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<link:definition>1017 - Disclosure - COMMON STOCK WARRANTS</link:definition>
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<link:definition>1018 - Disclosure - FAIR VALUE MEASUREMENTS</link:definition>
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<link:definition>1021 - Disclosure - NET LOSS PER SHARE</link:definition>
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<link:definition>1022 - Disclosure - COMMITMENTS AND CONTINGENCIES</link:definition>
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<link:definition>1024 - Disclosure - REVENUE FROM CONTRACTS WITH CUSTOMERS (Tables)</link:definition>
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<link:definition>1025 - Disclosure - PROPERTY, PLANT AND EQUIPMENT (Tables)</link:definition>
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<link:definition>1026 - Disclosure - ACCRUED EXPENSES (Tables)</link:definition>
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<link:definition>1027 - Disclosure - DEBT (Tables)</link:definition>
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<link:definition>1028 - Disclosure - COMMON STOCK WARRANTS (Tables)</link:definition>
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<link:definition>1029 - Disclosure - SHARE-BASED COMPENSATION EXPENSE (Tables)</link:definition>
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<link:definition>1030 - Disclosure - NET LOSS PER SHARE (Tables)</link:definition>
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<link:definition>1031 - Disclosure - OPERATIONS AND BASIS OF PRESENTATION - Additional Information (Detail)</link:definition>
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<link:definition>1032 - Disclosure - LICENSE AND COLLABORATION AGREEMENTS - Additional Information (Detail)</link:definition>
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<link:definition>1034 - Disclosure - REVENUE FROM CONTRACTS WITH CUSTOMERS - Additional Information (Detail)</link:definition>
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<link:definition>1040 - Disclosure - RELATED PARTY TRANSACTIONS- Additional Information (Detail)</link:definition>
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<link:definition>1042 - Disclosure - COMMON STOCK WARRANTS - Additional Information (Detail)</link:definition>
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<link:definition>1044 - Disclosure - SHARE-BASED COMPENSATION EXPENSE - Stock Option Award Activity (Detail)</link:definition>
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<link:definition>1046 - Disclosure - SHARE-BASED COMPENSATION EXPENSE - Summary of RSU Plan (Detail)</link:definition>
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<link:definition>1047 - Disclosure - SHARE-BASED COMPENSATION EXPENSE- Additional Information (Detail)</link:definition>
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<link:definition>1048 - Disclosure - INCOME TAXES - Additional Information (Detail)</link:definition>
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<link:definition>1050 - Disclosure - COMMITMENTS AND CONTINGENCIES - Additional Information (Detail)</link:definition>
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<link:definition>1051 - Disclosure - SUBSEQUENT EVENT - Additional Information (Detail)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<import namespace="http://xbrl.sec.gov/stpr/2018-01-31" schemaLocation="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd" />
<import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
<import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd" />
<import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd" />
<import namespace="http://xbrl.sec.gov/dei/2018-01-31" schemaLocation="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd" />
<import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
<import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
<import namespace="http://fasb.org/us-types/2018-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2018/elts/us-types-2018-01-31.xsd" />
<import namespace="http://fasb.org/srt/2018-01-31" schemaLocation="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd" />
<element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DocumentAndEntityInformationAbstract" substitutionGroup="xbrli:item" />
<element name="RoyaltyReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_RoyaltyReceivable" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="SalesReturnsLiabilityCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_SalesReturnsLiabilityCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="InterestPayableNoncurrentRelatedParty" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_InterestPayableNoncurrentRelatedParty" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="RevenueFromLicenseFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_RevenueFromLicenseFee" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="OtherSaleRevenuesNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_OtherSaleRevenuesNet" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="RevenueFromRoyalty" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_RevenueFromRoyalty" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="SaleRevenueGoodsNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_SaleRevenueGoodsNet" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="CostOfSalesExcludingInventoryWriteDown" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_CostOfSalesExcludingInventoryWriteDown" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ProvisionForSalesReturns" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_ProvisionForSalesReturns" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="IncreaseDecreaseInCollaborationRevenueReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_IncreaseDecreaseInCollaborationRevenueReceivable" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="IncreaseDecreaseInRoyaltyReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_IncreaseDecreaseInRoyaltyReceivable" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="IncreaseDecreaseInSalesReturnLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_IncreaseDecreaseInSalesReturnLiability" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="IncreaseDecreaseInRefundableDeposits" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_IncreaseDecreaseInRefundableDeposits" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ProceedsFromSaleOfInventory" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_ProceedsFromSaleOfInventory" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DescriptionOfOperationAndSummaryOfSignificantAccountingPoliciesDisclosureAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DescriptionOfOperationAndSummaryOfSignificantAccountingPoliciesDisclosureAbstract" substitutionGroup="xbrli:item" />
<element name="LicenseAndCollaborationAgreementsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_LicenseAndCollaborationAgreementsAbstract" substitutionGroup="xbrli:item" />
<element name="ScheduleOfPropertyPlantAndEquipmentNetCarryingValueTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_ScheduleOfPropertyPlantAndEquipmentNetCarryingValueTableTextBlock" substitutionGroup="xbrli:item" />
<element name="SummaryOfInformationAboutNonVestedStockOptionsDisclosureAbstractAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_SummaryOfInformationAboutNonVestedStockOptionsDisclosureAbstractAbstract" substitutionGroup="xbrli:item" />
<element name="LiquidityMattersAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_LiquidityMattersAbstract" substitutionGroup="xbrli:item" />
<element name="SchutteNoteMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_SchutteNoteMember" substitutionGroup="xbrli:item" />
<element name="LoanAgreementWithOxfordMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_LoanAgreementWithOxfordMember" substitutionGroup="xbrli:item" />
<element name="WorkingCapital" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_WorkingCapital" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="CashCashEquivalentsAndRefundableDeposits" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_CashCashEquivalentsAndRefundableDeposits" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DisclosureLicenseDevelopmentAndCommercializationAgreementAdditionalInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DisclosureLicenseDevelopmentAndCommercializationAgreementAdditionalInformationAbstract" substitutionGroup="xbrli:item" />
<element name="LicenseDevelopmentAndCommercializationAgreementTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_LicenseDevelopmentAndCommercializationAgreementTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="KempharmAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_KempharmAgreementMember" substitutionGroup="xbrli:item" />
<element name="EgaletAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_EgaletAgreementMember" substitutionGroup="xbrli:item" />
<element name="MainPointeAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_MainPointeAgreementMember" substitutionGroup="xbrli:item" />
<element name="SouthKoreaMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_SouthKoreaMember" substitutionGroup="xbrli:item" />
<element name="LicenseDevelopmentAndCommercializationAgreementLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_LicenseDevelopmentAndCommercializationAgreementLineItems" substitutionGroup="xbrli:item" />
<element name="PaymentForTermination" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_PaymentForTermination" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="MinimumNetSalesReachingDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_MinimumNetSalesReachingDescription" substitutionGroup="xbrli:item" />
<element name="AgreementTerminationNoticeDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_AgreementTerminationNoticeDescription" substitutionGroup="xbrli:item" />
<element name="ProceedsFromMilestonePaymentOnAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_ProceedsFromMilestonePaymentOnAgreement" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="AdditionalUpfrontPaymentReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_AdditionalUpfrontPaymentReceivable" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="LicensingAgreementRoyaltyPercentage" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_LicensingAgreementRoyaltyPercentage" substitutionGroup="xbrli:item" />
<element name="LicenseAgreementOptionProductsDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_LicenseAgreementOptionProductsDescription" substitutionGroup="xbrli:item" />
<element name="FiniteLivedIntangibleAssetsAmortizationExpenseQuarter" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_FiniteLivedIntangibleAssetsAmortizationExpenseQuarter" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DisclosureOfRevenueFromContractsWithCustomerAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DisclosureOfRevenueFromContractsWithCustomerAbstract" substitutionGroup="xbrli:item" />
<element name="ContractBalanceAndPerformanceObligationsdescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_ContractBalanceAndPerformanceObligationsdescription" substitutionGroup="xbrli:item" />
<element name="ScientificEquipmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_ScientificEquipmentMember" substitutionGroup="xbrli:item" />
<element name="ComputerHardwareAndSoftwareMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_ComputerHardwareAndSoftwareMember" substitutionGroup="xbrli:item" />
<element name="DisclosureAccruedExpensesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DisclosureAccruedExpensesAbstract" substitutionGroup="xbrli:item" />
<element name="AccountsPayableAndAccruedLiabilitiesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_AccountsPayableAndAccruedLiabilitiesTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="AccountsPayableAndAccruedLiabilitiesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_AccountsPayableAndAccruedLiabilitiesLineItems" substitutionGroup="xbrli:item" />
<element name="AccruedCostSharingExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_AccruedCostSharingExpenses" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AccruedOtherProfessionalFeesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_AccruedOtherProfessionalFeesCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="OtherAccruedTaxesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_OtherAccruedTaxesCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="FinancedInsurancePremiums" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_FinancedInsurancePremiums" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="DebtInstrumentAdditions" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_DebtInstrumentAdditions" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="DebtDiscountAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DebtDiscountAbstract" substitutionGroup="xbrli:item" />
<element name="DebtIssuanceCostsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DebtIssuanceCostsAbstract" substitutionGroup="xbrli:item" />
<element name="DebtInstrumentIssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_DebtInstrumentIssuanceCosts" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="AmortizationExpenseOfDebtInstrumentIssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_AmortizationExpenseOfDebtInstrumentIssuanceCosts" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ScheduleOfInterestExpenseTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_ScheduleOfInterestExpenseTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="ScheduleOfInterestExpenseLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_ScheduleOfInterestExpenseLineItems" substitutionGroup="xbrli:item" />
<element name="InterestExpenseDebtDiscount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_InterestExpenseDebtDiscount" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="InterestExpenseTermLoanOne" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_InterestExpenseTermLoanOne" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="InterestExpenseTermLoanTwo" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_InterestExpenseTermLoanTwo" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="InterestExpenseFinanceInsurancePolicy" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_InterestExpenseFinanceInsurancePolicy" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DebtAgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DebtAgreementAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="DebtAgreementDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DebtAgreementDomain" substitutionGroup="xbrli:item" />
<element name="OxfordTermLoanAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_OxfordTermLoanAgreementMember" substitutionGroup="xbrli:item" />
<element name="LoanAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_LoanAgreementMember" substitutionGroup="xbrli:item" />
<element name="TermLoanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_TermLoanMember" substitutionGroup="xbrli:item" />
<element name="DebtConsultingPlacementFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_DebtConsultingPlacementFee" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ClassOfWarrantOrRightExpirationDate" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_ClassOfWarrantOrRightExpirationDate" substitutionGroup="xbrli:item" />
<element name="AdditionsToDebtInstrumentUnamortizedDiscount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_AdditionsToDebtInstrumentUnamortizedDiscount" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="NumberOfCommonStockNeedToHoldToDesignateAsDirector" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_NumberOfCommonStockNeedToHoldToDesignateAsDirector" substitutionGroup="xbrli:item" />
<element name="AssetTransferredLicenseAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_AssetTransferredLicenseAgreement" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="SaleOfStockIssuePriceDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_SaleOfStockIssuePriceDescription" substitutionGroup="xbrli:item" />
<element name="ClassOfWarrantsOrRightsExpiryPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_ClassOfWarrantsOrRightsExpiryPeriod" substitutionGroup="xbrli:item" />
<element name="DisclosureOfCommonStockWarrantActivityAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DisclosureOfCommonStockWarrantActivityAbstract" substitutionGroup="xbrli:item" />
<element name="DisclosureCommonStockWarrantsAdditionalInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DisclosureCommonStockWarrantsAdditionalInformationAbstract" substitutionGroup="xbrli:item" />
<element name="ClassOfWarrantOrRightTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_ClassOfWarrantOrRightTerm" substitutionGroup="xbrli:item" />
<element name="AllocatedSharebasedCompensationExpenseAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_AllocatedSharebasedCompensationExpenseAbstract" substitutionGroup="xbrli:item" />
<element name="StockOptionPlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_StockOptionPlanMember" substitutionGroup="xbrli:item" />
<element name="SummaryOfInformationAboutNonVestedStockOptionsDisclosureTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_SummaryOfInformationAboutNonVestedStockOptionsDisclosureTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="NonVestedStockOptionsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_NonVestedStockOptionsMember" substitutionGroup="xbrli:item" />
<element name="SummaryOfInformationAboutNonVestedStockOptionsDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_SummaryOfInformationAboutNonVestedStockOptionsDisclosureLineItems" substitutionGroup="xbrli:item" />
<element name="RsusMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_RsusMember" substitutionGroup="xbrli:item" />
<element name="VestedRestrictedStockUnitsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_VestedRestrictedStockUnitsMember" substitutionGroup="xbrli:item" />
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsDistributedInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsDistributedInPeriod" substitutionGroup="xbrli:item" />
<element name="EmployeeBenefitPlansDisclosureTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_EmployeeBenefitPlansDisclosureTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="RestrictedStockAwardPlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_RestrictedStockAwardPlanMember" substitutionGroup="xbrli:item" />
<element name="RestrictedStockAwardPlanTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_RestrictedStockAwardPlanTwoMember" substitutionGroup="xbrli:item" />
<element name="FourNonEmployeeDirectorsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_FourNonEmployeeDirectorsMember" substitutionGroup="xbrli:item" />
<element name="SettledInCashMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_SettledInCashMember" substitutionGroup="xbrli:item" />
<element name="DistributedInCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DistributedInCommonStockMember" substitutionGroup="xbrli:item" />
<element name="January42016AwardDistributedMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_January42016AwardDistributedMember" substitutionGroup="xbrli:item" />
<element name="EmployeeBenefitPlansDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_EmployeeBenefitPlansDisclosureLineItems" substitutionGroup="xbrli:item" />
<element name="ShareBasedCompensationArrangementShareBasedPaymentSharesReservedForFutureDistribution" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_ShareBasedCompensationArrangementShareBasedPaymentSharesReservedForFutureDistribution" substitutionGroup="xbrli:item" />
<element name="StockIssuedDuringPeriodSharesStockOptionsExercisedNetOfSharesForTaxWithholdings" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_StockIssuedDuringPeriodSharesStockOptionsExercisedNetOfSharesForTaxWithholdings" substitutionGroup="xbrli:item" />
<element name="IncomeTaxDisclosureTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_IncomeTaxDisclosureTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="IncomeTaxDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_IncomeTaxDisclosureLineItems" substitutionGroup="xbrli:item" />
<element name="OperatingLossCarryforwardsExpirationTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_OperatingLossCarryforwardsExpirationTerm" substitutionGroup="xbrli:item" />
<element name="OperatingLossCarryForwardsExpirationYear" type="xbrli:gYearItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="acur_OperatingLossCarryForwardsExpirationYear" substitutionGroup="xbrli:item" />
<element name="ExcludedDilutiveSecuritiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_ExcludedDilutiveSecuritiesAbstract" substitutionGroup="xbrli:item" />
<element name="CommonStockIssuableAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_CommonStockIssuableAbstract" substitutionGroup="xbrli:item" />
<element name="DisclosureCommitmentsAndContingenciesAdditionalInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_DisclosureCommitmentsAndContingenciesAdditionalInformationAbstract" substitutionGroup="xbrli:item" />
<element name="CommitmentsAndContingenciesDisclosureTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_CommitmentsAndContingenciesDisclosureTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="LocationAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_LocationAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="PalatineIllinoisMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_PalatineIllinoisMember" substitutionGroup="xbrli:item" />
<element name="PurduePharmaMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_PurduePharmaMember" substitutionGroup="xbrli:item" />
<element name="CommitmentsAndContingenciesDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="acur_CommitmentsAndContingenciesDisclosureLineItems" substitutionGroup="xbrli:item" />
<element name="AccruedCostSharingExpensesClinicalStudies" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="acur_AccruedCostSharingExpensesClinicalStudies" substitutionGroup="xbrli:item" xbrli:balance="credit" />
</schema>





