing, and in the exercise of its
commercially reasonable judgment, the Pledgee reasonably believes that Fraud has
occurred, the Pledgor hereby authorizes the Pledgee to send its agents and
representatives to any such meeting of shareholders or directors of any of the
Subsidiaries that the Pledgee wishes to attend, and agrees to take such steps as
may be necessary to confirm and effectuate such authority, including, without
limitation, causing such Subsidiary to give reasonable prior written notice to
the Pledgee of the time and place of any such meeting and the principal actions
to be taken thereat.

                  (c)      Notwithstanding the occurrence of an Event of Default
or the determination by the Pledgee that based on all the facts and
circumstances then existing, and in the exercise of its commercially reasonable
judgment, the Pledgee reasonably believes that Fraud has occurred, and subject
to the Subordination Agreement, the Pledgor may continue to exercise the voting
rights of the Pledgor as herein described (and subject to the limitations
herein) except to the extent that the Pledgee elects to exercise voting power
(as determined by it in its sole discretion) by providing written notice to the
Pledgor at any time during the continuance of an Event of Default or from and
after such time as the Pledgee has determined that based on all the facts and
circumstances then existing, and in the exercise of its commercially reasonable
judgment, the Pledgee reasonably believes that Fraud has occurred (a "VOTING
NOTICE"), whereupon the Pledgee shall have the exclusive right during the
continuance of an Event of Default and after the Pledgee's determination of
Fraud to exercise such rights to the extent specified in such Voting Notice, and
the Pledgor shall take all such steps as may be necessary to effectuate such
rights until the Pledgee notifies the Pledgor

                                        3

in writing of the release of such rights. Once any such Event of Default has
been cured or waived and such cure or waiver is confirmed by the Pledgee to the
Pledgor in writing, any relevant Voting Notice shall be deemed to be rescinded.

                  4.       No Restrictions on Transfer. The Pledgor warrants and
represents that except as provided pursuant to (a) that certain Stock Pledge
Agreement dated March 10, 1998 between the Company and the investors in the
March 1998 Debentures, (b) that certain Stock Pledge Agreement dated May 26,
1999 between the Company and the investors in the May 1999 Debentures and (c)
that certain Stock Pledge Agreement by and between the Company and Watson, dated
as of March 29, 2000, there are no restrictions on the transfer of the Pledged
Stock except for such restrictions imposed by operation of law, that there are
no options, warrants or rights pertaining thereto, and that the Pledgor has the
right to transfer the Pledged Stock free of any encumbrances and without the
consent of the creditors of the Pledgor or the consent of any of the
Subsidiaries or any other Person or any governmental agency whatsoever.

                  5.       No Transfer or Liens; Additional Securities. The
Pledgor agrees that it will not sell, transfer or convey any interest in, or
suffer or permit any lien or encumbrance to be created upon or with respect to,
any of the Pledged Collateral during the term of this Agreement, except to or in
favor of the Pledgee, or as agreed to in writing advance by the Pledgee in
accordance with the terms of the Purchase Agreement and the Subordination
Agreement. The Pledgor shall not cause, suffer or permit any Subsidiary to issue
any common or preferred stock, or any other equity security or any other
instruments convertible into equity securities, to any Person, unless the
Pledgee otherwise consents in writing (which consent may be withheld in the
Pledgee's reasonable credit judgment).

                  6.       Adjustments of Capital Stock; Payment and Application
of Dividends. Subject to the Subordination Agreement and the Debentureholders
Agreement, in the event that during the term of this Agreement any stock
dividend, reclassification, readjustment or other change is declared or made in
the capital structure of any Subsidiary or if any other or additional shares of
stock of any Subsidiary are issued to the Pledgor, all new, substituted and
additional shares or other securities issued by reason of any such change or
acquisition shall immediately be delivered by the Pledgor to the Pledgee and
shall be deemed to be part of the "Pledged Collateral" under the terms of this
Agreement in the same manner as the shares of capital stock originally pledged
hereunder. Subject to the Subordination Agreement and the Debentureholders
Agreement, upon the occurrence and during the continuance of an Event of Default
and from and after such time as the Pledgee determines that based on all the
facts and circumstances then existing, and in the exercise of its commercially
reasonable judgment, the Pledgee reasonably believes that Fraud has occurred,
all cash dividends received by or payable to the Pledgor in respect of the
Pledged Collateral, including any additional shares of stock or Investment
Property received by the Pledgor as a result of the Pledgor's record ownership
of the Pledged Stock, shall immediately be delivered by the Pledgor to the
Pledgee, to be held by the Pledgee as Pledged Collateral hereunder or to be
applied by the Pledgee against the Obligations. Upon the occurrence and during
the continuance of an Event of Default or from and after such time as the
Pledgee determines that based on all the facts and circumstances then existing,
and in the exercise of its commercially reasonable judgment, the Pledgee
reasonably believes that Fraud has occurred, the Pledgor will not demand and
will not be entitled to receive, any cash dividends or other income, interest or
property in or with respect to the Pledged Collateral, and if the

                                        4

Pledgor receives any of the same, the Pledgor shall immediately deliver it to
the Pledgee to be held by it and applied as provided in the preceding sentence.

                  7.       Warrants and Options. In the event that during the
term of this Agreement subscription warrants or other rights or options shall be
issued to the Pledgor in connection with the Pledged Collateral, all such stock
warrants, rights and options shall forthwith be assigned to the Pledgee by the
Pledgor, and said stock warrants, rights and options shall be, and, if exercised
by the Pledgor, all new stock issued pursuant thereto shall be, pledged by the
Pledgor to the Pledgee to be held as, and shall be deemed to be part of, the
Pledged Collateral under the terms of this Agreement in the same manner as the
shares of capital stock originally pledged hereunder.

                  8.       Return of Pledged Collateral Upon Termination. Upon
the Security Interest Termination Date and the termination of the Purchase
Agreement, the Pledgee shall cause to be transferred or returned to the Pledgor
all of the stock pledged by the Pledgor herein and any money, property and
rights received by the Pledgee pursuant hereto, to the extent the Pledgee has
not taken, sold or otherwise realized upon the same as permitted hereunder,
together with all other documents reasonably required by the Pledgor to evidence
termination of the pledge contemplated hereby.

                  9.       Events of Default; Remedies.

                  (a)      Upon the occurrence and during the continuance of any
Event of Default and from and after such time as the Pledgee determines that
based on all the facts and circumstances then existing, and in the exercise of
its commercially reasonable judgment, the Pledgee reasonably believes that Fraud
has occurred, subject to the Subordination Agreement, the Pledgee shall have and
at any time may exercise with respect to the Pledged Collateral, the proceeds
thereof, and any other property or money held by the Pledgee hereunder, all
rights and remedies available to it under law, including, without limitation,
those given, allowed or permitted to a secured party by or under the Code, and
all rights and remedies provided for herein and in the Purchase Agreement.

                  (b)      Without limiting the foregoing, in the event that the
Pledgee elects to sell the Pledged Stock (such term including, for purposes of
this Section 9, the Pledged Stock and all other shares of stock or securities at
any time forming part of the Pledged Collateral), the Pledgee shall have the
power and right in connection with any such sale, exercisable at its option and
in its absolute discretion, to sell, assign, and deliver the whole or any part
of the Pledged Stock or any additions thereto at a private or public sale for
cash, on credit or for future delivery and at such price as the Pledgee deems to
be satisfactory. Notice of any public sale shall be sufficient if it describes
the Pledged Collateral to be sold in general terms, and is published at least
once in The New York Times not less than ten (10) days prior to the date of
sale. If The New York Times is not then being published, publication may be made
in lieu thereof in any newspaper then being circulated in the City of New York,
New York, as the Pledgee may elect. All requirements of reasonable notice under
this Section 9 shall be met if such notice is mailed, postage prepaid at least
ten (10) days before the time of such sale or disposition, to the Pledgor at its
address set forth in Section 16 hereof or such other address as the Pledgor may
have, in writing, provided to the Pledgee. The Pledgee may, if it deems it
reasonable, postpone or adjourn any sale of any collateral from time to time by
an announcement at the time and place of the sale to be so postponed or
adjourned without being required to give a new notice of sale.

                                        5

                  (c)      Because federal and state securities laws may
restrict the methods of disposition of the Pledged Stock which are readily
available to the Pledgee, and specifically because a public sale thereof may be
impossible or impracticable by reason of certain restrictions under the
Securities Act of 1933, as amended, or under applicable Blue Sky or other state
securities laws as now or hereafter in effect, the Pledgor agrees that the
Pledgee may from time to time attempt to sell the Pledged Stock by means of a
private placement restricting the offering or sale to a limited number of
prospective purchasers who meet suitability standards the Pledgee deems
appropriate and who agree that they are purchasing for their own accounts for
investment and not with a view to distribution, and the Pledgee's acceptance of
the highest offer obtained therefrom shall be deemed to be a commercially
reasonable disposition of the Pledged Stock. To the extent permitted by law, the
Pledgee or its assigns may purchase all or any part of the Pledged Stock and any
purchaser thereof shall thereafter hold the same absolutely free from any right
or claim of any kind. To the fullest extent permitted by law, the Pledgee shall
not be obligated to make any such sale pursuant to notice and may, without
notice or publication, adjourn any public or private sale by announcement at the
time and place fixed for the sale, and such sale may be held at any time or
place to which the same may be adjourned. If any of the Pledged Stock is sold by
the Pledgee upon credit or for future delivery, the Pledgee shall not be liable
for the failure of the purchaser to pay for same and, in such event, the Pledgee
may resell such Pledged Stock and the Pledgor shall continue to be liable to the
Pledgee for the full amount of the Obligations to the extent the Pledgee does
not receive full and final payment in cash therefor.

                  (d)      Except as otherwise provided in the Purchase
Agreement or by applicable law, the Pledgee shall have the sole right to
determine the order in which Obligations shall be deemed discharged by the
application of the proceeds of Pledged Stock or any other property or money held
hereunder or any amount realized thereon.

                  10.      Certain Representations and Warranties. The Pledgor
represents and warrants to the Pledgee that:

                  (a)      All shares of Pledged Stock are fully paid, duly and
         properly issued, nonassessable and owned by the Pledgor free and clear
         of any lien or encumbrance of any kind whatsoever, excepting those
         herein granted to the Pledgee and those granted to the investors in the
         March 1998 Debentures, the May 1999 Debentures and Watson. The Pledged
         Stock constitutes all of the outstanding securities of any class or
         kind of all of the Subsidiaries.

                  (b)      Except in the case of the liens granted to the
         investors in the March 1998 Debentures, May 1999 Debentures and Watson,
         no effective financing statement or other instrument similar in effect
         covering all or any part of the Pledged Collateral is on file in any
         recording office.

                  (c)      The pledge of the Pledged Collateral pursuant to this
         Agreement creates a valid and perfected first-priority security
         interest, in accordance with and subject to the Subordination
         Agreement, securing the payment of the Obligations, and all filings and
         other actions necessary or desirable to perfect and protect such
         security interest having been duly made or taken.

                                        6

                  (d)      No authorization, approval or other action by, and no
         notice to or filing with, any governmental authority or regulatory body
         is required for (i) the pledge by the Pledgor of the Pledged Collateral
         pursuant to this Agreement, the grant by the Pledgor of the assignment
         or security interest granted hereby or the execution, delivery or
         performance of this Agreement by the Pledgor, (ii) the perfection of or
         exercise by the Pledgee of its rights and remedies provided for in this
         Agreement, or (iii) the exercise by the Pledgee of the voting or other
         rights provided for in this Agreement or the remedies in respect of the
         Pledged Collateral pursuant to this Agreement (except as may be
         required in connection with a judicial foreclosure, if applicable, or
         the disposition of the Pledged Stock by laws affecting the offering and
         sale of securities generally).

                  (e)      The Pledgor has full right, power and authority to
         enter into this Agreement and to grant the security interest in the
         Pledged Collateral made hereby, and this Agreement constitutes the
         legal, valid and binding obligation of the Pledgor enforceable against
         the Pledgor in accordance with its terms, except as the enforceability
         thereof may be (i) limited by bankruptcy, insolvency, reorganization,
         moratorium or similar laws affecting the enforceability of creditors'
         rights generally, and (ii) subject to general principles of equity
         (regardless of whether such enforceability is considered in a
         proceeding in equity or at law).

                  (f)      The execution, delivery and performance by the
         Company of this Agreement will not result in any violation, conflict
         with, or result in a breach of any of the terms of, or constitute a
         default under, any agreements, contracts, court orders or consent
         decrees, the Certificates of Incorporation or the By-laws, as amended,
         of the Company.

                  11.      Indemnity and Expenses.

                  (a)      The Pledgor agrees to and hereby indemnifies the
Pledgee and each of the Purchasers from and against any and all claims, actions,
damages, losses, liabilities and expenses arising out of, or in connection with,
or resulting from this Agreement (including, without limitation, enforcement of
this Agreement) unless resulting from or arising out of the gross negligence or
willful misconduct of the Pledgee or such Purchaser.

                  (b)      The Pledgor agrees promptly upon the Pledgee's or
such Purchaser's demand to pay or reimburse the Pledgee or such Purchaser for
all reasonable expenses (including, without limitation, reasonable fees and
disbursements of counsel) incurred by the Pledgee or such Purchaser in
connection with (i) any modification or amendment to or waiver of any provision
of this Agreement requested by the Pledgor, (ii) the custody or preservation of
the Pledged Collateral, (iii) any actual or attempted sale or exchange of, or
any enforcement, collection, compromise or settlement respecting, the Pledged
Collateral or any other property or money held hereunder or any other action
taken by the Pledgee or such Purchaser hereunder reasonably necessary to enforce
its rights, whether directly or as attorney-in-fact pursuant to the power of
attorney herein conferred, or (iv) the failure by the Pledgor to perform or
observe any of the provisions hereof. All such expenses shall be deemed a part
of the Obligations for all purposes of this Agreement and the Pledgee may apply
the Pledged Collateral or any other property or money held hereunder to payment
of or reimbursement for such expenses after notice and demand to the Pledgor.

                                        7

                  12.      Pledgee May Perform. If the Pledgor fails to perform
any representation, warranty, covenant or agreement required to be performed by
it contained herein, the Pledgee may, but shall not be obligated to, perform, or
cause performance of, such representation, warranty, covenant or agreement, and
the out-of-pocket expenses of the Pledgee incurred in connection therewith shall
be payable by the Pledgor.

                  13.      Waivers and Amendment. The rights and remedies given
hereby are in addition to all others however arising, but it is not intended
that any right or remedy be exercised in any jurisdiction in which such exercise
would be prohibited by law. No action, failure to act or knowledge of the
Pledgee shall be deemed to constitute a waiver of any power, right or remedy
hereunder, nor shall any single or partial exercise thereof preclude any further
exercise thereof or the exercise of any other power, right or remedy. Any right
or power of the Pledgee hereunder in respect of the Pledged Collateral and any
other property or money held hereunder may at the option of the Pledgee be
exercised as to all or any part of the same and the term the "Pledged
Collateral" wherever used herein, unless the context clearly requires otherwise,
shall be deemed to mean (and shall be read as) "the Pledged Collateral and any
other property or money held hereunder or any part thereof." This Agreement
shall not be amended nor shall any right hereunder be deemed waived except by a
written agreement expressly setting forth the amendment or waiver and signed by
the Pledgee.

                  14.      Continuing Security Interest; Assignments of Secured
Debt. This Agreement shall create a continuing security interest having priority
over any and all security interests (except as otherwise provided in the
Subordination Agreement) in the Pledged Collateral and shall (a) remain in full
force and effect until the Security Interest Termination Date, (b) be binding
upon the Pledgor, and the Pledgor's successors and assigns, and upon each of the
Subsidiaries, and their successors and assigns, and (c) inure, together with the
rights and remedies of the Pledgee and the Purchasers hereunder, to the benefit
of the Pledgee, its successors and permitted assigns. Without limiting the
generality of the foregoing clause (c), the Pledgee may assign or otherwise
transfer all or any portion of its rights and obligations under this Agreement
to any other person or entity, to the extent and in the manner provided in the
Purchase Agreement and the Subordination Agreement and such other person or
entity shall thereupon become vested with all the benefits in respect hereof
granted to the Pledgee herein; the Pledgee shall, however, retain all of its
rights and powers with respect to any part of the Pledged Collateral not
transferred. Any agent or nominee of the Pledgee shall have the benefit of this
Agreement as if named herein and may exercise all the rights and powers given to
the Pledgee hereunder.

                  15.      Governing Law; Suits.

                  (a)      This Agreement and the rights of the parties
hereunder shall be governed in all respects by the laws of the State of New York
wherein the terms of this Agreement were negotiated, excluding to the greatest
extent permitted by law any rule of law that would cause the application of the
laws of any jurisdiction other than the State of New York.

                  (b)      Each of the parties hereto hereby irrevocably and
unconditionally submits, for itself and its property, to the nonexclusive
jurisdiction of any New York State court or United States Federal court sitting
in New York City, and any appellate court from any thereof, in any action or
proceeding arising our of or relating to this Agreement or any of the other
Transaction Documents

                                        8

to which it is a party, or for recognition or enforcement of any judgment, and
each of the parties hereto irrevocably and unconditionally agrees that all
claims in respect of any such action or proceeding may be heard and determined
in any such New York State court or, to the fullest extent permitted by law, in
such United States Federal court. Each of the parties hereto agrees that a final
judgment in any such action or proceeding shall be conclusive and may be
enforced in other jurisdictions by suit on the right that any party may
otherwise have to bring any action or proceeding relating to this Agreement or
any of the other Transaction Documents in the courts of any other jurisdiction.

                  (c)      Each of the parties hereto irrevocably and
unconditionally waives, to the fullest extent it may legally and effectively do
so, any objection that it may now or hereafter have to the laying of venue of
any suit, action or proceeding arising out of or in relation to this Agreement
or any other Transaction Document to which it is a party in any such New York
State or United States Federal court sitting in New York City. Each of the
parties hereto hereby irrevocably waives, to the fullest extent permitted by
law, the defense of an inconvenient forum to the maintenance of such action or
proceeding in any such court.

                  16.      Notices. All notices hereunder shall be in writing
(except only as otherwise provided in Section 13) and shall be conclusively
deemed to have been received and shall be effective (a) on the day on which
delivered if delivered personally (including delivery by courier or overnight
mail providing evidence of delivery), or transmitted by telex or telegram or
telecopier with transmission confirmed, or (b) five (5) days after the date on
which the same is deposited in the United States mail (certified or registered
if required under Section 15), with postage prepaid and properly addressed, and
any notice mailed shall be addressed:

                           (a)      in the case of the Pledgor, to:

                                    Halsey Drug Co., Inc.
                                    695 N. Perryville Road
                                    Rockford, Illinois 61107
                                    Telecopier No.: (815) 399-9710

                                    with copies to:

                                    St. John & Wayne
                                    2 Penn Plaza East
                                    Newark, New Jersey 07105
                                    Attention:  John P. Reilly, Esq.
                                    Telephone No.:   (973) 491-3600
                                    Telecopier No.:  (973) 491-3555

                                        9

                           (b)      in the case of the Pledgee, to:

                                    Galen Partners III, L.P.
                                    610 Fifth Avenue, Fifth Floor
                                    New York, NY 10020
                                    Telecopier No.: (212) 218-4999
                                    Attention: Bruce F. Wesson

                                    with a copies to:

                                    Care Capital LLC
                                    47 Hulfish Street, Suite 310
                                    Princeton, New Jersey 08542
                                    Attn:  David Ramsey
                                    Telephone No.:  (    ) ___- ____

                                    Wolf, Block, Schorr & Solis-Cohen
                                    250 Park Avenue
                                    New York, NY 10177
                                    Attention: George N. Abrahams, Esq.
                                    Telephone No.:  (212) 986-1116
                                    Telecopier No.: (212) 986-0604

or at such other address as the party giving such notice shall have been advised
of in writing for such purpose by the party to whom or to which the same is
directed.

                  17.      Severability: Entire Agreement.

                  (a)      If any provision of this Agreement shall be invalid,
illegal, or unenforceable in any jurisdiction, the validity, legality or
enforceability of any such provision in any other jurisdiction shall not be
affected or impaired, and to the extent any provision is held invalid, illegal
or unenforceable, then such provision shall be deemed severable from, and shall
in no way affect the validity or enforceability of the remaining provisions of
this Agreement.

                  (b)      This Agreement and the Subordination Agreement
constitute the entire agreement of the Pledgor and replaces any other or prior
agreements or undertakings, with respect to the subject matter hereof, and there
are no other agreements or undertakings, oral or written, respecting such
subject matter which are intended to have any force or effect after the
execution hereof.

                  (c)      Notwithstanding anything to the contrary contained
herein, the rights and remedies of the Pledgee, and the obligations of the
Pledgor, under this Stock Pledge Agreement are subject to the Subordination
Agreement, as it may be amended, supplemented or otherwise modified from time to
time.

                                       10

                  18.      Miscellaneous. This Agreement shall be binding upon
and shall inure to the benefit of the Pledgor and the Pledgee and their
respective successors and permitted assigns. Section headings used herein are
for convenience only and shall not affect the meaning or construction of any of
the provisions hereof.

                  19.      Counterparts. This Agreement may be executed in any
number of counterparts, each executed counterpart constituting an original but
all counterparts together constituting only one instrument.

                  20.      Further Assurances. Pledgor and the Pledgee shall
execute, in a proper and timely manner, at or after the date hereof, such
additional documents and instruments as may be reasonably requested by the other
parties in connection with the consummation or confirmation of the transactions
contemplated by this Agreement.

                  21.      No Assignment. This Agreement may not be assigned by
the Pledgor without the prior express written consent of the Pledgee.

                  22.      WAIVERS OF JURY TRIAL AND CONSEQUENTIAL DAMAGES. THE
PLEDGOR AND, BY ITS ACCEPTANCE HEREOF, THE PLEDGEE HEREBY IRREVOCABLY WAIVE ALL
RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED
ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR RELATING TO ANY TRANSACTION
DOCUMENT OR THE ACTIONS OF ANY PARTY IN THE NEGOTIATION, ADMINISTRATION,
PERFORMANCE OR ENFORCEMENT THEREOF.

                  NEITHER THE PLEDGOR OR THE PLEDGEE, NOR ANY EMPLOYEE AGENT OR
ATTORNEY OF EITHER OF THEM, SHALL BE LIABLE TO THE OTHER FOR CONSEQUENTIAL
DAMAGES ARISING FROM ANY BREACH OF CONTRACT, TORT OR OTHER WRONG RELATING TO
THIS AGREEMENT OR THE ESTABLISHMENT, ADMINISTRATION OR COLLECTION OF THE
OBLIGATIONS, EXCEPT FOR BAD FAITH.

                           [SIGNATURE PAGE TO FOLLOW]

                                       11

                  IN WITNESS WHEREOF, the Pledgor has caused this Agreement to
be executed by its duly authorized officer as of the day and year first above
written.

                                        HALSEY DRUG CO., INC.

                                        By:_____________________________________
                                        Name:   Michael Reicher
                                        Title:  Chief Executive Officer

Accepted and Agreed to
on December 20, 2002

GALEN PARTNERS III, L.P.
on behalf of itself and as Agent
By: Claudius, L.L.C., General Partner

By:______________________
   Name:
   Title:

                                       12

                                   SCHEDULE A

                            Designation and Number of
                    shares of capital stock owned by Pledgor

============================================================================================== Certificate Number of Issuer No. Designation Shares ------ ----------- ----------- ------ - ---------------------------------------------------------------------------------------------- Houba, Inc. 1 Common Stock, $.01 par value 100 - ---------------------------------------------------------------------------------------------- Halsey Pharmaceuticals, Inc. 1 Common Stock, $.01 par value 100 ==============================================================================================
13

                                                                    EXHIBIT 10.6

                                VOTING AGREEMENT

                  This VOTING AGREEMENT (this "Agreement") dated as of December
20, 2002, among the Parties signatory hereto (the "Parties").

                  WHEREAS, Halsey Drug Co., Inc., a New York corporation (the
"Company"), has entered into the Debenture Purchase Agreement dated of even date
herewith (the "Purchase Agreement"), by and among the Company, Care Capital
Investments II, LP ("Care Capital"), Essex Woodlands Health Ventures ("Essex")
and other signatories thereto, providing for the issuance by the Company of 5%
Convertible Senior Secured Debentures due March 31, 2006 (the "2002 Debentures")
in the aggregate principal amount of $35,000,000; and

                  WHEREAS, Care Capital and Essex will purchase $5,000,000 and
$5,000,000, respectively, in principal amount of the 2002 Debentures pursuant to
the terms of the Purchase Agreement; and

                  WHEREAS, the Company does not have enough authorized and
unreserved shares of its Common Stock, $.01 par value per share (the "Common
Stock") available for issuance upon the conversion of the 2002 Debentures; and

                  WHEREAS, the Purchase Agreement contemplates that the
purchasers of the 2002 Debentures shall have the right to vote as part of a
single class with all holders of the Company's common stock on an as-converted
basis; provided, however, that for so long as Care Capital holds any 2002
Debentures, such voting rights shall not apply to Care Capital; and

                  WHEREAS, the Company desires to amend its Certificate of
Incorporation to provide for (a) an increase in the number of shares of its
Common Stock in order to reserve a sufficient number of shares for issuance upon
the conversion of the Debenture; and (b) the as-converted voting rights to the
holders of the 2002 Debentures (including the proviso set forth in the
immediately preceding recital); and

                  WHEREAS, as additional consideration for the investment by
Care Capital and Essex, the Purchase Agreement provides that so long as Care
Capital and Essex remain a holder of the 2002 Debentures, the Parties desire to
vote their Securities (as defined below) in such a manner so as to elect a Care
Capital nominee and an Essex nominee to the Board of Directors of the Company.

                  NOW, THEREFORE, in consideration of the foregoing and the
mutual agreements herein contained, the Parties hereto agree as follows:

                  1.       Amendment to Company's Certificate of Incorporation.
At the Company's next upcoming Annual Meeting of Shareholders, each Party hereto
will vote all (x) shares of Common Stock; (y) 5% Convertible Senior Secured
Debentures issued pursuant to that certain

Debenture and Warrant Purchase Agreement dated March 10, 1998 between the
Company and the purchasers listed on the signature page thereto (the "1998
Debentures"), and (z) 5% Convertible Senior Secured Debentures issued pursuant
to that certain Debenture and Warrant Purchase Agreement dated May 26, 1999
between the Company and the purchasers listed on the signature page thereto (the
"1999 Debentures", and together with the 1998 Debentures, the "Existing
Debentures") (collectively with the shares of the Company's Common Stock,
issuable upon conversion of the Existing Debentures, the "Securities") then
owned by such Party in favor of the following proposed amendments to the
Company's Certificate of Incorporation:

                  (a)      Increasing the number of shares of the Company's
                           Common Stock authorized for issuance from 80,000,000
                           to such number as shall equal the sum of (i) the
                           Company's issued and outstanding Common Stock, plus
                           (ii) the number of shares of Common Stock issuable
                           upon the conversion and exercise of the Company's
                           outstanding convertible securities, plus (iii) the
                           number of shares of Common Stock issuable upon
                           conversion of the 2002 Debentures and the exercise of
                           the Watson Warrant (as such term is defined in the
                           Purchase Agreement), plus (iv) 50 million shares, as
                           such sum shall be rounded up to the nearest whole
                           five million shares; and

                  (b)      Providing that the holders of the 2002 Debentures
                           shall have the right to vote as part of a single
                           class with all holders of the Common Stock of the
                           Company on all matters to be voted on by such
                           stockholders with each holder having such number of
                           votes as shall equal the number of votes they would
                           have had such holders converted the entire
                           outstanding principal amount of the 2002 Debentures
                           immediately prior to the record date relating to such
                           vote.

                  2.       Election of Care Capital Nominee and Essex Nominee.
From the date hereof, each Party and Care Capital and Essex (each of Care
Capital and Essex, and their permitted transferees and assigns, being referred
to herein as a "Designating Party") agree as follows:

                  (a)      Each Party holding Securities shall vote its
                           Securities, and take or cause to be taken such other
                           actions, as may be required from time to time to
                           elect to the Board of Directors of the Company one
                           person designated by each Designating Party. Without
                           limiting the generality of the foregoing, at each
                           annual meeting of the shareholders of the Company,
                           and at each special meeting of the shareholders and
                           debentureholders of the Company called for the
                           purpose of electing directors of the Company, and at
                           any time at which the shareholders and
                           debentureholders of the Company have the right to
                           elect directors of the Company, in each such event,
                           each Party shall vote all Securities owned by them
                           (or shall consent in writing in lieu of a meeting of
                           shareholders and debentureholders of the Company, as
                           the case may be), or take such other actions as shall
                           be necessary, to elect the Designating Party's
                           designee as a director of the Company in accordance
                           with the preceding provisions of this Section 2(a);

                                        2

                  (b)      Each Party shall take all actions necessary to remove
                           forthwith the director designated by a Designating
                           Party when such removal is requested for any reason,
                           with or without cause, by such Designating Party. In
                           the case of the death, resignation or removal as
                           herein provided of a Designating Party's designee,
                           each Party shall vote all Securities held by it to
                           elect another person designated by such Designating
                           Party pursuant to Section 2(a);

                  (c)      Each Party hereby agrees that it will not vote any of
                           its Securities in favor of the removal of any
                           director that shall have been designated by a
                           Designating Party, unless the Designating Party that
                           has designated such director shall have consented to
                           such removal in writing.

                           In the event that any Party shall fail to vote the
                           Securities held by it in accordance with Section 2(a)
                           and (b), such Party shall, upon such failure to so
                           vote, be deemed immediately to have granted to each
                           Designating Party a proxy to vote its Securities
                           solely for the election of the nominee of such
                           Designating Party or the removal of such Designating
                           Party's designated director, as the case may be. Such
                           Party acknowledges that each such proxy granted
                           hereby, including any successive proxy, if necessary,
                           is being given to secure the performance of an
                           obligation hereunder, is coupled with an interest,
                           and shall be irrevocable until such obligation is
                           performed;

                  (d)      No Party shall grant any proxy or enter into or agree
                           to be bound by any voting trust with respect to the
                           Securities held by such Party, or enter into any
                           shareholder agreement or arrangement of any kind with
                           any person with respect to the Securities held by
                           such person that is, in either case, inconsistent
                           with the terms of this Agreement (whether or not such
                           agreement and arrangement was or is with other
                           shareholders of the Company that are or are not
                           parties to this Agreement);

                  (e)      The Company shall take, or cause to be taken, such
                           actions as may be required from time to time to
                           establish and maintain executive, audit and
                           compensation committees of the Board of Directors, as
                           well as such other committees of the boards of
                           directors of the Company as the Board of Directors
                           shall determine, having such duties and
                           responsibilities as are customary for such
                           committees. The designees of each Designating Party
                           shall be, if so requested by such Designating Party
                           in its sole discretion, a member of each such
                           committee; and

                  (f)      The rights and obligations provided in this Section 2
                           shall be applied separately for each Designating
                           Party, with the rights of a Designating Party
                           terminating on the date such Designating Party ceases
                           to be a holder of the 2002 Debentures.

                                        3

                  3.       Liability. No Party who shall vote or consent or
withhold consent or make a request with respect to any Securities subject to
this Agreement on, to or from any matter in compliance with the terms hereof
that shall, as a result of any such vote or consent or withholding of consent or
making of a request, have any obligation or liability to any other Party
(whether such other Party shall also vote or consent or withhold consent or make
a request with respect to any Securities, then subject to this Agreement).

                  4.       Certain Remedies. Without intending to limit the
remedies available to any of the Parties, each Party agrees that damages at law
will be an insufficient remedy in the event such Party violates the terms hereof
or the powers granted hereunder and each of the Parties hereto further agrees
that each of the other Parties hereto may apply for and have injunctive or other
equitable relief in any court of competent jurisdiction to restrain the breach
or threatened breach of, or otherwise specifically to enforce, any of such
Party's agreements or the powers granted hereunder set forth herein.

                  5.       Representations. Each Party represents and warrants
to each other Party that this Agreement is its legal, valid and binding
obligation, enforceable against such Party in accordance with its terms, and
will not result in any (a) violation or breach of, or be in conflict with, each
Party's respective organizational documents or material contracts, or (b)
violation of any statutes, laws, rules, regulations, orders or judgments
applicable to such Party.

                  6.       Transfer of Securities. Except as otherwise set forth
in the Transaction Documents (as defined in the Purchase Agreement), nothing
shall prohibit or in any manner restrict any Party's ability to freely transfer,
assign, convey, or otherwise dispose of or convert its Securities; provided,
however, that upon the transfer, assignment, conveyance or disposition of any
Securities by a Party, such transferring Party shall cause the Person to which
the Securities are transferred, assigned, conveyed or otherwise disposed to
agree to be bound by the terms hereof..

                  7.       Term. This Agreement and the Parties' obligations
hereunder shall continue in effect for so long as Care Capital and Essex owns
any 2002 Debentures.

                  8.       Amendment. (a) Any term of this Agreement or the
powers granted hereunder may be amended and the observance of any such term or
power may be waived (either generally or in a particular instance and either
retroactively or prospectively) only with the written consent of Care Capital
and Essex and the holders of a majority of the Securities then subject to this
Agreement.

                  (b)      This Agreement and the powers granted hereunder may
be terminated only with the written consent of Care Capital, Essex and all
Parties hereto.

                  9.       Binding Effect. (a) This Agreement and the powers
granted hereunder shall be binding upon, and shall inure to the benefit of, Care
Capital, Essex and the Parties.

                  (b)      Nothing in this Agreement or the powers granted
hereunder shall obligate any Party hereto, in his or her capacity as an
employee, officer or director of the Company or any of its subsidiaries, to take
or refrain from taking any action in any such capacity or shall

                                        4

otherwise affect the rights or obligations of any such party in any such
capacity.

                  10.      Notices. All notices, demands or other communications
given hereunder shall be in writing and shall be sufficiently given if
transmitted by facsimile or delivered either personally or by a nationally
recognized courier service marked for next business day delivery or sent in a
sealed envelope by first class mail, postage prepaid and either registered or
certified, return receipt requested, to the address for each Party as provided
on the signature pages hereto, or to such other address as any such Party shall
designate in writing at the address hereinabove provided. Any such notice,
demand or communication shall be deemed to have been given (a) on the date of
delivery, if delivered personally, (b) on the date of facsimile transmission,
receipt confirmed, (c) one business day after delivery to a nationally
recognized overnight courier service, if marked for next day delivery or (d)
five business days after the date of mailing, if mailed.

                  11.      Miscellaneous. The section headings herein are
inserted for convenience of reference only and shall not affect the meaning or
interpretation hereof. This Agreement and the powers granted hereunder contain
the entire agreement among the Parties hereto with respect to the matters
contemplated herein. If for any reason any provision hereof shall be invalid,
unenforceable or inoperative, the validity and effect of the other provisions
hereof shall not be affected herein. This Agreement may be executed in one or
more counterparts, and by the Parties hereto in separate counterparts, each of
which, when so executed and delivered, shall be deemed to be an original but all
of which taken together shall constitute one and the same agreement. This
Agreement shall become effective as to each signatory hereto upon the execution
and delivery hereof by such signatory. This Agreement and the powers granted
hereunder shall be governed in all respects by the laws of the State of New York
wherein the terms of this Agreement were negotiated, excluding to the greatest
extent permitted by law any rule of law that would cause the application of the
laws of any jurisdiction other than the State of New York.

                            [SIGNATURE PAGES FOLLOW]

                                        5

         IN WITNESS WHEREOF, each of the Parties hereto has executed this
Agreement on the date first above written.

                                           
ORACLE STRATEGIC PARTNERS, L.P.               GALEN PARTNERS III, L.P.
By: Oracle Strategic Capital L.L.C.,          By: Claudius, L.L.C., General Partner
General Partner                               610 Fifth Avenue, 5th Fl.
200 Greenwich Avenue                          New York, New York 10019
3rd Floor
Greenwich, CT 06830

____________________________________          ______________________________________
By:  Joel Liffmann                            By:  Srini Conjeevaram
Its: Authorized Agent                         Its: General Partner

GALEN EMPLOYEE FUND III, L.P.                 GALEN PARTNERS INTERNATIONAL III, L.P.
By: Wesson Enterprises, Inc.                  By: Claudius, L.L.C., General Partner
610 Fifth Avenue, 5th Floor                   610 Fifth Avenue, 5th Floor
New York, New York 10020                      New York, New York 10020

____________________________________          ______________________________________
By:  Bruce F. Wesson                          By:  Srini Conjeevaram
Its: General Partner                          Its: General Partner

MICHAEL REICHER TRUST                         ROBERT W. BAIRD & CO., INC., TTEE
c/o Halsey Drug Co., Inc.                     FBO Michael K. Reicher IRA
695 North Perryville Rd.                      c/o Halsey Drug Co., Inc.
Crimson Building #2                           695 North Perryville Rd.
Rockford, Ill. 61107                          Crimson Building #2
                                              Rockford, Ill. 61107

____________________________________          ______________________________________
By:  Michael K. Reicher                       By:  Robert W. Baird
Its: Trustee                                  Its: Trustee

PETER CLEMENS
c/o Halsey Drug Co., Inc.
695 North Perryville Rd.
Crimson Building #2
Rockford, Ill. 61107

____________________________________
6 ACKNOWLEDGED AND CONSENTED TO as of the date set forth above by: ESSEX WOODLANDS HEATH VENTURES V, L.P., By: Essex Woodlands Heath Ventures V, L.L.C., its General Partner 190 South LaSalle Street Suite 2800 Chicago IL 60603 ____________________________________ Name: Immanuel Thangaraj Title: Managing Director CARE CAPITAL INVESTMENTS II, LP By: Care Capital II, LLC, General Partner 47 Hulfish Street, Suite 310 Princeton, NJ 08542 ____________________________________ By: David R. Ramsay Its: Authorized Signatory 7 Consent of Spouse The undersigned, as the spouse of the Party who is the signatory to the foregoing Voting Agreement, hereby consents to, confirms and ratifies the terms of, and powers granted pursuant to, the foregoing Voting Agreement, and agrees to be bound by all the Party's obligations under the foregoing Agreement. _________________________________ Spouse of________________________ 8

                                                                    EXHIBIT 10.7

                           DEBENTUREHOLDERS AGREEMENT

         THIS DEBENTUREHOLDERS AGREEMENT (this "Debentureholders Agreement") is
entered into as of December 20, 2002 by and among HALSEY DRUG CO., INC., a
corporation organized and existing under the laws of the State of New York
("Halsey" or the "Company"), and each of the holders of the Company's 5%
Convertible Senior Secured Debentures due March 31, 2006 listed on the signature
page hereto.

         WHEREAS, Halsey is a party to a certain Debenture and Warrant Purchase
Agreement dated as of March 10, 1998, as amended (the "1998 Purchase
Agreement"), with the persons listed on the signature pages thereto and pursuant
to which the Company issued certain 5% Convertible Senior Secured Debentures due
March 31, 2006 (the "1998 Debentures"); and

         WHEREAS, Halsey entered into a certain Debenture and Warrant Purchase
Agreement dated as of May 26, 1999, as amended (the "1999 Purchase Agreement"),
with the persons listed on the signature pages thereto and pursuant to which the
Company issued certain 5% Convertible Senior Secured Debentures due March 31,
2006 (the "1999 Debentures" and together with the 1998 Debentures, the "Existing
Debentures"); and

         WHEREAS, the Company has concurrently herewith entered into a certain
Debenture Purchase Agreement dated as of December __, 2002 (the "2002 Purchase
Agreement"; capitalized terms used herein but not otherwise defined herein shall
have the meanings ascribed thereto in the 2002 Purchase Agreement) with Care
Capital, LLC, Essex Woodlands Health Ventures Fund V and those other persons
listed on the signature pages thereto and pursuant to which the Company proposes
to issue certain 5% Convertible Senior Secured Debentures due March 31, 2006
(the "2002 Debentures" and together with the Existing Debentures, the
"Debentures"); and

         WHEREAS, it is a condition to the completion of the transactions
contemplated pursuant to the 2002 Purchase Agreement that the Company shall have
executed this Debentureholders Agreement providing that the approval of the
holders of the Debentures shall be required as a condition to the Company's
completion of certain material transactions; and

         WHEREAS, the Company and the holders of the Debentures desire to enter
into this Agreement to provide for the approval rights of the holders of the
Debentures as hereinafter provided.

         NOW, THEREFORE, in consideration of the mutual covenants contained
herein and other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, the parties hereby agree as follows:

                  1.       DEBENTUREHOLDER APPROVAL FOR MATERIAL TRANSACTIONS.

                  (a)      Consent of Holders of 2002 Debentures. The Company
hereby covenants and agrees, that so long as any of the 2002 Debentures remain
outstanding, it will not, directly or indirectly, without the prior written
consent of the holders of at least sixty-six and two-thirds percent (66 2/3%) in
the aggregate principal amount of the 2002 Debentures then outstanding, take, or
permit to be taken, any of the following actions or complete, or permit to be
taken, any of the following transactions:

                      (i)      Any modification of the rights of the holders of
                  the 2002 Debentures;

                      (ii)     Any issuance of securities, or the incurrence
                  of indebtedness, by the Company or any Guarantor which rank
                  senior or equal in right of payment to the 2002 Debentures;

                      (iii)    Any declaration or payment of any dividends or
                  distributions on, or redemptions of, any securities ranking
                  junior in priority to the 2002 Debentures, other than
                  dividends or distributions payable in the Company's capital
                  stock or cash interest paid to individual investors in the
                  Existing Debentures;

                      (iv)     (A) A merger, reorganization, consolidation or
                  other business combination involving the Company or any
                  Guarantor, (B) a sale, transfer, lease, license or other
                  disposition of all or substantially all of the assets of the
                  Company or any Guarantor or (C) any other similar
                  extraordinary transaction involving the Company or any
                  Guarantor, in any single transaction or a series of related
                  transactions (the "Extraordinary Transactions"), other than
                  any such transaction where the cash, marketable securities and
                  other liquid consideration received by the holders of the
                  voting stock of the Company in such transaction is at least
                  equal to four (4) times the then applicable conversion price
                  of the 2002 Debentures;

                      (v)      The liquidation, dissolution, commencement of any
                  bankruptcy or other proceeding of the type referred to in
                  Section 12.1(j) of the 2002 Purchase Agreement,
                  recapitalization or reorganization of the Company (in each
                  case whether or not they constitute transactions of the type
                  referred to in Section 1(a)(vi) below); and

                      (vi)     Without limiting the generality of Section
                  1(a)(iv) above, the consummation of a strategic alliance,
                  Extraordinary Transaction, licensing arrangement or other
                  corporate partnering arrangement involving the issuance by the
                  Company or any Guarantor of in excess of ten million dollars
                  ($10,000,000) in equity securities of the Company or any
                  Guarantor.

                  (b)      Consent of Holders of Debentures. Without limiting in
any way the approval rights granted to the holders of the 2002 Debentures in
Section 1(a) above, the Company hereby covenants and agrees, that so long as any
of the Debentures remain outstanding, it will not, directly or indirectly,
without the prior written consent of the holders of at least sixty-six and
two-thirds percent (66 2/3%) in the aggregate principal amount of the Debentures
then

                                       2

outstanding, take, or permit to be taken, any of the following actions or
complete, or permit to be completed, any of the following transactions:

                      (i)      Any amendment to the Company's Certificate of
                  Incorporation;

                      (ii)     Any declaration or payment of any dividends or
                  distributions on, or redemptions of, the Company's capital
                  stock, other than dividends or distributions payable in the
                  Company's capital stock or cash interest paid to individual
                  investors in the 2002 Debentures, the 1999 Debentures and the
                  1998 Debentures;

                      (iii)    An Extraordinary Transaction; provided,
                  however, that (I) for purposes of calculating the consent of
                  at least sixty-six and two-thirds percent (66 2/3%) in the
                  aggregate principal amount of the Debentures where the cash,
                  marketable securities and other liquid consideration received
                  by the holders of the voting stock of the Company in such
                  Extraordinary Transaction is at least equal to four (4) times
                  the then applicable conversion price of (a) the 2002
                  Debentures, the 2002 Debentures shall be excluded, (b) the
                  1999 Debentures, the 1999 Debentures shall be excluded, and
                  (c) the 1998 Debentures, the 1998 Debentures shall be
                  excluded; and (II) no prior approval or consent of the holders
                  of the Debentures shall be required for any Extraordinary
                  Transaction where the cash, marketable securities and other
                  liquid consideration received by the holders of the voting
                  stock of the Company in such Extraordinary Transaction is at
                  least equal to four (4) times the then highest applicable
                  conversion price of the Debentures;

                      (iv)     The liquidation, dissolution, commencement of any
                  bankruptcy or other proceeding of the type referred to in
                  Section 12.1(j) of the 2002 Purchase Agreement,
                  recapitalization or reorganization of the Company (in each
                  case whether or not they constitute transactions of the type
                  referred to in Section 1(b)(vii) below);

                      (v)      Except as otherwise waived, any issuance of the
                  Company's securities which rank senior or equal in right of
                  payment to the Existing Debentures;

                      (vi)     Any increase in the number of members comprising
                  the Company's Board of Directors above eleven (11); and

                      (vii)    Without limiting the generality of Section
                  1(b)(iii) above, the consummation of a strategic alliance,
                  Extraordinary Transaction, licensing arrangement or other
                  corporate partnering arrangement involving the issuance by the
                  Company of in excess of ten million dollars ($10,000,000) in
                  equity securities of the Company or any Guarantor.

                  2.       AMENDMENT AND WAIVER. Except as otherwise provided
herein, no modification, amendment or waiver of any provision of this
Debentureholders Agreement shall be effective against the Company or the holders
of the Debentures unless such modification, amendment or waiver is approved in
writing by the Company and the holders of not less than fifty-one percent (51%)
of the aggregate principal amount of the Debentures then outstanding; provided
that notwithstanding the foregoing, (a) the prior written consent of each holder
of the 2002 Debentures will be required to amend any payment terms of the 2002
Debentures, (b) the prior

                                       3

written consent of the holders of at least sixty-six and two-thirds percent
(66 2/3%) in the aggregate principal amount of the 2002 Debentures will be
required to modify, amend or waive any provision of Sections 1(a), 2(a), 2(b)
and 3 of this Debentureholders Agreement and (c) the prior written consent of
the holders of at least sixty-six and two-thirds percent (66 2/3%) in the
aggregate principal amount of the Debentures then outstanding will be required
to modify, amend or waive any provision of Section 1(b) of this Debentureholders
Agreement. The failure of any party to enforce any of the provisions of this
Debentureholders Agreement shall in no way be construed as a waiver of such
provisions and shall not affect the right of such party thereafter to enforce
each and every provision of this Debentureholders Agreement in accordance with
its terms.

                  3.       TERMINATION. This Debentureholders Agreement shall
terminate on the earliest to occur of (a) mutual written agreement of the
parties hereto and (b) the conversion of Debentures into the Company's Common
Stock, or repayment of the Debentures with accrued and unpaid interest, or
combination of the foregoing, such that the aggregate outstanding principal
amount of the Debentures then outstanding is less than five million dollars
($5,000,000).

                  4.       SEVERABILITY. Whenever possible, each provision of
this Agreement shall be interpreted in such manner as to be effective and valid
under applicable law, but if any provision of this Debentureholders Agreement is
held to be invalid, illegal or unenforceable in any respect under any applicable
law or rule in any jurisdiction, such invalidity, illegality or unenforceability
shall not affect any other provision or any other jurisdiction, but this
Debentureholders Agreement shall be reformed, construed and enforced in such
jurisdiction as if such invalid, illegal or unenforceable provision had never
been contained herein.

                  5.       ENTIRE AGREEMENT. Except as otherwise expressly set
forth herein, this document, the 2002 Purchase Agreement, the 1998 Purchase
Agreement, as amended pursuant to the Amendment to Debenture and Warrant
Purchase Agreement dated of even date, and the 1999 Purchase Agreement, as
amended pursuant to the Amendment to Debenture and Warrant Purchase Agreement
dated of even date embody the complete agreement and understanding among the
parties hereto with respect to the subject matter hereof and supersede and
preempt any prior understandings, agreements or representations by or among the
parties, written or oral, which may have related to the subject matter hereof in
any way.

                  6.       SUCCESSORS AND ASSIGNS. Except as otherwise provided
herein, this Debentureholders Agreement shall bind and inure to the benefit of
and be enforceable by the Company and its successors and assigns, and the
holders of the Debentures and any subsequent holders of the Debentures and the
respective successors and assigns of each of them, so long as they hold the
Debentures.

                  7.       COUNTERPARTS. This Debentureholders Agreement may be
executed in separate counterparts each of which shall be an original and all of
which taken together shall constitute one and the same agreement.

                                       4

                  8.       NOTICES. All notices, demands or other communications
to be given or delivered under or by reason of the provisions of this
Debentureholders Agreement will be in writing and will be deemed to have been
given when delivered personally, mailed by certified or registered mail, return
receipt requested and postage prepaid, or sent via a nationally recognized
overnight courier, or sent via facsimile to the recipient accompanied by a
certified or registered mailing. Such notices, demands or other communications
will be sent to the address indicated below:

                  To the Company:

                           Halsey Drug Co., Inc.
                           695 N. Perryville Road
                           Rockford, Illinois 61107
                           Attn: President
                           Fax: 815-399-9710

                  If to the holders of the Debentures:

                           To the address provided
                           on the signature pages to
                           the 1998 Purchase Agreement,
                           1999 Purchase Agreement and
                           2002 Purchase Agreement

or such other address or to the attention of such other person as the recipient
party shall have specified by prior written notice to the sending party. Any
such notice, demand or communication shall be deemed to have been given (a) on
the date of delivery, if delivered personally, (a) on the date of facsimile
transmission, receipt confirmed, (c) one business day after delivery to a
nationally recognized overnight courier service, if marked for next day delivery
or (d) five business days after the date of mailing, if mailed.

                  9.       GOVERNING LAW. This Debentureholders Agreement shall
be governed by, and construed in accordance with, the laws of the State of New
York wherein the terms of this Debentureholder Agreement were negotiated,
excluding to the greatest extent permitted by law any rule of law that would
cause the application of the laws of any jurisdiction other than the State of
New York.

                  10.      JURISDICTION. (a) Each of the parties hereto hereby
irrevocably and unconditionally submits, for itself and its property, to the
nonexclusive jurisdiction of any New York State court or United States Federal
court sitting in New York City, and any appellate court from any thereof, in any
action or proceeding arising our of or relating to this Debentureholders
Agreement to which it is a party, or for recognition or enforcement of any
judgment, and each of the parties hereto irrevocably and unconditionally agrees
that all claims in respect of any such action or proceeding may be heard and
determined in any such New York State court or, to the fullest extent permitted
by law, in such United States Federal court. Each of the parties hereto agrees
that a final judgment in any such action or proceeding shall be conclusive and
may be enforced in other jurisdictions by suit on the right that any party may
otherwise have to bring any

                                       5

action or proceeding relating to this Debentureholders Agreement in the courts
of any other jurisdiction.

                  (b)      Each of the parties hereto irrevocably and
unconditionally waives, to the fullest extent it may legally and effectively do
so, any objection that it may now or hereafter have to the laying of venue of
any suit, action or proceeding arising out of or in relation to this
Debentureholders Agreement to which it is a party in any such New York State or
United States Federal court sitting in New York City. Each of the parties hereto
hereby irrevocably waives, to the fullest extent permitted by law, the defense
of an inconvenient forum to the maintenance of such action or proceeding in any
such court.

                  11.      WAIVER OF JURY TRIAL. EACH OF THE PARTIES HERETO
HEREBY IRREVOCABLY WAIVES ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING
OR COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR
RELATING TO THIS DEBENTUREHOLDERS AGREEMENT OR THE ACTIONS OF ANY PARTY IN THE
NEGOTIATION, ADMINISTRATION, PERFORMANCE OR ENFORCEMENT THEREOF.

                                       6

IN WITNESS WHEREOF, the parties hereto have executed this Debentureholders
Agreement as of the date first above written.

                                               Halsey Drug Co., Inc.

                                               By:___________________________

                                               Name:_________________________

                                               Title:________________________

                                       7

                              2002 DEBENTUREHOLDERS

                                                  
GALEN PARTNERS III, L.P.                             GALEN PARTNERS INTERNATIONAL, III, L.P.
By: Claudius, L.L.C., General Partner                By: Claudius, L.L.C., General Partner
610 Fifth Avenue, 5th Fl.                            610 Fifth Avenue, 5th Floor
New York, New York 10019                             New York, New York 10020

______________________________________               ___________________________________
By:  Srini Conjeevaram                               By:  Srini Conjeevaram
Its: General Partner                                 Its: General Partner

GALEN EMPLOYEE FUND III, L.P.                        ESSEX WOODLANDS HEALTH
By: Wesson Enterprises, Inc.                         VENTURES V, L.P.
610 Fifth Avenue, 5th Floor                          By: Essex Woodlands Health Ventures V, L.L.C.,
New York, New York 10020                                 its General Partner
                                                     190 South LaSalle Street, Suite 2800
                                                     Chicago, IL 60603

______________________________________               ___________________________________
By:  Bruce F. Wesson                                 By:  Immanuel Thangaraj
Its: General Partner                                 Its: Managing Director

CARE CAPITAL INVESTMENTS II, LP                      BERNARD SELZ
By: Care Capital II, LLC, General Partner            c/o Furman Selz
47 Hulfish Street, Suite 310                         230 Park Avenue
Princeton, NJ 08542                                  New York, New York 10069

______________________________________               ___________________________________
By:  David R. Ramsay
Its: Authorized Signatory

MICHAEL WEISBROT                                     SUSAN WEISBROT
1136 Rock Creek Road                                 1136 Rock Creek Road
Gladwyne, Pennsylvania 19035                         Gladwyne, Pennsylvania 19035

______________________________________               ___________________________________
8 GREG WOOD ROGER GRIGGS c/o D.R. International c/o Tom Jennings 7474 No. Figueroa Street 7300 Turfway Road Los Angeles, California 90041 Suite 300 Florence, KY 41042 ______________________________________ ___________________________________ GEORGE E. BOUDREAU 222 Elbow Lane Haverford, PA 19041 ______________________________________
9 EXISTING DEBENTUREHOLDERS ORACLE STRATEGIC PARTNERS, L.P. GALEN PARTNERS III, L.P. By: Oracle Strategic Capital L.L.C., By: Claudius, L.L.C., General Partner General Partner 610 Fifth Avenue, 5th Fl. 200 Greenwich Avenue New York, New York 10019 3rd Floor Greenwich, CT 06830 ______________________________________ ___________________________________ By: Joel Liffmann By: Srini Conjeevaram Its: Authorized Agent Its: General Partner GALEN EMPLOYEE FUND III, L.P. GALEN PARTNERS INTERNATIONAL, III, L.P. By: Wesson Enterprises, Inc. By: Claudius, L.L.C., General Partner 610 Fifth Avenue, 5th Floor 610 Fifth Avenue, 5th Floor New York, New York 10020 New York, New York 10020 ______________________________________ ___________________________________ By: Bruce F. Wesson By: Srini Conjeevaram Its: General Partner Its: General Partner ALAN SMITH PATRICK COYNE 21 Bedlow Avenue 800 Merion Square Road Newport, Rhode Island 02840 Gladwyne, PA 19035 ______________________________________ ___________________________________ MICHAEL WEISBROT SUSAN WEISBROT 1136 Rock Creek Road 1136 Rock Creek Road Gladwyne, Pennsylvania 19035 Gladwyne, Pennsylvania 19035 ______________________________________ ___________________________________ GREG WOOD DENNIS ADAMS c/o D.R. International 120 Kynlyn Road 7474 No. Figueroa Street Radnor, Pennsylvania 19312 Los Angeles, California 90041 ______________________________________ ___________________________________
10 BERNARD SELZ ROBERT W. BAIRD & CO., INC., TTEE c/o Furman Selz FBO Michael K. Reicher IRA 230 Park Avenue c/o Halsey Drug Co., Inc. New York, New York 10069 695 North Perryville Rd. Crimson Building #2 Rockford, Ill. 61107 ______________________________________ ___________________________________ By: Michael K. Reicher Its: Trustee MICHAEL REICHER PETER CLEMENS c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 ______________________________________ ___________________________________ CONNIE REICHER TRUST STEPHANIE HEITMEYER c/o Halsey Drug Co., Inc. 17759 Road, Route 66 695 North Perryville Rd. Ft. Jennings, Ohio 45844 Crimson Building #2 Rockford, Ill. 61107 ______________________________________ ___________________________________ By: Connie Reicher Its: Trustee VARSHA H. SHAH HEMANT K. SHAH 29 Christy Drive 29 Christy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 ______________________________________ ___________________________________ VARSHA H. SHAH AS CUSTODIAN VARSHA H. SHAH AS CUSTODIAN FOR SACHIN H. SHAH FOR SUMEET H. SHAH 29 Christy Drive 29 Christy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 ______________________________________ ___________________________________ By: Varshah H. Shah By: Varshah H. Shah Its: Custodian Its: Custodian
11 MICHAEL RAINISCH ILENE RAINISCH c/o Alvin Rainisch c/o Alvin Rainisch 31 Congressional Road 31 Congressional Road Jackson, New Jersey 08527 Jackson, New Jersey 08527 ______________________________________ ___________________________________ KENNETH GIMBEL, IRA ACCOUNT KENNETH GIMBEL FBO KENNETH GIMBEL 2455 Montgomery Avenue 2455 Montgomery Avenue Highland Park, Ill. 60035 Highland Park, Ill. 60035 ______________________________________ ___________________________________ By:___________________________________ Its: Trustee JESSICA K. CLEMENS JAKE P. CLEMENS c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 ______________________________________ ___________________________________ BROOKE EMILY REICHER ALEC JOHN REICHER c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 ______________________________________ ___________________________________ COURTNEY PAIGE REICHER DEANA REICHER c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 ______________________________________ ___________________________________
12 MICHAEL K. REICHER II TODD ALLEN REICHER c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 ______________________________________ ___________________________________
13 ROBERT W. BAIRD & CO., INC., TTEE ROBERT W. BAIRD & CO., INC., TTEE FBO Michael Reicher IRA FBO Connie Reicher IRA c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Illinois 61107 Rockford, Illinois 61107 ______________________________________ ___________________________________ By: Robert W. Baird By: Robert W. Baird Its: Trustee Its: Trustee MICHAEL REICHER TRUST c/o Halsey Drug Co., Inc. 695 North Perryville Rd. Crimson Building #2 Rockford, Illinois 61107 ______________________________________ By: Michael K. Reicher Its: Trustee
14

                                                                    EXHIBIT 10.8

                              HALSEY DRUG CO., INC.

                                  AMENDMENT TO
                    DEBENTURE AND WARRANT PURCHASE AGREEMENT

                         DATED AS OF DECEMBER 20th, 2002

         This Amendment to the Debenture and Warrant Purchase Agreement is made
as of this 20th day of December, 2002, by and among Halsey Drug Co., Inc., a New
York corporation (the "Company"), and each of the Purchasers set forth on the
signature page hereto (the "Purchasers").

                                R E C I T A L S :

         WHEREAS, pursuant to that certain Debenture and Warrant Purchase
Agreement dated as of March 10, 1998 (the "Purchase Agreement") executed by the
Company in favor of the Purchasers, the Company issued its 5% Convertible Senior
Secured Debentures due March 15, 2003 (the "Existing Debentures"); and

         WHEREAS, pursuant to a certain Debenture Purchase Agreement dated on or
about December 20, 2002 (the "2002 Purchase Agreement"), proposed to be executed
by the Company in favor of Care Capital LLC, Essex Woodlands Health Ventures and
the other purchasers listed on the signature page thereto, the Company proposes
to issue its 5% Convertible Senior Secured Debentures due March 31, 2006 (the
"New Debentures");

         WHEREAS, as a condition to the investment in the New Debentures to be
made by the Purchasers listed in the 2002 Purchase Agreement (the "New
Holders"), the New Holders have required that the Purchase Agreement be amended
to (i) extend the maturity date of the Existing Debentures from March 15, 2003
to March 31, 2006, (ii) provide that the holders of the Existing Debentures have
veto rights for certain material Company transactions, (iii) provide that the
right of first refusal provided to the holders of the Existing Debentures be
exercisable on a pro rata basis with the New Holders under the 2002 Purchase
Agreement; and (iv) reduce the number of representatives designated by the
holders of the Existing Debentures from three (3) to two (2) commencing with the
second Annual Meeting of Shareholders following the date of this Amendment.

         WHEREAS, as an inducement for the New Holders to make the investment
pursuant to the 2002 Purchase Agreement, the Company and the Purchasers desire
to amend the Purchase Agreement as hereinafter provided;

         NOW, THEREFORE, in consideration of the foregoing recitals and the
covenants herein contained, the parties hereto agree as follows:

         1.       Capitalized terms used herein and not otherwise defined shall
have the meanings provided in the Purchase Agreement.

         2.       Section 1.1 of the Purchase Agreement is hereby amended to
delete Subsection (a) of such Section and replace same with the following:

                  "(a) its 5% Convertible Senior Secured Debentures due March
                  31, 2006 in the aggregate principal amount of $20,800,000 (the
                  "Debentures"),"

         3.       The Purchase Agreement is hereby amended to provide that the
maturity date of the Debentures shall be March 31, 2006 and that any reference
to a maturity date of March 15, 2003 shall be deemed changed to March 31, 2006.

         4.       The definition of Debentures as contained in Section 1.1 of
the Purchase Agreement is hereby revised to include all 5% Convertible Senior
Secured Debentures having an original maturity date of March 15, 2003 issued
pursuant to the Purchase Agreement, including, without limitation, all 5%
Convertible Senior Secured Debentures issued by the Company to the Purchasers in
satisfaction of interest payments due and payable thereunder. Exhibit A-1 to
this Amendment to the Debenture and Warrant Purchase Agreement sets forth all
Debentures and Warrants issued to the Purchasers pursuant to the Purchase
Agreement through the date hereof.

         5.       Each Purchaser agrees to surrender to the Company each
Debenture instrument issued to such Purchaser as described in Exhibit A-1 to
this Amendment to the Debenture and Warrant Purchase Agreement against the
issuance by the Company of an Amended and Restated 5% Convertible Senior Secured
Debenture of like principal amount due March 31, 2006 in substantially the form
attached as Exhibit B to this Amendment to Debenture and Warrant Purchase
Agreement.

         6.       Section 9.8 of the Purchase Agreement is hereby amended to
delete subsection (a) of such Section and replace same with the following:

                           "(a) The Company agrees to hold meetings of its Board
                  of Directors at least four (4) times a year, at no more than
                  three-month intervals. So long as the Purchasers own any
                  Securities, at each annual meeting of the Company's
                  Stockholders, the Purchasers shall have the right to nominate
                  three (3) designees to be members of the Board of Directors;
                  provided, however, that commencing with the Company's 2004
                  Annual Meeting of Shareholders, the Purchasers shall have the
                  right to nominate two (2) designees to be members of the Board
                  of Directors."

         7.       A new Section 9.18 is hereby added to the Purchase Agreement
as follows:

                  "9.18 Debentureholders Agreement. Each of the Company and the
                  holders of the Debentures has concurrently executed the form
                  of Debentureholders Agreement attached as Exhibit N hereto."

         8.       Section 12.1(c) of the Purchase Agreement is hereby deleted in
its entirety and the following inserted in lieu thereof:

                           "If the Company shall default in the performance of
                  any other material agreement or covenant contained in this
                  Agreement or in any other agreement executed in connection
                  with this Agreement, including that certain Registration
                  Rights Agreement dated December 20, 2002 among the Company,
                  the Purchasers and the other parties thereto, and such default
                  shall not have been remedied to the satisfaction of the Holder
                  or Holders of at least a majority in aggregate principal
                  amount of the Debentures then outstanding, within forty-five
                  (45) days after a Default Notice shall have been given to the
                  Company (the Company to give forwith to all other Holders of
                  Debentures at the time outstanding written notice of the
                  receipt of such Default Notice, specifying the default
                  referred to therein);"

         9.       Article XVI of the Purchase Agreement is hereby deleted in its
entirety and the following inserted in its place:

                                       2

                                   ARTICLE 16

                  RIGHT OF FIRST REFUSAL: ADDITIONAL INVESTMENT

                  16.1     Right of First Refusal. Each Holder of the
Debentures, Holder of Shares (provided any Debentures remain outstanding and the
Shares received upon conversion have not been sold, transferred or otherwise
disposed of) (the "Common Holder"), holders of the 2002 Debentures (the "2002
Debentureholders") and holders of shares of Common Stock issued upon the
conversion of the 2002 Debentures (provided any 2002 Debentures remain
outstanding and the shares of Common Stock received upon conversion have not
been sold, transferred or otherwise disposed of) (the "New Common Holders")
shall be entitled to the following right of first refusal:

                  (a)      Except in the case of Excluded Securities (as
hereinafter defined), the Company shall not issue, sell or exchange, agree to
issue, sell or exchange, or reserve or set aside for issuance, sale or exchange
(i) any shares of Common Stock, (ii) any other equity security of the Company,
(iii) any debt security of the Company which by its terms is convertible into or
exchangeable for, with or without consideration, any equity security of the
Company, (iv) any security of the Company that is a combination of debt and
equity or (v) any option, warrant or other right to subscribe for, purchase or
otherwise acquire any equity security or any such debt security of the Company
(collectively, the "Equity Securities") unless in each case, the Company shall
have first offered to sell to the holders of Debentures, the Common Holders, the
2002 Debentureholders and the New Common Holders, the Equity Securities, at a
price and on such other terms as shall have been specified by the Company in
writing delivered to each of the Holders of Debentures, the Common Holders, the
2002 Debentureholders and the New Common Holders (the "Offer"), which Offer by
its terms shall remain open and irrevocable for a period of thirty (30) days
from the date it is delivered by the Company to the Holders of Debentures, the
Common Holders, the 2002 Debentureholders and the New Common Holders; provided,
however, that such issuance, sale or exchange of equity securities shall result
in gross proceeds to the Company (whether at the time of issuance or upon
conversion, exercise, or exchange thereof) of an amount in excess of $200,000
(the "Minimum Offering Threshold"). For purposes of computing the Minimum
Offering Threshold, any offering, issuance, sale or exchange of Equity
Securities during any rolling 12 month period shall be aggregated.

                  (b)      Each of the Holders of Debentures, the Common
Holders, the 2002 Debentureholders and the New Common Holders shall have the
right to purchase its pro rata share of the Equity Securities. The "pro rata
share" of each Holder of Debentures, Common Holder, 2002 Debentureholders and
the New Common Holders shall be that amount of the Equity Securities multiplied
by a fraction, the numerator of which is the sum of (i) the Shares underlying
the Debenture held by such person if such person is the holder of a Debenture,
(ii) the number of Shares of Common Stock issued to such Common Holder upon
conversion of a Debenture if such person is a Common Holder, (iii) the number of
shares of Common Stock underlying the 2002 Debentures held by such person if
such person is a 2002 Debentureholder and (iv) the number of shares of Common
Stock issued to a 2002 Debentureholder upon conversion of a 2002 Debenture if
such person is an New Common Holder, and the denominator of which is the sum of
(x) the total number of shares of Common Stock underlying the Debentures issued
pursuant to this Agreement and (y) the total number of shares of Common Stock
underlying the 2002 Debentures.

                  (c)      Notice of the intention of each Holder of a
Debenture, Common Holder, 2002 Debentureholder or New Common Holder to accept,
in whole or in part, an Offer shall be evidenced by a writing signed by such
person, as the case may be and delivered to the Company prior to the end of the
30-day period commencing with the date of such Offer or, if later within ten
(10) days after the delivery of giving of any written notice of a material
change in such Offer, setting forth such portion (specifying number of shares,
principal amount or the like) of the Equity Securities as such person elects to
purchase (the "Notice of Acceptance").

                  (d)      In the event that all Holders of Debentures, Common
Holders, 2002 Debentureholders and New Common Holders do not elect to purchase
all of the Equity Securities, the persons

                                       3

which have provided notice of their intention to exercise the refusal rights as
provided in subparagraph (c) above shall have the right to purchase, on a pro
rata basis, any unsubscribed portion of the Equity Securities during a period of
ten (10) days following the 30-day period provided in subparagraph (c) above.
Following such additional 10-day period, in the event the Holders of the
Debentures, the Common Holders, 2002 Debentureholders and the New Common Holders
have not elected to purchase all of the Equity Securities, the Company shall
have 90 days from the expiration of the foregoing 40-day period to sell all or
any part of such Equity Securities as to which a Notice of Acceptance has not
been given by any of such persons (the "Refused Securities") to any other person
or persons, but only upon terms and conditions in all material respects,
including without limitation, unit price and interest rates, which are no more
favorable, in the aggregate, to such other person or persons or less favorable
to the Company than those set forth in the Offer. Upon the closing of the sale
to such other person or persons of all of the Refused Securities, which shall
include payment of the purchase price to the Company in accordance with the
terms of the Offer, if the Holders of Debentures, the Common Holders, the 2002
Debentureholders and the New Common Holders have timely submitted a Notice of
Acceptance, it and/or they shall purchase from the Company, and the Company
shall sell to the Holders of Debentures, the Common Holders, 2002
Debentureholders and the New Common Holders, as the case may be, the Equity
Securities in respect of which a Notice of Acceptance was delivered to the
Company, at the terms specified it the Offer. The purchase by the Holders of
Debentures, Common Holders, the 2002 Debentureholders and the New Common Holders
of any Equity Securities is subject in all cases to the preparation, execution
and delivery by the Company and such persons of a purchase agreement and other
customary documentation relating to such Equity Securities as is satisfactory in
form and substance to such persons and each of their respective counsel.

                  (e)      In each case, any Equity Securities not purchased by
the Holders of Debentures, the Common Holders, the 2002 Debentureholders and the
New Common Holders or by a person or persons in accordance with Section 16.1(d)
hereof may not be sold or otherwise disposed of until they are again offered to
such persons under the procedures specified in Section 16.1(a), (b), (c) and (d)
hereof.

                  (f)      The rights of the Holders of Debentures, the Common
Holders, 2002 Debentureholders and the New Common Holders under this Section
16.1 shall not apply to the following securities (the "Excluded Securities"):

                           (i)      Common Stock or options to purchase such
                                    Common Stock, issued to officers, employees
                                    or directors of, or consultants to, the
                                    Company, pursuant to any agreement, plan or
                                    arrangement approved by the Board of
                                    Directors of the Company;

                           (ii)     Common Stock issued as a stock dividend or
                                    upon any stock split or other subdivision or
                                    combination of shares of Common Stock;

                           (iii)    Common Stock issued upon conversion of the
                                    Debentures or the 1999 Debentures, or
                                    exercise of the Warrants or the warrants
                                    issued in connection with the 1999
                                    Debentures, or Common Stock issued upon
                                    conversion of the 2002 Debentures or
                                    exercise of the warrants issued pursuant to
                                    the 2002 Purchase Agreement;

                           (iv)     Common Stock or debentures issued in
                                    satisfaction of interest payments on the
                                    Debentures, the 1999 Debentures and the 2002
                                    Debentures, including the issuance of Common
                                    Stock or Debentures issued in satisfaction
                                    of interest payments on Debenture
                                    instruments issued by the Company in
                                    satisfaction of the interest payments on the
                                    Debentures, the 1999 Debenture and the 2002
                                    Debentures; or

                           (v)      any securities issued for consideration
                                    other than cash pursuant to a merger,
                                    consolidation, acquisition, strategic
                                    alliance or similar business

                                       4

                                    combination approved by the Board of
                                    Directors and/or at the Company's Annual
                                    Meeting of Shareholders.

                  (g)      Notwithstanding anything to the contrary contained
herein, a Holder of a Debenture, a Common Holder (other than an initial
Purchaser), a 2002 Debentureholders or a New Common Holder (other than an
initial purchaser of a 2002 Debenture) shall not be considered as such for
purposes of this Section 16.1 only, unless such person then holds Debentures or
2002 Debentures with an outstanding principal amount of at least $200,000 or
shares issued upon conversion of at least $200,000 in principal of Debentures or
2002 Debentures or a combination of Debentures or 2002 Debentures and shares of
Common Stock received upon conversion of the Debentures and 2002 Debentures such
that the outstanding principal of the Debentures or 2002 Debentures held by such
person plus the amount of principal of Debentures or 2002 Debentures converted
into shares held by such person equals or exceeds $200,000."

         10.      Subparagraph (a) of Article XIII is hereby amended to add the
following at the end of such Subparagraph:

                  "Notwithstanding the foregoing or anything to the contrary
                  contained in this Article XIII, no amendment to Section 9.18
                  shall be valid unless the same shall be in writing and signed
                  by the Company and the holders of at least 66 2/3% in the
                  aggregate principal amount of the Debenture (including for
                  purposes such calculation the principal amount of those
                  Debentures that at such time have been converted into shares).

         11.      Except as amended above, the terms of the Purchase Agreement
shall remain in full force and effect.

         12.      This Amendment to Debenture and Warrant Purchase Agreement and
the rights of the parties hereunder shall be governed in all respects by laws in
the State of New York wherein the terms of this Amendment were negotiated.

         13.      This Amendment to Debenture and Warrant Purchase Agreement may
be executed in any number of counterparts, each of which shall be original, but
all of which together shall constitute one instrument.

                           [SIGNATURE PAGES TO FOLLOW]

                                       5

         IN WITNESS WHEREOF, the Company and the Purchasers have caused this
Amendment to be duly executed all on the day and year first above written.

HALSEY DRUG CO., INC.

                                      
By:__________________________________
   Name:  Michael Reicher
   Title: Chief Executive Officer

PURCHASERS

GALEN PARTNERS III, L.P.                 GALEN PARTNERS INTERNATIONAL, III, L.P.
By: Claudius, L.L.C., General Partner    By: Claudius, L.L.C., General Partner
610 Fifth Avenue, 5th Fl.                610 Fifth Avenue, 5th Floor
New York, New York 10019                 New York, New York 10020

_____________________________________    _______________________________________
By:  Srini Conjeevaram                   By:  Srini Conjeevaram
Its: General Partner                     Its: General Partner

GALEN EMPLOYEE FUND III, L.P.            ALAN SMITH
By: Wesson Enterprises, Inc.             21 Bedlow Avenue
610 Fifth Avenue, 5th Floor              Newport, Rhode Island 02840
New York, New York 10020

_____________________________________    _______________________________________
By:  Bruce F. Wesson
Its: General Partner

PATRICK COYNE                            BERNARD SELZ
800 Merion Square Road                   c/o Furman Selz
Gladwyne, PA 19035                       230 Park Avenue
                                         New York, New York 10069

_____________________________________    _______________________________________

MICHAEL WEISBROT                         SUSAN WEISBROT
1136 Rock Creek Road                     1136 Rock Creek Road
Gladwyne, Pennsylvania 19035             Gladwyne, Pennsylvania 19035

_____________________________________    _______________________________________
6 GREG WOOD DENNIS ADAMS c/o D.R. International 120 Kynlyn Road 7474 No. Figueroa Street Radnor, Pennsylvania 19312 Los Angeles, California 90041 _____________________________________ _______________________________________ MICHAEL REICHER ROBERT W. BAIRD & CO., INC., TTEE c/o Halsey Drug Co., Inc. FBO Michael K. Reicher IRA 695 North Perryville Rd. c/o Halsey Drug Co., Inc. Crimson Building #2 695 North Perryville Rd. Rockford, Ill. 61107 Crimson Building #2 Rockford, Ill. 61107 _____________________________________ _______________________________________ By: Michael K. Reicher Its: Trustee CONNIE REICHER TRUST PETER CLEMENS c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 _____________________________________ _______________________________________ By: Connie Reicher Its: Trustee VARSHA H. SHAH HEMANT K. SHAH 29 Chrissy Drive 29 Chrissy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 _____________________________________ _______________________________________ VARSHA H. SHAH AS CUSTODIAN VARSHA H. SHAH AS CUSTODIAN FOR SACHIN H. SHAH FOR SUMEET H. SHAH 29 Chrissy Drive 29 Chrissy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 _____________________________________ _______________________________________ By: Varshah H. Shah By: Varshah H. Shah Its: Custodian Its: Custodian MICHAEL RAINISCH ILENE RAINISCH c/o Alvin Rainisch c/o Alvin Rainisch
7 300 Flower Lane 300 Flower Lane Morganville, New Jersey 07751 Morganville, New Jersey 07751 _____________________________________ _______________________________________ KENNETH GIMBEL, IRA ACCOUNT KENNETH GIMBEL FBO KENNETH GIMBEL 2455 Montgomery Avenue 2455 Montgomery Avenue Highland Park, Ill. 60035 Highland Park, Ill. 60035 _____________________________________ _______________________________________ By:__________________________________ Its: Trustee STEFANIE HEITMEYER C/o Halsey Drug Co., Inc. 695 North Perryville Rd. Crimson Building #2 Rockford, Ill. 61107 _____________________________________
8 ROBERT W. BAIRD & CO., INC., TTEE ROBERT W. BAIRD & CO., INC., TTEE FBO Michael Reicher IRA FBO Connie Reicher IRA c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Illinois 61107 Rockford, Illinois 61107 _____________________________________ _______________________________________ By: Robert W. Baird By: Robert W. Baird Its: Trustee Its: Trustee MICHAEL REICHER TRUST c/o Halsey Drug Co., Inc. 695 North Perryville Rd. Crimson Building #2 Rockford, Illinois 61107 _____________________________________ By: Michael K. Reicher Its: Trustee
9 EXHIBIT A-1 LIST OF DEBENTURE HOLDERS 10 EXHIBIT B FORM OF AMENDED AND RESTATED 5% CONVERTIBLE SENIOR SECURED DEBENTURE 11 EXHIBIT N DEBENTUREHOLDER AGREEMENT 12

                                                                    EXHIBIT 10.9

                              HALSEY DRUG CO., INC.

                                  AMENDMENT TO
                    DEBENTURE AND WARRANT PURCHASE AGREEMENT

                          DATED AS OF DECEMBER 20, 2002

         This Amendment to the Debenture and Warrant Purchase Agreement is made
as of this 20th day of December, 2002, by and among Halsey Drug Co., Inc., a New
York corporation (the "Company"), and each of the Purchasers set forth on the
signature page hereto (the "Purchasers").

                                R E C I T A L S :

         WHEREAS, pursuant to that certain Debenture and Warrant Purchase
Agreement dated as of May 26, 1999 (the "Purchase Agreement") executed by the
Company in favor of the Purchasers, the Company issued its 5% Convertible Senior
Secured Debentures due March 15, 2003 (the "Existing Debentures"); and

         WHEREAS, pursuant to a certain Debenture Purchase Agreement dated on or
about December 20, 2002 (the "2002 Purchase Agreement"), proposed to be executed
by the Company in favor of Care Capital LLC, Essex Woodlands Health Ventures and
the other purchasers listed on the signature page thereto, the Company proposes
to issue its 5% Convertible Senior Secured Debentures due March 31, 2006 (the
"New Debentures"); and

         WHEREAS, as a condition to the investment in the New Debentures to be
made by the Purchasers listed in the 2002 Purchase Agreement (the "New
Holders"), the New Holders have required that the Purchase Agreement be amended
to (i) extend the maturity date of the Existing Debentures from March 15, 2003
to March 31, 2006, and (ii) provide that the holders of the Existing Debentures
have veto rights for certain material Company transactions; and

         WHEREAS, as an inducement for the New Holders to make the investment
pursuant to the 2002 Purchase Agreement, the Company and the Purchasers desire
to amend the Purchase Agreement as hereinafter provided;

         NOW, THEREFORE, in consideration of the foregoing recitals and the
covenants herein contained, the parties hereto agree as follows:

         1.       Capitalized terms used herein and not otherwise defined shall
have the meanings provided in the Purchase Agreement.

         2.       Section 1.1 of the Purchase Agreement is hereby amended to
delete Subsection (a) of such Section and replace same with the following:

                  "(a) its 5% Convertible Senior Secured Debentures due March
                  31, 2006 in the aggregate principal amount of $22,862,603.04
                  (the "Debentures"),"

         3.       The Purchase Agreement is hereby amended to provide that the
maturity date of the Debentures shall be March 31, 2006 and that any reference
to a maturity date of March 15, 2003 shall be deemed changed to March 31, 2006.

         4.       The definition of Debentures as contained in Section 1.1 of
the Purchase Agreement is hereby revised to include all 5% Convertible Senior
Secured Debentures having an original maturity date of March 15, 2003 issued
pursuant to the Purchase Agreement, including, without limitation, all 5%
Convertible Senior Secured Debentures issued by the Company to the Purchasers in
satisfaction of interest payments due and payable thereunder. Exhibit A-1 to
this Amendment to the Debenture and Warrant Purchase Agreement sets forth all
Debentures and Warrants issued to the Purchasers pursuant to the Purchase
Agreement through the date hereof.

         5.       Each Purchaser agrees to surrender to the Company each
Debenture instrument issued to such Purchaser as described in Exhibit A-1 to
this Amendment to Debenture and Warrant Purchase Agreement against the issuance
by the Company of an Amended and Restated 5% Convertible Senior Secured
Debenture of like principal amount due March 31, 2006 in substantially the form
attached as Exhibit B to this Amendment to the Debenture and Warrant Purchase
Agreement.

         6.       A new Section 9.16 is hereby added to the Purchase Agreement
                  as follows:

                  "9.16 Debentureholders Agreement. Each of the Company and the
                  holders of the Debentures has concurrently executed the form
                  of Debentureholders Agreement attached as Exhibit O hereto."

         7.       Section 12.1(c) of the Purchase Agreement is hereby deleted in
                  its entirety and the following inserted in lieu thereof:

                  "If the Company shall default in the performance of any other
                  material agreement or covenant contained in this Agreement or
                  in any other agreement executed in connection with this
                  Agreement, including that certain Registration Rights
                  Agreement dated December 20, 2002 among the Company, the
                  Purchasers and the other parties thereto, and such default
                  shall not have been remedied to the satisfaction of the Holder
                  or Holders of at least a majority in aggregate principal
                  amount of the Debentures then outstanding, within thirty-five
                  (35) days after a Default Notice shall have been given to the
                  Company (the Company to give forwith to all other Holders of
                  Debentures at the time outstanding written notice of the
                  receipt of such Default Notice, specifying the default
                  referred to therein);"

         8.       Subparagraph (a) of Article XIII is hereby amended to add the
                  following at the end of such Subparagraph:

                  "Notwithstanding the foregoing or anything to the contrary
                  contained in this Article XIII, no amendment to Section 9.16
                  shall be valid unless the same shall be in writing and signed
                  by the Company and the holders of at least 66 2/3% in the
                  aggregate principal amount of the Debentures (including for
                  purposes of such calculation the principal amount of those
                  Debentures that at such time have been converted into shares).

         9.       Except as amended above, the terms of the Purchase Agreement
shall remain in full force and effect.

         10.      This Amendment to Debenture and Warrant Purchase Agreement and
the rights of the parties hereunder shall be governed in all respects by laws in
the State of New York wherein the terms of this Amendment were negotiated.

         11.      This Amendment to Debenture and Warrant Purchase Agreement may
be executed in any number of counterparts, each of which shall be original, but
all of which together shall constitute one instrument.

                           [SIGNATURE PAGES TO FOLLOW]

                                       2

         IN WITNESS WHEREOF, the Company and the Purchasers have caused this
Amendment to be duly executed all on the day and year first above written.

HALSEY DRUG CO., INC.

By:___________________________________
   Name:  Michael Reicher
   Title: Chief Executive Officer

PURCHASERS

                                     
ORACLE STRATEGIC PARTNERS, L.P.         GALEN PARTNERS III, L.P.
By: Oracle Strategic Capital L.L.C.,    By: Claudius, L.L.C., General Partner
General Partner                         610 Fifth Avenue, 5th Fl.
200 Greenwich Avenue                    New York, New York 10019
3rd Floor
Greenwich, CT 06830

___________________________________     ________________________________________
By:  Joel Liffmann                      By:  Srini Conjeevaram
Its: Authorized Agent                   Its: General Partner

GALEN EMPLOYEE FUND III, L.P.           GALEN PARTNERS INTERNATIONAL, III, L.P.
By: Wesson Enterprises, Inc.            By: Claudius, L.L.C., General Partner
610 Fifth Avenue, 5th Floor             610 Fifth Avenue, 5th Floor
New York, New York 10020                New York, New York 10020

___________________________________     ________________________________________
By:  Bruce F. Wesson                    By:  Srini Conjeevaram
Its: General Partner                    Its: General Partner

ALAN SMITH                              PATRICK COYNE
21 Bedlow Avenue                        800 Merion Square Road
Newport, Rhode Island 02840             Gladwyne, PA 19035

___________________________________     ________________________________________

MICHAEL WEISBROT                        SUSAN WEISBROT
1136 Rock Creek Road                    1136 Rock Creek Road
Gladwyne, Pennsylvania 19035            Gladwyne, Pennsylvania 19035

___________________________________     ________________________________________
3 GREG WOOD DENNIS ADAMS c/o D.R. International 120 Kynlyn Road 7474 No. Figueroa Street Radnor, Pennsylvania 19312 Los Angeles, California 90041 ___________________________________ ________________________________________ BERNARD SELZ c/o Furman Selz 230 Park Avenue New York, New York 10069 ___________________________________
4 EXHIBIT A-1 LIST OF DEBENTUREHOLDERS 5 EXHIBIT B FORM OF AMENDED AND RESTATED 5% CONVERTIBLE SENIOR SECURED DEBENTURE 6 EXHIBIT O DEBENTUREHOLDER AGREEMENT 7

                                                                   EXHIBIT 10.10

THIS CONVERTIBLE SENIOR SECURED DEBENTURE AND THE COMMON STOCK ISSUABLE UPON
CONVERSION HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED (THE "ACT"), NOR UNDER ANY STATE SECURITIES LAW AND MAY NOT BE PLEDGED,
SOLD, ASSIGNED, HYPOTHECATED OR OTHERWISE TRANSFERRED UNTIL (1) A REGISTRATION
STATEMENT WITH RESPECT THERETO IS EFFECTIVE UNDER THE ACT AND ANY APPLICABLE
STATE SECURITIES LAW OR (2) THE COMPANY RECEIVES AN OPINION OF COUNSEL TO THE
COMPANY OR OTHER COUNSEL TO THE HOLDER OF SUCH DEBENTURE REASONABLY SATISFACTORY
TO THE COMPANY THAT SUCH DEBENTURE AND/OR COMMON STOCK MAY BE PLEDGED, SOLD,
ASSIGNED, HYPOTHECATED OR TRANSFERRED WITHOUT AN EFFECTIVE REGISTRATION
STATEMENT UNDER THE ACT OR APPLICABLE STATE SECURITIES LAWS.

                              HALSEY DRUG CO., INC.
                              AMENDED AND RESTATED
                     5% CONVERTIBLE SENIOR SECURED DEBENTURE
                               DUE MARCH 31, 2006

$________________                                                      No. _____
December 20, 2002

         HALSEY DRUG CO., INC., a corporation organized under the laws of the
State of New York (the "Company"), for value received, hereby promises to pay
to_______________________ or its registered assigns (the "Payee" or "Holder")
upon due presentation and surrender of this Debenture, on March 31, 2006 (the
"Maturity Date"), the principal amount of _______________________($_______) and
accrued interest thereon as hereinafter provided.

         This Debenture was issued by the Company pursuant to a certain
Debenture and Warrant Purchase Agreement dated as of March 10, 1998 among the
Company and certain persons, including the Payee, as amended pursuant to that
certain Amendment to Debenture and Warrant Purchase Agreement dated as of
December __, 2002 among the Company and the other signatories thereto (together
with the Schedules and Exhibits thereto, the "Purchase Agreement") relating to
the purchase and sale of 5% Convertible Senior Secured Debentures maturing March
31, 2006 (the "Debentures") in the aggregate principal amount of $20,800,000.00
and pursuant to which Payee and others have exercised the right provided in the
Purchase Agreement to purchase additional Debentures for an aggregate purchase
price of $5,000,000.00. The holders of such Debentures are referred to
hereinafter as the "Holders." The Payee is entitled to the benefits of the
Purchase Agreement. Reference is made to the Purchase Agreement with respect to
certain additional rights of the Holder and obligations of the Company not set
forth herein. Capitalized terms used and not defined herein shall have the
meaning provided in the Purchase Agreement.

                                       1

                                    ARTICLE I

              PAYMENT OF PRINCIPAL AND INTEREST; METHOD OF PAYMENT

                  1.1      Payment of the principal and accrued interest on this
Debenture shall be made in such coin or currency of the United States of America
as at the time of payment shall be legal tender for the payment of public and
private debts. Interest (computed on the basis of a 360-day year of twelve
30-day months) shall accrue on the unpaid portion of said principal amount from
time to time outstanding at the rate of five percent (5%) per annum (the "Stated
Interest Rate"), in like coin and currency, and shall be paid by the Company to
the Payee at three (3) month intervals on each January 1, April 1, July 1 and
October 1 during the term of this Debenture (commencing July 1, 1998) (each
being an "Interest Payment Date") and on the Maturity Date. Both principal
hereof and interest thereon are payable at the Holder's address as provided in
the Purchase Agreement or such other address as the Holder shall designate from
time to time by written notice to the Company. The Company will pay or cause to
be paid all sums becoming due hereon for principal and interest by check sent to
the Holder's address as provided in the Purchase Agreement or to such other
address as the Holder may designate for such purpose from time to time by
written notice to the Company, without any requirement for the presentation of
this Debenture or making any notation thereon, except that the Holder hereof
agrees that payment of the final amount due shall be made only upon surrender of
this Debenture to the Company for cancellation. Prior to any sale or other
disposition of this instrument, the Holder hereof agrees to endorse hereon the
amount of principal paid hereon and the last date to which interest has been
paid hereon and to notify the Company of the name and address of the transferee.

                  1.2      Notwithstanding anything to the contrary contained
herein, including, without limitation, Section 1.1 hereof, this Amended and
Restated 5% Convertible Senior Secured Debenture shall in no way terminate,
modify, or otherwise waive any irrevocable election executed by such Holder and
delivered to the Company providing for the Company's payment, and such Holder's
acceptance, of any and all interest payments due under this Debenture in the
form of like debentures of the Company in full satisfaction of the Company's
interest payment obligations hereunder.

                  1.3      In the event any payment of principal or interest or
both shall remain unpaid for a period of ten (10) days or more, a late charge
equivalent to five (5%) percent of each installment shall be charged. Interest
on the indebtedness evidenced by this Debenture after default or maturity
accelerated or otherwise shall be due and payable at the rate of seven (7%)
percent per annum, subject to the limitations of applicable law.

                  1.4      If this Debenture or any installment hereof becomes
due and payable on a Saturday, Sunday or public holiday under the laws of the
State of New York, the due date hereof shall be extended to the next succeeding
full business day and interest shall be payable at the rate of five (5%) percent
per annum during such extension. All payments received by the Holder shall be
applied first to the payment of all accrued interest payable hereunder.

                                   ARTICLE II

                                    SECURITY

                  2.1      The obligations of the Company under this Debenture
are secured pursuant to security interests on and collateral assignments of,
assets, tangible and intangible, of the Company granted by the Company to the
Payee pursuant to a security agreement dated as of March 10, 1998 and collateral
assignments referred to in the Purchase Agreement. In addition, each of Houba,
Inc. ("Houba"), Halsey

                                       2

Pharmaceuticals, Inc., Indiana Fine Chemicals Corporation and Cenci Powder
Products, Inc. ("CPP"), each a wholly-owned subsidiary of the Company, and H.R.
Cenci Laboratories, Inc. ("HR Cenci"), a 97% owned subsidiary of the Company
(collectively, the "Guarantors"), has executed in favor of the Holder a certain
Continuing Unconditional Guaranty, dated as of March 10, 1998, guaranteeing the
full and unconditional payment when due of the amounts payable by the Company to
the Holder pursuant to the terms of this Debenture (each a "Guaranty"). The
obligations of each Guarantor under its Guaranty are secured pursuant to
security interests on and collateral assignments of, assets, tangible and
intangible, of such Guarantor granted by the Guarantor to the Payee pursuant to
a security agreement dated March 10, 1998 and collateral assignments referred to
in the Purchase Agreement. The obligations of Houba under its Guaranty are also
secured pursuant to a Mortgage on real property located at 16235 State Road 17,
Culver, Indiana. The obligations of each of CPP and HR Cenci under their
Guaranties are also secured pursuant to a Mortgage on real property located at
152 North Broadway, Fresno, California. The rights of the Holders with respect
to the collateral described in the security agreements and collateral
assignments with the Company and the Guarantors as provided in the Purchase
Agreement are subject to the terms of the Subordination Agreement dated of even
date by and among the Company, Watson Pharmaceuticals, Inc., the Holders and the
other signatories thereto.

                                   ARTICLE III

                                   CONVERSION

                  3.1      Conversion at Option of Holder. At any time and from
time to time on and after as of March 10, 1998 (the "Initial Conversion Date")
until the earlier of (i) the Maturity Date or (ii) the conversion of the
Debenture in accordance with Section 3.2 hereof, this Debenture is convertible
in whole or in part at the Holder's option into shares of Common Stock of the
Company upon surrender of this Debenture, at the office of the Company,
accompanied by a written notice of conversion in form reasonably satisfactory to
the Company duly executed by the registered Holder or its duly authorized
attorney. "Common Stock" of the Company means common stock of the Company as it
exists on the date this Debenture is originally signed. This Debenture is
convertible on or after the Initial Conversion Date into shares of Common Stock
at a price per share of Common Stock equal to $1.404 per share (the "Conversion
Price"), as such conversion price may be adjusted as provided in Sections 3.5,
3.6 and 3.7 hereof (as so adjusted). Interest shall accrue to and including the
day prior to the date of conversion and shall be paid on the last day of the
month in which conversion rights hereunder are exercised. No fractional shares
or scrip representing fractional shares will be issued upon any conversion, but
an adjustment in cash will be made, in respect of any fraction of a share of
Common Stock which would otherwise be issuable upon the surrender of this
Debenture for conversion. The Conversion Price is subject to adjustment as
provided in Section 3.5 and Section 3.7 hereof. As soon as practicable following
conversion and upon the Holder's compliance with the conversion procedure
described in Section 3.3 hereof, the Company shall deliver a certificate for the
number of full shares of Common Stock issuable upon conversion and a check for
any fractional share and, in the event the Debenture is converted in part, a new
Debenture in the principal amount equal to the remaining principal balance of
this Debenture after giving effect to such partial conversion.

                  3.2      Conversion at Option of the Company. So long as an
Event of Default as provided in Section 12.1(a) of the Purchase Agreement
(concerning the Company's failure to pay principal and interest under the
Debentures) shall not have occurred and then be continuing, in the event that
either (a) following the second anniversary of March 10, 1998, the closing price
per share of the Company's Common Stock on the American Stock Exchange ("AMEX")
or the NASDAQ National Market ("NNM") exceeds $4.75 per share for each of twenty
(20) consecutive trading days or (b) following the third anniversary of March
10, 1998, the

                                       3

closing price per share of the Company's Common Stock on the AMEX or NNM exceeds
$7.125 per share for each of twenty (20) consecutive trading days, then at any
time thereafter until the earlier of (i) the Maturity Date, (ii) the conversion
of all of the outstanding Debentures in accordance with Section 3.1 hereof or
(iii) the date a Change of Control (as defined in the Purchase Agreement)
occurs, the Company may upon written notice to the Holders of all Debentures
(the "Mandatory Conversion Notice") require that all, but not less than all, of
the outstanding principal amount of the Debentures be converted into shares of
Common Stock at a price per share equal to the Conversion Price (as such
Conversion Price may be adjusted as provided in Sections 3.5 and 3.7 hereof).
The Mandatory Conversion Notice shall state (1) the date fixed for conversion
(the "Conversion Date") (which date shall not be prior to the date the Mandatory
Conversion Notice is given), (2) any disclosures required by law, (3) the
trading dates and closing prices of the Common Stock giving rise to the
Company's option to require conversion of the Debenture, (4) that the Debentures
shall cease to accrue interest after the day immediately preceding the
Conversion Date, (5) the place where the Debentures shall be delivered and (6)
any other instructions that Holders must follow in order to tender their
Debentures in exchange for certificates for Common Stock. No failure to mail
such notice nor any defect therein or in the mailing thereof shall affect the
validity of the proceedings for such conversion, except as to a Holder (x) to
whom notice was not mailed or (y) whose notice was defective. An affidavit of
the Secretary or an Assistant Secretary of the Company or an agent employed by
the Company that the Mandatory Conversion Notice has been mailed postage prepaid
to the last address of the Holder appearing on the Debenture registry books kept
by the Company shall, in the absence of fraud, be prima facie evidence of the
facts stated therein. On and after the Conversion Date, except as provided in
the next two sentences, Holders of the Debentures shall have no further rights
except to receive, upon surrender of the Debentures, a certificate or
certificates for the number of shares of Common Stock as to which the Debenture
shall have been converted. Interest shall accrue to and including the day prior
to the Conversion Date and shall be paid on the last day of the month in which
the Conversion Date occurs. No fractional shares or scrip representing
fractional shares will be issued upon any conversion, but an adjustment in cash
will be made, in respect of any fraction of a share of Common Stock which would
otherwise be issuable upon the surrender of this Debenture for conversion.

                  3.3      Registration of Transfer; Conversion Procedure. The
Company shall maintain books for the transfer and registration of the
Debentures. Upon the transfer of any Debenture in accordance with the provisions
of the Purchase Agreement, the Holder shall complete, execute and deliver to the
Company the Assignment attached hereto as Attachment I. Upon receipt of a
properly completed and executed Assignment in the form attached as Attachment I,
the Company shall issue and register the Debenture in the names of the new
Holders. The Debentures shall be signed manually by the Chairman, Chief
Executive Officer, President or any Vice President and the Secretary or
Assistant Secretary of the Company. The Company shall convert, from time to
time, any outstanding Debentures upon the books to be maintained by the Company
for such purpose upon surrender thereof for conversion properly endorsed and, in
the case of a conversion pursuant to Section 3.1 hereof, accompanied by a
properly completed and executed Conversion Notice attached hereto as Attachment
II. Subject to the terms of this Debenture, upon surrender of this Debenture the
Company shall issue and deliver with all reasonable dispatch to or upon the
written order of the Holder of such Debenture and in such name or names as such
Holder may designate, a certificate or certificates for the number of full
shares of Common Stock due to such Holder upon the conversion of this Debenture.
Such certificate or certificates shall be deemed to have been issued and any
person so designated to be named therein shall be deemed to have become the
Holder of record of such Shares as of the date of the surrender of this
Debenture; provided, however, that if, at the date of surrender the transfer
books of the Common Stock shall be closed, the certificates for the Shares shall
be issuable as of the date on which such books shall be opened and until such
date the Company shall be under no duty to deliver any certificate for such
Shares; provided, further, however, that such transfer books, unless otherwise
required by law or by applicable rule of any national securities exchange, shall
not be closed at any one time for a period longer than twenty (20) days.

                                       4

                  3.4      Company to Provide Common Stock. The Company shall
reserve out of its authorized but unissued shares of Common Stock a sufficient
number of shares to permit the conversion of the Debentures in full. The shares
of Common Stock which may be issued upon the conversion of the Debentures shall
be fully paid and non-assessable and free of preemptive rights. The Company will
endeavor to comply with all securities laws regulating the offer and delivery of
the Shares upon conversion of the Debentures and will endeavor to list such
shares on each national securities exchange upon which the Common Stock is
listed.

                  3.5      Dividends; Reclassifications, etc.. In the event that
the Company shall, at any time prior to the earlier to occur of (a) the exercise
of conversion rights hereunder by the Holder and (b) the Maturity Date: (i)
declare or pay to the holders of the Common Stock a dividend payable in any kind
of shares of capital stock of the Company; or (ii) change or divide or otherwise
reclassify its Common Stock into the same or a different number of shares with
or without par value, or in shares of any class or classes; or (iii) transfer
its property as an entirety or substantially as an entirety to any other company
or entity; or (iv) make any distribution of its assets to holders of its Common
Stock as a liquidation or partial liquidation dividend or by way of return of
capital; then, upon the subsequent exercise of conversion rights, the Holder
thereof shall receive, in addition to or in substitution for the shares of
Common Stock to which it would otherwise be entitled upon such exercise, such
additional shares of stock or scrip of the Company, or such reclassified shares
of stock of the Company, or such shares of the securities or property of the
Company resulting from transfer, or such assets of the Company, which it would
have been entitled to receive had it exercised these conversion rights prior to
the happening of any of the foregoing events.

                  3.6      Notice to Holder. If, at any time while this
Debenture is outstanding, the Company shall pay any dividend payable in cash or
in Common Stock, shall offer to the holders of its Common Stock for subscription
or purchase by them any shares of stock of any class or any other rights, shall
enter into an agreement to merge or consolidate with another corporation, shall
propose any capital reorganization or reclassification of the capital stock of
the Company, including any subdivision or combination of its outstanding shares
of Common Stock or there shall be contemplated a voluntary or involuntary
dissolution, liquidation or winding up of the Company, the Company shall cause
notice thereof to be mailed to the registered Holder of this Debenture at its
address appearing on the registration books of the Company, at least thirty (30)
days prior to the record date as of which holders of Common Stock shall
participate in such dividend, distribution or subscription or other rights or at
least thirty (30) days prior to the effective date of the merger, consolidation,
reorganization, reclassification or dissolution.

                  3.7      Adjustments to Conversion Price. In order to prevent
dilution of the conversion right granted hereunder, the Conversion Price shall
be subject to adjustment from time to time in accordance with this Section 3.7.
Upon each adjustment of the Conversion Price pursuant to this Section 3.7, the
Holder shall thereafter be entitled to acquire upon conversion under Section 3.1
or Section 3.2, at the Applicable Conversion Price (as hereinafter defined), the
number of shares of Common Stock obtainable by multiplying the Conversion Price
in effect immediately prior to such adjustment by the number of shares of Common
Stock acquirable immediately prior to such adjustment and dividing the product
thereof by the Applicable Conversion Price resulting from such adjustment.

                  The Conversion Price in effect at the time of the exercise of
conversion rights hereunder set forth in Section 3.1 shall be subject to
adjustment from time to time as follows:

                                       5

                           (a)      If at any time after the date of issuance
hereof the Company shall grant or issue any shares of Common Stock, or grant or
issue any rights or options for the purchase of, or stock or other securities
convertible into, Common Stock (such convertible stock or securities being
herein collectively referred to as "Convertible Securities") other than:

                                    (i)      shares issued in a transaction
         described in subsection (b) of this Section 3.7; or

                                    (ii)     shares issued, subdivided or
         combined in transactions described in Section 3.5 if and to the extent
         that the number of shares of Common Stock received upon conversion of
         this Debenture shall have been previously adjusted pursuant to Section
         3.5 as a result of such issuance, subdivision or combination of such
         securities;

for a consideration per share which is less than the Fair Market Value (as
hereinafter defined) of the Common Stock, then the Conversion Price in effect
immediately prior to such issuance or sale (the "Applicable Conversion Price")
shall, and thereafter upon each issuance or sale for a consideration per share
which is less than the Fair Market Value of the Common Stock, such Applicable
Conversion Price shall, simultaneously with such issuance or sale, be adjusted,
so that such Applicable Conversion Price shall equal a price determined by
multiplying the Applicable Conversion Price by a fraction, of which:

                  (A)      the numerator shall be the sum of (x) the total
number of shares of Common Stock outstanding when the Applicable Conversion
Price became effective, plus (y) the number of shares of Common Stock which the
aggregate consideration received, as determined in accordance with subsection
3.7(c) for the issuance or sale of such additional Common Stock or Convertible
Securities deemed to be an issuance of Common Stock as provided in subsection
3.7(d), would purchase (including any consideration received by the Company upon
the issuance of any shares of Common Stock since the date the Applicable
Conversion Price became effective not previously included in any computation
resulting in an adjustment pursuant to this Section 3.7(a)) at the Fair Market
Value of the Common Stock; and

                  (B)      the denominator shall be the total number of shares
of Common Stock outstanding (or deemed to be outstanding as provided in
subsection 3.7(d) hereof) immediately after the issuance or sale of such
additional shares.

                  For purposes of this Section 3.7, "Fair Market Value" shall
mean the average of the closing price of the Common Stock for each of the twenty
(20) consecutive trading days prior to such issuance or sale on the principal
national securities exchange on which the Common Stock is traded, or if shares
of Common Stock are not listed on a national securities exchange during such
period, the closing price per share as reported by the National Association of
Securities Dealers Automatic Quotation System ("NASDAQ") National Market System
if the shares are quoted on such system during such period, or the average of
the bid and asked prices of the Common Stock in the over-the-counter market at
the close of trading during such period if the shares are not traded on an
exchange or listed on the NASDAQ National Market System, or if the Common Stock
is not traded on a national securities exchange or in the over-the-counter
market, the fair market value of a share of Common Stock during such period as
determined in good faith by the Board of Directors.

                  If, however, the Applicable Conversion Price thus obtained
would result in the issuance of a lesser number of shares upon conversion than
would be issued at the initial Conversion Price specified in Section 3.1, as
appropriate, the Applicable Conversion Price shall be such initial Conversion
Price.

                                       6

                  Upon each adjustment of the Conversion Price pursuant to this
subsection (a), the total number of shares of Common Stock into which this
Debenture shall be convertible shall be such number of shares (calculated to the
nearest tenth) purchasable at the Applicable Conversion Price multiplied by a
fraction, the numerator of which shall be the Conversion Price in effect
immediately prior to such adjustment and the denominator of which shall be the
Conversion Price in effect immediately after such adjustment.

                           (b)      Anything in this Section 3.7 to the contrary
notwithstanding, no adjustment in the Conversion Price shall be made in
connection with:

                  (i)      the grant, issuance or exercise of any Convertible
                  Securities pursuant to the Company's qualified or
                  non-qualified Employee Stock Option Plans or any other bona
                  fide employee benefit plan or incentive arrangement, adopted
                  or approved by the Company's Board of Directors and approved
                  by the Company's shareholders, as may be amended from time to
                  time, or under any other bona fide employee benefit plan
                  hereafter adopted by the Company's Board of Directors; or

                  (ii)     the grant, issuance or exercise of any Convertible
                  Securities in connection with the hire or retention of any
                  officer, director or key employee of the Company, provided
                  such grant is approved by the Company's Board of Directors; or

                  (iii)    the issuance of any shares of Common Stock pursuant
                  to the grant or exercise of Convertible Securities outstanding
                  as of March 10, 1998 (exclusive of any subsequent amendments
                  thereto).

                           (c)      For the purpose of subsection 3.7(a), the
following provisions shall also be applied:

                  (i)      In case of the issuance or sale of additional shares
                  of Common Stock for cash, the consideration received by the
                  Company therefor shall be deemed to be the amount of cash
                  received by the Company for such shares, before deducting
                  therefrom any commissions, compensation or other expenses paid
                  or incurred by the Company for any underwriting of, or
                  otherwise in connection with, the issuance or sale of such
                  shares.

                  (ii)     In the case of the issuance of Convertible
                  Securities, the consideration received by the Company therefor
                  shall be deemed to be the amount of cash, if any, received by
                  the Company for the issuance of such rights or options, plus
                  the minimum amounts of cash and fair value of other
                  consideration, if any, payable to the Company upon the
                  exercise of such rights or options or payable to the Company
                  upon conversion of such Convertible Securities.

                  (iii)    In the case of the issuance of shares of Common Stock
                  or Convertible Securities for a consideration in whole or in
                  part, other than cash, the consideration other than cash shall
                  be deemed to be the fair market value thereof as reasonably
                  determined in good faith by the Board of Directors of the
                  Company (irrespective of accounting treatment thereof);
                  provided, however, that if such consideration consists of the
                  cancellation of debt issued by the Company, the consideration
                  shall be deemed to be the amount the Company received upon
                  issuance of such debt (gross proceeds) plus accrued interest
                  and, in the case of original issue discount or zero coupon
                  indebtedness, accrued value to the date of such cancellation,
                  but not

                                       7

                  including any premium or discount at which the debt may then
                  be trading or which might otherwise be appropriate for such
                  class of debt.

                  (iv)     In case of the issuance of additional shares of
                  Common Stock upon the conversion or exchange of any
                  obligations (other than Convertible Securities), the amount of
                  the consideration received by the Company for such Common
                  Stock shall be deemed to be the consideration received by the
                  Company for such obligations or shares so converted or
                  exchanged, before deducting from such consideration so
                  received by the Company any expenses or commissions or
                  compensation incurred or paid by the Company for any
                  underwriting of, or otherwise in connection with, the issuance
                  or sale of such obligations or shares, plus any consideration
                  received by the Company in connection with such conversion or
                  exchange other than a payment in adjustment of interest and
                  dividends. If obligations or shares of the same class or
                  series of a class as the obligations or shares so converted or
                  exchanged have been originally issued for different amounts of
                  consideration, then the amount of consideration received by
                  the Company upon the original issuance of each of the
                  obligations or shares so converted or exchanged shall be
                  deemed to be the average amount of the consideration received
                  by the Company upon the original issuance of all such
                  obligations or shares. The amount of consideration received by
                  the Company upon the original issuance of the obligations or
                  shares so converted or exchanged and the amount of the
                  consideration, if any, other than such obligations or shares,
                  received by the Company upon such conversion or exchange shall
                  be determined in the same manner as provided in paragraphs (i)
                  and (ii) above with respect to the consideration received by
                  the Company in case of the issuance of additional shares of
                  Common Stock or Convertible Securities.

                  (v)      In the case of the issuance of additional shares of
                  Common Stock as a dividend, the aggregate number of shares of
                  Common Stock issued in payment of such dividend shall be
                  deemed to have been issued at the close of business on the
                  record date fixed for the determination of stockholders
                  entitled to such dividend and shall be deemed to have been
                  issued without consideration; provided, however, that if the
                  Company, after fixing such record date, shall legally abandon
                  its plan to so issue Common Stock as a dividend, no adjustment
                  of the Applicable Conversion Price shall be required by reason
                  of the fixing of such record date.

                           (d)      For purposes of the adjustment provided for
in subsection 3.7(a) above, if at any time the Company shall issue any
Convertible Securities, the Company shall be deemed to have issued at the time
of the issuance of such Convertible Securities the maximum number of shares of
Common Stock issuable upon conversion of the total amount of such Convertible
Securities.

                           (e)      On the expiration, cancellation or
redemption of any Convertible Securities, the Conversion Price then in effect
hereunder shall forthwith be readjusted to such Conversion Price as would have
been obtained (a) had the adjustments made upon the issuance or sale of such
expired, canceled or redeemed Convertible Securities been made upon the basis of
the issuance of only the number of shares of Common Stock theretofore actually
delivered upon the exercise or conversion of such Convertible Securities (and
the total consideration received therefor) and (b) had all subsequent
adjustments been made on only the basis of the Conversion Price as readjusted
under this subsection 3.7(e) for all transactions (which would have affected
such adjusted Conversion Price) made after the issuance or sale of such
Convertible Securities.

                                       8

                           (f)      Anything in this Section 3.7 to the contrary
notwithstanding, no adjustment in the Conversion Price shall be required unless
such adjustment would require an increase or decrease of at least 1% in such
Conversion Price; provided, however, that any adjustments which by reason of
this subsection 3.7(f) are not required to be made shall be carried forward and
taken into account in making subsequent adjustments. All calculations under this
Section 3.7 shall be made to the nearest cent.

                           (g)      Upon any adjustment of any Conversion Price,
then and in each such case the Company shall promptly deliver a notice to the
registered Holder of this Debenture, which notice shall state the Conversion
Price resulting from such adjustment, setting forth in reasonable detail the
method of calculation and the facts upon which such calculation is based.

                  3.8      Reorganization of the Company. If the Company is a
party to a merger or other transaction which reclassifies or changes its
outstanding Common Stock, upon consummation of such transaction this Debenture
shall automatically become convertible into the kind and amount of securities,
cash or other assets which the Holder of this Debenture would have owned
immediately after such transaction if the Holder had converted this Debenture at
the Conversion Price in effect immediately before the effective date of the
transaction. Concurrently with the consummation of such transaction, the person
obligated to issue securities or deliver cash or other assets upon conversion of
this Debenture shall execute and deliver to the Holder a supplemental Debenture
so providing and further providing for adjustments which shall be as nearly
equivalent as may be practical to the adjustments provided in this Article III.
The successor Company shall mail to the Holder a notice describing the
supplemental Debenture.

                  If securities deliverable upon conversion of this Debenture,
as provided above, are themselves convertible into the securities of an
affiliate of a corporation formed, surviving or otherwise affected by the merger
or other transaction, that issuer shall join in the supplemental Debenture which
shall so provide. If this section applies, Section 3.5 does not apply.

                                   ARTICLE IV

                                  MISCELLANEOUS

                  4.1      Default. Upon the occurrence of any one or more of
the events of default specified or referred to in the Purchase Agreement or in
the other documents or instruments executed in connection therewith, all amounts
then remaining unpaid on this Debenture may be declared to be immediately due
and payable as provided in the Purchase Agreement.

                  4.2      Collection Costs. In the event that this Debenture
shall be placed in the hands of an attorney for collection by reason of any
event of default hereunder, the undersigned agrees to pay reasonable attorney's
fees and disbursements and other reasonable expenses incurred by the Holder in
connection with the collection of this Debenture.

                  4.3      Rights Cumulative. The rights, powers and remedies
given to the Payee under this Debenture shall be in addition to all rights,
powers and remedies given to it by virtue of the Purchase Agreement, any
document or instrument executed in connection therewith, or any statute or rule
of law.

                  4.4      No Waivers. Any forbearance, failure or delay by the
Payee in exercising any right, power or remedy under this Debenture, the
Purchase Agreement, any documents or instruments executed in connection
therewith or otherwise available to the Payee shall not be deemed to be a waiver
of such right,

                                       9

power or remedy, nor shall any single or partial exercise of any right, power or
remedy preclude the further exercise thereof.

                  4.5      Amendments in Writing. Except as expressly provided
in the Purchase Agreement, no modification or waiver of any provision of this
Debenture or any documents or instruments executed in connection herewith shall
be effective unless it shall be in writing and signed by the Payee, and any such
modification or waiver shall apply only in the specific instance for which
given.

                  4.6      Governing Law. This Debenture and the rights and
obligations of the parties hereto, shall be governed, construed and interpreted
according to the laws of the State of New York, wherein it was negotiated and
executed, and the undersigned consents and agrees that the State and Federal
Courts which sit in the State of New York, County of New York shall have
exclusive jurisdiction of all controversies and disputes arising hereunder.

                  4.7      No Counterclaims. The undersigned waives the right to
interpose counterclaims or set-offs of any kind and description in any
litigation arising hereunder and waives the right in any litigation with the
Payee (whether or not arising out of or relating to this Debenture) to trial by
jury.

                  4.8      Successors. The term "Payee" and "Holder" as used
herein shall be deemed to include the Payee and its successors, endorsees and
assigns.

                  4.9      Certain Waivers. The Company hereby waives
presentment, demand for payment, protest, notice of protest and notice of
non-payment hereof.

                  4.10     Stamp Tax. The Company will pay any documentary stamp
taxes attributable to the initial issuance of the Common Stock issuable upon the
conversion of this Debenture; provided, however, that the Company shall not be
required to pay any tax or taxes which may be payable in respect of any transfer
involved in the issuance or delivery of any certificates for the Common Stock in
a name other than that of the Holder in respect of which such Common Stock is
issued, and in such case the Company shall not be required to issue or deliver
any certificate for the Common Stock until the person requesting the same has
paid to the Company the amount of such tax or has established to the Company's
satisfaction that such tax has been paid.

                  4.11     Mutilated, Lost, Stolen or Destroyed Debentures. In
case this Debenture shall be mutilated, lost, stolen or destroyed, the Company
shall issue and deliver in exchange and substitution for and upon cancellation
of the mutilated Debenture, or in lieu of and substitution for the Debenture,
mutilated, lost, stolen or destroyed, a new Debenture of like tenor and
representing an equivalent right or interest, but only upon receipt of evidence
satisfactory to the Company of such loss, theft or destruction and an indemnity,
if requested, also satisfactory to it.

                  4.12     Maintenance of Office. The Company covenants and
agrees that so long as this Debenture shall be outstanding, it will maintain an
office or agency in New York (or such other place as the Company may designate
in writing to the holder of this Debenture) where notices, presentations and
demands to or upon the Company in respect of this Debenture may be given or
made.

                  4.13     Amended and Restated Debenture. This Amended and
Restated 5% Convertible Senior Secured Debenture dated as of December ___, 2002
issued by the Company in favor of the Payee is issued in accordance with that
certain Amendment to Debenture and Warrant Purchase Agreement dated as December
__, 2002 between the Company and the Purchasers listed on the signature page
thereto (the

                                       10

"Amendment") and amends and restates in their entirety, and is issued by the
Company in replacement of and substitution for, each of those certain 5%
Convertible Senior Secured Debenture instruments described on Schedule A,
attached hereto, issued by the Company to the Payee (collectively, the "Original
Debentures"). The Company and the Payee acknowledge and agree that upon the
execution delivery of this Amended and Restated 5% Convertible Senior Secured
Debenture due March 31, 2006, each of the Original Debentures shall be null and
void and of no further legal force or effect.

                                       11

                  IN WITNESS WHEREOF, Halsey Drug Co., Inc. has caused this
Debenture to be signed by its Chief Executive Officer and to be dated the day
and year first above written.

ATTEST [SEAL]                             HALSEY DRUG CO., INC.

______________________________            By:___________________________________
                                                 Name: Michael Reicher
                                                 Title: Chief Executive Officer

                                       12

                                  ATTACHMENT I

                                   Assignment

         For value received, the undersigned hereby assigns subject to the
provisions of Section of the Purchase Agreement, to ________ $_______________
principal amount of the Amended and Restated 5% Convertible Senior Secured
Debenture due March 31, 2006 evidenced hereby and hereby irrevocably
appoint ______________ attorney to transfer the Debenture on the books of the
within named corporation with full power of substitution in the premises.

Dated:

In the presence of:

________________________      _______________________

                                       13

                                  ATTACHMENT II

                                CONVERSION NOTICE

                    TO:   HALSEY DRUG CO., INC.

         The undersigned holder of this Debenture hereby irrevocably exercises
the option to convert $ ______ principal amount of such Debenture (which may be
less than the stated principal amount thereof) into shares of Common Stock of
Halsey Drug Co., Inc., in accordance with the terms of such Debenture, and
directs that the shares of Common Stock issuable and deliverable upon such
conversion, together with a check (if applicable) in payment for any fractional
shares as provided in such Debenture, be issued and delivered to the undersigned
unless a different name has been indicated below. If shares of Common Stock are
to be issued in the name of a person other than the undersigned holder of such
Debenture, the undersigned will pay all transfer taxes payable with respect
thereto.

                             ___________________________________________________
                                      Name and address of Holder

                             ___________________________________________________
                                      Signature of Holder

         Principal amount of Debenture to be converted $________________________

         If shares are to be issued otherwise then to the holder:

___________________________
Name of Transferee
                                          Address of Transferee

                                          ______________________________________

                                          ______________________________________

                                          ______________________________________

                                          Social Security Number of Transferee

                                          ______________________________________

                                       14


                                                                   EXHIBIT 10.11

                                SECOND AMENDMENT

                                       TO

                                 LOAN AGREEMENT

         THIS SECOND AMENDMENT TO LOAN AGREEMENT, dated as of December 20, 2002
(the "Second Amendment"), is made and entered into by and between Halsey Drug
Co., Inc., a New York corporation ("Borrower"), and Watson Pharmaceuticals,
Inc., a Nevada corporation ("Lender").

                                    RECITALS

         WHEREAS, Borrower and Lender are parties to that certain Loan
Agreement, dated as of March 29, 2000, as amended by a certain Amendment to Loan
Agreement dated as of March 31, 2000 (as so amended, the "Loan Agreement"); and

         WHEREAS, pursuant to a certain Debenture Purchase Agreement dated of
even date herewith (the "2002 Purchase Agreement") executed by Borrower in favor
of the several purchasers named therein (the "Purchasers"), Borrower will issue
its 5% Convertible Senior Secured Debentures due March 31, 2006 in the aggregate
principal amount of up to approximately $35,000,000 (the "2002 Debentures"); and

         WHEREAS, as a condition to their investment in the 2002 Debentures, the
Purchasers have required that Lender amend the Loan Agreement to extend the
maturity date of the Loan Agreement from March 31, 2003 to March 31, 2006; and

         WHEREAS, as a condition to its agreement to so extend the Maturity
Date, the Lender has required that (i) the $3,901,331 principal amount of
Borrower's payment obligations to Watson as of the date hereof under that
certain Core Products Supply Agreement (as hereinafter defined) be added to the
Borrower's secured Obligations under the Loan Agreement (such new obligations,
the "New Obligations"), and (ii) that the interest rate on both the $17,500,000
principal amount currently outstanding pursuant to the Loan Agreement be
increased to the interest rate on the New Obligations; and

         NOW, THEREFORE, the parties hereto agree as follows.

                                    AGREEMENT

         1.       Article One of the Loan Agreement is hereby amended in its
entirety to read as follows:

              "1. AMOUNT AND TERMS OF LOAN.

                  1.1      Term Loans. Subject to the terms herein, Lender has
         previously loaned to Borrower the aggregate principal amount of
         Seventeen Million Five Hundred Thousand Dollars ($17,500,000), and, as
         described in this Second Amendment, is adding to such principal amount
         the additional principal amount of Three Million Nine Hundred and One
         Thousand Three Hundred Thirty One Dollars ($3,901,331), representing
         excess payments made by Lender to Borrower pursuant to that certain
         Finished Goods Supply Agreement (Core Products), as defined and
         provided in Section 12.15 hereof (collectively, the "Loan").
         Notwithstanding any prepayment of the Loan by Borrower, sums repaid
         hereunder may not be re-borrowed.

                  1.2      Promissory Notes. Borrower's obligation to pay the
         principal of, and interest on, the Loan shall be evidenced by two
         secured promissory notes (the "Notes"), duly executed and delivered by
         Borrower, the first such Note (the "Replacement Note") to be in the
         form attached as Exhibit A to this Second Amendment and representing
         the $17,500,000 principal balance originally loaned to Borrower
         pursuant to the Loan Agreement, and the second such Note (the "New
         Note") to be in the form attached as Exhibit B to this Second Amendment
         and representing the $3,901,331 principal balance being added to the
         Obligations as described in this Second Amendment. Upon execution and
         delivery of the Replacement Note, the Secured Promissory Note dated
         March 31, 2000 issued by Borrower to Lender in the principal amount of
         $17,500,000 shall be null and void and of no further legal force or
         effect."

         2.       The definition of "Obligations" set forth in Section 12.1 of
the Loan Agreement is hereby amended in its entirety to read as follows:

              " 'Obligations' shall mean all obligations, liabilities and
         indebtedness of every kind, nature and description of the Borrower and
         the Guarantors from time to time owing to the Lender or any Indemnitee
         under or in connection with the Loan Documents and the New

                                       2

         Note, whether direct or indirect, primary or secondary, joint or
         several, absolute or contingent, due or to become due, now existing or
         hereafter arising and however acquired and shall include, without
         limitation, all principal and interest on the Loan and, to the extent
         chargeable under any Loan Document or the New Note, all charges,
         expenses, fees and reasonable attorney's fees."

         3.       A new Section 12.15 is hereby added to the Loan Agreement as
follows:

              "12.15 Core Products Supply Agreement. Borrower and Lender are
         parties to a certain Finished Goods Supply Agreement (Core Products)
         dated March 29, 2000 (the "Original Core Products Supply Agreement"),
         as amended by that certain Amendment and Supplement No. 1 to Finished
         Goods Supply Agreement (Core Products) dated as of August 8, 2001 (the
         "Amendment to Core Products Supply Agreement," and together with the
         Original Core Products Supply Agreement as so amended, the "Core
         Products Supply Agreement"). In accordance with the terms of the
         Original Core Products Supply Agreement, Lender made certain minimum
         quarterly payments to Borrower resulting in payments to Borrower
         exceeding the purchase price of the quantities of products provided by
         Borrower to Lender under the Core Products Supply Agreement. As a
         result, Borrower and Lender executed the Amendment to Core Products
         Supply Agreement providing, among other items, (i) for the parties'
         agreement on the amount by which Lender's aggregate minimum quarterly
         payments made through and including the quarter ended December 31, 2000
         exceeded the aggregate purchase price of the products supplied by
         Borrower during such period (the "Excess Payments"), and (ii) for
         Borrower's repayment obligation to Lender of the Excess Payments.
         Borrower and Lender acknowledge and agree that the outstanding balance
         of the Excess Payments as of December 20, 2002 equals Three Million
         Nine Hundred and One Thousand Three Hundred Thirty One Dollars
         ($3,901,331) (the "Core Products Amount"). In accordance with the terms
         of Article One hereof, the Core Products Amount has been added to the
         Obligations of Borrower hereunder. On the date of execution by the
         parties of the Second Amendment, Borrower shall execute and deliver to
         Lender the New Note, which shall evidence the New Obligations. Borrower
         and Lender covenant and agree to execute the Second Amendment to
         Finished Goods Supply Agreement (Core Products) in the form attached as
         Exhibit C to the Second Amendment in order to give effect to the terms
         of this Section 12.15."

                                       3

         4.       Limitation of Amendment. Except as amended above, the terms of
the Loan Agreement shall remain in full force and effect.

         5.       Governing Law. This Second Amendment and the rights of the
parties hereunder shall be governed in all respects by the laws of the State of
California wherein the terms of this Second Amendment were negotiated.

         6.       Counterparts. This Second Amendment may be executed in any
number of counterparts, each of which shall be an original, but all of which
together shall constitute one instrument.

         IN WITNESS WHEREOF, Borrower and Lender have caused this Second
Amendment to be duly executed by their duly authorized officers all as of the
day and year first above written.

"BORROWER"                                  "LENDER"

HALSEY DRUG CO., INC.                       WATSON PHARMACEUTICALS, INC.

By:____________________________             By:_________________________________
Name:  Michael Reicher                      Name:  _____________________________
Title: Chief Executive Officer              Title: _____________________________

                                       4

                                    EXHIBIT A

                                Replacement Note

                                    EXHIBIT B

                                    New Note

                                    EXHIBIT C

                          Second Amendment to Finished
                     Goods Supply Agreement (Core Products)


                                                                   EXHIBIT 10.12

                             SECURED PROMISSORY NOTE

$17,500,000                                                   December 20, 2002
                                                              Corona, California

1.       Promise to Pay. For good and valuable consideration, the receipt of
which is hereby acknowledged, HALSEY DRUG CO., INC., a New York corporation
("Maker"), promises to pay to WATSON PHARMACEUTICALS, INC., a Nevada corporation
("Watson"), or order (either, the "Holder"), on the Maturity Date (as defined
below), unless sooner paid as provided in Section 4 hereof, the principal sum of
Seventeen Million Five Hundred Thousand Dollars ($17,500,000), plus accrued
unpaid interest thereon. The outstanding principal balance of this Note shall
bear interest at a variable rate equal to the prime rate announced from time to
time by Bank of America (the "Prime Rate") plus four and one-half percent (4.5%)
per annum (the "Interest Rate") from the date such principal amount becomes
outstanding to the date the principal sum is paid in full; provided, however,
that if this Note is not paid in full on the Maturity Date, the unpaid balance
of the Note shall bear interest therefrom and until paid at the Default Rate (as
defined below). Payments of interest shall be due on the each March 31, June 30,
September 30 and December 31 during the term of this Note commencing December
31, 2002. All payments under this Note shall be made to the order of the Holder
at 311 Bonnie Circle, Corona, California, 92880, or such other address as Holder
may designate in writing to Maker, in U.S. dollars, and shall be applied first
to accrued unpaid interest, if any, and then to principal.

2.       Maturity Date. The date that this Note shall mature, and the principal
amount outstanding hereunder, plus accrued unpaid interest thereon and any
charges pertaining thereto, shall become due and payable (the "Maturity Date")
shall be March 31, 2006.

3.       Loan and Security Agreements. Maker and Watson are party to that
certain Loan Agreement, dated as of March 29, 2000, as amended by that certain
Amendment to Loan Agreement dated as of March 31, 2000 and as further amended by
that certain Second Amendment to Loan Agreement dated as of December 20, 2002
(as so amended, the "Loan Agreement"). The full and punctual payment and
performance of this Note by Maker are secured and guaranteed by the Company
General Security Agreement, the Company Collateral Assignments, the Stock Pledge
Agreement, the Guaranties, the Guarantors Security Agreement, the Guarantor
Collateral Assignments and the Mortgage, as those terms are defined in the Loan
Agreement (the "Security Agreements"). The security interest granted to Holder
under the Security Agreements extends to the proceeds of any sale or other
transfer or disposition of such assets, whether by Maker, its affiliates, the
Holder or any other person, that occurs prior to the payment in full of this
Note. Copies of the Loan Agreement and the Security Agreements may be obtained
from Maker without charge.

4.       Prepayments. Maker may voluntarily prepay this Note either in whole or
in part without penalty or premium.

5.       Waivers. Maker hereby waives diligence, presentment for payment,
demand, protest, notice of non-payment, notice of dishonor, notice of protest,
and any and all other notices and demands whatsoever. Maker shall remain bound
under this Note until all principal and interest and any other amounts that are
payable hereunder or under the Loan Agreement or the Security Agreements have
been paid in full, notwithstanding any extensions or renewals granted with
respect to this Note or the release of any party liable hereunder or any
security for the payment of this Note. Maker, and any and all endorsers hereof,
also waive the right to plead any and all statutes of limitations as a defense
to any demand on this Note or any and all obligations or liabilities arising out
of or in connection with this Note, the Loan Agreement or the Security
Agreements, to the fullest extent permitted by law.

6.       Events of Default. Any of the following events shall constitute an
event of default by Maker under this Note (an "Event of Default"):

         (a)      the failure of Maker to pay to Holder, on the Maturity Date,
any and all principal amounts due and owing under this Note;

         (b)      the failure of Maker to pay to Holder interest payments when
due; or

         (c)      there occurs any other event or circumstance that constitutes
an "Event of Default" as defined in Section 9.1 of the Loan Agreement.

Upon the occurrence of any Event of Default, as defined hereinabove, at Holder's
option, Holder may declare immediately due and payable, and on any such
declaration there shall become immediately due and payable, the entire unpaid
principal balance of this Note, together with all accrued and unpaid interest
under this Note and any other sums owing at the time of such declaration
pursuant to this Note, the Loan Agreement or the Security Agreements, and Holder
shall be entitled to exercise all rights and remedies available to Holder under
this Note, under the Loan Agreement and the Security Agreements and under
applicable law, all of which rights and remedies shall be cumulative. Without
limiting the generality of the foregoing, upon the occurrence of an Event of
Default, the interest rate at which interest shall accrue on the principal sum
and any other amounts that are due under this Note shall increase to the lower
of (i) the Prime Rate plus six and one-half percent (6.5%) per annum or (ii) the
maximum interest rate permitted under applicable law (the "Default Rate"), until
all such amounts have been paid in full.

7.       No Waiver by Holder. Any delay or omission on the part of Holder to
exercise any of Holder's rights or remedies hereunder, under the Loan Agreement
or the Security Agreements or under applicable law, including, without
limitation, the right to accelerate amounts owing under this Note, shall not be
deemed a waiver of that right or remedy or of any other right or remedy of
Holder in respect thereof. The acceptance by Holder of any payment pursuant to
the terms of this Note which is less than payment in full of all

                                        2

amounts due and payable at the time of such payment shall not constitute a
waiver of the right to exercise any of the Holder's rights or remedies under
this Note, the Loan Agreement, the Security Agreements or under applicable law
at that time or at any subsequent time or nullify any prior exercise of any such
rights or remedies without the express written consent of Holder, except as and
to the extent provided to the contrary by applicable law.

8.       Governing Law. This Note shall be governed by and construed
according to and enforced under the internal laws of the State of California
without giving effect to its choice of laws rules.

9.       Enforcement of the Note. Maker agrees that the Superior Court in and
for the County of Orange, California shall have exclusive jurisdiction over any
disputes, between the Maker and Holder and any action, suit or other proceeding
brought by Maker or Holder relating to the interpretation or enforcement of this
Note, and Maker agrees as follows: (a) Maker shall accept and not contest the
personal or subject matter jurisdiction of such Court; (b) Maker shall accept
and not object to or challenge the venue of such Court or assert the doctrine of
forum non conveniens with respect to such Court; (c) Maker shall accept and not
contest the validity or effectiveness of service of process in any such action,
suit or other proceeding by registered or certified first class mail; and (d) TO
THE MAXIMUM EXTENT PERMITTED BY LAW, MAKER WAIVES AND SHALL WAIVE ANY RIGHT TO A
TRIAL BY JURY IN ANY ACTION OR OTHER PROCEEDING BROUGHT WITH RESPECT TO THIS
NOTE OR ITS ENFORCEMENT OR INTERPRETATION. If Maker fails to pay any amounts due
hereunder when due, or if an Event of Default occurs, then Maker shall pay all
costs of enforcement and collection, including, without limitation, reasonable
attorneys' fees and costs incurred by Holder, whether or not enforcement and
collection includes the filing of a lawsuit, and whether or not that lawsuit is
prosecuted to judgment. The costs of enforcement and collection shall be added
to the principal amount of the Note and shall accrue interest at the Default
Rate from the date incurred by Holder to the date paid by Maker.

10.      Binding Nature. The provisions of this Note shall be binding on Maker
and shall inure to the benefit of Holder.

11.      Usury Savings Provisions. In the event Holder receives any sums under
this Note which constitute interest in an amount in excess of that permitted by
any applicable law, then, all such sums constituting interest in excess of that
permitted to be paid under applicable law shall, at Holder's option, either be
credited to the payment of principal owing hereunder or returned to Maker. The
provisions of this Section 11 control the other provisions of this Note and any
other agreement between Maker and Holder.

12.      Severability. If, but only to the extent that, any provision of this
Note shall be invalid or unenforceable, then, such offending provision shall be
deleted from this Note, but only to the extent necessary to preserve the
validity and effectiveness of this Note to the fullest extent permitted by
applicable law.

                                        3

13.      Interpretation. No provision of this Note shall be interpreted for or
against Maker or Holder because that person or that person's legal
representative drafted such provision. Unless otherwise indicated elsewhere in
this Note, (a) the term "or" shall not be exclusive, (b) the term "including"
shall mean "including, but not limited to," and (c) the terms "below," "above,"
"herein," "hereof," "hereto," "hereunder" and other terms similar to such terms
shall refer to this Note as a whole and not merely to the specific section,
subsection, paragraph or clause where such terms may appear. The section and
sub-section headings in this Note are included for convenience of reference only
and shall be ignored in the construction or interpretation of this Note.

14.      Replacement Note. This Note is issued in accordance with that certain
Second Amendment to Loan Agreement dated as of December 20, 2002, between Maker
and Watson (the "Second Amendment"), and is issued by Maker in replacement of
and substitution for, and represents the agreement of Maker and Watson to
increase the interest rate on, and extend the maturity date of, that certain
Secured Promissory Note issued by Maker to Watson in the principal amount of
$17,500,000 dated March 31, 2000 (the "Original Note"). Upon execution and
delivery of this Secured Promissory Note to Watson, the Original Note shall be
null and void and of no further legal force or effect.

                           [SIGNATURE PAGE TO FOLLOW]

                                        4

                                                   "MAKER"

                                                   HALSEY DRUG CO., INC.

                                                   ___________________________
                                                   By:  Michael Reicher
                                                   Its: Chief Executive Officer

                                        5


                                                                   EXHIBIT 10.13

                             SECURED PROMISSORY NOTE

$3,901,331                                                    December 20, 2002
                                                              Corona, California

1.       Promise to Pay. For good and valuable consideration, the receipt of
which is hereby acknowledged, HALSEY DRUG CO., INC., a New York corporation
("Maker"), promises to pay to WATSON PHARMACEUTICALS, INC., a Nevada corporation
("Watson"), or order (either, the "Holder"), on the Maturity Date (as defined
below), unless sooner paid as provided in Section 4 hereof, the principal sum of
Three Million Nine Hundred and One Thousand Three Hundred Thirty One Dollars
($3,901,331), plus accrued unpaid interest thereon. The outstanding principal
balance of this Note shall bear interest at a variable rate equal to the prime
rate announced from time to time by Bank of America (the "Prime Rate") plus four
and one-half percent (4.5%) per annum (the "Interest Rate") from the date such
principal amount becomes outstanding to the date the principal sum is paid in
full; provided, however, that if this Note is not paid in full on the Maturity
Date, the unpaid balance of the Note shall bear interest therefrom and until
paid at the Default Rate (as defined below). Payments of interest shall be due
on the each March 31, June 30, September 30 and December 31 during the term of
this Note commencing December 31, 2002. All payments under this Note shall be
made to the order of the Holder at 311 Bonnie Circle, Corona, California, 92880,
or such other address as Holder may designate in writing to Maker, in U.S.
dollars, and shall be applied first to accrued unpaid interest, if any, and then
to principal.

2.       Maturity Date. The date that this Note shall mature, and the principal
amount outstanding hereunder, plus accrued unpaid interest thereon and any
charges pertaining thereto, shall become due and payable (the "Maturity Date")
shall be March 31, 2006.

3.       Loan and Security Agreements. Maker and Watson are party to that
certain Loan Agreement, dated as of March 29, 2000, as amended by that certain
Amendment to Loan Agreement dated as of March 31, 2000 and as further amended by
that certain Second Amendment to Loan Agreement dated as of December 20, 2002
(as so amended, the "Loan Agreement"). This Note is being issued pursuant to
said Second Amendment, and it is the intention of the Maker and Watson that the
full and punctual payment and performance of this Note by Maker be secured and
guaranteed by the Company General Security Agreement, the Company Collateral
Assignments, the Stock Pledge Agreement, the Guaranties, the Guarantors Security
Agreement, the Guarantor Collateral Assignments and the Mortgage, as those terms
are defined in the Loan Agreement (the "Security Agreements"). The security
interest granted to Holder under the Security Agreements extends to the proceeds
of any sale or other transfer or disposition of such assets, whether by Maker,
its affiliates, the Holder or any other person, that occurs prior to the payment
in full of this Note. Copies of the Loan Agreement and the Security Agreements
may be obtained from Maker without charge.

4.       Prepayments. Maker may voluntarily prepay this Note either in whole or
in part without penalty or premium.

5.       Waivers. Maker hereby waives diligence, presentment for payment,
demand, protest, notice of non-payment, notice of dishonor, notice of protest,
and any and all other notices and demands whatsoever. Maker shall remain bound
under this Note until all principal and interest and any other amounts that are
payable hereunder or under the Loan Agreement or the Security Agreements have
been paid in full, notwithstanding any extensions or renewals granted with
respect to this Note or the release of any party liable hereunder or any
security for the payment of this Note. Maker, and any and all endorsers hereof,
also waive the right to plead any and all statutes of limitations as a defense
to any demand on this Note or any and all obligations or liabilities arising out
of or in connection with this Note, the Loan Agreement or the Security
Agreements, to the fullest extent permitted by law.

6.       Events of Default. Any of the following events shall constitute an
event of default by Maker under this Note (an "Event of Default"):

         (a)      the failure of Maker to pay to Holder, on the Maturity Date,
any and all principal amounts due and owing under this Note;

         (b)      the failure of Maker to pay to Holder interest payments when
due; or

         (c)      there occurs any other event or circumstance that constitutes
an "Event of Default" as defined in Section 9.1 of the Loan Agreement.

Upon the occurrence of any Event of Default, as defined hereinabove, at Holder's
option, Holder may declare immediately due and payable, and on any such
declaration there shall become immediately due and payable, the entire unpaid
principal balance of this Note, together with all accrued and unpaid interest
under this Note and any other sums owing at the time of such declaration
pursuant to this Note, the Loan Agreement or the Security Agreements, and Holder
shall be entitled to exercise all rights and remedies available to Holder under
this Note, under the Loan Agreement and the Security Agreements and under
applicable law, all of which rights and remedies shall be cumulative. Without
limiting the generality of the foregoing, upon the occurrence of an Event of
Default, the interest rate at which interest shall accrue on the principal sum
and any other amounts that are due under this Note shall increase to the lower
of (i) the Prime Rate plus six and one-half percent (6.5%) per annum or (ii) the
maximum interest rate permitted under applicable law (the "Default Rate"), until
all such amounts have been paid in full.

7.       No Waiver by Holder. Any delay or omission on the part of Holder to
exercise any of Holder's rights or remedies hereunder, under the Loan Agreement
or the Security Agreements or under applicable law, including, without
limitation, the right to accelerate amounts owing under this Note, shall not be
deemed a waiver of that right or remedy or of any other right or remedy of
Holder in respect thereof. The acceptance by Holder of any payment pursuant to
the terms of this Note which is less than payment in full of all

                                        2

amounts due and payable at the time of such payment shall not constitute a
waiver of the right to exercise any of the Holder's rights or remedies under
this Note, the Loan Agreement, the Security Agreements or under applicable law
at that time or at any subsequent time or nullify any prior exercise of any such
rights or remedies without the express written consent of Holder, except as and
to the extent provided to the contrary by applicable law.

8.       Governing Law. This Note shall be governed by and construed
according to and enforced under the internal laws of the State of California
without giving effect to its choice of laws rules.

9.       Enforcement of the Note. Maker agrees that the Superior Court in and
for the County of Orange, California shall have exclusive jurisdiction over any
disputes, between the Maker and Holder and any action, suit or other proceeding
brought by Maker or Holder relating to the interpretation or enforcement of this
Note, and Maker agrees as follows: (a) Maker shall accept and not contest the
personal or subject matter jurisdiction of such Court; (b) Maker shall accept
and not object to or challenge the venue of such Court or assert the doctrine of
forum non conveniens with respect to such Court; (c) Maker shall accept and not
contest the validity or effectiveness of service of process in any such action,
suit or other proceeding by registered or certified first class mail; and (d) TO
THE MAXIMUM EXTENT PERMITTED BY LAW, MAKER WAIVES AND SHALL WAIVE ANY RIGHT TO A
TRIAL BY JURY IN ANY ACTION OR OTHER PROCEEDING BROUGHT WITH RESPECT TO THIS
NOTE OR ITS ENFORCEMENT OR INTERPRETATION. If Maker fails to pay any amounts due
hereunder when due, or if an Event of Default occurs, then Maker shall pay all
costs of enforcement and collection, including, without limitation, reasonable
attorneys' fees and costs incurred by Holder, whether or not enforcement and
collection includes the filing of a lawsuit, and whether or not that lawsuit is
prosecuted to judgment. The costs of enforcement and collection shall be added
to the principal amount of the Note and shall accrue interest at the Default
Rate from the date incurred by Holder to the date paid by Maker.

10.      Binding Nature. The provisions of this Note shall be binding on Maker
and shall inure to the benefit of Holder.

11.      Usury Savings Provisions. In the event Holder receives any sums under
this Note which constitute interest in an amount in excess of that permitted by
any applicable law, then, all such sums constituting interest in excess of that
permitted to be paid under applicable law shall, at Holder's option, either be
credited to the payment of principal owing hereunder or returned to Maker. The
provisions of this Section 11 control the other provisions of this Note and any
other agreement between Maker and Holder.

12.      Severability. If, but only to the extent that, any provision of this
Note shall be invalid or unenforceable, then, such offending provision shall be
deleted from this Note, but only to the extent necessary to preserve the
validity and effectiveness of this Note to the fullest extent permitted by
applicable law.

                                        3

13.      Interpretation. No provision of this Note shall be interpreted for or
against Maker or Holder because that person or that person's legal
representative drafted such provision. Unless otherwise indicated elsewhere in
this Note, (a) the term "or" shall not be exclusive, (b) the term "including"
shall mean "including, but not limited to," and (c) the terms "below," "above,"
"herein," "hereof," "hereto," "hereunder" and other terms similar to such terms
shall refer to this Note as a whole and not merely to the specific section,
subsection, paragraph or clause where such terms may appear. The section and
sub-section headings in this Note are included for convenience of reference only
and shall be ignored in the construction or interpretation of this Note.

14.      Relation Back of Note. This Note is issued in accordance with that
certain Second Amendment to Loan Agreement dated as of December 20, 2002,
between Maker and Watson (the "Second Amendment"). Maker and Watson acknowledge
and agree that the principal amount of this Secured Promissory Note represents
the full amount of the Core Products Amount of $3,901,331 (as defined and
provided in the Second Amendment), which was heretofore unsecured, and expressly
intend that Maker's obligations pursuant to this Secured Promissory Note be
added to the obligations of Maker secured by the Security Agreements.

                                                 "MAKER"

                                                 HALSEY DRUG CO., INC.

                                                 ____________________________
                                                 By:  Michael Reicher
                                                 Its: Chief Executive Officer

                                        4


                                                                   EXHIBIT 10.14

                                SECOND AMENDMENT
                       TO FINISHED GOODS SUPPLY AGREEMENT
                                 (CORE PRODUCTS)

         This Second Amendment (this "Second Amendment") to the Finished Goods
Supply Agreement (Core Products) dated the 29th day of March, 2000, between
Watson Pharmaceuticals, Inc., a Nevada corporation ("Watson"), and Halsey Drug
Co., Inc., a New York corporation ("Halsey") (the "Original Core Products
Agreement"), as amended pursuant to that certain Amendment and Supplement No. 1
to Finished Goods Supply Agreement (Core Products) dated as of August 8, 2001,
(the "First Amendment" and collectively with the Original Core Products
Agreement, the "Core Products Agreement"), is made as of this 20th day of
December, 2002.

                                    RECITALS

         A.       Watson and Halsey entered into the Original Core Products
Agreement pursuant to which Halsey (or its appropriate Affiliates) agreed to
supply and Watson (or its appropriate Affiliates) agreed to purchase the
Commercial Products.

         B.       Pursuant to Section 2.6 of the Original Core Products
Agreement Watson made certain minimum quarterly payments to Halsey for
Commercial Products (the "Minimum Payments").

         C.       The Minimum Payments made by Watson exceeded the aggregate
purchase price of the Commercial Products supplied by Halsey, resulting in a
credit to Watson for excess Minimum Payments of $4,402,682.60 through and
including the quarter ended December 31, 2000 (the "Core Products Credit
Amount").

         D.       Watson and Halsey entered into the First Amendment to, among
other things, (i) agree upon the Core Products Credit Amount, (ii) reduce
Watson's minimum quarterly payments to Halsey and (iii) provide for the
application of the Core Products Credit Amount against future purchases of
Commercial Products from Halsey, and for the repayment by Halsey of the
remaining balance of the Core Products Credit Amount in equal monthly
installments in October and November 2002.

         E.       Watson and Halsey are parties to a certain Loan Agreement
dated as of March 29, 2000, as amended by that certain Amendment to Loan
Agreement dated as of March 31, 2000 (as so amended, the "Loan Agreement")
pursuant to which Watson has made a term loan to Halsey in the principal amount
of $17,500,000 (the "Loan").

         F.       Watson and Halsey propose to amend the Loan Agreement pursuant
to a certain Second Amendment to Loan Agreement dated as of even date providing,
among other items, for the inclusion of the current balance of the Core Products
Credit Amount

as of the date hereof of $3,901,331 (the "Core Products Rollover Amount") in the
principal amount of the Loan.

         G.       Watson and Halsey desire to amend the Core Products Agreement
to reflect the inclusion of the Core Products Rollover Agreement in the Loan.

         In consideration of the foregoing premises, and the mutual covenants
and obligations set forth herein, Halsey and Watson hereby agree as follows:

         1.       Definitions. All capitalized terms used herein and not
otherwise defined shall have the meaning set forth in the Core Products
Agreement.

         2.       Section 2.7 of the Agreement is hereby deleted in its entirety
and the following inserted in its place:

                  "2.7 Credits. Halsey acknowledges that as of December 20,
                  2002, Watson has paid to Halsey an aggregate of $3,901,331 in
                  excess of the aggregate purchase price of Commercial Products
                  supplied by Halsey to Watson under the Agreement (the "Core
                  Products Rollover Amount"). Watson and Halsey acknowledge and
                  agree that effective as of December 20, 2002 (i) the Core
                  Products Rollover Amount shall be included in the Loan (as
                  defined in the Second Amendment hereto) and subject to the
                  terms and provisions of the principal amount of the Loan
                  Agreement (as defined in the Second Amendment hereto), and
                  (ii) except for its obligations under the Loan, Halsey shall
                  have no further liability to Watson for the Core Products
                  Rollover Amount."

         3.       Surviving Provisions. Watson and Halsey agree that except as
expressly modified herein all provisions of the Core Products Agreement shall
remain in full force and effect.

                                        2

         IN WITNESS WHEREOF, the parties have caused this Second Amendment to be
executed by their respective duly authorized officers as of the date first above
written.

                                        WATSON PHARMACEUTICALS, INC.

                                        By:__________________________________
                                            Name:____________________________
                                            Title:___________________________

                                        HALSEY DRUG CO., INC.

                                        By:__________________________________
                                            Name: Michael Reicher
                                            Title: Chief Executive Officer

                                        3


                                                                   EXHIBIT 10.15

                               WARRANT TO PURCHASE
                     COMMON STOCK, PAR VALUE $.01 PER SHARE

                                       OF

                              HALSEY DRUG CO., INC.

THIS WARRANT AND THE COMMON STOCK ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT") NOR UNDER
ANY STATE SECURITIES LAW AND MAY NOT BE PLEDGED, SOLD, ASSIGNED, HYPOTHECATED OR
OTHERWISE TRANSFERRED UNTIL (1) A REGISTRATION STATEMENT WITH RESPECT THERETO IS
EFFECTIVE UNDER THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS OR (2) THE
COMPANY RECEIVES AN OPINION OF COUNSEL TO THE COMPANY OR OTHER COUNSEL TO THE
HOLDER OF SUCH WARRANT REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH WARRANT
AND/OR COMMON STOCK MAY BE PLEDGED, SOLD, ASSIGNED, HYPOTHECATED OR TRANSFERRED
WITHOUT AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT OR APPLICABLE STATE
SECURITIES LAWS.

                  This certifies that, for value received, WATSON
PHARMACEUTICALS, INC., or its registered assigns ("Warrantholder"), is entitled
to purchase from HALSEY DRUG CO., INC. (the "Company"), subject to the
provisions of this Warrant, at any time during the Exercise Period (as
hereinafter defined) 10,700,665 shares of the Company's Common Stock, par value
$.01 per share ("Warrant Shares"). The purchase price payable upon the exercise
of this Warrant shall be $.34 per Warrant Share. The purchase price and the
number of Warrant Shares which the Warrantholder is entitled to purchase are
subject to adjustment upon the occurrence of the contingencies set forth in this
Warrant, and as adjusted from time to time, such purchase price is hereinafter
referred to as the "Warrant Price".

                  For purposes of this Warrant, the term "Exercise Period" means
the period commencing on the date of issuance of this Warrant and ending on
December 31, 2009.

                  This Warrant is subject to the following terms and conditions:

                  1.       Exercise of Warrant.

                           (a)       This Warrant may be exercised in whole
or in part but not for a fractional share. Upon delivery of this Warrant at the
offices of the Company or at such other address as the Company may designate by
notice in writing to the registered holder hereof with the Subscription Form
annexed hereto duly executed, accompanied by payment of the Warrant Price for
the number of Warrant Shares purchased (in cash, by certified, cashier's or
other check acceptable to the Company), the registered holder of this Warrant
shall be entitled to receive a certificate or certificates for the Warrant
Shares so purchased. Such certificate or certificates shall be promptly

                                        1

delivered to the Warrantholder. Upon any partial exercise of this Warrant, the
Company shall execute and deliver a new Warrant of like tenor for the balance of
the Warrant Shares purchasable hereunder.

                           (b)      In lieu of exercising this Warrant
pursuant to Section 1(a), the holder may elect to receive shares of Common Stock
equal to the value of this Warrant determined in the manner described below (or
any portion thereof remaining unexercised) upon delivery of this Warrant at the
offices of the Company or at such other address as the Company may designate by
notice in writing to the registered holder hereof with the Notice of Cashless
Exercise Form annexed hereto duly executed. In such event the Company shall
issue to the holder a number of shares of the Company's Common Stock computed
using the following formula:

                                 X = Y (A-B)
                                     -------
                                        A

Where X = the number of shares of Common Stock to be issued to the holder.

      Y = the number of shares of Common Stock purchasable under this Warrant
            (at the date of such calculation).

      A = the Market Value of the Company's Common Stock on the business day
          immediately preceding the day on which the Notice of Cashless Exercise
          is received by the Company.

      B = Warrant Price (as adjusted to the date of such calculation).

                           (c)      The Warrant Shares deliverable hereunder
shall, upon issuance, be fully paid and non-assessable and the Company agrees
that at all times during the term of this Warrant it shall cause to be reserved
for issuance such number of shares of its Common Stock as shall be required for
issuance and delivery upon exercise of this Warrant.

                           (d)      For purposes of Section 1(b) of this
Warrant, the Market Value of a share of Common Stock on any date shall be equal
to (i) the closing sale price per share as published by a national securities
exchange on which shares of Common Stock are traded (an "Exchange") on such date
or, if there is no sale of Common Stock on such date, the average of the bid and
asked prices on such Exchange at the close of trading on such date or, (ii) if
shares of Common Stock are not listed on an Exchange on such date, the closing
price per share as published on the National Association of Securities Dealers
Automatic Quotation System ("NASDAQ") National Market System if the shares are
quoted on such system on such date, or (iii) the average of the bid and asked
prices in the over-the-counter market at the close of trading on such date if
the shares are not traded on an Exchange or listed on the NASDAQ National Market
System, or (iv) if the security is not traded on an Exchange or in the
over-the-counter market, the fair market value of a share of Common Stock on
such date as determined in good faith by the Board of Directors of the Company.
If the holder disagrees with the determination of the Market Value of any
securities of the Common Stock determined by the Board of Directors under
Section 1(d)(iv) the Market Value shall be

                                        2

determined by an independent appraiser acceptable to the Company and the holder.
If they cannot agree on such an appraiser, then each of the Company and the
holder shall select an independent appraiser, such two appraisers shall select a
third independent appraiser and Market Value shall be the median of the
appraisals made by such appraisers. If there is one appraiser, the cost of the
appraisal shall be shared equally between the Company and the holder. If there
are three appraisers, each of the Company and the holder shall pay for its own
appraiser and shall share equally the cost of the third appraiser.

                  2.       Transfer or Assignment of Warrant.

                           (a)      Any assignment or transfer of this
Warrant shall be made by surrender of this Warrant at the offices of the Company
or at such other address as the Company may designate in writing to the
registered holder hereof with the Assignment Form annexed hereto duly executed
and accompanied by payment of any requisite transfer taxes, and the Company
shall, without charge, execute and deliver a new Warrant of like tenor in the
name of the assignee for the portion so assigned in case of only a partial
assignment, with a new Warrant of like tenor to the assignor for the balance of
the Warrant Shares purchasable.

                           (b)      Prior to any assignment or transfer of this
Warrant, the holder thereof shall deliver an opinion of counsel to the Company
to the effect that the proposed transfer may be effected without registration
under the Act. Each Warrant issued upon or in connection with such transfer
shall bear the restrictive legend set forth on the front of this Warrant unless,
in the opinion of the Company's counsel, such legend is no longer required to
insure compliance with the Act.

                  3.       Adjustments to Warrant Price and Warrant Shares --
Anti-Dilution Provisions. In order to prevent dilution of the exercise right
granted hereunder, the Warrant Price shall be subject to adjustment from time to
time in accordance with this Section 3.

                  The Warrant Price in effect at the time of the exercise of
this Warrant shall be subject to adjustment from time to time as follows:

                  (a)      In the event that the Company shall at any time: (i)
declare or pay to the holders of the Common Stock a dividend payable in any kind
of shares of capital stock of the Company; or (ii) change or divide or otherwise
reclassify its Common Stock into the same or a different number of shares with
or without par value, or in shares of any class or classes; or (iii) transfer
its property as an entirety or substantially as an entirety to any other company
or entity; or (iv) make any distribution of its assets to holders of its Common
Stock as a liquidation or partial liquidation dividend or by way of return of
capital; then, upon the subsequent exercise of this Warrant, the holder thereof
shall receive, in addition to or in substitution for the shares of Common Stock
to which it would otherwise be entitled upon such exercise, such additional
shares of stock or scrip of the Company, or such reclassified shares of stock of
the Company, or such shares of the securities or property of the company
resulting from transfer, or such assets of the Company, which it would have been
entitled to receive had it exercised these rights prior to the happening of any
of the foregoing events. If, at any time during the Exercise Period, the number
of outstanding shares of Common Stock is (i) increased by a stock dividend
payable in shares of Common Stock or by a

                                        3

subdivision or split up of shares of Common Stock, or (ii) decreased by a
combination of shares of Common Stock, then, simultaneously with the occurrence
of such event, the Warrant Price shall be adjusted automatically to a new amount
equal to the product of (A) the Warrant Price in effect on such record date and
(B) the quotient obtained by dividing (x) the number of shares of Common Stock
outstanding on such record date (without giving effect to the events referred to
in the foregoing clauses (i) or (ii)) by (y) the number of shares of Common
Stock which would be outstanding immediately after the event referred to in the
foregoing clauses (i) or (ii).

                  (b)      Until such time as the Company completes a Subsequent
Material Offering (as defined in Section 3(k) hereof), if the Company shall
grant or issue any shares of Common Stock, or grant or issue any rights or
options for the purchase of, or stock or other securities convertible into,
Common Stock (such convertible stock or securities being herein collectively
referred to as "Convertible Securities"), including in connection with a
Subsequent Material Offering, other than:

                  (i)      shares issued in a transaction described in
                           subsection (d) of this Section 3; or

                  (ii)     shares issued, subdivided or combined in transactions
                           described in Section 3(a) if and to the extent that
                           the number of shares of Common Stock received upon
                           exercise of this Warrant shall have been previously
                           adjusted pursuant to Section 3(a) as a result of such
                           issuance, subdivision or combination of such
                           securities;

for a consideration per share which is less than the Warrant Price in effect
immediately prior to such issuance or sale (the "Applicable Warrant Price"),
then the Applicable Warrant Price in effect immediately prior to such issuance
or sale shall, and thereafter, except as otherwise provided in Subsection 3(c)
hereof, upon each issuance or sale for a consideration per share which is less
than the Applicable Warrant Price, the Applicable Warrant Price shall,
simultaneously with such issuance or sale, be adjusted, so that such Applicable
Warrant Price shall equal (A) the price per share received by the Company, in
the case of the issuance of Common Stock by the Company, or (B) the exercise or
conversion price of the Convertible Securities issued by the Company, as
applicable.

                  (c)      If at any time following the Company's completion of
a Subsequent Material Offering the Company shall grant or issue any shares of
Common Stock, or grant or issue any Convertible Securities, other than:

                  (i)      shares issued in a transaction described in
                           subsection (d) of this Section 3; or

                  (ii)     shares issued, subdivided or combined in transactions
                           described in Section 3(a) if and to the extent that
                           the number of shares of Common Stock received upon
                           conversion of this Debenture shall have been
                           previously adjusted pursuant to

                                        4

                           Section 3(a) as a result of such issuance,
                           subdivision or combination of such securities;

for a consideration per share which is less than the Fair Market Value (as
hereinafter defined) of the Common Stock, then the Applicable Warrant Price
shall, and thereafter upon each issuance or sale for a consideration per share
which is less than the Fair Market Value of the Common Stock, the Applicable
Warrant Price shall, simultaneously with such issuance or sale, be adjusted, so
that the Applicable Warrant Price shall equal a price determined by multiplying
the Applicable Warrant Price by a fraction, of which:

                  (A)      the numerator of which shall be the sum of (x) the
                  total number of shares of Common Stock outstanding when the
                  Applicable Warrant Price became effective, plus (y) the number
                  of shares of Common Stock which the aggregate consideration
                  received, as determined in accordance with Section 3(e) for
                  the issuance or sale of such additional Common Stock or
                  Convertible Securities deemed to be an issuance of Common
                  Stock as provided in Section 3(f), would purchase (including
                  any consideration received by the Company upon the issuance of
                  any shares of Common Stock since the date the Applicable
                  Warrant Price became effective not previously included in any
                  computation resulting in an adjustment pursuant to this
                  subsection 3(c)) at the Fair Market Value of the Common Stock;
                  and

                  (B)      the denominator of which shall be the total number of
                  shares of Common Stock outstanding (or deemed to be
                  outstanding as provided in subsection 3(f) hereof) immediately
                  after the issuance or sale of such additional shares.

                  For purposes of this Section 3, "Fair Market Value" shall mean
the average of the closing price of the Common Stock for each of the twenty (20)
consecutive trading days prior to such issuance or sale on an Exchange or if
shares of Common Stock are not listed on an Exchange during such period, the
closing price per share as reported by NASDAQ National Market System if the
shares are quoted on such system during such period, or the average of the bid
and asked prices of the Common Stock in the over-the-counter market at the close
of trading during such period if the shares are not traded on an Exchange or
listed on the NASDAQ National Market System, or if the Common Stock is not
traded on an Exchange or in the over-the-counter market, the fair market value
of a share of Common Stock during such period as determined in good faith by the
Board of Directors.

                  If, however, the Applicable Warrant Price thus obtained would
result in the issuance of a lesser number of shares upon conversion than would
be issued at the initial Warrant Price, the Applicable Warrant Price shall be
such initial Warrant Price.

                  Upon each adjustment of the Warrant Price solely pursuant to
this subsection 3(c), the Warrantholder shall thereafter be entitled to acquire
upon exercise under Section 1, at the Applicable Warrant Price, the number of
shares of Common Stock obtainable by multiplying the Warrant Price in effect
immediately prior to such adjustment by the number of shares of Common

                                        5

Stock acquirable immediately prior to such adjustment and dividing the product
thereof by the Applicable Warrant Price resulting from such adjustment.

                  (d)      Anything in this Section 3 to the contrary
notwithstanding, no adjustment in the Warrant Price shall be made in connection
with:

                  (i)      the grant, issuance or exercise of any Convertible
                           Securities pursuant to the Company's qualified or
                           non-qualified Employee Stock Option Plans or any
                           other bona fide employee benefit plan or incentive
                           arrangement, adopted or approved by the Company's
                           Board of Directors or approved by the Company's
                           shareholders, as may be amended from time to time, or
                           under any other bona fide employee benefit plan
                           hereafter adopted by the Company's Board of
                           Directors; or

                  (ii)     the grant, issuance or exercise of any Convertible
                           Securities in connection with the hire or retention
                           of any officer, director or key employee of the
                           Company, provided such grant is approved by the
                           Company's Board of Directors; or

                  (iii)    the issuance of any shares of Common Stock or
                           Convertible Securities issued in satisfaction of
                           interest payments on all of the Company's 5%
                           convertible senior secured debentures due March 31,
                           2006, including (i) the 5% convertible senior
                           secured debentures issued pursuant to the Debenture
                           and Warrant Purchase Agreement dated as of March 10,
                           1998 between the Company, Galen Partners III, L.P.
                           and the other signatories thereto, the Debenture and
                           Warrant Purchase Agreement dated as of May 26, 1999
                           between the Company, Oracle Strategic Partners, L.P.
                           and the other signatories thereto, and the Debenture
                           Purchase Agreement dated December 20, 2002 between
                           the Company, Care Capital LLC, Essex Woodlands
                           Health Ventures Fund V and the other signatories
                           thereto, and (ii) the issuance of Common Stock or
                           Convertible Securities issued in satisfaction of
                           interest payments on debentures instruments issued
                           by the Company in satisfaction of interest payments
                           on the Company's 5% convertible senior secured
                           debentures due March 31, 2006; or

                  (iv)     the issuance of any shares of Common Stock pursuant
                           to the grant or exercise or conversion of Convertible
                           Securities outstanding as of the date hereof
                           (exclusive of any subsequent amendments thereto); or

                  (v)      the issuance of the Company's 5% convertible senior
                           secured debentures due March 31, 2006 issued pursuant
                           to that certain Debenture Purchase Agreement dated
                           December 20, 2002 between the Company, Care Capital,
                           LLC, Essex Woodlands Health Ventures Fund V and the
                           other purchasers listed on the signature page
                           thereto; or

                                        6

                  (vi)     the issuance of 5,970,083 shares of the Company's
                           Common Stock pursuant to that certain Warrant
                           Recapitalization Agreement dated December 20, 2002
                           between the Company, Oracle Strategic Partners, L.P.
                           and the other parties listed on the signature page
                           thereto.

                  (e)      For the purpose of Sections 3(b), 3(c) and 3(d), the
following provisions shall also be applied:

                  (i)      In case of the issuance or sale of additional shares
                           of Common Stock for cash, the consideration received
                           by the Company therefor shall be deemed to be the
                           amount of cash received by the Company for such
                           shares, before deducting therefrom any commissions,
                           compensation or other expenses paid or incurred by
                           the Company for any underwriting of, or otherwise in
                           connection with, the issuance or sale of such shares.

                  (ii)     In the case of the issuance of Convertible
                           Securities, the consideration received by the Company
                           therefor shall be deemed to be the amount of cash, if
                           any, received by the Company for the issuance of such
                           rights or options, plus the minimum amounts of cash
                           and fair market value of other consideration, if any,
                           payable to the Company upon the exercise of such
                           rights or options or payable to the Company upon
                           conversion of such Convertible Securities.

                  (iii)    In the case of the issuance of shares of Common Stock
                           or Convertible Securities for a consideration in
                           whole or in part, other than cash, the consideration
                           other than cash shall be deemed to be the fair
                           market value thereof as reasonably determined in
                           good faith by the Board of Directors of the Company
                           (irrespective of accounting treatment thereof);
                           provided, however, that if such consideration
                           consists of the cancellation of debt issued by the
                           Company, the consideration shall be deemed to be the
                           amount the Company received upon issuance of such
                           debt (gross proceeds) plus accrued interest and, in
                           the case of original issue discount or zero coupon
                           indebtedness, accrued value to the date of such
                           cancellation, but not including any premium or
                           discount at which the debt may then be trading or
                           which might otherwise be appropriate for such class
                           of debt.

                  (iv)     In case of the issuance of additional shares of
                           Common Stock upon the conversion or exchange of any
                           obligations (other than Convertible Securities), the
                           amount of the consideration received by the Company
                           for such Common Stock shall be deemed to be the
                           consideration received by the Company for such
                           obligations or shares so converted or exchanged,
                           before deducting from such consideration so received
                           by the Company any expenses or commissions or
                           compensation incurred or paid by the Company for any
                           underwriting of, or otherwise in connection with,
                           the issuance or sale of such

                                        7

                           obligations or shares, plus any consideration
                           received by the Company in connection with such
                           conversion or exchange other than a payment in
                           adjustment of interest and dividends. If
                           obligations or shares of the same class or series of
                           a class as the obligations or shares so converted or
                           exchanged have been originally issued for different
                           amounts of consideration, then the amount of
                           consideration received by the Company upon the
                           original issuance of each of the obligations or
                           shares so converted or exchanged shall be deemed to
                           be the average amount of the consideration received
                           by the Company upon the original issuance of all
                           such obligations or shares. The amount of
                           consideration received by the Company upon the
                           original issuance of the obligations or shares so
                           converted or exchanged and the amount of the
                           consideration, if any, other than such obligations
                           or shares, received by the Company upon such
                           conversion or exchange shall be determined in the
                           same manner as provided in paragraphs (i) and (ii)
                           above with respect to the consideration received by
                           the Company in case of the issuance of additional
                           shares of Common Stock or Convertible Securities.

                  (v)      In the case of the issuance of additional shares of
                           Common Stock as a dividend, the aggregate number of
                           shares of Common Stock issued in payment of such
                           dividend shall be deemed to have been issued at the
                           close of business on the record date fixed for the
                           determination of stockholders entitled to such
                           dividend and shall be deemed to have been issued
                           without consideration; provided, however, that if the
                           Company, after fixing such record date, shall legally
                           abandon its plan to so issue Common Stock as a
                           dividend, no adjustment of the Applicable Conversion
                           Price shall be required by reason of the fixing of
                           such record date.

                  (f)      For purposes of the adjustment provided for in
Sections 3(b) and 3(c) above, if at any time the Company shall issue any
Convertible Securities, the Company shall be deemed to have issued at the time
of the issuance of such Convertible Securities the maximum number of shares of
Common Stock issuable upon conversion of the total amount of such Convertible
Securities.

                  (g)      On the expiration, cancellation or redemption of any
Convertible Securities, the Warrant Price then in effect hereunder shall
forthwith be readjusted to such Warrant Price as would have been obtained (i)
had the adjustments made upon the issuance or sale of such expired, canceled or
redeemed Convertible Securities been made upon the basis of the issuance of only
the number of shares of Common Stock theretofore actually delivered upon the
exercise or conversion of such Convertible Securities (and the total
consideration received therefor) and (ii) had all subsequent adjustments been
made on only the basis of the Warrant Price as readjusted under this Section
3(g) for all transactions (which would have affected such adjusted Warrant
Price) made after the issuance or sale of such Convertible Securities.

                  (h)      Anything in this Section 3 to the contrary
notwithstanding, no adjustment in the Warrant Price shall be required unless
such adjustment would require an increase or decrease of at least 1% in such
Warrant Price; provided, however, that any adjustments which by reason of this

                                        8

Section 3(h) are not required to be made shall be carried forward and taken into
account in making subsequent adjustments. All calculations under this Section 3
shall be made to the nearest cent.

                  (i)      If, at any time while this Warrant is outstanding,
the Company shall pay any dividend payable in cash or in Common Stock, shall
offer to the holders of its Common Stock for subscription or purchase by them
any shares of stock of any class or any other rights, shall enter into an
agreement to merge or consolidate with another corporation, shall propose any
capital reorganization or reclassification of the capital stock of the Company,
including any subdivision or combination of its outstanding shares of Common
Stock or there shall be contemplated a voluntary or involuntary dissolution,
liquidation or winding up of the Company, the Company shall cause notice thereof
to be mailed to the registered holder of this Warrant at its address appearing
on the registration books of the Company, at least 30 days prior to the record
date as of which holders of Common Stock shall participate in such dividend,
distribution or subscription or other rights or at least 30 days prior to the
effective date of the merger, consolidation, reorganization, reclassification or
dissolution. Upon any adjustment of any Warrant Price, then and in each such
case the Company shall promptly deliver a notice to the registered holder of
this Warrant, which notice shall state the Warrant Price resulting from such
adjustment, setting forth in reasonable detail the method of calculation and the
facts upon which such calculation is based.

                  (j)      If the Company is a party to a merger or other
transaction which reclassifies or changes its outstanding Common Stock, upon
consummation of such transaction this Warrant shall automatically become
exercisable for the kind and amount of securities, cash or other assets which
the holder of this Warrant would have owned immediately after such transaction
if the holder had converted this Warrant at the Warrant Price in effect
immediately before the effective date of the transaction. Concurrently with the
consummation of such transaction, the person obligated to issue securities or
deliver cash or other assets upon exercise of this Warrant shall execute and
deliver to the holder a supplemental Warrant so providing and further providing
for adjustments which shall be as nearly equivalent as may be practical to the
adjustments provided in this Section 3. The successor company shall mail to the
holder a notice describing the supplemental Warrant.

                  If securities deliverable upon exercise of this Warrant, as
provided above, are themselves convertible into or exercisable for the
securities of an affiliate of a corporation formed, surviving or otherwise
affected by the merger or other transaction, that issuer shall join in the
supplemental Warrant which shall so provide. If this Section 3(j) applies,
Section 3(a) does not apply.

                  (k)      For purposes hereof, "Subsequent Material Offering"
shall mean the grant or issuance of shares of Common Stock, or the grant or
issuance of Convertible Securities, during any six (6) month period for an
aggregate gross consideration (determined in accordance with Section 3(e)
hereof) of at least ten million dollars ($10,000,000) for a consideration per
share that is in excess of the then Applicable Exercise Price.

                  4.       Charges, Taxes and Expenses. The issuance of
certificates for Warrant Shares upon any exercise of this Warrant shall be made
without charge to the holder of this Warrant for any tax or other expense in
respect to the issuance of such certificates, all of which taxes and

                                        9

expenses shall be paid by the Company, and such certificates shall be issued
only in the name of the holder of this Warrant.

                  5.       Miscellaneous.

                           (a)      The terms of this Warrant shall be binding
upon and shall inure to the benefit of any successors or assigns of the Company
and of the holder or holders hereof and of the shares of Common Stock issued or
issuable upon the exercise hereof.

                           (b)      No holder of this Warrant, as such, shall
be entitled to vote or receive dividends or be deemed to be a stockholder of the
Company for any purpose, nor shall anything contained in this Warrant be
construed to confer upon the holder of this Warrant, as such, any rights of a
stockholder of the Company or any right to vote, give or withhold consent to any
corporate action, receive notice of meetings, receive dividends or subscription
rights, or otherwise.

                           (c)      Receipt of this Warrant by the holder
hereof shall constitute acceptance of an agreement to the foregoing terms and
conditions.

                           (d)      The Warrant and the performance of the
parties hereunder shall be construed and interpreted in accordance with the laws
of the State of New York without giving effect to its conflict of laws rules
wherein it was negotiated and executed and the parties hereunder consent and
agree that the State and Federal Courts which sit in the State of New York and
the County of New York shall have exclusive jurisdiction with respect to all
controversies and disputes arising hereunder.

                                       10

                  IN WITNESS WHEREOF, the Company has caused this Warrant to be
signed by its duly authorized officer and its corporate seal to be affixed
hereto.

Dated as of December  20, 2002

                                     HALSEY DRUG CO., INC.

                                     BY:________________________________________
                                         Name:  Michael Reicher
                                         Title: Chief Executive Officer

                                SUBSCRIPTION FORM

                    (TO BE EXECUTED BY THE REGISTERED HOLDER
                     IF HE DESIRES TO EXERCISE THE WARRANT)

         To:      HALSEY DRUG CO., INC.

                  The undersigned hereby exercises the right to purchase
_________ shares of Common Stock, par value $.01 per share, covered by the
attached Warrant in accordance with the terms and conditions thereof, and
herewith makes payment of the Warrant Price for such shares in full.

                                       _________________________________________
                                       SIGNATURE

                                       _________________________________________
                                       ADDRESS

                                       _________________________________________

DATED:______________

                   NOTICE OF EXERCISE OF COMMON STOCK WARRANT
             PURSUANT TO NET ISSUE ("CASHLESS") EXERCISE PROVISIONS

                                                               [ Date ]

                                                         
Halsey Drug Co., Inc.                  Aggregate Price of      $________________
a New York corporation                 of Warrant
695 N. Perryville Road                 Aggregate Price Being
Rockford, Illinois 61107               Exercised:              $________________
Attention: _______________

                                       Warrant Price (per
                                       share):                 $________________

                                       Market Value (per
                                       share):                 $________________

                                       Number of Shares of
                                       Common Stock under
                                       this Warrant:           _________________

                                       Number of Shares of
                                       Common Stock to be
                                       Issued Under this
                                       Notice:                 _________________
CASHLESS EXERCISE Gentlemen: The undersigned, the registered holder of the Warrant to Purchase Common Stock delivered herewith ("Warrant"), hereby irrevocably exercises such Warrant for, and purchases thereunder, shares of the Common Stock of HALSEY DRUG CO., INC., a New York corporation, as provided below. Capitalized terms used herein, unless otherwise defined herein, shall have the meanings given in the Warrant. The portion of the Aggregate Price (as hereinafter defined) to be applied toward the purchase of Common Stock pursuant to this Notice of Exercise is $______, thereby leaving a remainder Aggregate Price (if any) equal to $______. Such exercise shall be pursuant to the net issue exercise provisions of Section 1(b) of the Warrant; therefore, the holder makes no payment with this Notice of Exercise. The number of shares to be issued pursuant to this exercise shall be determined by reference to the formula in Section 1(b) of the Warrant which requires the use of the Market Value (as defined in Section 1(d) of the Warrant) of the Company's Common Stock on the business day immediately preceding the day on which this Notice is received by the Company. To the extent the foregoing exercise is for less than the full Aggregate Price of the Warrant, the remainder of the Warrant representing a number of Shares equal to the quotient obtained by dividing the remainder of the Aggregate Price by the Warrant Price (and otherwise of like form, tenor and effect) may be exercised under Section 1(a) of the Warrant. For purposes of this Notice the term "Aggregate Price" means the product obtained by multiplying the number of shares of Common Stock for which the Warrant is exercisable times the Warrant Price. _________________________________________ SIGNATURE DATE:_______________ _________________________________________ ADDRESS 2 ASSIGNMENT (TO BE EXECUTED BY THE REGISTERED HOLDER IF HE DESIRES TO TRANSFER THE WARRANT) FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers unto________ the right to purchase shares of Common Stock of HALSEY DRUG CO., INC., evidenced by the within Warrant, and does hereby irrevocably constitute and appoint_____________ Attorney to transfer the said Warrant on the books of the Company, with full power of substitution. _________________________________________ SIGNATURE _________________________________________ ADDRESS DATED:______________ IN THE PRESENCE OF: ____________________ 3

                                                                   EXHIBIT 10.16

                          REGISTRATION RIGHTS AGREEMENT

                  THIS REGISTRATION RIGHTS AGREEMENT (this "Agreement") dated as
of December 20, 2002, by and between HALSEY DRUG CO., INC., a New York
corporation (the "Company") and the investors listed on Schedule 1 attached
hereto (each an "Investor"; collectively, the "Investors").

                  WHEREAS, the Company and certain purchasers are parties to
that certain Debenture and Warrant Purchase Agreement dated March 10, 1998 (as
such agreement may be supplemented, amended, or otherwise modified from time to
time, the "1998 Purchase Agreement"), whereby the Company issued to such parties
the Company's 5% convertible secured debentures due March 15, 2003 (as such
debentures may be supplemented, amended, or otherwise modified from time to
time, the "1998 Debentures"; each such holder of 1998 Debentures, or any
permitted successor, assign or transferee thereof, a "1998 Holder") and warrants
to purchase Common Stock (the "1998 Warrants");

                  WHEREAS, in connection with the 1998 Purchase Agreement, the
Company granted to the 1998 Holders registration rights as set forth in Article
XI of the 1998 Purchase Agreement;

                  WHEREAS, the Company and certain purchasers are parties to
that certain Debenture and Warrant Purchase Agreement dated May 26, 1999 (as
such agreement may be supplemented, amended, or otherwise modified from time to
time, the "1999 Purchase Agreement"), whereby the Company issued to such parties
the Company's 5% convertible secured debentures due March 15, 2003 (as such
debentures may be supplemented, amended, or otherwise modified from time to
time, the "1999 Debentures"; each such holder of 1999 Debentures, or any
permitted successor, assign or transferee thereof, a "1999 Holder") and warrants
to purchase Common Stock (the "1999 Warrants");

                  WHEREAS, in connection with the 1999 Purchase Agreement, the
Company granted to the 1999 Holders registration rights as set forth in Article
XI of the 1999 Purchase Agreement;

                  WHEREAS, in connection with the Bridge Loan Agreements, Galen
Partners III, L.P., Galen Partners International III, L.P. and Galen Employee
Fund III, L.P. (collectively, "Galen") holds warrants to purchase an aggregate
of 5,385,229 shares of the Company's common stock, $.01 par value per share (the
"Common Stock") as more particularly described on Schedule 2 hereof (the "Bridge
Loan Warrants");

                  WHEREAS, the Company and Watson Pharmaceuticals, Inc.
("Watson") are parties to that certain Loan Agreement, dated as of March 29,
2000, as amended by a certain Amendment to Loan Agreement dated as of March 31,
2000 (as so amended, the "Loan Agreement");

                  WHEREAS, in consideration of further amending the Loan
Agreement to, among other things, extend the maturity date of the loan by
execution of a Second Amendment to the Loan Agreement dated as of December __,
2002, simultaneously with the execution of this Agreement, the Company will
issue to Watson a warrant (the "Watson Warrant") to purchase 10,700,665 shares
of the Common Stock;

                  WHEREAS, in connection with the 2002 Purchase Agreement, all
of the holders (except Galen) (the "Recap Shareholders") of the 1998 Warrants
and the 1999 Warrants have entered into an agreement (the "Recapitalization
Agreement"), dated the date hereof, to recapitalize their interests in the
Company by, inter alia, exchanging their respective warrants for shares of
Common Stock (the "Recap Shares");

                  WHEREAS, the Company and certain purchasers are parties to
that certain Debenture Purchase Agreement, dated the date hereof (as such
agreement may be supplemented, amended, or otherwise modified from time to time,
the "2002 Purchase Agreement"), whereby the Company issued to such parties the
Company's 5% convertible senior secured debentures due March 31, 2006 (as such
debentures may be supplemented, amended, or otherwise modified from time to
time, the "2002 Debentures"; each such holder of 2002 Debentures, or any
permitted successor, assign or transferee thereof, a "2002 Holder");

                  WHEREAS, in connection with the 2002 Purchase Agreement, the
Company has agreed to grant to the 2002 Holders registration rights as set forth
in this Agreement;

                  WHEREAS, the 1998 Holders desire to terminate the
registration rights provisions of the 1998 Purchase Agreement, the 1999 Holders
desire to terminate the registration rights provisions of the 1999 Purchase
Agreement, the holders of the 1998 Warrants desire to terminate the registration
rights applicable to the 1998 Warrants, the holders of the 1999 Warrants desire
to terminate the registration rights applicable to the 1999 Warrants, and Galen
desires to terminate the registration rights applicable to the Bridge Loan
Warrants and such parties desire to enter into this Agreement in lieu therefor
to provide for generally applicable registration rights for all such parties, to
the extent applicable, and to Watson and the 2002 Holders;

                  WHEREAS, the Company desires to grant and Watson, the 1998
Holders, the 1999 Holders, the 2002 Holders, the Recap Shareholders and Galen
desire to obtain, certain registration rights in connection with the Recap
Shares, the Watson Warrant, the 1998 Debentures, the 1999 Debentures, the 1998
Warrants held by Galen, the 1999 Warrants held by Galen, the Bridge Loan
Warrants and the 2002 Debentures (collectively, the "Securities"); and

                                        2

                  WHEREAS, unless otherwise provided in this Agreement,
capitalized terms used herein shall have the meanings set forth in Section 14
hereof.

                  NOW, THEREFORE, in consideration of the foregoing and the
mutual covenants and promises contained herein, the parties agree as follows:

1.       Demand Registrations.

(A)      Requests for Registration. The Holders may request registration under
the Securities Act of all or any part of their Registrable Securities as
provided for below in Section 1(b). Within ten days after receipt of any such
request, the Company will give written notice of such requested registration to
all other Holders of Registrable Securities. The Company will include in such
registration all Registrable Securities with respect to which it has received
written requests for inclusion therein within 30 days after receipt of the
Company's notice. The Company shall cause its management to cooperate fully and
to use its best efforts to support the registration of the Registrable
Securities and the sale of the Registrable Securities pursuant to such
registration as promptly as is practicable. Such cooperation shall include, but
not be limited to, management's attendance and reasonable presentations in
respect of the Company at road shows with respect to the offering of Registrable
Securities. The registration requested under this Section 1 is referred to
herein as a "Demand Registration".

(B)      Number of Registrations. The Holders of Registrable Securities will be
entitled to request the following number and types of registrations: (i) Galen
shall be entitled to request two Demand Registrations on Form S-1 (or any
successor to such form), (ii) Watson shall be entitled to request two Demand
Registrations on Form S-1 (or any successor to such form), (iii) the Holders of
at least 20% of the Registrable Securities then outstanding shall be entitled to
request one Demand Registration on Form S-1 (or any successor to such form),
provided that all Demand Registrations requested pursuant to subsections (i) and
(ii) above shall be deemed to have occurred prior to the Demand Registration
pursuant to this subsection (iii), and (iv) the Holders of Registrable
Securities will be entitled to unlimited Demand Registrations on Form S-3 (or
any successor to such form), for which the Company will pay all Registration
Expenses. A registration will not count as a Demand Registration (x) until it
has become effective, (y) the Holders have sold, in the aggregate, no less than
50% of the shares of Registrable Securities requested to be registered in the
Demand Registration and (z) if the offering of the Registrable Securities
pursuant to such registration is interfered with for any reason by any stop
order, injunction or other order or requirement of the Commission (other than
any stop order, injunction or other requirement of the Commission prompted by
acts or omissions of Holders of Registrable Securities); provided, however, that
except as otherwise provided herein whether or not it becomes effective the
Company will pay all Registration Expenses in connection with any registration
so initiated.

(C)      Priority on Demand Registrations. If a Demand Registration is with
respect to an underwritten offering, and the managing underwriters advise the
Company in writing that in their opinion the number of Registrable Securities
requested to be included exceeds the number which can be sold in such offering,
the Company will include in such registration such number of

                                       3

Shares, which in the opinion of such underwriters, may be sold, allocated among
the Holders electing to participate pro rata in accordance with the amounts of
securities requested to be so included by the respective Holders. If the amount
of such Registrable Securities does not exceed the maximum number which can be
sold in such offering, the Company may include such number of securities which
are not Registrable Securities in the Demand Registration which will not,
together with the Holder's Registrable Securities, exceed the maximum number
which can be sold in the Offering; provided, however, the Company will not
include in any Demand Registration any securities which are not Registrable
Securities without the written consent of the Holders of sixty and two-thirds
percent (66 2/3%) of the Registrable Securities participating in such
registration. A registration shall not count as a Demand Registration if less
than fifty percent (50%) of the Shares which any Holder desires to include
therein are not included due to the determination of the managing underwriters
referred to in the first sentence of this Section 1(c).

(D)      Restrictions on Demand Registrations. The Company will not be obligated
to effect any Demand Registration within six months after the effective date of
a previous registration in which the Holders of Registrable Securities were
given piggyback rights pursuant to Section 2 other than a registration of
Registrable Securities intended to be offered on a continuous or delayed basis
under Rule 415 or any successor rule under the Securities Act (a "Shelf
Registration").

2.       Piggyback Registrations.

(A)      Right to Piggyback. Whenever the Company proposes to register any of
its securities under the Securities Act (other than pursuant to a Demand
Registration or pursuant to a registration on Forms S-4 or S-8 or any successors
to such forms) and the registration form to be used may be used for the
registration and contemplated disposition of Registrable Securities (a
"Piggyback Registration"), the Company will give prompt written notice to all
the Holders of Registrable Securities. The Company will include in such
registration all Registrable Securities with respect to which the Company has
received written requests for inclusion therein within 30 days after the receipt
of the Company's notice, subject to any other priority cutback provisions below.

(B)      Piggyback Expenses. The Registration Expenses of the Holders of
Registrable Securities in such Piggyback Registration will be paid by the
Company.

(C)      Priority on Primary Registrations. If a Piggyback Registration is an
underwritten primary registration on behalf of the Company, and the managing
underwriters advise the Company in writing that in their opinion the number of
securities requested to be included in such registration exceeds the number
which can be sold in such offering, the Company will include in such
registration (i) first, the securities the Company proposes to sell, (ii)
second, the Registrable Securities, pro rata in accordance with the amounts of
Registrable Securities requested to be so included by each Requesting
Stockholder, and (iii) third, any other securities requested to be included in
such registration.

                                       4

(D)      Priority on Secondary Registrations. If a Piggyback Registration is an
underwritten secondary registration on behalf of holders of the Company's
securities, and the managing underwriters advise the Company in writing that in
their opinion the number of securities requested to be included in such
registration exceeds the number which can be sold in such offering, the Company
will include in such registration (i) first, the securities requested to be
included therein by the holders requesting such registration, (ii) second, the
Registrable Securities, pro rata in accordance with the amounts of Registrable
Securities requested to be so included by each Requesting Stockholder, and (iii)
third, other securities requested to be included in such registration.

(E)      Other Restrictions. The Company hereby agrees that if it has previously
filed a registration statement with respect to Registrable Securities pursuant
to Section 1 or pursuant to this Section 2, and if such previous registration
has not been withdrawn or abandoned, the Company will not file or cause to be
effected any other registration of any of its equity securities or securities
convertible or exchangeable into or exercisable for its equity securities under
the Securities Act except on Form S-8 or any other similar form for employee
benefit plans, whether on its own behalf or at the request of any holder or
holders of such securities, until a period of at least six months has elapsed
from the effective date of such previous registration or, if sooner, until all
Registrable Securities included in such previous registration have been sold.

3.       Holdback Agreements.

(A)      Holders of Registrable Securities. The Investors and each other Holder
of Registrable Securities who is or becomes a party to this Agreement, agrees
not to effect any public sale or distribution of equity securities of the
Company, or any securities convertible into or exchangeable or exercisable for
such securities, during the seven days prior to and the 90-day period beginning
on the effective date of any underwritten Demand Registration or any
underwritten Piggyback Registration except as part of such underwritten
registration or, if sooner, until all Registrable Securities included within
such registration have been sold.

(B)      The Company. The Company agrees (i) not to effect any public sale or
distribution of its equity securities, or any securities convertible into or
exchangeable or exercisable for such securities, during the seven days prior to
and the 90-day period beginning on the effective date of any underwritten Demand
Registration or any underwritten Piggyback Registration except as part of such
underwritten registration or pursuant to registrations on Form S-8 or any other
similar form for employee benefit plans or, if sooner, until all Registrable
Securities included within such registration have been sold, and (ii) to use its
reasonable best efforts to cause each holder of its equity securities, or any
securities convertible into or exchangeable or exercisable for such securities,
purchased from the Company at any time after the date of this Agreement (other
than in a registered public offering) to agree not to effect any public sale or
distribution of any such securities during such period except as part of such
underwritten registration, if otherwise permitted or, if sooner, until all
Registrable Securities included within such registration have been sold;
provided, however, that the provisions of this Section 3(b) shall continue to
apply with respect to a registration until the provisions of Section 3(a) no
longer apply with respect to such registration.

                                       5

(C)      Registration Procedures. Whenever the Holders of Registrable Securities
have requested that any Registrable Securities be registered pursuant to Section
1 or 2 of this Agreement, the Company shall use its best efforts to effect the
registration and the sale of such Registrable Securities in accordance with the
intended method of disposition thereof, and pursuant thereto the Company shall
as expeditiously as possible:

                  (i)      prepare and file with the Commission a registration
         statement with respect to such Registrable Securities, which
         registration statement will state that the Holders of Registrable
         Securities covered thereby may sell such Registrable Securities either
         under such registration statement or, at any Holder's proper request,
         pursuant to Rule 144 (or any successor rule under the Securities Act),
         and use its best efforts to cause such registration statement to become
         effective (provided that before filing a registration statement or
         prospectus or any amendments or supplements thereto, the Company will
         furnish to the counsel selected by (A) Galen, in the event of a Demand
         Registration requested pursuant to Section 1(b)(i), (B) Watson, in the
         event of a Demand Registration requested pursuant to Section 1(b)(ii),
         or (C) the Holders of sixty and two-thirds percent (66 2/3%) of the
         Registrable Securities included in such registration, in the event of
         any other registration, copies of all such documents proposed to be
         filed, which documents will be subject to the review of such counsel);

                  (ii)     prepare and file with the Commission such amendments
         and supplements to such registration statement and the prospectus used
         in connection therewith as may be necessary to keep such registration
         statement effective for the period set forth in Section 4(i) hereof and
         comply with the provisions of the Securities Act with respect to the
         disposition of all securities covered by such registration statement
         during such period in accordance with the intended methods of
         disposition by the sellers thereof set forth in such registration
         statement;

                  (iii)    furnish to each seller of Registrable Securities such
         number of copies of such registration statement, each amendment and
         supplement thereto, the prospectus included in such registration
         statement (including each preliminary prospectus) and such other
         documents as such seller may reasonably request in order to facilitate
         the disposition of the Registrable Securities owned by such seller;

                  (iv)     use its best efforts to register or qualify, if
         applicable, such Registrable Securities under such other securities or
         blue sky laws of such jurisdictions as any seller reasonably requests
         and do any and all other acts and things which may be reasonably
         necessary or advisable to enable such seller to consummate the
         disposition in such jurisdictions of the Registrable Securities owned
         by such seller (provided that the Company will not be required to (A)
         qualify generally to do business in any jurisdiction where it would not
         otherwise be required to qualify but for this subsection, (B) subject
         itself to taxation in any such jurisdiction, or (C) consent to general
         service of process in any such jurisdiction);

                                       6

                  (v)      within one business day of its occurrence, notify
         each seller of such Registrable Securities, at any time when a
         prospectus relating thereto is required to be delivered under the
         Securities Act, of the happening of any event as a result of which the
         prospectus included in such registration statement contains an untrue
         statement of a material fact or omits to state any fact necessary to
         make the statements therein not misleading, and, at the request of any
         such seller, the Company will promptly prepare a supplement or
         amendment to such prospectus so that, as thereafter delivered to the
         purchasers of such Registrable Securities, such prospectus will not
         contain an untrue statement of a material fact or omit to state any
         fact necessary to make the statements therein not misleading;

                  (vi)     cause all such Registrable Securities to be listed on
         each securities exchange or market on which similar securities issued
         by the Company are then listed;

                  (vii)    provide a transfer agent and registrar for all such
         Registrable Securities not later than the effective date of such
         registration statement;

                  (viii)   make available for inspection by any seller of
         Registrable Securities, any underwriter participating in any
         disposition pursuant to such registration statement, and any attorney,
         accountant or other agent retained by any such seller or underwriter,
         all financial and other records, pertinent corporate documents and
         properties of the Company, and cause the Company's officers, directors
         and employees to supply all information reasonably requested by any
         such seller, underwriter, attorney, accountant or agent in connection
         with such registration statement;

                  (ix)     cause the Registrable Securities to be registered on
         such appropriate registration form or forms of the Commission as shall
         permit a delayed or continuous offering of the Registrable Securities
         pursuant to Rule 415 under the Securities Act and permit the
         disposition of the Registrable Securities in accordance with the method
         or methods of disposition requested by the Holders of sixty-six and
         two-thirds percent (66-2/3%) of the Registrable Securities included in
         such registration, and keep such registration statement effective until
         the Holders of a sixty-six and two-thirds percent (66-2/3%) of
         Registrable Securities included in such registration have completed the
         sale and distribution of the Registrable Securities;

                  (x)      if such registration is an underwritten registration,
         cause the Company's officers, directors and holders of in excess of one
         percent of the Company's outstanding Common to execute lock-up
         agreements, containing customary terms and provisions, required by an
         underwriter in any such registered offering restricting such parties
         from selling shares of the Company's Common Stock for a period of up to
         180 days; and

                  (xi)     furnish, at the request of any Holder requesting
         registration of Registrable Securities pursuant to Section 1 or 2, if
         the method of distribution is by means of an underwriting, on the date
         that the shares of Registrable Securities are delivered to the
         underwriters for sale pursuant to such registration, or if such
         Registrable Securities are not being sold through underwriters, on the
         date that the registration statement with

                                       7

         respect to such shares of Registrable Securities becomes effective, (A)
         a signed opinion, dated such date, of the independent legal counsel
         representing the Company for the purpose of such registration,
         addressed to the underwriters, if any, and if such Registrable
         Securities are not being sold through underwriters, then to the Holders
         making such request, as to such matters as such underwriters or the
         Holders holding a majority of the Registrable Securities included in
         such registration, as the case may be, may reasonably request; and (B)
         letters dated such date and the date the offering is priced from the
         independent certified public accountants of the Company, addressed to
         the underwriters, if any, and if such Registrable Securities are not
         being sold through underwriters, then to the Holders making such
         request (x) stating that they are independent certified public
         accountants within the meaning of the Act and that, in the opinion of
         such accountants, the financial statements and other financial data of
         the Company included in the Registration Statement or the prospectus,
         or any amendment or supplement thereto, comply as to form in all
         material respects with the applicable accounting requirements of the
         Act and (y) covering such other financial matters (including
         information as to the period ending not more than five business days
         prior to the date of such letters) with respect to the registration in
         respect of which such letter is being given as such underwriters or the
         Holders holding a majority of the Registrable Securities included in
         such registration, as the case may be, may reasonably request and as
         would be customary in such a transaction.

4.       Registration Expenses. All Registration Expenses incurred in connection
with a registration, qualification or compliance pursuant to this Agreement
shall be borne by the Company, and all Selling Expenses shall be borne by the
Holders, the Requesting Stockholders and any other holders of the securities so
registered pro rata on the basis of the number of their shares so registered;
provided, however, that the Company shall not be required to pay any
Registration Expenses if, as a result of the withdrawal of a request for
registration by a majority of Registrable Securities (other than as a result of
any failure of the Company to comply with the terms of this Agreement, or the
disclosure of any adverse development relating to the Company after the initial
request for registration by any Holder), the registration statement does not
become effective, in which case the Holders and Requesting Stockholders
requesting registration shall bear such Registration Expenses pro rata on the
basis of the number of their shares so included in the registration request,
and, further, that such registration shall not be counted as a Demand
Registration pursuant to Section 1.

5.       Indemnification.

(A)      The Company will indemnify each Holder, each Holder's officers,
directors, employees, agents, members and partners, and each Person controlling,
controlled by or under common control with such Holder, with respect to which
registration, qualification or compliance of such Holder's securities has been
effected pursuant to this Agreement, and each underwriter, if any, and each
Person who controls any underwriter, against all claims, losses, damages and
liabilities (or actions in respect thereof), joint or several, arising out of or
based on any untrue statement (or alleged untrue statement) of a material fact
contained in any registration statement, prospectus, offering circular or other
document (including any related registration statement notification or the like)
incident to any such registration, qualification or compliance,

                                       8

or based on any omission (or alleged omission) to state therein a material fact
required to be stated therein or necessary to make the statements therein not
misleading, or any violation by the Company of the Securities Act or any rule or
regulation thereunder applicable to the Company and relating to action or
inaction required of the Company in connection with any such registration,
qualification or compliance, and will reimburse each such Holder, each Holder's
officers, directors, employees, agents, members and partners, and each Person
controlling each such Holder, each such underwriter and each Person who controls
any such underwriter, for any legal and any other expenses reasonably incurred
in connection with investigating or defending any such claim, loss, damage,
liability or action, provided that the Company will not be liable to a Holder in
any such case to the extent that any such claim, loss, damage, liability or
action arises out of or is based on any untrue statement or omission of material
fact based upon written information furnished to the Company by such Holder or
underwriter and stated to be specifically for use therein.

(B)      Each Holder and Requesting Stockholder will severally not jointly, if
Registrable Securities held by it are included in the securities as to which
such registration, qualification or compliance is being effected, indemnify the
Company, each of the Company's directors and officers and each underwriter, if
any, of the Company's securities covered by such registration statement, each
Person who controls the Company or such underwriter within the meaning of the
Securities Act and the rules and regulations thereunder, each other Holder,
Requesting Stockholder or any other holder of securities included in the
offering and each of their respective officers, directors, employees, agents,
members and partners, and each Person controlling such other Holder, Requesting
Stockholder and any other holders of securities included in the offering,
against all claims, losses, damages and liabilities (or actions in respect
thereof), joint or several, arising out of or based on any untrue statement (or
alleged untrue statement) of a material fact contained in any such registration
statement, prospectus, offering circular or other document incident to any such
registration, qualification or compliance, or based on any omission (or alleged
omission) to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading, and will reimburse the
Company, its officers and directors, each underwriter, each Person controlling
the Company or such underwriter, each other Holder and Requesting Stockholders,
their officers, directors, employees, agents, members, partners and control
persons for any legal or any other expenses reasonably incurred in connection
with investigating or defending any such claim, loss, damage, liability or
action, in each case to the extent, but only to the extent, that such untrue
statement (or alleged untrue statement) or omission (or alleged omission) is
made in such registration statement, prospectus, offering circular or other
document in reliance upon and in conformity with written information furnished
to the Company by such Holder or Requesting Stockholder and stated to be
specifically for use therein; provided, however, that the obligations of each
such Holder and Requesting Stockholder hereunder shall be limited to an amount
equal to the net proceeds (after deduction of underwriting discounts and selling
commissions, if any) received by each such Holder or Requesting Stockholder of
securities sold as contemplated herein.

(C)      Each party entitled to indemnification under this Section 5 (the
"Indemnified Party") shall give notice to the party required to provide
indemnification (the "Indemnifying Party") promptly after such Indemnified Party
has actual knowledge of any claim as to which indemnity may be sought, and shall
permit the Indemnifying Party to assume the defense of any such claim or any

                                       9

litigation resulting therefrom, provided that counsel for the Indemnifying
Party, who shall conduct the defense of such claim or any litigation resulting
therefrom, shall be approved by the Indemnified Party (whose approval shall not
be unreasonably withheld) and the Indemnified Party may participate in such
defense at such party's expense, and provided further that the failure of any
Indemnified Party to give notice as provided herein shall not relieve the
Indemnifying Party of its obligations under this Agreement unless such failure
has had a material adverse effect on such claim. The parties to this Agreement
reserve any rights to claim under this Agreement for damages actually incurred
by reason of any failure of the Indemnified Party to give prompt notice of a
claim. To the extent counsel for the Indemnifying Party shall in such counsel's
reasonable judgment, have a conflict in representing an Indemnified Party in
conjunction with the Indemnifying Party or other Indemnified Parties, such
Indemnified Party shall be entitled to separate counsel at the expense of the
Indemnifying Party subject to the approval of such counsel by the Indemnified
Party (whose approval shall not be unreasonably withheld). No Indemnifying
Party, in the defense of any such claim or litigation, shall, except with the
consent of each Indemnified Party, consent to entry of any judgment or enter
into any settlement which does not include as an unconditional term thereof the
giving by the claimant or plaintiff to such Indemnified Party of a release from
all liability in respect of such claim or litigation. Each Indemnified Party
shall furnish such information regarding itself or the claim in question as an
Indemnifying Party may reasonably request in writing and as shall be reasonably
required in connection with the defense of such claim and any litigation
resulting therefrom.

                  6.       Restrictive Legend. Each certificate representing (a)
the Securities or (b) any Shares or other securities issued in respect thereof,
upon any stock split, stock dividend, recapitalization, merger, consolidation or
similar event shall be stamped or otherwise imprinted with a legend in the
following form (in addition to any legend required under applicable state
securities laws and any other applicable agreement(s)):

                  "THIS WARRANT/DEBENTURE [AND THE COMMON STOCK ISSUABLE UPON
                  COVERSION HEREOF] HAVE NOT BEEN REGISTERED UNDER THE
                  SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), NOR ANY STATE
                  SECURITIES LAW AND MAY NOT BE PLEDGED, SOLD, ASSIGNED,
                  HYPOTHECATED OR OTHERWISE TRANSFERRED UNTIL (1) A REGISTRATION
                  STATEMENT WITH RESPECT THERETO IS EFFECTIVE UNDER THE ACT AND
                  ANY APPLICABLE STATE SECURITIES LAWS OR (2) THE COMPANY
                  RECEIVES AN OPINION OF COUNSEL TO THE COMPANY OR OTHER COUNSEL
                  TO THE HOLDER OF SUCH [WARRANT/DEBENTURE AND/OR COMMON STOCK]
                  REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH
                  [WARRANT/DEBENTURE AND/OR COMMON STOCK] MAY BE PLEDGED, SOLD,
                  ASSIGNED, HYPOTHECATED OR TRANSFERRED WITHOUT AN EFFECTIVE
                  REGISTRATION STATEMENT UNDER THE ACT OR APPLICABLE STATE
                  SECURITIES LAWS."

                                       10

                  7.       Information by the Holders and Requesting
Stockholders. Each Holder of Registrable Securities, and each Requesting
Stockholder holding securities included in any registration, shall furnish to
the Company such information regarding such Holder or Requesting Stockholder and
the distribution proposed by such Holder or Requesting Stockholder as the
Company may reasonably request in writing and as shall be reasonably required in
connection with any registration, qualification or compliance referred to in
this Agreement.

                  8.       Limitations on Registration of Issues of Securities.
From and after the date of this Agreement, the Company shall not enter into any
agreement with any holder or prospective holder of any securities of the Company
giving such holder or prospective holder the right to require the Company to
register any securities of the Company that are more favorable to such holder or
prospective holder than the rights granted under this Agreement.

                  9.       Rule 144 Reporting. With a view to making available
the benefits of certain rules and regulations of the Commission which may permit
the sale of the Restricted Securities to the public without registration, the
Company agrees to:

                           (a)      make and keep public information available
         as those terms are understood and defined and interpreted in and under
         Rule 144 under the Securities Act ("Rule 144"), at all times from and
         after the date hereof;

                           (b)      file with the Commission in a timely manner
         all reports and other documents required of the Company under the
         Securities Act and the Exchange Act at any time after it has become
         subject to such reporting requirements; and

                           (c)      so long as the Holders own any Restricted
         Securities, furnish to the Holders forthwith upon request a written
         statement by the Company as to its compliance with the reporting
         requirements of Rule 144 and of the Securities Act and the Exchange Act
         (at any time after it has become subject to such reporting
         requirements), a copy of the most recent annual or quarterly report of
         the Company, and such other reports and documents so filed as any
         Holder may reasonably request in availing itself of any rule or
         regulation of the Commission allowing any Holder to sell any such
         securities without registration.

                  10.      Participation in Underwritten Registrations. Subject
to the right of any Holder or Holders to withdraw any request for registration,
no Person may participate in any underwritten registration hereunder unless such
Person (a) agrees to sell such Person's securities on the basis provided in any
underwriting arrangements approved by the Persons entitled hereunder to approve
such arrangements and (b) completes and executes all reasonable and customary
questionnaires, powers of attorney, indemnities, underwriting agreements and
other documents required under the terms of such underwriting arrangements.

                  11.      Selection of Underwriters. If any Demand Registration
is an underwritten offering, (a) Galen, in the event of a Demand Registration
requested pursuant to Section 1(b)(i), (b) Watson, in the event of a Demand
Registration requested pursuant to Section 1(b)(ii), and (c) the Holders of
sixty and two-thirds percent (66 2/3%) of the Registrable Securities included in
such registration, in the event of any other registration shall have the right
to select the

                                       11

investment banking firm to be lead manager of the offering, subject to the
approval of the Company (which approval will not be unreasonably withheld). If
any registration other than a Demand Registration is an underwritten offering,
the Company will have the right to select the investment banking firm to be lead
manager of the offering, subject to the approval of the Holders of sixty and
two-thirds percent (66 2/3%) of the Registrable Securities included in such
registration (which approval will not be unreasonably withheld).

                  12.      Termination of Registration Rights. The rights of
Holders to request a Demand Registration or participate in a Piggyback
Registration shall expire on March 31, 2008.

                  13.      Termination of Other Registration Rights Agreements.

                  (a)      The 1998 Holders hereby agree and acknowledge that in
consideration for the registration rights granted hereunder that Article XI (or
any successor or equivalent article or provision) of the 1998 Purchase Agreement
and any other agreement, instrument or understanding that grants or purports to
grant registration rights to such parties are hereby terminated and of no
further force or effect.

                  (b)      The holders of the 1998 Warrants hereby agree and
acknowledge that in consideration for the registration rights granted hereunder
that Article XI (or any successor or equivalent article or provision) of the
1998 Purchase Agreement and any other agreement, instrument or understanding
that grants or purports to grant registration rights to such parties are hereby
terminated and of no further force or effect.

                  (c)      The 1999 Holders hereby agree and acknowledge that in
consideration for the registration rights granted hereunder that Article XI (or
any successor or equivalent article or provision) of the 1999 Purchase Agreement
and any other agreement, instrument or understanding that grants or purports to
grant registration rights to such parties are hereby terminated and of no
further force or effect.

                  (d)      The holders of the 1999 Warrants hereby agree and
acknowledge that in consideration for the registration rights granted hereunder
that Article XI (or any successor or equivalent article or provision) of the
1999 Purchase Agreement and any other agreement, instrument or understanding
that grants or purports to grant registration rights to such parties are hereby
terminated and of no further force or effect.

                  (e)      Galen hereby agrees and acknowledges that in
consideration for the registration rights granted hereunder that any provision
or Section in the Bridge Loan Agreements, the Bridge Loan Warrants and any other
agreement, instrument or understanding that grants or purports to grant
registration rights to Galen are hereby terminated and of no further force or
effect.

                  14.      Definitions. As used herein, the following terms have
the following meanings:

                  "Act" means the Securities Act of 1933, as amended.

                                       12

                  "Agreement" means this Registration Rights Agreement.

                  "Bridge Loan Agreements" means any and all of the separate
         Bridge Loan Agreements between the Company, Galen Partners III, L.P.
         and the other parties listed on the signature pages thereto entered
         into between such parties commencing as of August 12, 1998 through and
         including December __, 2002 pursuant to which the Bridge Loan Warrants
         were issued, including, without limitation, that certain Bridge Loan
         Agreement dated as of August 15, 2001 among the Company, Galen Partners
         III, L.P., Galen Partners International III L.P., Galen Employee Fund
         III, L.P., those individuals listed on the signature page thereto, and
         Galen Partners III, L.P., as agent for the lenders, as amended by the
         First Amendment to Bridge Loan Agreement dated as of January 8, 2002,
         the Second Amendment to Bridge Loan Agreement dated as of April 5,
         2002, and the Third Amendment to Bridge Loan Agreement dated as of May
         8, 2002, as such may be supplemented, amended or otherwise modified
         from time to time.

                  "Common Stock" has the meaning set forth in the recitals.

                  "Commission" means the Securities and Exchange Commission.

                  "Company" has the meaning set forth in the preamble.

                  "Demand Registration" has the meaning set forth in Section
         1(a) of this Agreement.

                  "Exchange Act" means the Securities Exchange Act of 1934, as
         amended.

                  "Holders" means the Investors or any Person to whom an
         Investor or transferee(s) of an Investor has assigned, transferred or
         otherwise conveyed the Securities or the Shares.

                  "Indemnified Party" has the meaning set forth in Section 5
         hereof.

                  "Indemnifying Party" has the meaning set forth in Section 5
         hereof.

                  "Investors" has the meaning set forth in the preamble.

                  "Loan Agreement" has the meaning set forth in the recitals.

                  "1998 Debentures" has the meaning set forth in the recitals.

                  "1998 Holder" has the meaning set forth in the recitals.

                  "1998 Purchase Agreement" has the meaning set forth in the
         recitals.

                  "1998 Warrants" has the meaning set forth in the recitals.

                                       13

                  "1999 Debentures" has the meaning set forth in the recitals.

                  "1999 Holder" has the meaning set forth in the recitals.

                  "1999 Purchase Agreement" has the meaning set forth in the
         recitals.

                  "1999 Warrants" has the meaning set forth in the recitals.

                  "Person" means any individual, corporation, limited liability
         company, partnership, association, trust or any other entity or
         organization, including a government or political subdivision or an
         agency or instrumentality thereof.

                  "Piggyback Registration" has the meaning set forth in Section
         2 of this Agreement.

                  "Registrable Securities" means any Shares issued or issuable
         upon the exercise or conversion of the Securities (including any
         Securities that may be issued as interest with respect to any Security)
         or in respect of the Shares issued or issuable upon the exercise or
         conversion of any Securities upon any stock split, stock dividend,
         recapitalization or similar event.

                  "Registration Expenses" means all expenses incurred by the
         Company in compliance with Sections 1 and 2 hereof, including, without
         limitation, all registration and filing fees, printing expenses, fees,
         and disbursements of counsel for the Company and blue sky fees and
         expenses, reasonable fees and disbursements for one counsel, as such
         counsel is selected in accordance with Section 4(a), and the expense of
         any special audits incident to or required by any such registration,
         exclusive of the Selling Expenses.

                  "Restricted Securities" means the securities of the Company
         required to bear or bearing the legend set forth in Section 6 of this
         Agreement.

                  "Requesting Stockholders" means holders of securities of the
         Company entitled to have securities included in any registration
         pursuant to Section 2 and who shall request such inclusion.

                  "Rule 144" has the meaning set forth in Section 9 of this
         Agreement.

                  "Securities" has the meaning set forth in the recitals.

                  "Securities Act" means the Securities Act of 1933, as amended.

                  "Selling Expenses" means all underwriting discounts and
         selling commissions applicable to the sale of Registrable Securities
         and, except as otherwise provided in "Registration Expenses", all fees
         and disbursements of counsel for any Holder.

                                       14

                  "Shares" means the shares of Common Stock which may be issued
         upon the exercise of all or a portion of the Securities. The term
         Shares does not include any other shares of Common Stock or other
         capital stock of the Company.

                  "Shelf Registration" has the meaning set forth in Section 1 of
         this Agreement.

                  "2002 Debentures" has the meaning set forth in the recitals.

                  "2002 Holder" has the meaning set forth in the recitals.

                  "2002 Purchase Agreement" has the meaning set forth in the
         recitals.

                  "Watson Warrant" has the meaning set forth in the recitals.

                  15.      Remedies. Any Person having rights under any
provision of this Agreement shall be entitled to enforce such rights
specifically to recover damages caused by reason of any breach of any provision
of this Agreement and to exercise all other rights granted by law. The parties
hereto agree and acknowledge that money damages may not be an adequate remedy
for any breach of the provisions of this Agreement and that any party may in its
sole discretion apply to any court of law or equity of competent jurisdiction
(without posting any bond or other security) for specific performance and for
other injunctive relief in order to enforce or prevent violation of the
provisions of this Agreement.

                  16.      Amendments and Waivers. The provisions of this
Agreement may be amended or waived only upon the prior written consent of the
Company and the Holders of sixty and two-thirds percent (66 2/3%) of the
Registrable Securities, provided that the prior written consent of all of the
Holders will be required to amend Section 1 and 2 hereof.

                  17       Delays or Omissions. No delay or omission to exercise
any right, power or remedy accruing to any Investor or Holder upon any breach or
default of the Company under this Agreement shall impair any such right, power
or remedy of such Holder or Investor nor shall it be construed to be a waiver of
any such breach or default, or an acquiescence, therein, or of or in any similar
breach or default thereafter occurring; nor shall any waiver of any single
breach or default be deemed a waiver of any other breach or default theretofore
or thereafter occurring. Any waiver, permit, consent or approval of any kind or
character on the part of any holder of any breach or default under this
Agreement, or any waiver on the part of any Investor or Holder of any provisions
or conditions of this Agreement must be, made in writing and shall be effective
only to the extent specifically set forth in such writing. All remedies, either
under this Agreement or by law or otherwise afforded to any holder, shall be
cumulative and not alternative.

                  18.      Successors and Assigns. All covenants and agreements
in this Agreement by or on behalf of any of the parties hereto shall bind and
inure to the benefit of the respective successors and assigns of the parties
hereto whether so expressed or not. In addition, whether or not any express
assignment has been made, the provisions of this Agreement which are for the
benefit of the Holders of Registrable Securities are also for the benefit of,
and enforceable by, any subsequent holder of Registrable Securities. The
registration rights provided in this

                                       15

Agreement may be transferred without restriction and shall inure to and be
enforceable by any and all Holders of Registrable Securities, including, without
limitation, any successors, assigns, transferees, heirs, executors and
administrators of the Investors.

                  19.      Severability. Unless otherwise expressly provided
herein, each Investor's or Holders rights and obligations hereunder are several
rights and obligations, not rights and obligations jointly held with any other
person. In case any provision of this Agreement shall be invalid, illegal or
unenforceable, the validity, legality and enforceability of the remaining
provisions shall not in any way be affected or impaired thereby.

                  20.      Counterparts; Facsimile Transmission. This Agreement
may be executed simultaneously in two or more counterparts, any one of which
need not contain the signatures of more than one party, but all such
counterparts taken together shall constitute one and the same Agreement. Each
party to this Agreement agrees that it will be bound by its own facsimilied
signature and that it accepts the facsimilied signature of each other party to
this Agreement.

                  21.      Descriptive Headings. The titles of the articles,
sections and subsections of this Agreement are for convenience of reference only
and are not to be considered in construing this Agreement.

                  22.      Governing Law. This Agreement and the rights of the
parties hereunder shall be governed in all respects by the laws of the State of
New York wherein the terms of this Agreement were negotiated, excluding to the
greatest extent permitted by law any rule of law that would cause the
application of the laws of any jurisdiction other than the State of New York.

                  23.      Notices. All notices, demands or other communications
to be given or delivered under or by reason of the provisions of this Agreement
shall be in writing and shall be deemed to have been given when delivered
personally to the recipient, sent to the recipient by reputable overnight
courier service (charges prepaid) or 48 hours after deposited in the United
States mail, certified or registered to the recipient by postage prepaid or by
facsimile. Such notices, demands and other communications shall be sent to the
Investors and to any Holder at the addresses indicated on the Schedule of
Investors attached hereto and to the Company at the address of its corporate
headquarters or to such other address or to the attention of such other Person
as the recipient party has specified by prior written notice to the sending
party.

                      [THIS SPACE INTENTIONALLY LEFT BLANK]

                                       16

                  IN WITNESS WHEREOF, the parties have executed this Agreement
as of the date first written above.
                                       COMPANY

                                       HALSEY DRUG CO., INC.

                                       By:  ____________________________
                                            Name:  _____________________
                                            Title: _____________________

                                       WATSON

                                       WATSON PHARMACEUTICALS, INC.

                                       By:  ____________________________
                                            Name:  _____________________
                                            Title: _____________________

                                       17

                                  2002 HOLDERS

                                          
GALEN PARTNERS III, L.P.                     GALEN PARTNERS INTERNATIONAL, III, L.P.
By: Claudius, L.L.C., General Partner        By: Claudius, L.L.C., General Partner
610 Fifth Avenue, 5th Fl.                    610 Fifth Avenue, 5th Floor
New York, New York 10019                     New York, New York 10020

__________________________________________   _______________________________________________
By: Srini Conjeevaram                        By: Srini Conjeevaram
Its: General Partner                         Its: General Partner

GALEN EMPLOYEE FUND III, L.P.                ESSEX WOODLANDS VENTURES FUND V, L.P.
By: Wesson Enterprises, Inc.                 By: Essex Woodlands Health Ventures V, L.L.C.,
610 Fifth Avenue, 5th Floor                      Its General Partner
New York, New York 10020                     190 South LaSalle Street, Suite 2800
                                             Chicago, IL 60603

__________________________________________   _______________________________________________
By: Bruce F. Wesson                          By: Immanuel Thangaraj
Its: General Partner                         Its: Managing Director

CARE CAPITAL INVESTMENTS II, L.P.            BERNARD SELZ
By: Care Capital II, LLC, General Partner    c/o Furman Selz
47 Hulfish Street, Suite 310                 230 Park Avenue
Princeton, NJ 08542                          New York, New York 10069

__________________________________________   _______________________________________________
By: David R. Ramsay
Its: Authorized Signatory

MICHAEL WEISBROT                             SUSAN WEISBROT
1136 Rock Creek Road                         1136 Rock Creek Road
Gladwyne, Pennsylvania 19035                 Gladwyne, Pennsylvania 19035

__________________________________________   _______________________________________________

VARSHA H. SHAH                               HEMANT K. SHAH
29 Christy Drive                             29 Christy Drive
Warren, New Jersey  07059                    Warren, New Jersey 07059

__________________________________________   _______________________________________________
18 GREG WOOD ROGER GRIGGS c/o D.R. International c/o Tom Jennings 7474 No. Figueroa Street 7300 Turfway Road Los Angeles, California 90041 Suite 300 Florence, KY 41042 __________________________________________ _______________________________________________ GEORGE E. BOUDREAU 222 Elbow Lane Haverford, PA 19041 __________________________________________
19 1998 HOLDERS GALEN PARTNERS III, L.P. By: Claudius, L.L.C., General Partner 610 Fifth Avenue, 5th Fl. New York, New York 10019 _______________________________________________ By: Srini Conjeevaram Its: General Partner GALEN EMPLOYEE FUND III, L.P. GALEN PARTNERS INTERNATIONAL, III, L.P. By: Wesson Enterprises, Inc. By: Claudius, L.L.C., General Partner 610 Fifth Avenue, 5th Floor 610 Fifth Avenue, 5th Floor New York, New York 10020 New York, New York 10020 __________________________________________ _______________________________________________ By: Srini Conjeevaram By: Bruce F. Wesson Its: General Partner Its: General Partner ALAN SMITH PATRICK COYNE 21 Bedlow Avenue 800 Merion Square Road Newport, Rhode Island 02840 Gladwyne, PA 19035 __________________________________________ _______________________________________________ MICHAEL WEISBROT SUSAN WEISBROT 1136 Rock Creek Road 1136 Rock Creek Road Gladwyne, Pennsylvania 19035 Gladwyne, Pennsylvania 19035 __________________________________________ _______________________________________________ GREG WOOD DENNIS ADAMS c/o D.R. International 120 Kynlyn Road 7474 No. Figueroa Street Radnor, Pennsylvania 19312 Los Angeles, California 90041 __________________________________________ _______________________________________________
20 ROBERT W. BAIRD & CO., INC., TTEE ROBERT W. BAIRD & CO., INC., TTEE FBO Connie Reicher IRA FBO Michael K. Reicher IRA c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 __________________________________________ _______________________________________________ By: Robert W. Baird By: Robert W. Baird Its: Trustee Its: Trustee CONNIE REICHER TRUST MICHAEL REICHER TRUST c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 __________________________________________ _______________________________________________ By: Connie Reicher By: Michael Reicher Its: Trustee Its: Trustee PETER CLEMENS STEPHANIE HEITMEYER c/o Halsey Drug Co., Inc. 17759 Road, Route 66 695 North Perryville Rd. Ft. Jennings, Ohio 45844 Crimson Building #2 Rockford, Ill. 61107 __________________________________________ _______________________________________________ VARSHA H. SHAH HEMANT K. SHAH 29 Christy Drive 29 Christy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 __________________________________________ _______________________________________________ BERNARD SELZ c/o Furman Selz 230 Park Avenue New York, New York 10069 __________________________________________
21 VARSHA H. SHAH AS CUSTODIAN VARSHA H. SHAH AS CUSTODIAN FOR SACHIN H. SHAH FOR SUMEET H. SHAH 29 Christy Drive 29 Christy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 __________________________________________ _______________________________________________ By: Varshah H. Shah By: Varshah H. Shah Its: Custodian Its: Custodian MICHAEL RAINISCH ILENE RAINISCH c/o Alvin Rainisch c/o Alvin Rainisch 315 Devon Place 315 Devon Place Morganville, New Jersey 07751 Morganville, New Jersey 07751 __________________________________________ _______________________________________________ KENNETH GIMBEL, IRA ACCOUNT KENNETH GIMBEL FBO KENNETH GIMBEL 2455 Montgomery Avenue 2455 Montgomery Avenue Highland Park, Ill. 60035 Highland Park, Ill. 60035 __________________________________________ _______________________________________________ By: ______________________________________ Its: Trustee JESSICA K. CLEMENS JAKE P. CLEMENS c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 __________________________________________ _______________________________________________ BROOKE EMILY REICHER ALEC JOHN REICHER c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 __________________________________________ _______________________________________________
22 COURTNEY PAIGE REICHER DEANA REICHER c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 __________________________________________ _______________________________________________ MICHAEL K. REICHER II TODD ALLEN REICHER c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 __________________________________________ _______________________________________________
23 1999 HOLDERS ORACLE STRATEGIC PARTNERS, L.P. GALEN PARTNERS III, L.P. By: Oracle Strategic Capital L.L.C., By: Claudius, L.L.C., General Partner General Partner 610 Fifth Avenue, 5th Fl. 200 Greenwich Avenue New York, New York 10019 3rd Floor Greenwich, CT 06830 __________________________________________ _______________________________________________ By: Joel Liffmann By: Srini Conjeevaram Its: Authorized Agent Its: General Partner GALEN EMPLOYEE FUND III, L.P. GALEN PARTNERS INTERNATIONAL, III, L.P. By: Wesson Enterprises, Inc. By: Claudius, L.L.C., General Partner 610 Fifth Avenue, 5th Floor 610 Fifth Avenue, 5th Floor New York, New York 10020 New York, New York 10020 __________________________________________ _______________________________________________ By: Bruce F. Wesson By: Srini Conjeevaram Its: General Partner Its: General Partner ALAN SMITH PATRICK COYNE 21 Bedlow Avenue 800 Merion Square Road Newport, Rhode Island 02840 Gladwyne, PA 19035 __________________________________________ _______________________________________________ MICHAEL WEISBROT SUSAN WEISBROT 1136 Rock Creek Road 1136 Rock Creek Road Gladwyne, Pennsylvania 19035 Gladwyne, Pennsylvania 19035 __________________________________________ _______________________________________________
24 GREG WOOD DENNIS ADAMS c/o D.R. International 120 Kynlyn Road 7474 No. Figueroa Street Radnor, Pennsylvania 19312 Los Angeles, California 90041 _______________________________________ _________________________________ BERNARD SELZ c/o Furman Selz 230 Park Avenue New York, New York 10069 _______________________________________
25 HOLDERS OF RECAP SHARES ORACLE STRATEGIC PARTNERS, L.P. DANIEL HILL By: Oracle Strategic Capital L.L.C., 6725 Lynch Avenue General Partner Riverbank, CA 95367 200 Greenwich Avenue 3rd Floor Greenwich, CT 06830 _______________________________________ _________________________________ By: Joel Liffmann Its: Authorized Agent BERNARD SELZ PETER CLEMENS c/o Furman Selz c/o Halsey Drug Co., Inc. 230 Park Avenue 695 North Perryville Rd. New York, New York 10069 Crimson Building #2 Rockford, Ill. 61107 _______________________________________ _________________________________ ALAN SMITH PATRICK COYNE 21 Bedlow Avenue 800 Merion Square Road Newport, Rhode Island 02840 Gladwyne, PA 19035 _______________________________________ _________________________________ MICHAEL WEISBROT SUSAN WEISBROT 1136 Rock Creek Road 1136 Rock Creek Road Gladwyne, Pennsylvania 19035 Gladwyne, Pennsylvania 19035 _______________________________________ _________________________________ GREG WOOD DENNIS ADAMS c/o D.R. International 120 Kynlyn Road 7474 No. Figueroa Street Radnor, Pennsylvania 19312 Los Angeles, California 90041 _______________________________________ _________________________________
26 ROBERT W. BAIRD & CO., INC., TTEE ROBERT W. BAIRD & CO., INC., TTEE FBO Connie Reicher IRA FBO Michael K. Reicher IRA c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 _______________________________________ _________________________________ By: Robert W. Baird By: Robert W. Baird Its: Trustee Its: Trustee CONNIE REICHER TRUST MICHAEL REICHER TRUST c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 _______________________________________ _________________________________ By: Connie Reicher By: Michael Reicher Its: Trustee Its: Trustee KENNETH GIMBEL STEPHANIE HEITMEYER 2455 Montgomery Avenue 17759 Road, Route 66 Highland Park, Ill. 60035 Ft. Jennings, Ohio 45844 _______________________________________ _________________________________ VARSHA H. SHAH HEMANT K. SHAH 29 Christy Drive 29 Christy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 _______________________________________ _________________________________ VARSHA H. SHAH AS CUSTODIAN VARSHA H. SHAH AS CUSTODIAN FOR SACHIN H. SHAH FOR SUMEET H. SHAH 29 Christy Drive 29 Christy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 _______________________________________ _________________________________ By: Varshah H. Shah By: Varshah H. Shah Its: Custodian Its: Custodian
27 MICHAEL RAINISCH ILENE RAINISCH c/o Alvin Rainisch c/o Alvin Rainisch 31 Congressional Road 35 Congressional Road Jackson, New Jersey 08527 Jackson, New Jersey 08527 _______________________________________ _________________________________
28 GALEN GALEN PARTNERS III, L.P. By: Claudius, L.L.C., General Partner 610 Fifth Avenue, 5th Fl. New York, New York 10019 ______________________________________ By: Srini Conjeevaram Its: General Partner GALEN EMPLOYEE FUND III, L.P. GALEN PARTNERS INTERNATIONAL, III, By: Wesson Enterprises, Inc. L.P. 610 Fifth Avenue, 5th Floor By: Claudius, L.L.C., General Partner New York, New York 10020 610 Fifth Avenue, 5th Floor New York, New York 10020 ______________________________________ _____________________________________ By: Bruce F. Wesson By: Srini Conjeevaram Its: General Partner Its: General Partner
29 SCHEDULE 1 SCHEDULE OF INVESTORS Watson: Watson Pharmaceuticals, Inc. 311 Bonnie Circle Corona, California 92880 Attention: Michael Boxer Tel: ____________________ Fax: ____________________ 2002 HOLDERS GALEN PARTNERS III, L.P. GALEN PARTNERS INTERNATIONAL, III, L.P. By: Claudius, L.L.C., General Partner By: Claudius, L.L.C., General Partner 610 Fifth Avenue, 5th Fl. 610 Fifth Avenue, 5th Floor New York, New York 10019 New York, New York 10020 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ GALEN EMPLOYEE FUND III, L.P. ESSEX WOODLANDS VENTURES FUND V, L.P. By: Wesson Enterprises, Inc. By: Essex Woodlands Health Ventures V, 610 Fifth Avenue, 5th Floor L.L.C., Its General Partner New York, New York 10020 190 South LaSalle Street, Suite 2800 Chicago, IL 60603 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ CARE CAPITAL INVESTMENTS II, LP BERNARD SELZ c/o Furman Selz By: Care Capital II, LLC, as general 230 Park Avenue partner New York, New York 10069 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________
30 MICHAEL WEISBROT SUSAN WEISBROT 1136 Rock Creek Road 1136 Rock Creek Road Gladwyne, Pennsylvania 19035 Gladwyne, Pennsylvania 19035 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ VARSHA H. SHAH HEMANT K. SHAH 29 Christy Drive 29 Christy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ GREG WOOD GEORGE E. BOUDREAU c/o D.R. International 222 Elbow Lane 7474 No. Figueroa Street Havenford, PA 19041 Los Angeles, California 90041 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ ROGER GRIGGS c/o Tom Griggs 7300 Turfway Road Suite 300 Florence, KY 41042 Tel: ____________________ Fax: ____________________
31 1998 HOLDERS GALEN PARTNERS III, L.P. By: Claudius, L.L.C., General Partner 610 Fifth Avenue, 5th Fl. New York, New York 10019 Tel: ____________________ Fax: ____________________ GALEN EMPLOYEE FUND III, L.P. GALEN PARTNERS INTERNATIONAL, III, L.P. By: Wesson Enterprises, Inc. By: Claudius, L.L.C., General Partner 610 Fifth Avenue, 5th Floor 610 Fifth Avenue, 5th Floor New York, New York 10020 New York, New York 10020 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ ALAN SMITH PATRICK COYNE 21 Bedlow Avenue 800 Merion Square Road Newport, Rhode Island 02840 Gladwyne, PA 19035 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ MICHAEL WEISBROT SUSAN WEISBROT 1136 Rock Creek Road 1136 Rock Creek Road Gladwyne, Pennsylvania 19035 Gladwyne, Pennsylvania 19035 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ GREG WOOD DENNIS ADAMS c/o D.R. International 120 Kynlyn Road 7474 No. Figueroa Street Radnor, Pennsylvania 19312 Los Angeles, California 90041 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________
32 BERNARD SELZ ROBERT W. BAIRD & CO., INC., TTEE c/o Furman Selz FBO Michael K. Reicher IRA 230 Park Avenue c/o Halsey Drug Co., Inc. New York, New York 10069 695 North Perryville Rd. Crimson Building #2 Rockford, Ill. 61107 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ MICHAEL REICHER PETER CLEMENS c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ CONNIE REICHER TRUST STEPHANIE HEITMEYER c/o Halsey Drug Co., Inc. 17759 Road, Route 66 695 North Perryville Rd. Ft. Jennings, Ohio 45844 Crimson Building #2 Rockford, Ill. 61107 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ VARSHA H. SHAH HEMANT K. SHAH 29 Christy Drive 29 Christy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ VARSHA H. SHAH AS CUSTODIAN VARSHA H. SHAH AS CUSTODIAN FOR SACHIN H. SHAH FOR SUMEET H. SHAH 29 Christy Drive 29 Christy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________
33 1999 HOLDERS ORACLE STRATEGIC PARTNERS, L.P. GALEN PARTNERS III, L.P. By: Oracle Strategic Capital L.L.C., By: Claudius, L.L.C., General Partner General Partner 610 Fifth Avenue, 5th Fl. 200 Greenwich Avenue New York, New York 10019 3rd Floor Greenwich, CT 06830 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ GALEN EMPLOYEE FUND III, L.P. GALEN PARTNERS INTERNATIONAL, III, L.P. By: Wesson Enterprises, Inc. By: Claudius, L.L.C., General Partner 610 Fifth Avenue, 5th Floor 610 Fifth Avenue, 5th Floor New York, New York 10020 New York, New York 10020 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ ALAN SMITH PATRICK COYNE 21 Bedlow Avenue 800 Merion Square Road Newport, Rhode Island 02840 Gladwyne, PA 19035 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ MICHAEL WEISBROT SUSAN WEISBROT 1136 Rock Creek Road 1136 Rock Creek Road Gladwyne, Pennsylvania 19035 Gladwyne, Pennsylvania 19035 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________
34 GREG WOOD DENNIS ADAMS c/o D.R. International 120 Kynlyn Road 7474 No. Figueroa Street Radnor, Pennsylvania 19312 Los Angeles, California 90041 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ BERNARD SELZ c/o Furman Selz 230 Park Avenue New York, New York 10069 Tel: ____________________ Fax: ____________________
35 HOLDERS OF RECAP SHARES ORACLE STRATEGIC PARTNERS, L.P. DANIEL HILL By: Oracle Strategic Capital L.L.C., 6725 Lynch Avenue General Partner Riverbank, CA 95367 200 Greenwich Avenue 3rd Floor Greenwich, CT 06830 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ BERNARD SELZ PETER CLEMENS c/o Furman Selz c/o Halsey Drug Co., Inc. 230 Park Avenue 695 North Perryville Rd. New York, New York 10069 Crimson Building #2 Rockford, Ill. 61107 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ ALAN SMITH PATRICK COYNE 21 Bedlow Avenue 800 Merion Square Road Newport, Rhode Island 02840 Gladwyne, PA 19035 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ MICHAEL WEISBROT SUSAN WEISBROT 1136 Rock Creek Road 1136 Rock Creek Road Gladwyne, Pennsylvania 19035 Gladwyne, Pennsylvania 19035 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ GREG WOOD DENNIS ADAMS c/o D.R. International 120 Kynlyn Road 7474 No. Figueroa Street Radnor, Pennsylvania 19312 Los Angeles, California 90041 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________
36 ROBERT W. BAIRD & CO., INC., TTEE ROBERT W. BAIRD & CO., INC., TTEE FBO Connie Reicher IRA FBO Michael K. Reicher IRA c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ CONNIE REICHER TRUST MICHAEL REICHER TRUST c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ KENNETH GIMBEL STEPHANIE HEITMEYER 2455 Montgomery Avenue 17759 Road, Route 66 Highland Park, Ill. 60035 Ft. Jennings, Ohio 45844 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ VARSHA H. SHAH HEMANT K. SHAH 29 Christy Drive 29 Christy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________ VARSHA H. SHAH AS CUSTODIAN VARSHA H. SHAH AS CUSTODIAN FOR SACHIN H. SHAH FOR SUMEET H. SHAH 29 Christy Drive 29 Christy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________
37 MICHAEL RAINISCH ILENE RAINISCH c/o Alvin Rainisch c/o Alvin Rainisch 31 Congressional Road 35 Congressional Road Jackson, New Jersey 08527 Jackson, New Jersey 08527 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________
38 GALEN GALEN PARTNERS III, L.P. By: Claudius, L.L.C., General Partner 610 Fifth Avenue, 5th Fl. New York, New York 10019 Tel: ____________________ Fax: ____________________ GALEN EMPLOYEE FUND III, L.P. GALEN PARTNERS INTERNATIONAL, III, L.P. By: Wesson Enterprises, Inc. By: Claudius, L.L.C., General Partner 610 Fifth Avenue, 5th Floor 610 Fifth Avenue, 5th Floor New York, New York 10020 New York, New York 10020 Tel: ____________________ Tel: ____________________ Fax: ____________________ Fax: ____________________
39 SCHEDULE 2 BRIDGE LOAN WARRANTS See attached. 40
GALEN PARTNERS GALEN WARRANT EXERCISE GALEN PARTNERS III, INTERNATIONAL III, EMPLOYEES DATE OF WARRANT PRICE L.P. L.P. FUND III, L.P. August 12, 1998 $ 2.2100 47,646 4,611 209 September 17, 1998 $ 1.8900 23,824 2,305 104 October 2, 1998 $ 1.7300 23,824 2,305 104 October 19, 1998 $ 1.5000 7,147 692 31 October 19, 1998 $ 1.4700 35,735 3,459 156 November 6, 1998 $ 1.4700 71,471 6,917 311 December 2, 1998 $ 1.3000 654,098 59,208 2,679 March 8, 1999 $ 1.1400 64,120 5,804 262 May 3, 1999 $ 1.1200 11,863 1,073 49 January 7, 2000 $ 1.4000 23,965 2,169 99 January 21, 2000 $ 1.4300 47,931 4,339 196 February 19, 2000 $ 1.1300 23,965 2,169 99 March 4, 2000 $ 1.5500 23,965 2,169 99 August 15, 2001 $ 3.0120 140,459 12,715 576 January 9, 2002 $ 1.8370 146,157 13,230 598 January 9, 2002 $ 1.8370 66,805 6,047 273 February 1, 2002 $ 1.8700 68,518 6,202 280 March 1, 2002 $ 2.0870 68,518 6,202 280 April 1, 2002 $ 2.0100 45,678 4,135 187 May 8, 2002 $ 2.1600 1,635,580 148,044 6,696 May 8, 2002 $ 2.1600 548,142 49,614 2,244 May 8, 2002 $ 2.1600 241,586 21,867 989 June 3, 2002 $ 1.9000 215,194 19,478 881 July 23, 2002 $ 1.7200 186,772 16,905 765 July 23, 2002 $ 1.4500 82,220 7,442 337 August 5, 2002 $ 1.4200 151,245 13,690 619 September 3, 2002 $ 1.5100 121,808 11,025 499 October 1, 2002 $ 1.7545 93,386 8,453 382 November 4, 2002 $ 1.7565 11,775 1,066 48 November 12, 2002 $ 1.7730 10,151 919 42 November 21, 2002 $ 1.5770 24,971 2,260 102 ------------------------------------------------------------- 4,918,519 446,514 20,196 =============================================================
41

                                                                   EXHIBIT 10.17

                       WARRANT RECAPITALIZATION AGREEMENT

This WARRANT RECAPITALIZATION AGREEMENT is dated as of December 20, 2002,
between Halsey Drug Co., Inc., a New York corporation (the "Company"), and the
Investors listed on the signature page of this Agreement (the "Investors").

                             W I T N E S S E T H :

WHEREAS, the Company desires to recapitalize (the "Recapitalization") 8,104,336
of the outstanding Warrants ("Warrants") to purchase one share of the Company's
common stock, par value $.01 per share (the "Common Stock") into an aggregate of
5,938,520 shares of the Company's Common Stock and the Investors have agreed to
participate in the Recapitalization on the terms and subject to the conditions
set forth herein;

WHEREAS, the Company is a party to a certain Debenture Purchase Agreement dated
of even date herewith with the Purchasers listed on the signature pages thereto
providing for the Company's issuance of 5% convertible senior secured debentures
due March 21, 2006 in the principal amount of up to $35 million (the "Purchase
Agreement") and it is a condition to the completion of the transactions
contemplated in the Purchase Agreement that the Recapitalization shall be
completed in accordance with the terms of this Agreement;

NOW, THEREFORE, in consideration of the mutual covenants and agreements set
forth herein and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties agree as follows:

SECTION 1.    RECAPITALIZATION OF WARRANTS

(a)      Subject to the terms and conditions hereof and in reliance upon the
representations and warranties of the Company contained herein, each Investor
agrees to tender to the Company on the Closing Date specified in Section 2
hereof, the number of Warrants set forth opposite such Investor's name on
Schedule 1 hereto to be recapitalized for, and the Company agrees to issue
and/or deliver to the Investor on the Closing Date, the number of shares of
Common Stock in certificate form as set forth opposite such Investor's name on
Schedule 1 hereto.

(b)      Each of the Company and the Investors agrees that for purposes of
calculating the number of shares of Common Stock issuable to the Investors for
the Warrants described in Schedule 1 hereto, the definition of "Fair Market
Value" as provided in Section 3(b) of each of the Warrants described on Schedule
1 is hereby amended and restated to provide as follows:

"Fair Market Value"

         shall mean the average of the closing bid and asked prices of the
         Common Stock in the over-the-counter market at the close of trading
         for each of the ten (10) consecutive trading days through and
         including December 4, 2002.

(c)      The Company intends to treat the Recapitalization as a reorganization
within the meaning of Section 368(a)(1) of the U.S. Internal Revenue Code of
1986, as amended.

SECTION 2.    THE CLOSING

(a)      Subject to the terms and conditions hereof, the closing of the
Recapitalization (the "Closing") will take place at the offices of St. John &
Wayne, L.L.C., Two Penn Plaza East, Newark, New Jersey 07105 at 10:00 a.m. local
time on the earliest practicable date following satisfaction or waiver of the
conditions set forth in Section 6 hereof and concurrent with the closing of the
transactions contemplated in the Purchase Agreement. Such time and date are
herein referred to as the "Closing Date".

(b)      Subject to the terms and conditions hereof, on the Closing Date (i)
the Company will deliver to each Investor a certificate registered in such
Investor's name (or the name of its nominee, if any, as specified on Schedule 1
hereto) evidencing the number of shares of Common Stock set forth opposite such
Investor's name on Schedule 1 hereto, and (ii) the Investor will deliver to the
Company certificates evidencing the number of Warrants set forth opposite such
Investor's name on Schedule 1 hereto.

SECTION 3.    REPRESENTATIONS AND WARRANTIES OF THE COMPANY

The Company represents and warrants to the Investors as follows as of the date
hereof and as of the Closing Date:

3.1      Corporate Power and Authority.

The Company is duly organized, validly existing and in good standing under the
laws of the State of New York. The Company has all requisite corporate power and
authority to enter into and deliver this Agreement and to perform its
obligations hereunder and to consummate the transactions contemplated by this
Agreement. The execution, delivery and performance of this Agreement by the
Company have been duly authorized by all necessary corporate action on the part
of the Company. This Agreement has been duly executed and delivered by the
Company and (assuming due authorization, execution and delivery by each
Investor) constitutes the legal, valid and binding obligation of the Company
enforceable against the Company in accordance with its terms subject to (a)
applicable bankruptcy, insolvency, fraudulent conveyance and other similar laws,
and (b) general principles of equity, including equitable defenses and limits as
to the availability of equitable remedies, whether such principles are
considered in a proceeding at law or in equity.

3.2      Capitalization of the Company.

As of the date of this Agreement, the Company's authorized capital stock
consists solely of 80,000,000 shares of Common Stock, of which 15,065,240 shares
are outstanding and 66,037,354 shares are reserved for issuance upon conversion
of outstanding convertible debentures, common stock purchase warrants and stock
options. All of the issued and outstanding shares of capital stock of the
Company (i) have been duly authorized and validly

                                       2

issued, (ii) are fully paid and non-assessable and (iii) have been offered,
issued, sold and delivered by the Company in compliance with applicable Federal
and state securities laws.

3.3      Conflicts; Consents and Approvals.

The execution and delivery of this Agreement and the consummation of the
transactions contemplated by this Agreement do not and will not (a) violate,
conflict with, or result in a breach of any provision of, or constitute a
default under, the Company's Certificate of Incorporation, as amended, or
By-laws; (b) violate, or conflict with, or result in a breach of any provision
of, or constitute a default (or an event which, with the giving of notice or
lapse of time or both, would become a default) under, or entitle any party to
terminate, accelerate, modify or cause a default under, or result in the
creation of any encumbrance or lien upon any of the properties or assets of the
Company under, any of the terms, conditions or provisions of any note, bond,
mortgage, indenture, deed of trust, license, contract, undertaking, agreement,
lease or other instrument or obligation to which the Company is a party; (c)
violate any order, writ, injunction, decree, statute, rule or regulation
applicable to the Company; or (d) other than required filings with the
Securities and Exchange Commission (the "Commission") or with state securities
regulators pursuant to state securities or "blue sky" laws, require any action
or consent or approval of, or review by, or registration or material filing by
the Company with, any third party or any local, state or federal court, arbitral
tribunal, administrative agency or commission or other governmental or
regulatory body, agency, instrumentality or authority, except, with respect to
clauses (b), (c) and (d), as would not have a material adverse effect on the
Company.

3.4      Board Recommendation.

In accordance with the applicable provisions of the New York Business
Corporation Law and the Company's Certificate of Incorporation, as amended, and
By-laws, the Board of Directors of the Company, at a meeting duly called and
held, at which a quorum was present throughout, upon the recommendation of an
independent committee of the Board of Directors, has adopted a resolution
proposing and declaring the advisability of this Agreement and the transactions
contemplated hereby.

3.5      Litigation.

As of the date immediately preceding the date hereof, to the Company's
knowledge, there are no actions, suits or proceedings pending against the
Company (or any of its properties, rights or franchises), at law or in equity,
or before any federal or state commission, board, bureau, agency, regulatory or
administrative instrumentality or other governmental authority or any arbitrator
or arbitration tribunal, that would be reasonably expected to, individually or
in the aggregate, prevent, materially impair or materially delay the
consummation of the transactions contemplated hereby.

3.6      Other Information.

Since December 31, 2001, except as disclosed on Schedule 2 hereto or in the
Company's quarterly reports on Form 10-Q for the quarter and nine months ended
September 30, 2002, (a)

                                       3

the business of the Company has been conducted in the ordinary course, and (b)
there have been no material adverse changes in the assets, properties,
liabilities, business, affairs, results of operations, condition (financial or
otherwise) or prospects of the Company. There are no material liabilities of the
Company which would be required to be provided for in a consolidated balance
sheet of the Company prepared in accordance with United States generally
accepted accounting principles consistently applied, other than liabilities
provided for in the historical financial statements included in the Company's
filings with the Commission pursuant to the Securities Exchange Act of 1934, as
amended (the "Exchange Act.").

3.7      SEC Reports.

The Company has filed all proxy statements, reports and other documents required
to be filed by it under the Exchange Act. The Company has furnished each
Investor with copies of (a) its Annual Report on Form 10-K for the fiscal year
ended December 31, 2001, (b) its Quarterly Report on Form 10-Q for the quarter
and nine months ended September 30, 2002, and (c) its Proxy Statement dated May
7, 2001 (collectively, the "SEC Reports"). Each SEC Report was in substantial
compliance with the requirements of its respective form and none of the SEC
Reports, nor the financial statements (and the notes thereto) included in the
SEC Reports, as of their respective dates or as subsequently supplemented or
amended, contained any untrue statement of a material fact or omitted to state a
material fact required to be stated therein or necessary to make the statements
therein, in light of the circumstances under which they were made, not
misleading.

SECTION 4.    REPRESENTATIONS AND WARRANTIES OF THE INVESTORS

Each Investor, on a several and not joint basis, represents and warrants to the
Company as follows as of the date hereof and as of the Closing Date:

4.1      Corporate Power and Authority.

The Investor has all requisite power, authority and legal right to execute,
deliver, enter into, consummate the transactions contemplated by and perform its
obligations under this Agreement. The execution, delivery and performance of
this Agreement by the Investor have been duly authorized by all required
corporate and other actions. The Investor has duly executed and delivered this
Agreement and this Agreement constitutes the legal, valid and binding
obligations of the Investor enforceable against the Investor in accordance with
its terms, subject to bankruptcy, insolvency, reorganization, moratorium,
fraudulent transfer and other similar laws relating to the rights of creditors
generally from time to time in effect, to general principles of equity,
including without limitation, concepts of materiality, reasonableness, good
faith and fair dealing, regardless of whether in a proceeding in equity or at
law.

4.2      Investment Intent.

The Investor is acquiring the Common Stock to be delivered in the
Recapitalization for its own account for investment and not with a view to, or
for resale in connection with, any distribution thereof in violation of
applicable securities laws; provided, however, that the Investor may

                                       4

transfer record and/or beneficial ownership of the Common Stock to one or more
affiliates, officers or employees of affiliates so long as the transfer is made
in compliance with the Securities Act of 1933, as amended (the "Securities
Act"), and applicable state laws. The Investor understands that none of the
Common Stock to be received in the Recapitalization has been registered under
the Securities Act. If the Investor should in the future decide to dispose of
any of its Common Stock, it is understood that it may do so only in compliance
with the Securities Act, applicable securities laws and this Agreement. The
Investor is an "accredited investor" as defined in Rule 501(a) under the
Securities Act.

4.3      Access.

The Investor has had access to such financial and other information, and has
been afforded the opportunity to ask such questions of representatives of the
Company, including the Chairman and the Chief Financial Officer, and receive
answers with respect thereto, as the Investor deems necessary in connection with
its decision to participate in the Recapitalization.

4.4      Investor Qualification.

(a)      The Investor owns the Warrants set forth opposite the Investor's name
in Schedule 1 hereto.

(b)      The Investor (alone or with the aid of its investment advisors) has
such knowledge and experience in financial and business matters that the
Investor is capable of evaluating the merits and risks of its investment in the
Common Stock.

(c)      The Investor is able to bear the economic risk of an investment in the
Common Stock and has the ability to hold the Common Stock to be acquired by such
Investor indefinitely and the ability to suffer a complete loss of such
investment.

(d)      The Investor is familiar with the type of investment which the Common
Stock constitutes and has reviewed the investment in the Common Stock subscribed
herein with tax and legal counsel and investment representatives to the extent
deemed advisable. The Investor believes that the Common Stock and the amount of
such Investor's investment are consistent with such Investor's overall
investment program and financial position.

(e)      All information the Investor has supplied to the Company is true and
accurate.

(f)      The Investor will immediately notify the Company if any of the
representations and warranties made herein become untrue.

SECTION 5.    TRANSFER OF SECURITIES

5.1      Restrictions.

Each Investor agrees that it will not sell or otherwise dispose of any Common
Stock, unless such Common Stock shall have been registered under the Securities
Act and, to the extent required,

                                       5

under any applicable state securities laws, or pursuant to an applicable
exemption from such registration requirements. The Company may endorse on all
certificates evidencing the Common Stock a legend stating or referring to such
transfer restrictions and require, as a condition to transfer, from such
Investor and any proposed transferee of such Investor, such certifications,
legal opinions or other information as the Company may reasonably require to
confirm that such transfer is being made in compliance with, pursuant to an
exemption from, or in a transaction not subject to, the registration
requirements of the Securities Act or any state securities laws; provided,
however, that no such legend shall be endorsed on any such certificates which,
when issued, are no longer subject to the restrictions of this Section 5.

SECTION 6.    CONDITIONS PRECEDENT

6.1      Conditions to Each Party's Obligation.

The respective obligation of each party to effect the Recapitalization shall be
subject to the condition that no statute, rule, regulation, executive order,
decree, temporary restraining order, preliminary or permanent injunction or
other order issued by any court of competent jurisdiction or other governmental
entity or other legal restraint or prohibition preventing the consummation of
the Recapitalization shall be in effect; provided, however, that each of the
parties shall have used reasonable efforts to prevent the entry of any such
injunction or other order and to appeal as promptly as possible any injunction
or other order that may be entered.

6.2      Conditions to the Company's Obligation.

The obligation of the Company to effect the Recapitalization shall be subject to
the satisfaction at or prior to the Closing Date of the following additional
conditions (any of which may be waived by the Company): (a) Each of the
Investors shall have performed in all material respects each of its agreements
contained in this Agreement required to be performed at or prior to the Closing
Date, and (b) each of the representations and warranties of each of the
Investors contained in this Agreement shall be true and correct in all material
respects on and as of the Closing Date as if made on and as of such date (other
than to the extent that any such representation and warranty, by its terms, is
expressly limited to a specific date, in which case such representation and
warranty shall be true and correct in all material respects as of such date).

6.3      Conditions to the Investors' Obligations.

The obligation of the Investors to effect the Recapitalization shall be subject
to the satisfaction at or prior to the Closing Date of the following additional
conditions (any of which may be waived by such Investor): (a) The Company shall
have performed in all material respects each of its agreements contained in this
Agreement required to be performed at or prior to the Closing Date, and (b) each
of the representations and warranties of the Company contained in this Agreement
shall be true and correct in all material respects on and as of the Closing Date
as if made on and as of such date (other than to the extent that any such
representation and warranty, by its terms, is expressly limited to a specific
date, in which case such representation and warranty shall be true and correct
in all material respects as of such date).

                                       6

SECTION 7.    INDEMNIFICATION

(a)      The representations, warranties, covenants and agreements of the
Company and the Investors contained in this Agreement or in any document or
certificate delivered pursuant hereto or thereto or in connection herewith shall
survive, and shall continue in effect following, the execution and delivery of
this Agreement and the Closing for a period of two (2) years from the date of
this Agreement.

(b)      The Company agrees to indemnify and hold the Investors harmless from
and against any loss, damage, liability or expense (including amounts paid in
settlement and reasonable attorneys' fees and expenses) to the Investors
resulting from any breach of the representations, warranties, covenants or
agreements of the Company contained in this Agreement or any other document or
certificate delivered by the Company pursuant hereto or thereto or in connection
herewith or therewith; provided, however, that the Company shall not be required
to indemnify the Investors for any diminution in the value of the Common Stock.

SECTION 8.    MISCELLANEOUS

8.1      Governing Law.

This Agreement and the rights of the parties hereunder shall be governed in all
respects by the laws of the State of New York wherein the terms of this
Agreement were negotiated, excluding to the greatest extent permitted by law any
rule of law that would cause the application of the laws of any jurisdiction
other than the State of New York.

8.2      Specific Performance.

The transactions contemplated by this Agreement are unique. Accordingly, each of
the parties acknowledges and agrees that, in addition to all other remedies to
which it may be entitled, each of the parties hereto is entitled to a decree of
a specific performance and injunctive and other equitable relief.

8.3      Amendments and Waiver.

The terms and provisions of this Agreement may be amended, waived, modified or
terminated only with the written consent of (1) the Company, and (2) the holders
of two-thirds of the outstanding Warrants; provided, however, that no such
amendment, waiver, modification or termination shall change this Section 8.4
without the written consent of all of the Investors then holding Warrants.

8.4      Successors and Assigns.

Except as otherwise expressly provided herein, the provisions hereof shall inure
to the benefit of, and be binding upon and enforceable by and against, the
parties hereto and their respective successors, assigns, heirs, executors and
administrators. No party may assign any of its rights

                                       7

hereunder without the prior written consent of the other parties; provided,
however, that any Investor may assign any of its rights under this Agreement to
any affiliate of such Investor.

8.5      Entire Agreement.

This Agreement (including the Schedules hereto) and the other documents
delivered pursuant hereto and simultaneously herewith constitute the full and
entire understanding and agreement between the parties with regard to the
subject matter hereof and thereof.

8.6      Notices, etc.

All notices, demands or other communications given hereunder shall be in writing
and shall be sufficiently given if transmitted by facsimile or delivered either
personally or by a nationally recognized courier service marked for next
business day delivery or sent in a sealed envelope by first class mail, postage
prepaid and either registered or certified, return receipt requested, addressed
as follows:

                  (a)      if to the Company:

                           Halsey Drug Co., Inc.
                           695 N. Perryville Road
                           Rockford, Illinois
                           Attention: Mr. Michael Reicher
                           Chief Executive Officer
                           Facsimile: (815) 399-9710

                  (b)     if to an Investor, to the address set forth on the
                          signature pages hereto, or to such other address with
                          respect to any party hereto as such party may from
                          time to time notify (as provided above) the other
                          parties hereto. Any such notice, demand or
                          communication shall be deemed to have been given (i)
                          on the date of delivery, if delivered personally, (ii)
                          on the date of facsimile transmission, receipt
                          confirmed, (iii) one business day after delivery to a
                          nationally recognized overnight courier service, if
                          marked for next day delivery or (iv) five business
                          days after the date of mailing, if mailed. Copies of
                          any notice, demand or communication given to the
                          Company, shall be delivered to St. John & Wayne,
                          L.L.C., Two Penn Plaza East, Newark, New Jersey
                          07105-2249 Attn.: John P. Reilly, Esq., or such other
                          address as may be directed.

8.7      Delays or Omissions.

No delay or omission to exercise any right, power or remedy accruing to any
party to this Agreement upon any breach or default of any other party to this
Agreement shall impair any such right, power or remedy of such party nor shall
it be construed to be a waiver of any such breach or default, or an
acquiescence, therein, or of or in any similar breach or default thereafter
occurring; nor shall any waiver of any single breach or default be deemed a
waiver of any other breach or default theretofore or thereafter occurring. Any
waiver, permit, consent or approval of any kind or character on the part of any
party of any breach or default under this Agreement, or

                                       8

any waiver on the part of any holder of any provisions or conditions of this
Agreement must be, made in writing and shall be effective only to the extent
specifically set forth in such writing. All remedies, either under this
Agreement or by law or otherwise afforded to any party, shall be cumulative and
not alternative.

8.8      Independence of Covenants and Representations and Warranties.

All covenants hereunder shall be given independent effect so that if a certain
action or condition constitutes a default under a certain covenant, the fact
that such action or condition is permitted by another covenant shall not affect
the occurrence of such default. In addition, all representations and warranties
hereunder shall be given independent effect so that if a particular
representation or warranty proves to be incorrect or is breached, the fact that
another representation or warranty concerning the same or similar subject matter
is correct or is not breached will not affect the incorrectness of or a breach
of a representation and warranty hereunder.

8.9      Rights and Obligations; Severability.

Unless otherwise expressly provided herein, each Investor's rights and
obligations hereunder are several rights and obligations, not rights and
obligations jointly held with any other person. In case any provision of this
Agreement shall be invalid, illegal or unenforceable, the validity, legality and
enforceability of the remaining provisions shall not in any way be affected or
impaired thereby.

8.10     Expenses.

All costs and expenses incurred in connection with this Agreement and the
transactions contemplated by this Agreement shall be the responsibility of and
shall be paid by the party incurring such fees and expenses, whether or not the
transactions contemplated by this Agreement are consummated.

8.11     Jurisdiction.

         (a)      Each of the parties hereto hereby irrevocably and
unconditionally submits, for itself and its property, to the nonexclusive
jurisdiction of any New York State court or United States Federal court sitting
in New York City, and any appellate court from any thereof, in any action or
proceeding arising our of or relating to this Agreement or for recognition or
enforcement of any judgment, and each of the parties hereto irrevocably and
unconditionally agrees that all claims in respect of any such action or
proceeding may be heard and determined in any such New York State court or, to
the fullest extent permitted by law, in such United States Federal court. Each
of the parties hereto agrees that a final judgment in any such action or
proceeding shall be conclusive and may be enforced in other jurisdictions by
suit on the right that any party may otherwise have to bring any action or
proceeding relating to this Agreement in the courts of any other jurisdiction.

         (b)      Each of the parties hereto irrevocably and unconditionally
waives, to the fullest extent it may legally and effectively do so, any
objection that it may now or hereafter have to the laying of venue of any suit,
action or proceeding arising out of or in relation to this Agreement in

                                       9

any such New York State or United States Federal court sitting in New York City.
Each of the parties hereto hereby irrevocably waives, to the fullest extent
permitted by law, the defense of an inconvenient forum to the maintenance of
such action or proceeding in any such court.

8.12     Titles and Subtitles. The titles of the articles, sections and
subsections of this Agreement are for convenience of reference only and are not
to be considered in construing this Agreement.

8.13     Counterparts. This Agreement may be executed in any number of
counterparts, each of which shall be an original, but all of which together
shall constitute one instrument.

8.14     Waiver of Jury Trial.

EACH OF THE PARTIES HERETO HEREBY IRREVOCABLY WAIVES ALL RIGHT TO TRIAL BY JURY
IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR
OTHERWISE) ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE ACTIONS OF ANY
PARTY IN THE NEGOTIATION, ADMINISTRATION, PERFORMANCE OR ENFORCEMENT HEREOF.

                                       10

         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
executed as of the date first above written.

HALSEY DRUG CO., INC.

By:____________________
Name: _________________
Title: ________________

INVESTORS

                                          
ORACLE STRATEGIC PARTNERS, L.P.              DANIEL HILL
By: Oracle Strategic Capital L.L.C.,         6725 Lynch Avenue
General Partner                              Riverbank, CA 95367
200 Greenwich Avenue
3rd Floor
Greenwich, CT 06830

_______________________________________      ___________________________________
By:  Joel Liffmann
Its: Authorized Agent

ALAN SMITH                                   PATRICK COYNE
21 Bedlow Avenue                             800 Merion Square Road
Newport, Rhode Island 02840                  Gladwyne, PA 19035

_______________________________________      ___________________________________

MICHAEL WEISBROT                             SUSAN WEISBROT
1136 Rock Creek Road                         1136 Rock Creek Road
Gladwyne, Pennsylvania 19035                 Gladwyne, Pennsylvania 19035

_______________________________________      ___________________________________

GREG WOOD                                    DENNIS ADAMS
c/o D.R. International                       120 Kynlyn Road
7474 No. Figueroa Street                     Radnor, Pennsylvania 19312
Los Angeles, California 90041

_______________________________________      ___________________________________
11 BERNARD SELZ ROBERT W. BAIRD & CO., INC., TTEE c/o Furman Selz FBO Michael K. Reicher IRA 230 Park Avenue c/o Halsey Drug Co., Inc. New York, New York 10069 695 North Perryville Rd. Crimson Building #2 Rockford, Ill. 61107 _______________________________________ ___________________________________ By: Michael K. Reicher Its: Trustee CONNIE REICHER TRUST PETER CLEMENS c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Ill. 61107 Rockford, Ill. 61107 _______________________________________ ___________________________________ By: Connie Reicher Its: Trustee KENNETH GIMBEL STEFANIE HEITMEYER 2455 Montgomery Avenue C/o Halsey Drug Co., Inc. Highland Park, Ill. 60035 695 North Perryville Rd. Crimson Building #2 Rockford, Ill. 61107 _______________________________________ ___________________________________ VARSHA H. SHAH HEMANT K. SHAH 29 Chrissy Drive 29 Chrissy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 _______________________________________ ___________________________________ VARSHA H. SHAH AS CUSTODIAN VARSHA H. SHAH AS CUSTODIAN FOR SACHIN H. SHAH FOR SUMEET H. SHAH 29 Chrissy Drive 29 Chrissy Drive Warren, New Jersey 07059 Warren, New Jersey 07059 _______________________________________ ___________________________________ By: Varshah H. Shah By: Varshah H. Shah Its: Custodian Its: Custodian
12 MICHAEL RAINISCH ILENE RAINISCH c/o Alvin Rainisch c/o Alvin Rainisch 315 Devon Place 315 Devon Place Morganville, New Jersey 07751 Morganville, New Jersey 07751 _______________________________________ ___________________________________ ROBERT W. BAIRD & CO., INC., TTEE ROBERT W. BAIRD & CO., INC., TTEE FBO Michael K. Reicher IRA FBO Connie Reicher IRA c/o Halsey Drug Co., Inc. c/o Halsey Drug Co., Inc. 695 North Perryville Rd. 695 North Perryville Rd. Crimson Building #2 Crimson Building #2 Rockford, Illinois 61107 Rockford, Illinois 61107 _______________________________________ ___________________________________ By: Robert W. Baird By: Robert W. Baird Its: Trustee Its: Trustee MICHAEL REICHER TRUST c/o Halsey Drug Co., Inc. 695 North Perryville Rd. Crimson Building #2 Rockford, Illinois 61107 _______________________________________ By: Michael K. Reicher Its: Trustee
13 SCHEDULE 1 INVESTOR WARRANTS 14

                                                                    EXHIBIT 99.1

Contact: Halsey Pharmaceuticals
Investor Relations - Peter A. Clemens, Vice President & CFO
                     (815) 399-2060

                              FOR IMMEDIATE RELEASE

            HALSEY PHARMACEUTICALS ANNOUNCES COMPLETION OF FINANCING

ROCKFORD, IL, DECEMBER 23, 2002: Halsey Pharmaceuticals (OTC.BB-HDGC) today
announced that it has completed a private offering of 5% convertible senior
debentures in the aggregate principal amount of approximately $26,385,000. The
lead investors in the offering were Essex Woodlands Health Ventures, Care
Capital LLC and Galen Partners III. A portion of this financing represents the
conversion of the Company's outstanding $15 million bridge loans and accrued
interest thereon into the new Debentures. The terms of the offering provide for
additional investors in an amount that would raise the total aggregate principal
amount of the offering to $35,000,000.

The new Debentures, which mature at March 31, 2006, are convertible into shares
of the Company's Common Stock at a price of $.34 per share and represent a
fully-diluted ownership interest of approximately 36% of the Company.

The Company intends to use the funds to proceed with development of its
proprietary opiate technology for use in the manufacture of controlled substance
active pharmaceutical ingredients as well as finished dosage products for pain
management.

As part of the offering, the Company recapitalized warrants to purchase
8,145,736 shares into 5,970,083 shares of the Company's Common Stock. As a
result, the Company's outstanding shares of Common Stock increased to 21,035,323
shares. Additionally, the Company restructured the terms of its outstanding
convertible debentures to extend the maturity date of such debentures from March
15, 2003 to March 31, 2006.

As a condition to the completion of the Debenture offering, the Company and
Watson Pharmaceuticals amended the terms of the Watson Term Loan Agreement with
the Company to (i) include in the principal amount of the Watson Term Loan the
Company's outstanding payment obligation to Watson of approximately $4 million
under a product supply agreement between the parties, and (ii) extend the
maturity date of the Watson Term Loan from March 31, 2003 to March 31, 2006. In
consideration for the amendments to the Watson Term Loan Agreement, the Company
issued to Watson a common stock purchase warrant exercisable for 10,700,665
shares of the Company's Common Stock at an exercise price per share equal to the
conversion price of the new Debentures.

After giving effect to the issuance of the new Debentures, the Watson Warrant,
the warrant recapitalization and the dilution protection provisions in the
Company's outstanding debentures and warrants, the Company has outstanding
securities convertible into an aggregate of approximately 201,390,000 shares of
the Company's Common Stock.

Commenting, Michael Reicher, Chairman & CEO said, "We see tremendous
opportunities in our areas of strategic focus concentrating on pain management
and are delighted that Essex Woodlands Health Ventures and Care Capital LLC as
well as Galen Partners have demonstrated confidence in our business model by
making this investment".

Halsey Pharmaceuticals, together with its subsidiaries, is an emerging
pharmaceutical company specializing in innovative drug development.

The statements in this press release are forward looking and are made pursuant
to the safe harbor provisions of the Private Securities Litigation Reform Act of
1995. Investors are cautioned that forward looking statements involve risk and
uncertainties which may affect Halsey's business prospects, including economic,
competitive, governmental, technological and other factors discussed in filings
with the Securities and Exchange Commission.

This and past press releases for Halsey Pharmaceuticals are available at the
Company's web site at WWW.HALSEYDRUG.COM.

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